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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 1382-1393 Body_part denotes bone marrow http://purl.org/sig/ont/fma/fma9608
T2 1437-1446 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T3 1448-1458 Body_part denotes leukocytes http://purl.org/sig/ont/fma/fma62852
T4 1464-1474 Body_part denotes hemoglobin http://purl.org/sig/ont/fma/fma62293
T5 1739-1750 Body_part denotes bone marrow http://purl.org/sig/ont/fma/fma9608

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1382-1393 Body_part denotes bone marrow http://purl.obolibrary.org/obo/UBERON_0002371
T2 1739-1750 Body_part denotes bone marrow http://purl.obolibrary.org/obo/UBERON_0002371

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 54-62 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T2 63-74 Disease denotes pneumonitis http://purl.obolibrary.org/obo/MONDO_0043905
T3 261-269 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T4 513-521 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T5 522-533 Disease denotes pneumonitis http://purl.obolibrary.org/obo/MONDO_0043905
T6 789-807 Disease denotes Pulmonary fibrosis http://purl.obolibrary.org/obo/MONDO_0002771
T7 937-955 Disease denotes pulmonary fibrosis http://purl.obolibrary.org/obo/MONDO_0002771
T8 1091-1103 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T9 1117-1125 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T10 1243-1251 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T11 1252-1263 Disease denotes pneumonitis http://purl.obolibrary.org/obo/MONDO_0043905
T12 1334-1346 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T13 1618-1626 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T14 1627-1638 Disease denotes pneumonitis http://purl.obolibrary.org/obo/MONDO_0043905
T15 1657-1675 Disease denotes pulmonary fibrosis http://purl.obolibrary.org/obo/MONDO_0002771

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 78-79 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T2 694-695 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T3 735-736 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4 782-783 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 973-978 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T6 973-978 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T7 1026-1032 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T8 1233-1234 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T9 1307-1308 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T10 1382-1386 http://purl.obolibrary.org/obo/UBERON_0002481 denotes bone
T11 1410-1411 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T12 1562-1563 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T13 1592-1593 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 1697-1702 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T15 1697-1702 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T16 1739-1743 http://purl.obolibrary.org/obo/UBERON_0002481 denotes bone

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 641-650 Chemical denotes lopinavir http://purl.obolibrary.org/obo/CHEBI_31781
T2 653-662 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T3 664-671 Chemical denotes Kaletra http://purl.obolibrary.org/obo/CHEBI_145924
T4 703-712 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T5 715-724 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T6 1464-1474 Chemical denotes hemoglobin http://purl.obolibrary.org/obo/CHEBI_35143

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 789-807 Phenotype denotes Pulmonary fibrosis http://purl.obolibrary.org/obo/HP_0002206
T2 937-955 Phenotype denotes pulmonary fibrosis http://purl.obolibrary.org/obo/HP_0002206
T3 1091-1103 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T4 1179-1197 Phenotype denotes reversed halo sign http://purl.obolibrary.org/obo/HP_0032983
T5 1527-1545 Phenotype denotes reversed halo sign http://purl.obolibrary.org/obo/HP_0032983
T6 1657-1675 Phenotype denotes pulmonary fibrosis http://purl.obolibrary.org/obo/HP_0002206

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 1334-1346 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-101 Sentence denotes First report on clinical and radiological features of COVID-19 pneumonitis in a Caucasian population:
T2 102-140 Sentence denotes Factors predicting fibrotic evolution.
T3 141-152 Sentence denotes BACKGROUND:
T4 153-270 Sentence denotes At the end of February, the Lombardy region (Northern Italy) was involved in the pandemic spread of the new COVID-19.
T5 271-420 Sentence denotes We here summarize the clinical and radiological characteristics of 90 confirmed cases and analyze their role in predicting the evolution of fibrosis.
T6 421-429 Sentence denotes METHODS:
T7 430-534 Sentence denotes We retrospectively analyzed the clinical and radiological data of 90 patients with COVID-19 pneumonitis.
T8 535-788 Sentence denotes All subjects underwent an HRCT study on the day of admission and eight weeks later, and were treated with lopinavir + ritonavir (Kaletra) 400/100 mg two times a day or darunavir + ritonavir two times a day, and Hydroxychloroquine 200 mg two times a day.
T9 789-895 Sentence denotes Pulmonary fibrosis was defined according to the Fleischner Society glossary of terms for thoracic imaging.
T10 896-904 Sentence denotes RESULTS:
T11 905-964 Sentence denotes Twenty-three patients developed pulmonary fibrosis (25.5%):
T12 965-1007 Sentence denotes 15 were males, whose mean age was 75 ± 15.
T13 1008-1134 Sentence denotes The majority were active smokers (60.8%) and had comorbidities (78.2%), above all, hypertension (47.8%), and diabetes (34.7%).
T14 1135-1272 Sentence denotes Interestingly, in our series of cases, the "reversed halo sign" is frequent (63%) and seems to be a typical COVID-19 pneumonitis pattern.
T15 1273-1475 Sentence denotes The patients showing fibrosis had a higher grade of systemic inflammation (ESR and PCR) and appeared to have bone marrow inhibition with a significant reduction in platelets, leukocytes, and hemoglobin.
T16 1476-1488 Sentence denotes CONCLUSIONS:
T17 1489-1639 Sentence denotes To conclude, our data showed that the reversed halo sign associated with a ground-glass pattern may be a typical HRCT pattern of COVID-19 pneumonitis.
T18 1640-1763 Sentence denotes The evolution to pulmonary fibrosis is frequent in older males and patients with comorbidities and bone marrow involvement.
T1 0-101 Sentence denotes First report on clinical and radiological features of COVID-19 pneumonitis in a Caucasian population:
T2 102-140 Sentence denotes Factors predicting fibrotic evolution.
T3 141-152 Sentence denotes BACKGROUND:
T4 153-270 Sentence denotes At the end of February, the Lombardy region (Northern Italy) was involved in the pandemic spread of the new COVID-19.
T5 271-420 Sentence denotes We here summarize the clinical and radiological characteristics of 90 confirmed cases and analyze their role in predicting the evolution of fibrosis.
T6 421-429 Sentence denotes METHODS:
T7 430-534 Sentence denotes We retrospectively analyzed the clinical and radiological data of 90 patients with COVID-19 pneumonitis.
T8 535-788 Sentence denotes All subjects underwent an HRCT study on the day of admission and eight weeks later, and were treated with lopinavir + ritonavir (Kaletra) 400/100 mg two times a day or darunavir + ritonavir two times a day, and Hydroxychloroquine 200 mg two times a day.
T9 789-895 Sentence denotes Pulmonary fibrosis was defined according to the Fleischner Society glossary of terms for thoracic imaging.
T10 896-904 Sentence denotes RESULTS:
T11 905-964 Sentence denotes Twenty-three patients developed pulmonary fibrosis (25.5%):
T12 965-1007 Sentence denotes 15 were males, whose mean age was 75 ± 15.
T13 1008-1134 Sentence denotes The majority were active smokers (60.8%) and had comorbidities (78.2%), above all, hypertension (47.8%), and diabetes (34.7%).
T14 1135-1272 Sentence denotes Interestingly, in our series of cases, the "reversed halo sign" is frequent (63%) and seems to be a typical COVID-19 pneumonitis pattern.
T15 1273-1475 Sentence denotes The patients showing fibrosis had a higher grade of systemic inflammation (ESR and PCR) and appeared to have bone marrow inhibition with a significant reduction in platelets, leukocytes, and hemoglobin.
T16 1476-1488 Sentence denotes CONCLUSIONS:
T17 1489-1639 Sentence denotes To conclude, our data showed that the reversed halo sign associated with a ground-glass pattern may be a typical HRCT pattern of COVID-19 pneumonitis.
T18 1640-1763 Sentence denotes The evolution to pulmonary fibrosis is frequent in older males and patients with comorbidities and bone marrow involvement.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1 54-74 Disease denotes COVID-19 pneumonitis MESH:C000657245
27 261-269 Disease denotes COVID-19 MESH:C000657245
28 411-419 Disease denotes fibrosis MESH:D005355
29 499-507 Species denotes patients Tax:9606
30 513-521 Disease denotes COVID-19 MESH:C000657245
31 522-533 Disease denotes pneumonitis MESH:D011014
32 641-662 Chemical denotes lopinavir + ritonavir MESH:C558899
33 664-671 Chemical denotes Kaletra MESH:C558899
34 703-712 Chemical denotes darunavir MESH:D000069454
35 715-724 Chemical denotes ritonavir MESH:D019438
36 746-764 Chemical denotes Hydroxychloroquine MESH:D006886
37 789-807 Disease denotes Pulmonary fibrosis MESH:D011658
38 918-926 Species denotes patients Tax:9606
39 937-955 Disease denotes pulmonary fibrosis MESH:D011658
40 1091-1103 Disease denotes hypertension MESH:D006973
41 1117-1125 Disease denotes diabetes MESH:D003920
42 1618-1626 Disease denotes COVID-19 MESH:C000657245
43 1627-1638 Disease denotes pneumonitis MESH:D011014
49 1657-1675 Disease denotes pulmonary fibrosis MESH:D011658
50 1707-1715 Species denotes patients Tax:9606
51 1739-1762 Disease denotes bone marrow involvement MESH:D001855

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-101 Sentence denotes First report on clinical and radiological features of COVID-19 pneumonitis in a Caucasian population:
T2 102-140 Sentence denotes Factors predicting fibrotic evolution.
T3 141-152 Sentence denotes BACKGROUND:
T4 153-270 Sentence denotes At the end of February, the Lombardy region (Northern Italy) was involved in the pandemic spread of the new COVID-19.
T5 271-420 Sentence denotes We here summarize the clinical and radiological characteristics of 90 confirmed cases and analyze their role in predicting the evolution of fibrosis.
T6 421-429 Sentence denotes METHODS:
T7 430-534 Sentence denotes We retrospectively analyzed the clinical and radiological data of 90 patients with COVID-19 pneumonitis.
T8 535-788 Sentence denotes All subjects underwent an HRCT study on the day of admission and eight weeks later, and were treated with lopinavir + ritonavir (Kaletra) 400/100 mg two times a day or darunavir + ritonavir two times a day, and Hydroxychloroquine 200 mg two times a day.
T9 789-895 Sentence denotes Pulmonary fibrosis was defined according to the Fleischner Society glossary of terms for thoracic imaging.
T10 896-904 Sentence denotes RESULTS:
T11 905-964 Sentence denotes Twenty-three patients developed pulmonary fibrosis (25.5%):
T12 965-1007 Sentence denotes 15 were males, whose mean age was 75 ± 15.
T13 1008-1134 Sentence denotes The majority were active smokers (60.8%) and had comorbidities (78.2%), above all, hypertension (47.8%), and diabetes (34.7%).
T14 1135-1272 Sentence denotes Interestingly, in our series of cases, the "reversed halo sign" is frequent (63%) and seems to be a typical COVID-19 pneumonitis pattern.
T15 1273-1475 Sentence denotes The patients showing fibrosis had a higher grade of systemic inflammation (ESR and PCR) and appeared to have bone marrow inhibition with a significant reduction in platelets, leukocytes, and hemoglobin.
T16 1476-1488 Sentence denotes CONCLUSIONS:
T17 1489-1639 Sentence denotes To conclude, our data showed that the reversed halo sign associated with a ground-glass pattern may be a typical HRCT pattern of COVID-19 pneumonitis.
T18 1640-1763 Sentence denotes The evolution to pulmonary fibrosis is frequent in older males and patients with comorbidities and bone marrow involvement.

hydroxychloroquine

Id Subject Object Predicate Lexical cue hp_id
T1 789-807 Phenotype denotes Pulmonary fibrosis http://purl.obolibrary.org/obo/HP_0002206
T2 937-955 Phenotype denotes pulmonary fibrosis http://purl.obolibrary.org/obo/HP_0002206
T3 1091-1103 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T4 1179-1197 Phenotype denotes reversed halo sign http://purl.obolibrary.org/obo/HP_0032983
T5 1527-1545 Phenotype denotes reversed halo sign http://purl.obolibrary.org/obo/HP_0032983
T6 1657-1675 Phenotype denotes pulmonary fibrosis http://purl.obolibrary.org/obo/HP_0002206