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sonoma2

Id Subject Object Predicate Lexical cue
T29 543-557 DISEASE denotes cardiovascular
T30 543-580 DISEASE denotes cardiovascular and pulmonary diseases
T31 562-580 DISEASE denotes pulmonary diseases
T32 602-612 REG denotes contribute
T33 620-627 CPA denotes outcome
T34 631-639 DISEASE denotes COVID-19
T35 656-664 DISEASE denotes COVID-19
T36 749-753 GENE denotes ACE1
T37 754-772 VAR denotes insertion/deletion
T38 777-781 GENE denotes ACE2
T0 0-30 GENE denotes Angiotensin-converting enzymes
T1 32-35 GENE denotes ACE
T2 37-41 GENE denotes ACE2
T3 48-56 VAR denotes variants
T4 61-69 DISEASE denotes COVID-19
T5 70-77 CPA denotes outcome
T6 105-115 REG denotes implicated
T7 123-135 MPA denotes pathogenesis
T8 139-147 DISEASE denotes COVID-19
T9 156-160 GENE denotes ACE2
T10 168-185 MPA denotes cellular receptor
T11 206-216 MPA denotes expression
T12 224-228 GENE denotes ACE2
T13 240-248 REG denotes regulate
T14 265-279 MPA denotes susceptibility
T15 283-292 DISEASE denotes infection
T16 327-331 GENE denotes ACE1
T17 336-340 GENE denotes ACE2
T18 341-349 MPA denotes activity
T19 359-369 REG denotes implicated
T20 377-389 MPA denotes pathogenesis
T21 393-413 DISEASE denotes respiratory diseases
T22 424-428 REG denotes play
T23 431-435 REG denotes role
T24 443-451 MPA denotes severity
T39 782-804 VAR denotes rs2285666 polymorphism
T40 923-927 GENE denotes ACE2
T41 971-986 DISEASE denotes Severe COVID-19
T42 978-986 DISEASE denotes COVID-19
T43 991-1001 REG denotes associated
T44 1007-1019 DISEASE denotes hypertension
T45 1045-1057 DISEASE denotes hypertension
T46 1071-1092 DISEASE denotes hypercholesterolaemia
T47 1114-1121 GENE denotes ACE1-DD
T48 1122-1130 VAR denotes genotype
T49 1180-1192 DISEASE denotes hypertension
T50 1328-1338 REG denotes predictors
T51 1342-1350 CPA denotes severity
T52 1356-1360 GENE denotes ACE2
T53 1361-1373 VAR denotes polymorphism
T54 1382-1392 REG denotes associated
T55 1402-1417 MPA denotes disease outcome
T56 1423-1427 GENE denotes ACE2
T57 1465-1473 VAR denotes variants
T58 1485-1492 REG denotes explain
T59 1496-1505 POSREG denotes increased
T60 1525-1533 DISEASE denotes COVID-19
T61 1553-1560 POSREG denotes adverse
T62 1561-1568 CPA denotes outcome
T63 1572-1580 DISEASE denotes COVID-19
T64 1585-1595 REG denotes associated
T65 1614-1626 DISEASE denotes hypertension
T66 1628-1648 DISEASE denotes hypercholesterolemia
T67 1657-1661 GENE denotes ACE1
T68 1662-1670 VAR denotes genotype
T69 1700-1708 GENE denotes ACE1-I/D
T70 1715-1724 REG denotes influence
T71 1725-1733 DISEASE denotes COVID-19
T72 1734-1742 MPA denotes severity
T73 1752-1758 REG denotes effect
T74 1763-1772 REG denotes dependent
T75 1780-1792 DISEASE denotes hypertensive
T25 455-463 DISEASE denotes COVID-19
T26 476-485 GENE denotes ACE1/ACE2
T27 491-504 VAR denotes polymorphisms
T28 515-525 REG denotes associated
R14 T15 T14 ThemeOf infection,susceptibility
R15 T15 T13 ThemeOf infection,regulate
R36 T27 T33 CauseOf polymorphisms,outcome
R37 T29 T28 ThemeOf cardiovascular,associated
R38 T29 T32 ThemeOf cardiovascular,contribute
R39 T31 T28 ThemeOf pulmonary diseases,associated
R40 T31 T32 ThemeOf pulmonary diseases,contribute
R41 T33 T32 ThemeOf outcome,contribute
R42 T34 T33 ThemeOf COVID-19,outcome
R43 T34 T32 ThemeOf COVID-19,contribute
R44 T36 T37 ThemeOf ACE1,insertion/deletion
R45 T36 T39 ThemeOf ACE1,rs2285666 polymorphism
R46 T38 T37 ThemeOf ACE2,insertion/deletion
R47 T38 T39 ThemeOf ACE2,rs2285666 polymorphism
R48 T41 T43 ThemeOf Severe COVID-19,associated
R49 T48 T43 CauseOf genotype,associated
R50 T51 T50 ThemeOf severity,predictors
R51 T52 T53 ThemeOf ACE2,polymorphism
R52 T53 T54 CauseOf polymorphism,associated
R53 T53 T55 CauseOf polymorphism,disease outcome
R54 T55 T54 ThemeOf disease outcome,associated
R55 T56 T57 ThemeOf ACE2,variants
R56 T57 T58 CauseOf variants,explain
R57 T57 T59 CauseOf variants,increased
R58 T60 T58 ThemeOf COVID-19,explain
R59 T60 T59 ThemeOf COVID-19,increased
R0 T0 T3 ThemeOf Angiotensin-converting enzymes,variants
R1 T1 T3 ThemeOf ACE,variants
R2 T2 T3 ThemeOf ACE2,variants
R3 T7 T6 ThemeOf pathogenesis,implicated
R4 T8 T7 ThemeOf COVID-19,pathogenesis
R5 T8 T6 ThemeOf COVID-19,implicated
R6 T9 T10 ThemeOf ACE2,cellular receptor
R7 T9 T11 ThemeOf ACE2,expression
R8 T11 T10 ThemeOf expression,cellular receptor
R9 T10 T13 ThemeOf cellular receptor,regulate
R10 T11 T13 ThemeOf expression,regulate
R11 T12 T10 ThemeOf ACE2,cellular receptor
R12 T12 T11 ThemeOf ACE2,expression
R13 T14 T13 ThemeOf susceptibility,regulate
R16 T18 T19 ThemeOf activity,implicated
R17 T20 T19 ThemeOf pathogenesis,implicated
R18 T21 T20 ThemeOf respiratory diseases,pathogenesis
R19 T20 T22 ThemeOf pathogenesis,play
R20 T20 T23 ThemeOf pathogenesis,role
R21 T24 T20 ThemeOf severity,pathogenesis
R22 T21 T19 ThemeOf respiratory diseases,implicated
R23 T21 T22 ThemeOf respiratory diseases,play
R24 T21 T23 ThemeOf respiratory diseases,role
R25 T23 T22 ThemeOf role,play
R26 T24 T19 ThemeOf severity,implicated
R27 T24 T22 ThemeOf severity,play
R28 T24 T23 ThemeOf severity,role
R29 T25 T24 ThemeOf COVID-19,severity
R30 T25 T19 ThemeOf COVID-19,implicated
R31 T25 T22 ThemeOf COVID-19,play
R32 T25 T23 ThemeOf COVID-19,role
R33 T26 T27 ThemeOf ACE1/ACE2,polymorphisms
R34 T27 T28 CauseOf polymorphisms,associated
R35 T27 T32 CauseOf polymorphisms,contribute
R60 T62 T61 ThemeOf outcome,adverse
R61 T63 T62 ThemeOf COVID-19,outcome
R62 T62 T64 ThemeOf outcome,associated
R63 T63 T61 ThemeOf COVID-19,adverse
R64 T63 T64 ThemeOf COVID-19,associated
R65 T67 T68 ThemeOf ACE1,genotype
R66 T68 T61 CauseOf genotype,adverse
R67 T68 T64 CauseOf genotype,associated
R68 T71 T70 ThemeOf COVID-19,influence
R69 T71 T72 ThemeOf COVID-19,severity
R70 T71 T73 ThemeOf COVID-19,effect
R71 T71 T74 ThemeOf COVID-19,dependent
R72 T72 T70 ThemeOf severity,influence
R73 T72 T73 ThemeOf severity,effect
R74 T72 T74 ThemeOf severity,dependent
R75 T73 T74 ThemeOf effect,dependent

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 43-47 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T2 229-233 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T3 486-490 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T4 935-946 Body_part denotes nucleotides http://purl.org/sig/ont/fma/fma82740

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 61-69 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T2 139-147 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T3 190-198 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T4 283-292 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T5 393-413 Disease denotes respiratory diseases http://purl.obolibrary.org/obo/MONDO_0005087
T6 455-463 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T7 562-580 Disease denotes pulmonary diseases http://purl.obolibrary.org/obo/MONDO_0005275
T8 631-639 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T9 656-664 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T10 978-986 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T11 1007-1019 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T12 1045-1057 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T13 1119-1121 Disease denotes DD http://purl.obolibrary.org/obo/MONDO_0009107|http://purl.obolibrary.org/obo/MONDO_0015613
T15 1180-1192 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T16 1525-1533 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T17 1572-1580 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T18 1614-1626 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T19 1725-1733 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 43-47 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T2 229-233 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T3 341-349 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T4 350-353 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T5 429-430 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6 486-490 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T7 950-951 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 1020-1024 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T9 1020-1024 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T10 1238-1242 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T11 1238-1242 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T12 1601-1605 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T13 1601-1605 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 0-11 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T2 83-94 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T3 935-946 Chemical denotes nucleotides http://purl.obolibrary.org/obo/CHEBI_36976
T4 952-957 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T5 1020-1024 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T6 1119-1121 Chemical denotes DD http://purl.obolibrary.org/obo/CHEBI_73446
T7 1238-1242 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T8 1601-1605 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 123-135 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T2 377-389 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-78 Sentence denotes Angiotensin-converting enzymes (ACE, ACE2) gene variants and COVID-19 outcome.
T2 79-148 Sentence denotes The Angiotensin system is implicated in the pathogenesis of COVID-19.
T3 149-293 Sentence denotes First, ACE2 is the cellular receptor for SARS-CoV-2, and expression of the ACE2 gene could regulate the individuaĺs susceptibility to infection.
T4 294-464 Sentence denotes In addition, the balance between ACE1 and ACE2 activity has been implicated in the pathogenesis of respiratory diseases and could play a role in the severity of COVID-19.
T5 465-640 Sentence denotes Functional ACE1/ACE2 gene polymorphisms have been associated with the risk of cardiovascular and pulmonary diseases, and could thus also contribute to the outcome of COVID-19.
T6 641-744 Sentence denotes We studied 204 COVID-19 patients (137 non-severe and 67 severe-ICU cases) and 536 age-matched controls.
T7 745-821 Sentence denotes The ACE1 insertion/deletion and ACE2 rs2285666 polymorphism were determined.
T8 822-900 Sentence denotes Variables frequencies were compared between the groups by logistic regression.
T9 901-970 Sentence denotes We also sequenced the ACE2 coding nucleotides in a group of patients.
T10 971-1143 Sentence denotes Severe COVID-19 was associated with hypertension male gender (p < 0.001), hypertension (p = 0.006), hypercholesterolaemia (p = 0.046), and the ACE1-DD genotype (p = 0.049).
T11 1144-1351 Sentence denotes In the multiple logistic regression hypertension (p = 0.02, OR = 2.26, 95%CI = 1.12-4.63) and male gender (p = 0.002; OR = 3.15, 95%CI = 1.56-6.66) remained as independent significant predictors of severity.
T12 1352-1418 Sentence denotes The ACE2 polymorphism was not associated with the disease outcome.
T13 1419-1534 Sentence denotes The ACE2 sequencing showed no coding sequence variants that could explain an increased risk of developing COVID-19.
T14 1535-1671 Sentence denotes In conclusion, an adverse outcome of COVID-19 was associated with male gender, hypertension, hypercholesterolemia and the ACE1 genotype.
T15 1672-1800 Sentence denotes Our work suggested that the ACE1-I/D might influence COVID-19 severity, but the effect was dependent on the hypertensive status.
T16 1801-1864 Sentence denotes This result requires further validation in other large cohorts.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id tao:has_standard_notation
4 0-30 Gene denotes Angiotensin-converting enzymes Gene:1636
5 32-35 Gene denotes ACE Gene:1636
6 37-41 Gene denotes ACE2 Gene:59272
7 61-69 Disease denotes COVID-19 MESH:C000657245
44 139-147 Disease denotes COVID-19 MESH:C000657245
45 156-160 Gene denotes ACE2 Gene:59272
46 190-200 Species denotes SARS-CoV-2 Tax:2697049
47 224-228 Gene denotes ACE2 Gene:59272
48 283-292 Disease denotes infection MESH:D007239
49 327-331 Gene denotes ACE1 Gene:1636
50 336-340 Gene denotes ACE2 Gene:59272
51 393-413 Disease denotes respiratory diseases MESH:D012140
52 455-463 Disease denotes COVID-19 MESH:C000657245
53 476-480 Gene denotes ACE1 Gene:1636
54 481-485 Gene denotes ACE2 Gene:59272
55 543-580 Disease denotes cardiovascular and pulmonary diseases MESH:D002318
56 631-639 Disease denotes COVID-19 MESH:C000657245
57 656-664 Disease denotes COVID-19 MESH:C000657245
58 665-673 Species denotes patients Tax:9606
59 749-753 Gene denotes ACE1 Gene:1636
60 777-781 Gene denotes ACE2 Gene:59272
61 782-791 Mutation denotes rs2285666 rs2285666
62 923-927 Gene denotes ACE2 Gene:59272
63 961-969 Species denotes patients Tax:9606
64 978-986 Disease denotes COVID-19 MESH:C000657245
65 1007-1019 Disease denotes hypertension MESH:D006973
66 1045-1057 Disease denotes hypertension MESH:D006973
67 1071-1092 Disease denotes hypercholesterolaemia
68 1114-1118 Gene denotes ACE1 Gene:1636
69 1180-1192 Disease denotes hypertension MESH:D006973
70 1356-1360 Gene denotes ACE2 Gene:59272
71 1423-1427 Gene denotes ACE2 Gene:59272
72 1525-1533 Disease denotes COVID-19 MESH:C000657245
73 1572-1580 Disease denotes COVID-19 MESH:C000657245
74 1614-1626 Disease denotes hypertension MESH:D006973
75 1628-1648 Disease denotes hypercholesterolemia MESH:D006937
76 1657-1661 Gene denotes ACE1 Gene:1636
77 1700-1704 Gene denotes ACE1 Gene:1636
78 1725-1733 Disease denotes COVID-19 MESH:C000657245
79 1780-1792 Disease denotes hypertensive MESH:D006973

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 265-292 Phenotype denotes susceptibility to infection http://purl.obolibrary.org/obo/HP_0002719
T2 1007-1019 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T3 1045-1057 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T4 1180-1192 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T5 1614-1626 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T6 1628-1648 Phenotype denotes hypercholesterolemia http://purl.obolibrary.org/obo/HP_0003124

LitCovid_AGAC_only

Id Subject Object Predicate Lexical cue
p149599s10 48-56 Var denotes variants