PubMed:32786685 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PubMed/sourceid/32786685","sourcedb":"PubMed","sourceid":"32786685","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/32786685","text":"Molecular Binding Mechanism and Pharmacology Comparative Analysis of Noscapine for Repurposing against SARS-CoV-2 Protease.\nOriginating in the city of Wuhan in China in December 2019, COVID-19 has emerged now as a global health emergency with a high number of deaths worldwide. COVID-19 is caused by a novel coronavirus, referred to as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), resulting in pandemic conditions around the globe. We are in the battleground to fight against the virus by rapidly developing therapeutic strategies in tackling SARS-CoV-2 and saving human lives from COVID-19. Scientists are evaluating several known drugs either for the pathogen or the host; however, many of them are reported to be associated with side effects. In the present study, we report the molecular binding mechanisms of the natural alkaloid, noscapine, for repurposing against the main protease of SARS-CoV-2, a key enzyme involved in its reproduction. We performed the molecular dynamics (MD) simulation in an explicit solvent to investigate the molecular mechanisms of noscapine for stable binding and conformational changes to the main protease (Mpro) of SARS-CoV-2. The drug repurposing study revealed the high potential of noscapine and proximal binding to the Mpro enzyme in a comparative binding pattern analyzed with chloroquine, ribavirin, and favipiravir. Noscapine binds closely to binding pocket-3 of the Mpro enzyme and depicted stable binding with RMSD 0.1-1.9 Å and RMSF profile peak conformational fluctuations at 202-306 residues, and a Rg score ranging from 21.9 to 22.4 Å. The MM/PB (GB) SA calculation landscape revealed the most significant contribution in terms of binding energy with ΔPB -19.08 and ΔGB -27.17 kcal/mol. The electrostatic energy distribution in MM energy was obtained to be -71.16 kcal/mol and depicted high free energy decomposition (electrostatic energy) at 155-306 residues (binding pocket-3) of Mpro by a MM force field. Moreover, the dynamical residue cross-correlation map also stated that the high pairwise correlation occurred at binding residues 200-306 of the Mpro enzyme (binding pocket-3) with noscapine. Principal component analysis depicted the enhanced movement of protein atoms with a high number of static hydrogen bonds. The obtained binding results of noscapine were also well correlated with the pharmacokinetic parameters of antiviral drugs.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":2025,"end":2028},"obj":"Body_part"},{"id":"T2","span":{"begin":2230,"end":2237},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma67847"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma67257"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":103,"end":111},"obj":"Disease"},{"id":"T2","span":{"begin":184,"end":192},"obj":"Disease"},{"id":"T3","span":{"begin":278,"end":286},"obj":"Disease"},{"id":"T4","span":{"begin":336,"end":383},"obj":"Disease"},{"id":"T5","span":{"begin":336,"end":369},"obj":"Disease"},{"id":"T6","span":{"begin":385,"end":393},"obj":"Disease"},{"id":"T7","span":{"begin":560,"end":568},"obj":"Disease"},{"id":"T8","span":{"begin":599,"end":607},"obj":"Disease"},{"id":"T9","span":{"begin":909,"end":917},"obj":"Disease"},{"id":"T10","span":{"begin":1169,"end":1177},"obj":"Disease"},{"id":"T11","span":{"begin":1610,"end":1612},"obj":"Disease"},{"id":"T12","span":{"begin":1719,"end":1721},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0019035"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0019035"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":193,"end":196},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T2","span":{"begin":212,"end":213},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T3","span":{"begin":243,"end":244},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T4","span":{"begin":300,"end":301},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T5","span":{"begin":497,"end":502},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T6","span":{"begin":582,"end":587},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T7","span":{"begin":918,"end":922},"obj":"http://purl.obolibrary.org/obo/CLO_0001236"},{"id":"T8","span":{"begin":1001,"end":1003},"obj":"http://purl.obolibrary.org/obo/CLO_0007622"},{"id":"T9","span":{"begin":1292,"end":1293},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T10","span":{"begin":1486,"end":1487},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T11","span":{"begin":1563,"end":1564},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T12","span":{"begin":1600,"end":1601},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T13","span":{"begin":1957,"end":1958},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T14","span":{"begin":1968,"end":1973},"obj":"http://purl.obolibrary.org/obo/UBERON_0007688"},{"id":"T15","span":{"begin":2249,"end":2250},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":649,"end":654},"obj":"Chemical"},{"id":"T2","span":{"begin":843,"end":851},"obj":"Chemical"},{"id":"T3","span":{"begin":853,"end":862},"obj":"Chemical"},{"id":"T4","span":{"begin":1001,"end":1003},"obj":"Chemical"},{"id":"T5","span":{"begin":1031,"end":1038},"obj":"Chemical"},{"id":"T6","span":{"begin":1082,"end":1091},"obj":"Chemical"},{"id":"T7","span":{"begin":1185,"end":1189},"obj":"Chemical"},{"id":"T8","span":{"begin":1239,"end":1248},"obj":"Chemical"},{"id":"T9","span":{"begin":1336,"end":1347},"obj":"Chemical"},{"id":"T10","span":{"begin":1349,"end":1358},"obj":"Chemical"},{"id":"T11","span":{"begin":1364,"end":1375},"obj":"Chemical"},{"id":"T12","span":{"begin":1565,"end":1567},"obj":"Chemical"},{"id":"T13","span":{"begin":1607,"end":1609},"obj":"Chemical"},{"id":"T15","span":{"begin":1610,"end":1612},"obj":"Chemical"},{"id":"T17","span":{"begin":1618,"end":1620},"obj":"Chemical"},{"id":"T21","span":{"begin":1719,"end":1721},"obj":"Chemical"},{"id":"T23","span":{"begin":1795,"end":1797},"obj":"Chemical"},{"id":"T25","span":{"begin":1959,"end":1961},"obj":"Chemical"},{"id":"T27","span":{"begin":2156,"end":2165},"obj":"Chemical"},{"id":"T28","span":{"begin":2230,"end":2237},"obj":"Chemical"},{"id":"T29","span":{"begin":2238,"end":2243},"obj":"Chemical"},{"id":"T30","span":{"begin":2273,"end":2281},"obj":"Chemical"},{"id":"T31","span":{"begin":2321,"end":2330},"obj":"Chemical"},{"id":"T32","span":{"begin":2396,"end":2411},"obj":"Chemical"},{"id":"T33","span":{"begin":2396,"end":2405},"obj":"Chemical"},{"id":"T34","span":{"begin":2406,"end":2411},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_22315"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_73237"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_74699"},{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_46787"},{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_73237"},{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_73237"},{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_3638"},{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_63580"},{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_134722"},{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_33368"},{"id":"A13","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_53458"},{"id":"A14","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_74707"},{"id":"A15","pred":"chebi_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_53319"},{"id":"A16","pred":"chebi_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_60686"},{"id":"A17","pred":"chebi_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/CHEBI_35962"},{"id":"A18","pred":"chebi_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/CHEBI_38358"},{"id":"A19","pred":"chebi_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/CHEBI_45373"},{"id":"A20","pred":"chebi_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/CHEBI_74801"},{"id":"A21","pred":"chebi_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/CHEBI_53319"},{"id":"A22","pred":"chebi_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/CHEBI_60686"},{"id":"A23","pred":"chebi_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_53458"},{"id":"A24","pred":"chebi_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_74707"},{"id":"A25","pred":"chebi_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/CHEBI_53458"},{"id":"A26","pred":"chebi_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/CHEBI_74707"},{"id":"A27","pred":"chebi_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/CHEBI_73237"},{"id":"A28","pred":"chebi_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A29","pred":"chebi_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/CHEBI_33250"},{"id":"A30","pred":"chebi_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A31","pred":"chebi_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/CHEBI_73237"},{"id":"A32","pred":"chebi_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/CHEBI_36044"},{"id":"A33","pred":"chebi_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A34","pred":"chebi_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T29","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T34","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":950,"end":962},"obj":"http://purl.obolibrary.org/obo/GO_0000003"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":123},"obj":"Sentence"},{"id":"T2","span":{"begin":124,"end":277},"obj":"Sentence"},{"id":"T3","span":{"begin":278,"end":448},"obj":"Sentence"},{"id":"T4","span":{"begin":449,"end":608},"obj":"Sentence"},{"id":"T5","span":{"begin":609,"end":762},"obj":"Sentence"},{"id":"T6","span":{"begin":763,"end":963},"obj":"Sentence"},{"id":"T7","span":{"begin":964,"end":1180},"obj":"Sentence"},{"id":"T8","span":{"begin":1181,"end":1376},"obj":"Sentence"},{"id":"T9","span":{"begin":1377,"end":1602},"obj":"Sentence"},{"id":"T10","span":{"begin":1603,"end":1753},"obj":"Sentence"},{"id":"T11","span":{"begin":1754,"end":1974},"obj":"Sentence"},{"id":"T12","span":{"begin":1975,"end":2166},"obj":"Sentence"},{"id":"T13","span":{"begin":2167,"end":2288},"obj":"Sentence"},{"id":"T14","span":{"begin":2289,"end":2412},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-sentences"},{"subj":"T2","pred":"source","obj":"LitCovid-sentences"},{"subj":"T3","pred":"source","obj":"LitCovid-sentences"},{"subj":"T4","pred":"source","obj":"LitCovid-sentences"},{"subj":"T5","pred":"source","obj":"LitCovid-sentences"},{"subj":"T6","pred":"source","obj":"LitCovid-sentences"},{"subj":"T7","pred":"source","obj":"LitCovid-sentences"},{"subj":"T8","pred":"source","obj":"LitCovid-sentences"},{"subj":"T9","pred":"source","obj":"LitCovid-sentences"},{"subj":"T10","pred":"source","obj":"LitCovid-sentences"},{"subj":"T11","pred":"source","obj":"LitCovid-sentences"},{"subj":"T12","pred":"source","obj":"LitCovid-sentences"},{"subj":"T13","pred":"source","obj":"LitCovid-sentences"},{"subj":"T14","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"2","span":{"begin":69,"end":78},"obj":"Chemical"},{"id":"3","span":{"begin":103,"end":113},"obj":"Species"},{"id":"30","span":{"begin":184,"end":192},"obj":"Disease"},{"id":"31","span":{"begin":260,"end":266},"obj":"Disease"},{"id":"32","span":{"begin":278,"end":286},"obj":"Disease"},{"id":"33","span":{"begin":302,"end":319},"obj":"Species"},{"id":"34","span":{"begin":336,"end":383},"obj":"Species"},{"id":"35","span":{"begin":385,"end":395},"obj":"Species"},{"id":"36","span":{"begin":560,"end":570},"obj":"Species"},{"id":"37","span":{"begin":582,"end":587},"obj":"Species"},{"id":"38","span":{"begin":599,"end":607},"obj":"Disease"},{"id":"39","span":{"begin":853,"end":862},"obj":"Chemical"},{"id":"40","span":{"begin":909,"end":919},"obj":"Species"},{"id":"41","span":{"begin":1082,"end":1091},"obj":"Chemical"},{"id":"42","span":{"begin":1160,"end":1164},"obj":"Gene"},{"id":"43","span":{"begin":1169,"end":1179},"obj":"Species"},{"id":"44","span":{"begin":1239,"end":1248},"obj":"Chemical"},{"id":"45","span":{"begin":1277,"end":1281},"obj":"Gene"},{"id":"46","span":{"begin":1336,"end":1347},"obj":"Chemical"},{"id":"47","span":{"begin":1349,"end":1358},"obj":"Chemical"},{"id":"48","span":{"begin":1364,"end":1375},"obj":"Chemical"},{"id":"49","span":{"begin":1377,"end":1386},"obj":"Chemical"},{"id":"50","span":{"begin":1428,"end":1432},"obj":"Gene"},{"id":"51","span":{"begin":1949,"end":1953},"obj":"Gene"},{"id":"52","span":{"begin":2120,"end":2124},"obj":"Gene"},{"id":"53","span":{"begin":2156,"end":2165},"obj":"Chemical"},{"id":"54","span":{"begin":2273,"end":2281},"obj":"Chemical"},{"id":"55","span":{"begin":2321,"end":2330},"obj":"Chemical"}],"attributes":[{"id":"A2","pred":"tao:has_database_id","subj":"2","obj":"MESH:D009665"},{"id":"A3","pred":"tao:has_database_id","subj":"3","obj":"Tax:2697049"},{"id":"A30","pred":"tao:has_database_id","subj":"30","obj":"MESH:C000657245"},{"id":"A31","pred":"tao:has_database_id","subj":"31","obj":"MESH:D003643"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"MESH:C000657245"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"Tax:2697049"},{"id":"A34","pred":"tao:has_database_id","subj":"34","obj":"Tax:2697049"},{"id":"A35","pred":"tao:has_database_id","subj":"35","obj":"Tax:2697049"},{"id":"A36","pred":"tao:has_database_id","subj":"36","obj":"Tax:2697049"},{"id":"A37","pred":"tao:has_database_id","subj":"37","obj":"Tax:9606"},{"id":"A38","pred":"tao:has_database_id","subj":"38","obj":"MESH:C000657245"},{"id":"A39","pred":"tao:has_database_id","subj":"39","obj":"MESH:D009665"},{"id":"A40","pred":"tao:has_database_id","subj":"40","obj":"Tax:2697049"},{"id":"A41","pred":"tao:has_database_id","subj":"41","obj":"MESH:D009665"},{"id":"A42","pred":"tao:has_database_id","subj":"42","obj":"Gene:8673700"},{"id":"A43","pred":"tao:has_database_id","subj":"43","obj":"Tax:2697049"},{"id":"A44","pred":"tao:has_database_id","subj":"44","obj":"MESH:D009665"},{"id":"A45","pred":"tao:has_database_id","subj":"45","obj":"Gene:8673700"},{"id":"A46","pred":"tao:has_database_id","subj":"46","obj":"MESH:D002738"},{"id":"A47","pred":"tao:has_database_id","subj":"47","obj":"MESH:D012254"},{"id":"A48","pred":"tao:has_database_id","subj":"48","obj":"MESH:C462182"},{"id":"A49","pred":"tao:has_database_id","subj":"49","obj":"MESH:D009665"},{"id":"A50","pred":"tao:has_database_id","subj":"50","obj":"Gene:8673700"},{"id":"A51","pred":"tao:has_database_id","subj":"51","obj":"Gene:8673700"},{"id":"A52","pred":"tao:has_database_id","subj":"52","obj":"Gene:8673700"},{"id":"A53","pred":"tao:has_database_id","subj":"53","obj":"MESH:D009665"},{"id":"A54","pred":"tao:has_database_id","subj":"54","obj":"MESH:D006859"},{"id":"A55","pred":"tao:has_database_id","subj":"55","obj":"MESH:D009665"},{"subj":"2","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3","pred":"source","obj":"LitCovid-PubTator"},{"subj":"30","pred":"source","obj":"LitCovid-PubTator"},{"subj":"31","pred":"source","obj":"LitCovid-PubTator"},{"subj":"32","pred":"source","obj":"LitCovid-PubTator"},{"subj":"33","pred":"source","obj":"LitCovid-PubTator"},{"subj":"34","pred":"source","obj":"LitCovid-PubTator"},{"subj":"35","pred":"source","obj":"LitCovid-PubTator"},{"subj":"36","pred":"source","obj":"LitCovid-PubTator"},{"subj":"37","pred":"source","obj":"LitCovid-PubTator"},{"subj":"38","pred":"source","obj":"LitCovid-PubTator"},{"subj":"39","pred":"source","obj":"LitCovid-PubTator"},{"subj":"40","pred":"source","obj":"LitCovid-PubTator"},{"subj":"41","pred":"source","obj":"LitCovid-PubTator"},{"subj":"42","pred":"source","obj":"LitCovid-PubTator"},{"subj":"43","pred":"source","obj":"LitCovid-PubTator"},{"subj":"44","pred":"source","obj":"LitCovid-PubTator"},{"subj":"45","pred":"source","obj":"LitCovid-PubTator"},{"subj":"46","pred":"source","obj":"LitCovid-PubTator"},{"subj":"47","pred":"source","obj":"LitCovid-PubTator"},{"subj":"48","pred":"source","obj":"LitCovid-PubTator"},{"subj":"49","pred":"source","obj":"LitCovid-PubTator"},{"subj":"50","pred":"source","obj":"LitCovid-PubTator"},{"subj":"51","pred":"source","obj":"LitCovid-PubTator"},{"subj":"52","pred":"source","obj":"LitCovid-PubTator"},{"subj":"53","pred":"source","obj":"LitCovid-PubTator"},{"subj":"54","pred":"source","obj":"LitCovid-PubTator"},{"subj":"55","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid_AGAC_only","denotations":[{"id":"p95180s0","span":{"begin":278,"end":283},"obj":"Disease"},{"id":"p95180s1","span":{"begin":283,"end":284},"obj":"Disease"},{"id":"p95180s2","span":{"begin":284,"end":286},"obj":"Disease"},{"id":"p95180s4","span":{"begin":290,"end":299},"obj":"Reg"}],"attributes":[{"subj":"p95180s0","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p95180s1","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p95180s2","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p95180s4","pred":"source","obj":"LitCovid_AGAC_only"}]},{"project":"sentences","denotations":[{"id":"T1","span":{"begin":0,"end":123},"obj":"Sentence"},{"id":"T2","span":{"begin":124,"end":277},"obj":"Sentence"},{"id":"T3","span":{"begin":278,"end":448},"obj":"Sentence"},{"id":"T4","span":{"begin":449,"end":608},"obj":"Sentence"},{"id":"T5","span":{"begin":609,"end":762},"obj":"Sentence"},{"id":"T6","span":{"begin":763,"end":963},"obj":"Sentence"},{"id":"T7","span":{"begin":964,"end":1180},"obj":"Sentence"},{"id":"T8","span":{"begin":1181,"end":1376},"obj":"Sentence"},{"id":"T9","span":{"begin":1377,"end":1602},"obj":"Sentence"},{"id":"T10","span":{"begin":1603,"end":1753},"obj":"Sentence"},{"id":"T11","span":{"begin":1754,"end":1974},"obj":"Sentence"},{"id":"T12","span":{"begin":1975,"end":2166},"obj":"Sentence"},{"id":"T13","span":{"begin":2167,"end":2288},"obj":"Sentence"},{"id":"T14","span":{"begin":2289,"end":2412},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":123},"obj":"Sentence"},{"id":"T2","span":{"begin":124,"end":277},"obj":"Sentence"},{"id":"T3","span":{"begin":278,"end":448},"obj":"Sentence"},{"id":"T4","span":{"begin":449,"end":608},"obj":"Sentence"},{"id":"T5","span":{"begin":609,"end":762},"obj":"Sentence"},{"id":"T6","span":{"begin":763,"end":963},"obj":"Sentence"},{"id":"T7","span":{"begin":964,"end":1180},"obj":"Sentence"},{"id":"T8","span":{"begin":1181,"end":1376},"obj":"Sentence"},{"id":"T9","span":{"begin":1377,"end":1602},"obj":"Sentence"},{"id":"T10","span":{"begin":1603,"end":1753},"obj":"Sentence"},{"id":"T11","span":{"begin":1754,"end":1974},"obj":"Sentence"},{"id":"T12","span":{"begin":1975,"end":2166},"obj":"Sentence"},{"id":"T13","span":{"begin":2167,"end":2288},"obj":"Sentence"},{"id":"T14","span":{"begin":2289,"end":2412},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"},{"subj":"T12","pred":"source","obj":"sentences"},{"subj":"T13","pred":"source","obj":"sentences"},{"subj":"T14","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"},{"subj":"T12","pred":"source","obj":"sentences"},{"subj":"T13","pred":"source","obj":"sentences"},{"subj":"T14","pred":"source","obj":"sentences"}]},{"project":"Glycosmos6-MAT","denotations":[{"id":"T1","span":{"begin":1253,"end":1261},"obj":"http://purl.obolibrary.org/obo/MAT_0000491"}],"attributes":[{"subj":"T1","pred":"source","obj":"Glycosmos6-MAT"}]},{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":103,"end":113},"obj":"Disease"},{"id":"T2","span":{"begin":184,"end":192},"obj":"Disease"},{"id":"T3","span":{"begin":278,"end":286},"obj":"Disease"},{"id":"T4","span":{"begin":336,"end":383},"obj":"Disease"},{"id":"T5","span":{"begin":385,"end":395},"obj":"Disease"},{"id":"T6","span":{"begin":560,"end":570},"obj":"Disease"},{"id":"T7","span":{"begin":599,"end":607},"obj":"Disease"},{"id":"T8","span":{"begin":909,"end":919},"obj":"Disease"},{"id":"T9","span":{"begin":1169,"end":1179},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T1","pred":"source","obj":"mondo_disease"},{"subj":"T2","pred":"source","obj":"mondo_disease"},{"subj":"T3","pred":"source","obj":"mondo_disease"},{"subj":"T4","pred":"source","obj":"mondo_disease"},{"subj":"T5","pred":"source","obj":"mondo_disease"},{"subj":"T6","pred":"source","obj":"mondo_disease"},{"subj":"T7","pred":"source","obj":"mondo_disease"},{"subj":"T8","pred":"source","obj":"mondo_disease"},{"subj":"T9","pred":"source","obj":"mondo_disease"}]},{"project":"Anatomy-MAT","denotations":[{"id":"T1","span":{"begin":1253,"end":1261},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"mat_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MAT_0000491"},{"subj":"T1","pred":"source","obj":"Anatomy-MAT"}]},{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":103,"end":111},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":160,"end":165},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":336,"end":369},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":385,"end":393},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":560,"end":568},"obj":"OrganismTaxon"},{"id":"T6","span":{"begin":582,"end":587},"obj":"OrganismTaxon"},{"id":"T7","span":{"begin":909,"end":917},"obj":"OrganismTaxon"},{"id":"T8","span":{"begin":1169,"end":1177},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"694009"},{"id":"A2","pred":"db_id","subj":"T2","obj":"3034371"},{"id":"A3","pred":"db_id","subj":"T3","obj":"694009"},{"id":"A4","pred":"db_id","subj":"T4","obj":"694009"},{"id":"A5","pred":"db_id","subj":"T5","obj":"694009"},{"id":"A6","pred":"db_id","subj":"T6","obj":"9606"},{"id":"A7","pred":"db_id","subj":"T7","obj":"694009"},{"id":"A8","pred":"db_id","subj":"T8","obj":"694009"},{"subj":"T1","pred":"source","obj":"NCBITAXON"},{"subj":"T2","pred":"source","obj":"NCBITAXON"},{"subj":"T3","pred":"source","obj":"NCBITAXON"},{"subj":"T4","pred":"source","obj":"NCBITAXON"},{"subj":"T5","pred":"source","obj":"NCBITAXON"},{"subj":"T6","pred":"source","obj":"NCBITAXON"},{"subj":"T7","pred":"source","obj":"NCBITAXON"},{"subj":"T8","pred":"source","obj":"NCBITAXON"}]},{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":442,"end":447},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0010230"},{"subj":"T1","pred":"source","obj":"Anatomy-UBERON"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#d393ec","default":true},{"id":"LitCovid-PD-MONDO","color":"#93ecb9"},{"id":"LitCovid-PD-CLO","color":"#ec9f93"},{"id":"LitCovid-PD-CHEBI","color":"#93a0ec"},{"id":"LitCovid-PD-GO-BP","color":"#baec93"},{"id":"LitCovid-sentences","color":"#ec93d4"},{"id":"LitCovid-PubTator","color":"#93ecea"},{"id":"LitCovid_AGAC_only","color":"#eccf93"},{"id":"sentences","color":"#b593ec"},{"id":"Glycosmos6-MAT","color":"#93ec9b"},{"id":"mondo_disease","color":"#ec93a4"},{"id":"Anatomy-MAT","color":"#93beec"},{"id":"NCBITAXON","color":"#d8ec93"},{"id":"Anatomy-UBERON","color":"#e693ec"}]}]}}