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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 554-561 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T2 853-857 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T3 1199-1206 Body_part denotes Heparin http://purl.org/sig/ont/fma/fma82839
T4 1332-1336 Body_part denotes face http://purl.org/sig/ont/fma/fma24728

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-83 Sentence denotes MATH+ protocol for the treatment of SARS-CoV-2 infection: the scientific rationale.
T2 84-162 Sentence denotes INTRODUCTION: COVID-19 disease progresses through a number of distinct phases.
T3 163-215 Sentence denotes The management of each phase is unique and specific.
T4 216-418 Sentence denotes The pulmonary phase of COVID-19 is characterized by an organizing pneumonia with profound immune dysregulation, activation of clotting, and a severe microvascular injury culminating in severe hypoxemia.
T5 419-579 Sentence denotes The core treatment strategy to manage the pulmonary phase includes the combination of methylprednisolone, ascorbic acid, thiamine, and heparin (MATH+ protocol).
T6 580-643 Sentence denotes The rationale for the MATH+ protocol is reviewed in this paper.
T7 644-658 Sentence denotes AREAS COVERED:
T8 659-875 Sentence denotes We provide an overview on the pathophysiological changes occurring in patients with COVID-19 respiratory failure and a treatment strategy to reverse these changes thereby preventing progressive lung injury and death.
T9 876-891 Sentence denotes EXPERT OPINION:
T10 892-1480 Sentence denotes While there is no single 'Silver Bullet' to cure COVID-19, we believe that the severely disturbed pathological processes leading to respiratory failure in patients with COVID-19 organizing pneumonia will respond to the combination of Methylprednisone, Ascorbic acid, Thiamine, and full anticoagulation with Heparin (MATH+ protocol).We believe that it is no longer ethically acceptable to limit management to 'supportive care' alone, in the face of effective, safe, and inexpensive medications that can effectively treat this disease and thereby reduce the risk of complications and death.
T1 0-83 Sentence denotes MATH+ protocol for the treatment of SARS-CoV-2 infection: the scientific rationale.
T2 84-162 Sentence denotes INTRODUCTION: COVID-19 disease progresses through a number of distinct phases.
T3 163-215 Sentence denotes The management of each phase is unique and specific.
T4 216-418 Sentence denotes The pulmonary phase of COVID-19 is characterized by an organizing pneumonia with profound immune dysregulation, activation of clotting, and a severe microvascular injury culminating in severe hypoxemia.
T5 419-579 Sentence denotes The core treatment strategy to manage the pulmonary phase includes the combination of methylprednisolone, ascorbic acid, thiamine, and heparin (MATH+ protocol).
T6 580-643 Sentence denotes The rationale for the MATH+ protocol is reviewed in this paper.
T7 644-658 Sentence denotes AREAS COVERED:
T8 659-875 Sentence denotes We provide an overview on the pathophysiological changes occurring in patients with COVID-19 respiratory failure and a treatment strategy to reverse these changes thereby preventing progressive lung injury and death.
T9 876-891 Sentence denotes EXPERT OPINION:
T10 892-1480 Sentence denotes While there is no single 'Silver Bullet' to cure COVID-19, we believe that the severely disturbed pathological processes leading to respiratory failure in patients with COVID-19 organizing pneumonia will respond to the combination of Methylprednisone, Ascorbic acid, Thiamine, and full anticoagulation with Heparin (MATH+ protocol).We believe that it is no longer ethically acceptable to limit management to 'supportive care' alone, in the face of effective, safe, and inexpensive medications that can effectively treat this disease and thereby reduce the risk of complications and death.

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 853-857 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T2 1332-1336 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 36-44 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T2 47-56 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T3 98-106 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T4 239-247 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T5 271-291 Disease denotes organizing pneumonia http://purl.obolibrary.org/obo/MONDO_0015265|http://purl.obolibrary.org/obo/MONDO_0056821
T7 282-291 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T8 379-385 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T9 743-751 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T10 752-771 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T11 858-864 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T12 941-949 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T13 1024-1043 Disease denotes respiratory failure http://purl.obolibrary.org/obo/MONDO_0021113
T14 1061-1069 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T15 1070-1090 Disease denotes organizing pneumonia http://purl.obolibrary.org/obo/MONDO_0015265|http://purl.obolibrary.org/obo/MONDO_0056821
T17 1081-1090 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 134-135 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T2 271-281 http://purl.obolibrary.org/obo/OBI_0000245 denotes organizing
T3 328-338 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T4 356-357 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 776-777 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6 853-857 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T7 853-857 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T8 1070-1080 http://purl.obolibrary.org/obo/OBI_0000245 denotes organizing
T9 1332-1336 http://purl.obolibrary.org/obo/UBERON_0001456 denotes face

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 505-523 Chemical denotes methylprednisolone http://purl.obolibrary.org/obo/CHEBI_6888
T2 525-538 Chemical denotes ascorbic acid http://purl.obolibrary.org/obo/CHEBI_22652|http://purl.obolibrary.org/obo/CHEBI_29073
T4 534-538 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T5 540-548 Chemical denotes thiamine http://purl.obolibrary.org/obo/CHEBI_18385|http://purl.obolibrary.org/obo/CHEBI_26948|http://purl.obolibrary.org/obo/CHEBI_33283
T8 554-561 Chemical denotes heparin http://purl.obolibrary.org/obo/CHEBI_28304
T9 918-924 Chemical denotes Silver http://purl.obolibrary.org/obo/CHEBI_9141
T10 1144-1157 Chemical denotes Ascorbic acid http://purl.obolibrary.org/obo/CHEBI_29073
T11 1153-1157 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T12 1159-1167 Chemical denotes Thiamine http://purl.obolibrary.org/obo/CHEBI_18385
T13 1199-1206 Chemical denotes Heparin http://purl.obolibrary.org/obo/CHEBI_28304

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 342-350 http://purl.obolibrary.org/obo/GO_0050817 denotes clotting

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-83 Sentence denotes MATH+ protocol for the treatment of SARS-CoV-2 infection: the scientific rationale.
T2 84-162 Sentence denotes INTRODUCTION: COVID-19 disease progresses through a number of distinct phases.
T3 163-215 Sentence denotes The management of each phase is unique and specific.
T4 216-418 Sentence denotes The pulmonary phase of COVID-19 is characterized by an organizing pneumonia with profound immune dysregulation, activation of clotting, and a severe microvascular injury culminating in severe hypoxemia.
T5 419-579 Sentence denotes The core treatment strategy to manage the pulmonary phase includes the combination of methylprednisolone, ascorbic acid, thiamine, and heparin (MATH+ protocol).
T6 580-643 Sentence denotes The rationale for the MATH+ protocol is reviewed in this paper.
T7 644-658 Sentence denotes AREAS COVERED:
T8 659-875 Sentence denotes We provide an overview on the pathophysiological changes occurring in patients with COVID-19 respiratory failure and a treatment strategy to reverse these changes thereby preventing progressive lung injury and death.
T9 876-891 Sentence denotes EXPERT OPINION:
T10 892-1480 Sentence denotes While there is no single 'Silver Bullet' to cure COVID-19, we believe that the severely disturbed pathological processes leading to respiratory failure in patients with COVID-19 organizing pneumonia will respond to the combination of Methylprednisone, Ascorbic acid, Thiamine, and full anticoagulation with Heparin (MATH+ protocol).We believe that it is no longer ethically acceptable to limit management to 'supportive care' alone, in the face of effective, safe, and inexpensive medications that can effectively treat this disease and thereby reduce the risk of complications and death.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1 36-56 Disease denotes SARS-CoV-2 infection MESH:C000657245
26 98-106 Disease denotes COVID-19 MESH:C000657245
27 239-247 Disease denotes COVID-19 MESH:C000657245
28 282-291 Disease denotes pneumonia MESH:D011014
29 365-385 Disease denotes microvascular injury MESH:D017566
30 408-417 Disease denotes hypoxemia MESH:D000860
31 505-523 Chemical denotes methylprednisolone MESH:D008775
32 525-538 Chemical denotes ascorbic acid MESH:D001205
33 540-548 Chemical denotes thiamine MESH:D013831
34 554-561 Chemical denotes heparin MESH:D006493
35 729-737 Species denotes patients Tax:9606
36 743-751 Disease denotes COVID-19 MESH:C000657245
37 752-771 Disease denotes respiratory failure MESH:D012131
38 853-864 Disease denotes lung injury MESH:D055370
39 869-874 Disease denotes death MESH:D003643
40 941-949 Disease denotes COVID-19 MESH:C000657245
41 1024-1043 Disease denotes respiratory failure MESH:D012131
42 1047-1055 Species denotes patients Tax:9606
43 1061-1069 Disease denotes COVID-19 MESH:C000657245
44 1081-1090 Disease denotes pneumonia MESH:D011014
45 1126-1142 Chemical denotes Methylprednisone
46 1144-1157 Chemical denotes Ascorbic acid MESH:D001205
47 1159-1167 Chemical denotes Thiamine MESH:D013831
48 1199-1206 Chemical denotes Heparin MESH:D006493
49 1474-1479 Disease denotes death MESH:D003643

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 282-291 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T2 306-326 Phenotype denotes immune dysregulation http://purl.obolibrary.org/obo/HP_0002958
T3 408-417 Phenotype denotes hypoxemia http://purl.obolibrary.org/obo/HP_0012418
T4 752-771 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T5 1024-1043 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T6 1081-1090 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090