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LitCovid-OGER-BB

Id Subject Object Predicate Lexical cue
T1 38-44 UBERON:0001969 denotes Plasma
T2 58-67 GO:0042157 denotes Metabolic
T3 104-109 UBERON:0000062 denotes organ
T4 136-146 SP_7 denotes SARS-CoV-2
T5 162-171 GO:0008152 denotes metabolic
T6 183-230 SP_7 denotes severe acute respiratory syndrome coronavirus 2
T7 196-207 UBERON:0001004 denotes respiratory
T8 232-242 SP_7 denotes SARS-CoV-2
T9 257-262 SP_6 denotes human
T10 257-262 NCBITaxon:9606 denotes human
T11 263-268 UBERON:0001969 denotes blood
T12 269-275 UBERON:0001969 denotes plasma
T13 316-325 GO:0008152 denotes metabolic
T14 511-523 CHEBI:17089 denotes glycoprotein
T15 511-523 BV_11 denotes glycoprotein
T16 511-523 CHEBI:17089 denotes glycoprotein
T17 525-532 CHEBI:17234 denotes glucose
T18 525-532 CHEBI:17234 denotes glucose
T19 537-545 CHEBI:15956 denotes biogenic
T20 537-545 CHEBI:15956 denotes biogenic
T21 546-552 CHEBI:32952 denotes amines
T22 546-552 CHEBI:32952 denotes amines
T23 591-602 NCBITaxon:11118 denotes coronavirus
T24 615-623 SP_7 denotes COVID-19
T25 666-676 SP_7 denotes SARS-CoV-2
T26 677-682 NCBITaxon:10239 denotes virus
T27 782-793 GO:0042995 denotes projections
T28 928-937 GO:0008152 denotes metabolic
T29 1026-1037 CHEBI:25212 denotes metabolites
T30 1026-1037 CHEBI:25212 denotes metabolites
T31 1103-1115 CHEBI:17089 denotes glycoprotein
T32 1103-1115 CHEBI:17089 denotes glycoprotein
T33 1103-1115 BV_11 denotes glycoprotein
T34 1202-1209 CHEBI:17234 denotes glucose
T35 1202-1209 CHEBI:17234 denotes glucose
T36 1264-1279 UBERON:0001621 denotes coronary artery
T37 1307-1321 CHEBI:39015 denotes Apolipoprotein
T38 1307-1321 CHEBI:39015 denotes Apolipoprotein
T39 1307-1324 PR:000004140 denotes Apolipoprotein A1
T40 1334-1347 CHEBI:17855 denotes triglycerides
T41 1334-1347 CHEBI:17855 denotes triglycerides
T42 1367-1380 CHEBI:17855 denotes triglycerides
T43 1367-1380 CHEBI:17855 denotes triglycerides
T44 1439-1444 UBERON:0002107 denotes liver
T45 1569-1579 SP_7 denotes SARS-CoV-2
T46 1694-1704 SP_7 denotes SARS-CoV-2
T47 1791-1801 SP_7 denotes SARS-CoV-2
T48 1886-1896 SP_7 denotes SARS-CoV-2
T49 1934-1939 UBERON:0002107 denotes liver
T50 1991-1996 UBERON:0000948 denotes heart
T51 2055-2063 SP_7 denotes COVID-19
T52 2105-2111 UBERON:0000062 denotes organs
T53 2116-2123 UBERON:0000467 denotes systems
T54 2125-2137 GO:0008152 denotes Metabolights

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-157 Sentence denotes Integrative Modelling of Quantitative Plasma Lipoprotein, Metabolic and Amino Acid Data Reveals a Multi-organ Pathological Signature of SARS-CoV-2 Infection.
T2 158-441 Sentence denotes The metabolic effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on human blood plasma were characterized using multi-platform metabolic phenotyping with Nuclear Magnetic Resonance (NMR) spectroscopy and liquid chromatography-mass spectrometry (LC-MS).
T3 442-742 Sentence denotes Quantitative measurements of lipoprotein sub-fractions, alpha-1-acid glycoprotein, glucose and biogenic amines were made on samples from symptomatic coronavirus disease 19 (COVID-19) patients who had tested positive for the SARS-CoV-2 virus (n = 17) and from age and gender-matched controls (n = 25).
T4 743-1008 Sentence denotes Data were analyzed using an orthogonal-projections to latent structures (O-PLS) method and used to construct an exceptionally strong (AUROC=1) hybrid NMR-MS model that enabled detailed metabolic discrimination between the groups and their biochemical relationships.
T5 1009-1161 Sentence denotes Key discriminant metabolites included markers of inflammation including elevated alpha-1 acid glycoprotein and an increased kynurenine/tryptophan ratio.
T6 1162-1382 Sentence denotes There was also an abnormal lipoprotein, glucose and amino acid signature consistent with diabetes and coronary artery disease (low total and HDL Apolipoprotein A1, low HDL triglycerides, high LDL and VLDL triglycerides).
T7 1383-1598 Sentence denotes Plus, multiple highly significant amino acid markers of liver dysfunction (including the elevated glutamine/glutamate and Fischer's ratios) that present themselves as part of a distinct SARS-CoV-2 infection pattern.
T8 1599-1736 Sentence denotes A multivariate training-test set model was validated using independent samples from additional SARS-CoV-2 positive patients and controls.
T9 1737-1813 Sentence denotes The predictive model showed a sensitivity of 100% for SARS-CoV-2 positivity.
T10 1814-2124 Sentence denotes The breadth of the disturbed pathways indicates a systemic signature of SARS-CoV-2 positivity that includes elements of liver dysfunction, dyslipidaemia, diabetes, and coronary heart disease risk that are consistent with recent reports that COVID-19 is a systemic disease affecting multiple organs and systems.
T11 2125-2165 Sentence denotes Metabolights study reference: MTBLS2014.
T1 0-157 Sentence denotes Integrative Modelling of Quantitative Plasma Lipoprotein, Metabolic and Amino Acid Data Reveals a Multi-organ Pathological Signature of SARS-CoV-2 Infection.
T2 158-441 Sentence denotes The metabolic effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on human blood plasma were characterized using multi-platform metabolic phenotyping with Nuclear Magnetic Resonance (NMR) spectroscopy and liquid chromatography-mass spectrometry (LC-MS).
T3 442-742 Sentence denotes Quantitative measurements of lipoprotein sub-fractions, alpha-1-acid glycoprotein, glucose and biogenic amines were made on samples from symptomatic coronavirus disease 19 (COVID-19) patients who had tested positive for the SARS-CoV-2 virus (n = 17) and from age and gender-matched controls (n = 25).
T4 743-1008 Sentence denotes Data were analyzed using an orthogonal-projections to latent structures (O-PLS) method and used to construct an exceptionally strong (AUROC=1) hybrid NMR-MS model that enabled detailed metabolic discrimination between the groups and their biochemical relationships.
T5 1009-1161 Sentence denotes Key discriminant metabolites included markers of inflammation including elevated alpha-1 acid glycoprotein and an increased kynurenine/tryptophan ratio.
T6 1162-1382 Sentence denotes There was also an abnormal lipoprotein, glucose and amino acid signature consistent with diabetes and coronary artery disease (low total and HDL Apolipoprotein A1, low HDL triglycerides, high LDL and VLDL triglycerides).
T7 1383-1598 Sentence denotes Plus, multiple highly significant amino acid markers of liver dysfunction (including the elevated glutamine/glutamate and Fischer's ratios) that present themselves as part of a distinct SARS-CoV-2 infection pattern.
T8 1599-1736 Sentence denotes A multivariate training-test set model was validated using independent samples from additional SARS-CoV-2 positive patients and controls.
T9 1737-1813 Sentence denotes The predictive model showed a sensitivity of 100% for SARS-CoV-2 positivity.
T10 1814-2124 Sentence denotes The breadth of the disturbed pathways indicates a systemic signature of SARS-CoV-2 positivity that includes elements of liver dysfunction, dyslipidaemia, diabetes, and coronary heart disease risk that are consistent with recent reports that COVID-19 is a systemic disease affecting multiple organs and systems.
T11 2125-2165 Sentence denotes Metabolights study reference: MTBLS2014.

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 38-44 Body_part denotes Plasma http://purl.org/sig/ont/fma/fma62970
T2 45-56 Body_part denotes Lipoprotein http://purl.org/sig/ont/fma/fma63169
T3 72-82 Body_part denotes Amino Acid http://purl.org/sig/ont/fma/fma82739
T4 104-109 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T5 263-275 Body_part denotes blood plasma http://purl.org/sig/ont/fma/fma62970
T6 471-482 Body_part denotes lipoprotein http://purl.org/sig/ont/fma/fma63169
T7 511-523 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T8 525-532 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743
T9 537-552 Body_part denotes biogenic amines http://purl.org/sig/ont/fma/fma67161
T10 1103-1115 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T11 1144-1154 Body_part denotes tryptophan http://purl.org/sig/ont/fma/fma82767
T12 1189-1200 Body_part denotes lipoprotein http://purl.org/sig/ont/fma/fma63169
T13 1202-1209 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743
T14 1214-1224 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T15 1264-1279 Body_part denotes coronary artery http://purl.org/sig/ont/fma/fma49893
T16 1303-1306 Body_part denotes HDL http://purl.org/sig/ont/fma/fma63171
T17 1322-1324 Body_part denotes A1 http://purl.org/sig/ont/fma/fma66592
T18 1330-1333 Body_part denotes HDL http://purl.org/sig/ont/fma/fma63171
T19 1354-1357 Body_part denotes LDL http://purl.org/sig/ont/fma/fma63170
T20 1417-1427 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T21 1439-1444 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T22 1481-1490 Body_part denotes glutamine http://purl.org/sig/ont/fma/fma82752
T23 1934-1939 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T24 1991-1996 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T25 2105-2123 Body_part denotes organs and systems http://purl.org/sig/ont/fma/fma7149

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 104-109 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T2 263-275 Body_part denotes blood plasma http://purl.obolibrary.org/obo/UBERON_0001969
T3 263-268 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T4 1264-1279 Body_part denotes coronary artery http://purl.obolibrary.org/obo/UBERON_0001621
T5 1273-1279 Body_part denotes artery http://purl.obolibrary.org/obo/UBERON_0001637
T6 1439-1444 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T7 1934-1939 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T8 1991-1996 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T9 2105-2111 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 136-144 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T2 147-156 Disease denotes Infection http://purl.obolibrary.org/obo/MONDO_0005550
T3 183-230 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T4 183-216 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T5 232-240 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 244-253 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T7 615-623 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T8 666-674 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T9 1058-1070 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T10 1251-1259 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T11 1264-1287 Disease denotes coronary artery disease http://purl.obolibrary.org/obo/MONDO_0005010
T12 1273-1287 Disease denotes artery disease http://purl.obolibrary.org/obo/MONDO_0000473
T13 1569-1577 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T14 1580-1589 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T15 1694-1702 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T16 1791-1799 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T17 1886-1894 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T18 1968-1976 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T19 1982-2004 Disease denotes coronary heart disease http://purl.obolibrary.org/obo/MONDO_0005010
T20 1991-2004 Disease denotes heart disease http://purl.obolibrary.org/obo/MONDO_0005267
T21 2055-2063 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T22 2069-2085 Disease denotes systemic disease http://purl.obolibrary.org/obo/MONDO_0015938

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 38-44 http://purl.obolibrary.org/obo/UBERON_0001969 denotes Plasma
T2 96-97 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T3 104-109 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T4 257-262 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T5 263-275 http://purl.obolibrary.org/obo/UBERON_0001969 denotes blood plasma
T6 434-436 http://purl.obolibrary.org/obo/CL_0000453 denotes LC
T7 437-439 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T8 642-648 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T9 677-682 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T10 897-899 http://purl.obolibrary.org/obo/CLO_0007874 denotes MS
T11 1273-1279 http://purl.obolibrary.org/obo/UBERON_0001637 denotes artery
T12 1273-1279 http://www.ebi.ac.uk/efo/EFO_0000814 denotes artery
T13 1439-1444 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T14 1439-1444 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T15 1558-1559 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T16 1599-1600 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T17 1623-1627 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T18 1765-1766 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T19 1862-1863 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T20 1934-1939 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T21 1934-1939 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T22 1991-1996 http://purl.obolibrary.org/obo/UBERON_0000948 denotes heart
T23 1991-1996 http://purl.obolibrary.org/obo/UBERON_0007100 denotes heart
T24 1991-1996 http://purl.obolibrary.org/obo/UBERON_0015228 denotes heart
T25 1991-1996 http://www.ebi.ac.uk/efo/EFO_0000815 denotes heart
T26 2067-2068 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T27 2105-2123 http://purl.obolibrary.org/obo/UBERON_0000467 denotes organs and systems

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 45-56 Chemical denotes Lipoprotein http://purl.obolibrary.org/obo/CHEBI_6495
T2 78-82 Chemical denotes Acid http://purl.obolibrary.org/obo/CHEBI_37527
T3 434-436 Chemical denotes LC http://purl.obolibrary.org/obo/CHEBI_73582
T4 437-439 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T5 471-482 Chemical denotes lipoprotein http://purl.obolibrary.org/obo/CHEBI_6495
T6 498-503 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T7 506-510 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T8 511-523 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T9 525-532 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167
T11 546-552 Chemical denotes amines http://purl.obolibrary.org/obo/CHEBI_32952
T12 897-899 Chemical denotes MS http://purl.obolibrary.org/obo/CHEBI_73613
T13 1026-1037 Chemical denotes metabolites http://purl.obolibrary.org/obo/CHEBI_25212
T14 1090-1095 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T15 1098-1102 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T16 1103-1115 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T17 1133-1143 Chemical denotes kynurenine http://purl.obolibrary.org/obo/CHEBI_28683
T18 1144-1154 Chemical denotes tryptophan http://purl.obolibrary.org/obo/CHEBI_16828|http://purl.obolibrary.org/obo/CHEBI_27897|http://purl.obolibrary.org/obo/CHEBI_57719|http://purl.obolibrary.org/obo/CHEBI_57912
T22 1189-1200 Chemical denotes lipoprotein http://purl.obolibrary.org/obo/CHEBI_6495
T23 1202-1209 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167
T25 1214-1224 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T26 1214-1219 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T27 1220-1224 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T28 1303-1306 Chemical denotes HDL http://purl.obolibrary.org/obo/CHEBI_39025
T29 1330-1333 Chemical denotes HDL http://purl.obolibrary.org/obo/CHEBI_39025
T30 1334-1347 Chemical denotes triglycerides http://purl.obolibrary.org/obo/CHEBI_17855
T31 1354-1357 Chemical denotes LDL http://purl.obolibrary.org/obo/CHEBI_39026
T32 1362-1366 Chemical denotes VLDL http://purl.obolibrary.org/obo/CHEBI_39027
T33 1367-1380 Chemical denotes triglycerides http://purl.obolibrary.org/obo/CHEBI_17855
T34 1417-1427 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T35 1417-1422 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T36 1423-1427 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T37 1481-1490 Chemical denotes glutamine http://purl.obolibrary.org/obo/CHEBI_28300
T38 1491-1500 Chemical denotes glutamate http://purl.obolibrary.org/obo/CHEBI_14321|http://purl.obolibrary.org/obo/CHEBI_29987

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 45-67 http://purl.obolibrary.org/obo/GO_0042157 denotes Lipoprotein, Metabolic
T2 1058-1070 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T3 1307-1321 http://purl.obolibrary.org/obo/GO_0005319 denotes Apolipoprotein

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-157 Sentence denotes Integrative Modelling of Quantitative Plasma Lipoprotein, Metabolic and Amino Acid Data Reveals a Multi-organ Pathological Signature of SARS-CoV-2 Infection.
T2 158-441 Sentence denotes The metabolic effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on human blood plasma were characterized using multi-platform metabolic phenotyping with Nuclear Magnetic Resonance (NMR) spectroscopy and liquid chromatography-mass spectrometry (LC-MS).
T3 442-742 Sentence denotes Quantitative measurements of lipoprotein sub-fractions, alpha-1-acid glycoprotein, glucose and biogenic amines were made on samples from symptomatic coronavirus disease 19 (COVID-19) patients who had tested positive for the SARS-CoV-2 virus (n = 17) and from age and gender-matched controls (n = 25).
T4 743-1008 Sentence denotes Data were analyzed using an orthogonal-projections to latent structures (O-PLS) method and used to construct an exceptionally strong (AUROC=1) hybrid NMR-MS model that enabled detailed metabolic discrimination between the groups and their biochemical relationships.
T5 1009-1161 Sentence denotes Key discriminant metabolites included markers of inflammation including elevated alpha-1 acid glycoprotein and an increased kynurenine/tryptophan ratio.
T6 1162-1382 Sentence denotes There was also an abnormal lipoprotein, glucose and amino acid signature consistent with diabetes and coronary artery disease (low total and HDL Apolipoprotein A1, low HDL triglycerides, high LDL and VLDL triglycerides).
T7 1383-1598 Sentence denotes Plus, multiple highly significant amino acid markers of liver dysfunction (including the elevated glutamine/glutamate and Fischer's ratios) that present themselves as part of a distinct SARS-CoV-2 infection pattern.
T8 1599-1736 Sentence denotes A multivariate training-test set model was validated using independent samples from additional SARS-CoV-2 positive patients and controls.
T9 1737-1813 Sentence denotes The predictive model showed a sensitivity of 100% for SARS-CoV-2 positivity.
T10 1814-2124 Sentence denotes The breadth of the disturbed pathways indicates a systemic signature of SARS-CoV-2 positivity that includes elements of liver dysfunction, dyslipidaemia, diabetes, and coronary heart disease risk that are consistent with recent reports that COVID-19 is a systemic disease affecting multiple organs and systems.
T11 2125-2165 Sentence denotes Metabolights study reference: MTBLS2014.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1 136-156 Disease denotes SARS-CoV-2 Infection MESH:C000657245
36 183-230 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
37 232-242 Species denotes SARS-CoV-2 Tax:2697049
38 244-253 Disease denotes infection MESH:D007239
39 257-262 Species denotes human Tax:9606
40 525-532 Chemical denotes glucose MESH:D005947
41 546-552 Chemical denotes amines MESH:D000588
42 591-613 Disease denotes coronavirus disease 19 MESH:C000657245
43 615-623 Disease denotes COVID-19 MESH:C000657245
44 625-633 Species denotes patients Tax:9606
45 666-676 Species denotes SARS-CoV-2 Tax:2697049
46 1058-1070 Disease denotes inflammation MESH:D007249
47 1090-1115 Gene denotes alpha-1 acid glycoprotein
48 1133-1143 Chemical denotes kynurenine MESH:D007737
49 1144-1154 Chemical denotes tryptophan MESH:D014364
50 1202-1209 Chemical denotes glucose MESH:D005947
51 1251-1259 Disease denotes diabetes MESH:D003920
52 1264-1287 Disease denotes coronary artery disease MESH:D003324
53 1307-1324 Gene denotes Apolipoprotein A1 Gene:335
54 1334-1347 Chemical denotes triglycerides MESH:D014280
55 1367-1380 Chemical denotes triglycerides MESH:D014280
56 1439-1456 Disease denotes liver dysfunction MESH:D017093
57 1481-1490 Chemical denotes glutamine MESH:D005973
58 1491-1500 Chemical denotes glutamate MESH:D018698
59 1574-1589 Disease denotes CoV-2 infection MESH:C000657245
60 1694-1704 Species denotes SARS-CoV-2 Tax:2697049
61 1714-1722 Species denotes patients Tax:9606
62 1791-1801 Species denotes SARS-CoV-2 Tax:2697049
63 1886-1896 Species denotes SARS-CoV-2 Tax:2697049
64 1934-1951 Disease denotes liver dysfunction MESH:D017093
65 1953-1966 Disease denotes dyslipidaemia MESH:D050171
66 1968-1976 Disease denotes diabetes MESH:D003920
67 1982-2004 Disease denotes coronary heart disease MESH:D003324
68 2055-2063 Disease denotes COVID-19 MESH:C000657245
69 2069-2085 Disease denotes systemic disease MESH:D034721

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1439-1456 Phenotype denotes liver dysfunction http://purl.obolibrary.org/obo/HP_0001410
T2 1934-1951 Phenotype denotes liver dysfunction http://purl.obolibrary.org/obo/HP_0001410

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 525-532 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T2 1202-1209 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG

sentences

Id Subject Object Predicate Lexical cue
T1 0-157 Sentence denotes Integrative Modelling of Quantitative Plasma Lipoprotein, Metabolic and Amino Acid Data Reveals a Multi-organ Pathological Signature of SARS-CoV-2 Infection.
T2 158-441 Sentence denotes The metabolic effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on human blood plasma were characterized using multi-platform metabolic phenotyping with Nuclear Magnetic Resonance (NMR) spectroscopy and liquid chromatography-mass spectrometry (LC-MS).
T3 442-742 Sentence denotes Quantitative measurements of lipoprotein sub-fractions, alpha-1-acid glycoprotein, glucose and biogenic amines were made on samples from symptomatic coronavirus disease 19 (COVID-19) patients who had tested positive for the SARS-CoV-2 virus (n = 17) and from age and gender-matched controls (n = 25).
T4 743-1008 Sentence denotes Data were analyzed using an orthogonal-projections to latent structures (O-PLS) method and used to construct an exceptionally strong (AUROC=1) hybrid NMR-MS model that enabled detailed metabolic discrimination between the groups and their biochemical relationships.
T5 1009-1161 Sentence denotes Key discriminant metabolites included markers of inflammation including elevated alpha-1 acid glycoprotein and an increased kynurenine/tryptophan ratio.
T6 1162-1382 Sentence denotes There was also an abnormal lipoprotein, glucose and amino acid signature consistent with diabetes and coronary artery disease (low total and HDL Apolipoprotein A1, low HDL triglycerides, high LDL and VLDL triglycerides).
T7 1383-1598 Sentence denotes Plus, multiple highly significant amino acid markers of liver dysfunction (including the elevated glutamine/glutamate and Fischer's ratios) that present themselves as part of a distinct SARS-CoV-2 infection pattern.
T8 1599-1736 Sentence denotes A multivariate training-test set model was validated using independent samples from additional SARS-CoV-2 positive patients and controls.
T9 1737-1813 Sentence denotes The predictive model showed a sensitivity of 100% for SARS-CoV-2 positivity.
T10 1814-2124 Sentence denotes The breadth of the disturbed pathways indicates a systemic signature of SARS-CoV-2 positivity that includes elements of liver dysfunction, dyslipidaemia, diabetes, and coronary heart disease risk that are consistent with recent reports that COVID-19 is a systemic disease affecting multiple organs and systems.
T11 2125-2165 Sentence denotes Metabolights study reference: MTBLS2014.
T1 0-157 Sentence denotes Integrative Modelling of Quantitative Plasma Lipoprotein, Metabolic and Amino Acid Data Reveals a Multi-organ Pathological Signature of SARS-CoV-2 Infection.
T2 158-441 Sentence denotes The metabolic effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on human blood plasma were characterized using multi-platform metabolic phenotyping with Nuclear Magnetic Resonance (NMR) spectroscopy and liquid chromatography-mass spectrometry (LC-MS).
T3 442-742 Sentence denotes Quantitative measurements of lipoprotein sub-fractions, alpha-1-acid glycoprotein, glucose and biogenic amines were made on samples from symptomatic coronavirus disease 19 (COVID-19) patients who had tested positive for the SARS-CoV-2 virus (n = 17) and from age and gender-matched controls (n = 25).
T4 743-1008 Sentence denotes Data were analyzed using an orthogonal-projections to latent structures (O-PLS) method and used to construct an exceptionally strong (AUROC=1) hybrid NMR-MS model that enabled detailed metabolic discrimination between the groups and their biochemical relationships.
T5 1009-1161 Sentence denotes Key discriminant metabolites included markers of inflammation including elevated alpha-1 acid glycoprotein and an increased kynurenine/tryptophan ratio.
T6 1162-1382 Sentence denotes There was also an abnormal lipoprotein, glucose and amino acid signature consistent with diabetes and coronary artery disease (low total and HDL Apolipoprotein A1, low HDL triglycerides, high LDL and VLDL triglycerides).
T7 1383-1598 Sentence denotes Plus, multiple highly significant amino acid markers of liver dysfunction (including the elevated glutamine/glutamate and Fischer's ratios) that present themselves as part of a distinct SARS-CoV-2 infection pattern.
T8 1599-1736 Sentence denotes A multivariate training-test set model was validated using independent samples from additional SARS-CoV-2 positive patients and controls.
T9 1737-1813 Sentence denotes The predictive model showed a sensitivity of 100% for SARS-CoV-2 positivity.
T10 1814-2124 Sentence denotes The breadth of the disturbed pathways indicates a systemic signature of SARS-CoV-2 positivity that includes elements of liver dysfunction, dyslipidaemia, diabetes, and coronary heart disease risk that are consistent with recent reports that COVID-19 is a systemic disease affecting multiple organs and systems.
T11 2125-2165 Sentence denotes Metabolights study reference: MTBLS2014.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 263-275 http://purl.obolibrary.org/obo/MAT_0000052 denotes blood plasma
T2 263-268 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T3 263-268 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T4 1273-1279 http://purl.obolibrary.org/obo/MAT_0000034 denotes artery
T5 1439-1444 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T6 1934-1939 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T7 1991-1996 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 525-532 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose
T2 1202-1209 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 136-146 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T2 147-156 Disease denotes Infection http://purl.obolibrary.org/obo/MONDO_0005550
T3 183-230 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T4 232-242 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T5 244-253 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T6 591-613 Disease denotes coronavirus disease 19 http://purl.obolibrary.org/obo/MONDO_0100096
T7 615-623 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T8 666-676 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T9 1058-1070 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T10 1251-1259 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T11 1264-1287 Disease denotes coronary artery disease http://purl.obolibrary.org/obo/MONDO_0005010
T12 1569-1579 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T13 1580-1589 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T14 1694-1704 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T15 1791-1801 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T16 1886-1896 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T17 1968-1976 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T18 1982-2004 Disease denotes coronary heart disease http://purl.obolibrary.org/obo/MONDO_0005010
T19 2055-2063 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T20 2069-2085 Disease denotes systemic disease http://purl.obolibrary.org/obo/MONDO_0015938

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1439-1456 Phenotype denotes liver dysfunction HP:0001410
T2 1934-1951 Phenotype denotes liver dysfunction HP:0001410
T3 1953-1966 Phenotype denotes dyslipidaemia HP:0003119

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 136-144 OrganismTaxon denotes SARS-CoV 694009
T2 183-216 OrganismTaxon denotes severe acute respiratory syndrome 694009
T3 232-240 OrganismTaxon denotes SARS-CoV 694009
T4 257-262 OrganismTaxon denotes human 9606
T5 666-674 OrganismTaxon denotes SARS-CoV 694009
T6 1569-1577 OrganismTaxon denotes SARS-CoV 694009
T7 1694-1702 OrganismTaxon denotes SARS-CoV 694009
T8 1791-1799 OrganismTaxon denotes SARS-CoV 694009
T9 1886-1894 OrganismTaxon denotes SARS-CoV 694009

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 38-44 Body_part denotes Plasma http://purl.obolibrary.org/obo/UBERON_0001969
T2 104-109 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062|http://purl.obolibrary.org/obo/UBERON_0003103
T4 263-275 Body_part denotes blood plasma http://purl.obolibrary.org/obo/UBERON_0001969
T5 1264-1279 Body_part denotes coronary artery http://purl.obolibrary.org/obo/UBERON_0001621
T6 1439-1444 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T7 1934-1939 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T8 1991-1996 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 263-275 Body_part denotes blood plasma http://purl.obolibrary.org/obo/MAT_0000052
T2 1273-1279 Body_part denotes artery http://purl.obolibrary.org/obo/MAT_0000034
T3 1439-1444 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T4 1934-1939 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T5 1991-1996 Body_part denotes heart http://purl.obolibrary.org/obo/MAT_0000036