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PubMed:32831324 JSONTXT

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sonoma2

Id Subject Object Predicate Lexical cue
T0 0-24 CPA denotes Cutaneous susceptibility
T1 28-48 DISEASE denotes SARS-CoV-2 infection
T2 39-48 CPA denotes infection
T3 49-58 REG denotes according
T4 66-76 MPA denotes expression
T5 271-285 CPA denotes manifestations
T6 302-310 DISEASE denotes COVID-1
T7 303-311 DISEASE denotes COVID-19
T8 331-348 CPA denotes cutaneous tropism
T9 403-409 REG denotes infect
T10 459-473 MPA denotes susceptibility
T11 487-507 DISEASE denotes o SARS-CoV-2 infecti
T12 500-509 CPA denotes infection
T13 523-533 MPA denotes expression
T14 555-559 GENE denotes s AC
T15 557-561 GENE denotes ACE2
T16 564-571 GENE denotes d TMPRS
T17 566-573 GENE denotes TMPRSS2
T18 696-704 MPA denotes presence
T19 709-713 GENE denotes he A
T20 712-716 GENE denotes ACE2
T21 718-725 GENE denotes nd TMPR
T22 721-728 GENE denotes TMPRSS2
T23 753-763 MPA denotes expression
T24 865-878 MPA denotes co-expression
T25 878-882 GENE denotes of
T26 882-886 GENE denotes ACE2
T27 887-894 GENE denotes and TMP
T28 891-898 GENE denotes TMPRSS2
T29 1046-1050 GENE denotes of
T30 1050-1054 GENE denotes ACE2
T31 1103-1110 GENE denotes sed TMP
T32 1107-1114 GENE denotes TMPRSS2
T33 1154-1178 CPA denotes cutaneous manifestations
T34 1191-1199 DISEASE denotes with COV
T35 1196-1204 DISEASE denotes COVID-19
T36 1224-1234 REG denotes attributed
T37 1242-1247 CPA denotes virus
T38 1285-1311 CPA denotes vessels endothelial damage
T39 1328-1334 REG denotes effect
T40 1350-1372 CPA denotes inflammatory mediators
T41 1416-1421 REG denotes cause
T42 1430-1441 CPA denotes involvement
R0 T0 T2 ThemeOf Cutaneous susceptibility,infection
R1 T0 T3 ThemeOf Cutaneous susceptibility,according
R2 T2 T3 ThemeOf infection,according
R3 T2 T4 ThemeOf infection,expression
R4 T4 T3 ThemeOf expression,according
R5 T7 T5 ThemeOf COVID-19,manifestations
R6 T7 T8 ThemeOf COVID-19,cutaneous tropism
R7 T7 T9 ThemeOf COVID-19,infect
R8 T8 T5 ThemeOf cutaneous tropism,manifestations
R9 T8 T9 ThemeOf cutaneous tropism,infect
R10 T12 T10 ThemeOf infection,susceptibility
R11 T13 T10 ThemeOf expression,susceptibility
R12 T12 T13 ThemeOf infection,expression
R13 T15 T10 ThemeOf ACE2,susceptibility
R14 T15 T12 ThemeOf ACE2,infection
R15 T15 T13 ThemeOf ACE2,expression
R16 T17 T10 ThemeOf TMPRSS2,susceptibility
R17 T17 T12 ThemeOf TMPRSS2,infection
R18 T17 T13 ThemeOf TMPRSS2,expression
R19 T20 T18 ThemeOf ACE2,presence
R20 T20 T23 ThemeOf ACE2,expression
R21 T22 T18 ThemeOf TMPRSS2,presence
R22 T22 T23 ThemeOf TMPRSS2,expression
R23 T26 T24 ThemeOf ACE2,co-expression
R24 T28 T24 ThemeOf TMPRSS2,co-expression
R25 T33 T36 ThemeOf cutaneous manifestations,attributed
R26 T35 T33 ThemeOf COVID-19,cutaneous manifestations
R27 T35 T36 ThemeOf COVID-19,attributed
R28 T37 T36 ThemeOf virus,attributed
R29 T39 T42 CauseOf effect,involvement
R30 T40 T39 ThemeOf inflammatory mediators,effect
R31 T40 T41 ThemeOf inflammatory mediators,cause
R32 T40 T42 CauseOf inflammatory mediators,involvement
R33 T42 T41 ThemeOf involvement,cause

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 107-111 Body_part denotes skin http://purl.org/sig/ont/fma/fma7163
T2 414-418 Body_part denotes skin http://purl.org/sig/ont/fma/fma7163
T3 481-485 Body_part denotes skin http://purl.org/sig/ont/fma/fma7163
T4 582-587 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T5 631-637 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T6 638-642 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T7 742-746 Body_part denotes skin http://purl.org/sig/ont/fma/fma7163
T8 748-752 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T9 782-786 Body_part denotes skin http://purl.org/sig/ont/fma/fma7163
T10 801-805 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T11 906-928 Body_part denotes gastrointestinal tract http://purl.org/sig/ont/fma/fma71132
T12 933-939 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T13 956-960 Body_part denotes skin http://purl.org/sig/ont/fma/fma7163
T14 990-1002 Body_part denotes keratinocyte http://purl.org/sig/ont/fma/fma62879
T15 1009-1013 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T16 1063-1067 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T17 1092-1096 Body_part denotes skin http://purl.org/sig/ont/fma/fma7163
T18 1279-1292 Body_part denotes blood vessels http://purl.org/sig/ont/fma/fma63183
T19 1279-1284 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T20 1425-1429 Body_part denotes skin http://purl.org/sig/ont/fma/fma7163

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 107-111 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014
T2 414-418 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014
T3 481-485 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014
T4 582-587 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T5 631-637 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T6 742-746 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014
T7 782-786 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014
T8 933-939 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T9 956-960 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014
T10 1092-1096 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014
T11 1279-1292 Body_part denotes blood vessels http://purl.obolibrary.org/obo/UBERON_0001981
T12 1279-1284 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T13 1285-1292 Body_part denotes vessels http://purl.obolibrary.org/obo/UBERON_0000055
T14 1425-1429 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 28-36 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T2 39-48 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T3 156-164 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T4 303-311 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T5 352-360 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 489-497 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T7 500-509 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T8 1196-1204 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 107-111 http://purl.obolibrary.org/obo/UBERON_0000014 denotes skin
T2 107-111 http://purl.obolibrary.org/obo/UBERON_0001003 denotes skin
T3 107-111 http://purl.obolibrary.org/obo/UBERON_0002097 denotes skin
T4 107-111 http://purl.obolibrary.org/obo/UBERON_0002199 denotes skin
T5 107-111 http://www.ebi.ac.uk/efo/EFO_0000962 denotes skin
T6 137-138 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7 219-221 http://purl.obolibrary.org/obo/CLO_0037161 denotes en
T8 320-321 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T9 394-399 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T10 414-418 http://purl.obolibrary.org/obo/UBERON_0000014 denotes skin
T11 414-418 http://purl.obolibrary.org/obo/UBERON_0001003 denotes skin
T12 414-418 http://purl.obolibrary.org/obo/UBERON_0002097 denotes skin
T13 414-418 http://purl.obolibrary.org/obo/UBERON_0002199 denotes skin
T14 414-418 http://www.ebi.ac.uk/efo/EFO_0000962 denotes skin
T15 431-440 http://purl.obolibrary.org/obo/BFO_0000030 denotes Objective
T16 481-485 http://purl.obolibrary.org/obo/UBERON_0000014 denotes skin
T17 481-485 http://purl.obolibrary.org/obo/UBERON_0001003 denotes skin
T18 481-485 http://purl.obolibrary.org/obo/UBERON_0002097 denotes skin
T19 481-485 http://purl.obolibrary.org/obo/UBERON_0002199 denotes skin
T20 481-485 http://www.ebi.ac.uk/efo/EFO_0000962 denotes skin
T21 574-587 http://purl.obolibrary.org/obo/OBI_0100026 denotes in this organ
T22 574-587 http://purl.obolibrary.org/obo/UBERON_0000468 denotes in this organ
T23 597-598 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T24 625-630 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T25 638-642 http://purl.obolibrary.org/obo/OGG_0000000002 denotes gene
T26 729-734 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T27 742-746 http://purl.obolibrary.org/obo/UBERON_0000014 denotes skin
T28 742-746 http://purl.obolibrary.org/obo/UBERON_0001003 denotes skin
T29 742-746 http://purl.obolibrary.org/obo/UBERON_0002097 denotes skin
T30 742-746 http://purl.obolibrary.org/obo/UBERON_0002199 denotes skin
T31 742-746 http://www.ebi.ac.uk/efo/EFO_0000962 denotes skin
T32 773-778 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T33 782-786 http://purl.obolibrary.org/obo/UBERON_0000014 denotes skin
T34 782-786 http://purl.obolibrary.org/obo/UBERON_0001003 denotes skin
T35 782-786 http://purl.obolibrary.org/obo/UBERON_0002097 denotes skin
T36 782-786 http://purl.obolibrary.org/obo/UBERON_0002199 denotes skin
T37 782-786 http://www.ebi.ac.uk/efo/EFO_0000962 denotes skin
T38 795-811 http://www.ebi.ac.uk/cellline#human_cell_line denotes human cell lines
T39 906-928 http://purl.obolibrary.org/obo/UBERON_0005409 denotes gastrointestinal tract
T40 933-939 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T41 933-939 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T42 933-939 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T43 956-960 http://purl.obolibrary.org/obo/UBERON_0000014 denotes skin
T44 956-960 http://purl.obolibrary.org/obo/UBERON_0001003 denotes skin
T45 956-960 http://purl.obolibrary.org/obo/UBERON_0002097 denotes skin
T46 956-960 http://purl.obolibrary.org/obo/UBERON_0002199 denotes skin
T47 956-960 http://www.ebi.ac.uk/efo/EFO_0000962 denotes skin
T48 971-976 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T49 990-1002 http://purl.obolibrary.org/obo/CL_0000312 denotes keratinocyte
T50 1009-1018 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell line
T51 1063-1072 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell line
T52 1092-1096 http://purl.obolibrary.org/obo/UBERON_0000014 denotes skin
T53 1092-1096 http://purl.obolibrary.org/obo/UBERON_0001003 denotes skin
T54 1092-1096 http://purl.obolibrary.org/obo/UBERON_0002097 denotes skin
T55 1092-1096 http://purl.obolibrary.org/obo/UBERON_0002199 denotes skin
T56 1092-1096 http://www.ebi.ac.uk/efo/EFO_0000962 denotes skin
T57 1242-1247 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T58 1279-1292 http://purl.obolibrary.org/obo/UBERON_0001981 denotes blood vessels
T59 1279-1292 http://www.ebi.ac.uk/efo/EFO_0000817 denotes blood vessels
T60 1401-1406 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T61 1425-1429 http://purl.obolibrary.org/obo/UBERON_0000014 denotes skin
T62 1425-1429 http://purl.obolibrary.org/obo/UBERON_0001003 denotes skin
T63 1425-1429 http://purl.obolibrary.org/obo/UBERON_0002097 denotes skin
T64 1425-1429 http://purl.obolibrary.org/obo/UBERON_0002199 denotes skin
T65 1425-1429 http://www.ebi.ac.uk/efo/EFO_0000962 denotes skin

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 219-221 Chemical denotes en http://purl.obolibrary.org/obo/CHEBI_30347

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 341-348 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T2 638-653 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T3 1385-1406 http://purl.obolibrary.org/obo/GO_0009615 denotes response to the virus

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-112 Sentence denotes Cutaneous susceptibility to SARS-CoV-2 infection according to the expression of viral entry factors in the skin.
T2 113-230 Sentence denotes Susceptibilidad cutánea a la infección por SARS-CoV-2 según la expresión de los factores de entrada viral en la piel.
T3 231-244 Sentence denotes Introduction:
T4 245-430 Sentence denotes Reports of dermatological manifestations in patients with COVID-19 suggest a possible cutaneous tropism of SARS-CoV-2; however, the capacity of this virus to infect the skin is unknown.
T5 431-441 Sentence denotes Objective:
T6 442-588 Sentence denotes To determine the susceptibility of the skin to SARS-CoV-2 infection based on the expression of viral entry factors ACE2 and TMPRSS2 in this organ.
T7 589-596 Sentence denotes Method:
T8 597-830 Sentence denotes A comprehensive analysis of human tissue gene expression databases was carried out looking for the presence of the ACE2 and TMPRSS2 genes in the skin. mRNA expression of these genes in skin-derived human cell lines was also assessed.
T9 831-839 Sentence denotes Results:
T10 840-961 Sentence denotes The analyses showed high co-expression of ACE2 and TMPRSS2 in the gastrointestinal tract and kidney, but not in the skin.
T11 962-1115 Sentence denotes Only the human immortalized keratinocyte HaCaT cell line expressed detectable levels of ACE2, and no cell line originating in the skin expressed TMPRSS2.
T12 1116-1128 Sentence denotes Conclusions:
T13 1129-1248 Sentence denotes Our results suggest that cutaneous manifestations in patients with COVID-19 cannot be directly attributed to the virus.
T14 1249-1442 Sentence denotes It is possible that cutaneous blood vessels endothelial damage, as well as the effect of circulating inflammatory mediators produced in response to the virus, are the cause of skin involvement.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1 28-48 Disease denotes SARS-CoV-2 infection MESH:C000657245
20 289-297 Species denotes patients Tax:9606
21 303-311 Disease denotes COVID-19 MESH:C000657245
22 352-362 Species denotes SARS-CoV-2 Tax:2697049
23 489-509 Disease denotes SARS-CoV-2 infection MESH:C000657245
24 557-561 Gene denotes ACE2 Gene:59272
25 566-573 Gene denotes TMPRSS2 Gene:7113
26 625-630 Species denotes human Tax:9606
27 712-716 Gene denotes ACE2 Gene:59272
28 721-728 Gene denotes TMPRSS2 Gene:7113
29 795-800 Species denotes human Tax:9606
30 882-886 Gene denotes ACE2 Gene:59272
31 891-898 Gene denotes TMPRSS2 Gene:7113
32 971-976 Species denotes human Tax:9606
33 1003-1008 CellLine denotes HaCaT CVCL:0038
34 1050-1054 Gene denotes ACE2 Gene:59272
35 1107-1114 Gene denotes TMPRSS2 Gene:7113
36 1182-1190 Species denotes patients Tax:9606
37 1196-1204 Disease denotes COVID-19 MESH:C000657245

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-112 Sentence denotes Cutaneous susceptibility to SARS-CoV-2 infection according to the expression of viral entry factors in the skin.
T2 113-230 Sentence denotes Susceptibilidad cutánea a la infección por SARS-CoV-2 según la expresión de los factores de entrada viral en la piel.
T3 231-244 Sentence denotes Introduction:
T4 245-430 Sentence denotes Reports of dermatological manifestations in patients with COVID-19 suggest a possible cutaneous tropism of SARS-CoV-2; however, the capacity of this virus to infect the skin is unknown.
T5 431-441 Sentence denotes Objective:
T6 442-588 Sentence denotes To determine the susceptibility of the skin to SARS-CoV-2 infection based on the expression of viral entry factors ACE2 and TMPRSS2 in this organ.
T7 589-596 Sentence denotes Method:
T8 597-830 Sentence denotes A comprehensive analysis of human tissue gene expression databases was carried out looking for the presence of the ACE2 and TMPRSS2 genes in the skin. mRNA expression of these genes in skin-derived human cell lines was also assessed.
T9 831-839 Sentence denotes Results:
T10 840-961 Sentence denotes The analyses showed high co-expression of ACE2 and TMPRSS2 in the gastrointestinal tract and kidney, but not in the skin.
T11 962-1115 Sentence denotes Only the human immortalized keratinocyte HaCaT cell line expressed detectable levels of ACE2, and no cell line originating in the skin expressed TMPRSS2.
T12 1116-1128 Sentence denotes Conclusions:
T13 1129-1248 Sentence denotes Our results suggest that cutaneous manifestations in patients with COVID-19 cannot be directly attributed to the virus.
T14 1249-1442 Sentence denotes It is possible that cutaneous blood vessels endothelial damage, as well as the effect of circulating inflammatory mediators produced in response to the virus, are the cause of skin involvement.
T1 0-112 Sentence denotes Cutaneous susceptibility to SARS-CoV-2 infection according to the expression of viral entry factors in the skin.
T2 113-230 Sentence denotes Susceptibilidad cutánea a la infección por SARS-CoV-2 según la expresión de los factores de entrada viral en la piel.
T3 231-244 Sentence denotes Introduction:
T4 245-430 Sentence denotes Reports of dermatological manifestations in patients with COVID-19 suggest a possible cutaneous tropism of SARS-CoV-2; however, the capacity of this virus to infect the skin is unknown.
T5 431-441 Sentence denotes Objective:
T6 442-588 Sentence denotes To determine the susceptibility of the skin to SARS-CoV-2 infection based on the expression of viral entry factors ACE2 and TMPRSS2 in this organ.
T7 589-596 Sentence denotes Method:
T8 597-830 Sentence denotes A comprehensive analysis of human tissue gene expression databases was carried out looking for the presence of the ACE2 and TMPRSS2 genes in the skin. mRNA expression of these genes in skin-derived human cell lines was also assessed.
T9 831-839 Sentence denotes Results:
T10 840-961 Sentence denotes The analyses showed high co-expression of ACE2 and TMPRSS2 in the gastrointestinal tract and kidney, but not in the skin.
T11 962-1115 Sentence denotes Only the human immortalized keratinocyte HaCaT cell line expressed detectable levels of ACE2, and no cell line originating in the skin expressed TMPRSS2.
T12 1116-1128 Sentence denotes Conclusions:
T13 1129-1248 Sentence denotes Our results suggest that cutaneous manifestations in patients with COVID-19 cannot be directly attributed to the virus.
T14 1249-1442 Sentence denotes It is possible that cutaneous blood vessels endothelial damage, as well as the effect of circulating inflammatory mediators produced in response to the virus, are the cause of skin involvement.