PubMed:32881209 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/32881209","sourcedb":"PubMed","sourceid":"32881209","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/32881209","text":"Approach to the Patient with COVID-19-Associated Thrombosis: A Case-Based Review.\nCoronavirus disease 2019 (COVID-19) is a current global pandemic caused by the novel coronavirus SARS-CoV-2. Alongside its potential to cause severe respiratory illness, studies have reported a distinct COVID-19-associated coagulopathy that is characterized by elevated D-dimer levels, hyperfibrinogenemia, mild thrombocytopenia, and slight prolongation of the prothrombin time. Studies have also reported increased rates of thromboembolism in patients with COVID-19, but variations in study methodologies, patient populations, and anticoagulation strategies make it challenging to distill implications for clinical practice. Here, we present a practical review of current literature and uses a case-based format to discuss the diagnostic approach and management of COVID-19-associated coagulopathy. IMPLICATIONS FOR PRACTICE: Coronavirus disease 2019 (COVID-19)-associated coagulopathy is characterized by elevated D-dimer levels, hyperfibrinogenemia, and increased rates of thromboembolism. Current management guidelines are based on limited evidence from retrospective studies that should be interpreted carefully. At this time, all hospitalized patients with suspected or confirmed COVID-19 should receive coagulation test surveillance and standard doses of prophylactic anticoagulation until prospective randomized controlled trials yield definitive information in support of higher prophylactic doses.","tracks":[{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":29,"end":37},"obj":"Disease"},{"id":"T2","span":{"begin":49,"end":59},"obj":"Disease"},{"id":"T3","span":{"begin":82,"end":106},"obj":"Disease"},{"id":"T4","span":{"begin":108,"end":116},"obj":"Disease"},{"id":"T5","span":{"begin":179,"end":187},"obj":"Disease"},{"id":"T6","span":{"begin":285,"end":293},"obj":"Disease"},{"id":"T7","span":{"begin":305,"end":317},"obj":"Disease"},{"id":"T8","span":{"begin":394,"end":410},"obj":"Disease"},{"id":"T9","span":{"begin":540,"end":548},"obj":"Disease"},{"id":"T10","span":{"begin":848,"end":856},"obj":"Disease"},{"id":"T11","span":{"begin":868,"end":880},"obj":"Disease"},{"id":"T12","span":{"begin":909,"end":933},"obj":"Disease"},{"id":"T13","span":{"begin":935,"end":943},"obj":"Disease"},{"id":"T14","span":{"begin":956,"end":968},"obj":"Disease"},{"id":"T15","span":{"begin":1268,"end":1276},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0000831"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0001531"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0002049"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0001531"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0001531"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":61,"end":62},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T2","span":{"begin":121,"end":122},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T3","span":{"begin":274,"end":275},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T4","span":{"begin":443,"end":454},"obj":"http://purl.obolibrary.org/obo/PR_000007299"},{"id":"T5","span":{"begin":725,"end":726},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T6","span":{"begin":775,"end":776},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T7","span":{"begin":1304,"end":1308},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":1292,"end":1303},"obj":"http://purl.obolibrary.org/obo/GO_0050817"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"3","span":{"begin":16,"end":23},"obj":"Species"},{"id":"4","span":{"begin":29,"end":37},"obj":"Disease"},{"id":"5","span":{"begin":49,"end":59},"obj":"Disease"},{"id":"28","span":{"begin":82,"end":106},"obj":"Disease"},{"id":"29","span":{"begin":108,"end":116},"obj":"Disease"},{"id":"30","span":{"begin":161,"end":178},"obj":"Species"},{"id":"31","span":{"begin":179,"end":189},"obj":"Species"},{"id":"32","span":{"begin":231,"end":250},"obj":"Disease"},{"id":"33","span":{"begin":285,"end":293},"obj":"Disease"},{"id":"34","span":{"begin":305,"end":317},"obj":"Disease"},{"id":"35","span":{"begin":368,"end":387},"obj":"Disease"},{"id":"36","span":{"begin":394,"end":410},"obj":"Disease"},{"id":"37","span":{"begin":507,"end":522},"obj":"Disease"},{"id":"38","span":{"begin":526,"end":534},"obj":"Species"},{"id":"39","span":{"begin":540,"end":548},"obj":"Disease"},{"id":"40","span":{"begin":589,"end":596},"obj":"Species"},{"id":"41","span":{"begin":848,"end":856},"obj":"Disease"},{"id":"42","span":{"begin":868,"end":880},"obj":"Disease"},{"id":"43","span":{"begin":909,"end":933},"obj":"Disease"},{"id":"44","span":{"begin":935,"end":943},"obj":"Disease"},{"id":"45","span":{"begin":956,"end":968},"obj":"Disease"},{"id":"46","span":{"begin":1014,"end":1033},"obj":"Disease"},{"id":"47","span":{"begin":1058,"end":1073},"obj":"Disease"},{"id":"48","span":{"begin":1231,"end":1239},"obj":"Species"},{"id":"49","span":{"begin":1268,"end":1276},"obj":"Disease"}],"attributes":[{"id":"A3","pred":"tao:has_database_id","subj":"3","obj":"Tax:9606"},{"id":"A4","pred":"tao:has_database_id","subj":"4","obj":"MESH:C000657245"},{"id":"A5","pred":"tao:has_database_id","subj":"5","obj":"MESH:D013927"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"MESH:C000657245"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"MESH:C000657245"},{"id":"A30","pred":"tao:has_database_id","subj":"30","obj":"Tax:2697049"},{"id":"A31","pred":"tao:has_database_id","subj":"31","obj":"Tax:2697049"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"MESH:D012140"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"MESH:C000657245"},{"id":"A34","pred":"tao:has_database_id","subj":"34","obj":"MESH:D001778"},{"id":"A36","pred":"tao:has_database_id","subj":"36","obj":"MESH:D013921"},{"id":"A37","pred":"tao:has_database_id","subj":"37","obj":"MESH:D013923"},{"id":"A38","pred":"tao:has_database_id","subj":"38","obj":"Tax:9606"},{"id":"A39","pred":"tao:has_database_id","subj":"39","obj":"MESH:C000657245"},{"id":"A40","pred":"tao:has_database_id","subj":"40","obj":"Tax:9606"},{"id":"A41","pred":"tao:has_database_id","subj":"41","obj":"MESH:C000657245"},{"id":"A42","pred":"tao:has_database_id","subj":"42","obj":"MESH:D001778"},{"id":"A43","pred":"tao:has_database_id","subj":"43","obj":"MESH:C000657245"},{"id":"A44","pred":"tao:has_database_id","subj":"44","obj":"MESH:C000657245"},{"id":"A45","pred":"tao:has_database_id","subj":"45","obj":"MESH:D001778"},{"id":"A47","pred":"tao:has_database_id","subj":"47","obj":"MESH:D013923"},{"id":"A48","pred":"tao:has_database_id","subj":"48","obj":"Tax:9606"},{"id":"A49","pred":"tao:has_database_id","subj":"49","obj":"MESH:C000657245"},{"subj":"3","pred":"source","obj":"LitCovid-PubTator"},{"subj":"4","pred":"source","obj":"LitCovid-PubTator"},{"subj":"5","pred":"source","obj":"LitCovid-PubTator"},{"subj":"28","pred":"source","obj":"LitCovid-PubTator"},{"subj":"29","pred":"source","obj":"LitCovid-PubTator"},{"subj":"30","pred":"source","obj":"LitCovid-PubTator"},{"subj":"31","pred":"source","obj":"LitCovid-PubTator"},{"subj":"32","pred":"source","obj":"LitCovid-PubTator"},{"subj":"33","pred":"source","obj":"LitCovid-PubTator"},{"subj":"34","pred":"source","obj":"LitCovid-PubTator"},{"subj":"35","pred":"source","obj":"LitCovid-PubTator"},{"subj":"36","pred":"source","obj":"LitCovid-PubTator"},{"subj":"37","pred":"source","obj":"LitCovid-PubTator"},{"subj":"38","pred":"source","obj":"LitCovid-PubTator"},{"subj":"39","pred":"source","obj":"LitCovid-PubTator"},{"subj":"40","pred":"source","obj":"LitCovid-PubTator"},{"subj":"41","pred":"source","obj":"LitCovid-PubTator"},{"subj":"42","pred":"source","obj":"LitCovid-PubTator"},{"subj":"43","pred":"source","obj":"LitCovid-PubTator"},{"subj":"44","pred":"source","obj":"LitCovid-PubTator"},{"subj":"45","pred":"source","obj":"LitCovid-PubTator"},{"subj":"46","pred":"source","obj":"LitCovid-PubTator"},{"subj":"47","pred":"source","obj":"LitCovid-PubTator"},{"subj":"48","pred":"source","obj":"LitCovid-PubTator"},{"subj":"49","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T1","span":{"begin":231,"end":250},"obj":"Phenotype"},{"id":"T2","span":{"begin":305,"end":317},"obj":"Phenotype"},{"id":"T3","span":{"begin":343,"end":359},"obj":"Phenotype"},{"id":"T4","span":{"begin":368,"end":387},"obj":"Phenotype"},{"id":"T5","span":{"begin":394,"end":410},"obj":"Phenotype"},{"id":"T6","span":{"begin":423,"end":459},"obj":"Phenotype"},{"id":"T7","span":{"begin":507,"end":522},"obj":"Phenotype"},{"id":"T8","span":{"begin":868,"end":880},"obj":"Phenotype"},{"id":"T9","span":{"begin":956,"end":968},"obj":"Phenotype"},{"id":"T10","span":{"begin":989,"end":1005},"obj":"Phenotype"},{"id":"T11","span":{"begin":1014,"end":1033},"obj":"Phenotype"},{"id":"T12","span":{"begin":1058,"end":1073},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0002086"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0003256"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0033106"},{"id":"A4","pred":"hp_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/HP_0011899"},{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0001873"},{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0008151"},{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0001907"},{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0003256"},{"id":"A9","pred":"hp_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/HP_0003256"},{"id":"A10","pred":"hp_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/HP_0033106"},{"id":"A11","pred":"hp_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/HP_0011899"},{"id":"A12","pred":"hp_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/HP_0001907"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":60},"obj":"Sentence"},{"id":"T2","span":{"begin":61,"end":81},"obj":"Sentence"},{"id":"T3","span":{"begin":82,"end":190},"obj":"Sentence"},{"id":"T4","span":{"begin":191,"end":460},"obj":"Sentence"},{"id":"T5","span":{"begin":461,"end":707},"obj":"Sentence"},{"id":"T6","span":{"begin":708,"end":881},"obj":"Sentence"},{"id":"T7","span":{"begin":882,"end":908},"obj":"Sentence"},{"id":"T8","span":{"begin":909,"end":1074},"obj":"Sentence"},{"id":"T9","span":{"begin":1075,"end":1199},"obj":"Sentence"},{"id":"T10","span":{"begin":1200,"end":1489},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-sentences"},{"subj":"T2","pred":"source","obj":"LitCovid-sentences"},{"subj":"T3","pred":"source","obj":"LitCovid-sentences"},{"subj":"T4","pred":"source","obj":"LitCovid-sentences"},{"subj":"T5","pred":"source","obj":"LitCovid-sentences"},{"subj":"T6","pred":"source","obj":"LitCovid-sentences"},{"subj":"T7","pred":"source","obj":"LitCovid-sentences"},{"subj":"T8","pred":"source","obj":"LitCovid-sentences"},{"subj":"T9","pred":"source","obj":"LitCovid-sentences"},{"subj":"T10","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-MONDO","color":"#93ecaa","default":true},{"id":"LitCovid-PD-CLO","color":"#ec9395"},{"id":"LitCovid-PD-GO-BP","color":"#93afec"},{"id":"LitCovid-PubTator","color":"#c9ec93"},{"id":"LitCovid-PD-HP","color":"#ec93e3"},{"id":"LitCovid-sentences","color":"#93ecdb"}]}]}}