PubMed:32735992 / 878-1048 JSONTXT

{"project":"LitCovid-OGER-BB","denotations":[{"id":"T33","span":{"begin":126,"end":140},"obj":"DG_37"},{"id":"T34","span":{"begin":126,"end":140},"obj":"PR:000036009"},{"id":"T35","span":{"begin":150,"end":161},"obj":"SO:0100019"},{"id":"T36","span":{"begin":165,"end":169},"obj":"PR:000003622"},{"id":"T37","span":{"begin":165,"end":169},"obj":"G_3"},{"id":"T38","span":{"begin":165,"end":169},"obj":"PG_10"}],"namespaces":[{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"}],"text":"The obtained resulted revealed that the Arg273Gln and Thr445Gly mutation have drastically reduced the binding affinity of the angiotensin-II into the active site of ACE2."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T8","span":{"begin":150,"end":156},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"The obtained resulted revealed that the Arg273Gln and Thr445Gly mutation have drastically reduced the binding affinity of the angiotensin-II into the active site of ACE2."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T8","span":{"begin":126,"end":137},"obj":"Chemical"},{"id":"T9","span":{"begin":138,"end":140},"obj":"Chemical"}],"attributes":[{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_74067"}],"text":"The obtained resulted revealed that the Arg273Gln and Thr445Gly mutation have drastically reduced the binding affinity of the angiotensin-II into the active site of ACE2."}

{"project":"LitCovid-PubTator","denotations":[{"id":"31","span":{"begin":126,"end":140},"obj":"Gene"},{"id":"32","span":{"begin":165,"end":169},"obj":"Gene"}],"attributes":[{"id":"A31","pred":"tao:has_database_id","subj":"31","obj":"Gene:183"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"Gene:59272"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The obtained resulted revealed that the Arg273Gln and Thr445Gly mutation have drastically reduced the binding affinity of the angiotensin-II into the active site of ACE2."}

{"project":"LitCovid-sentences","denotations":[{"id":"T7","span":{"begin":0,"end":170},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The obtained resulted revealed that the Arg273Gln and Thr445Gly mutation have drastically reduced the binding affinity of the angiotensin-II into the active site of ACE2."}

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{"project":"Zoonoses","denotations":[{"id":"T12","span":{"begin":165,"end":169},"obj":"Gene"},{"id":"T43","span":{"begin":40,"end":49},"obj":"Variation"},{"id":"T44","span":{"begin":54,"end":72},"obj":"Variation"},{"id":"T51","span":{"begin":150,"end":161},"obj":"Phenomena"},{"id":"T52","span":{"begin":126,"end":140},"obj":"Gene"},{"id":"T53","span":{"begin":102,"end":118},"obj":"Phenomena"},{"id":"T55","span":{"begin":90,"end":97},"obj":"NegativeRegulation"},{"id":"T56","span":{"begin":78,"end":89},"obj":"High"},{"id":"T74","span":{"begin":64,"end":72},"obj":"Variation"},{"id":"T75","span":{"begin":165,"end":169},"obj":"Gene"},{"id":"T76","span":{"begin":165,"end":169},"obj":"Gene"}],"relations":[{"id":"R17","pred":"has_a","subj":"T12","obj":"T53"},{"id":"R18","pred":"to","subj":"T52","obj":"T53"},{"id":"R20","pred":"is_a","subj":"T43","obj":"T55"},{"id":"R21","pred":"is_a","subj":"T55","obj":"T53"},{"id":"R22","pred":"is_a","subj":"T44","obj":"T55"},{"id":"R23","pred":"is_a","subj":"T55","obj":"T53"},{"id":"R24","pred":"is_a","subj":"T56","obj":"T55"},{"id":"R53","pred":"-","subj":"T43","obj":"T74"},{"id":"R74","pred":"of_a","subj":"T12","obj":"T51"},{"id":"R75","pred":"of_a","subj":"T12","obj":"T44"},{"id":"R76","pred":"of_a","subj":"T12","obj":"T43"}],"attributes":[{"id":"A68","pred":"tao:has_database_id","subj":"T52","obj":"Gene:183"},{"id":"A41","pred":"Memo","subj":"T74","obj":"MESH:D009154"},{"id":"A42","pred":"tao:has_standard_notation","subj":"T74","obj":"p.R273Q"},{"id":"A45","pred":"tao:has_database_id","subj":"T75","obj":"Gene:59272"},{"id":"A38","pred":"Memo","subj":"T43","obj":"MESH:D009154"},{"id":"A65","pred":"tao:has_database_id","subj":"T51","obj":"MESH:D020134"},{"id":"A40","pred":"Memo","subj":"T44","obj":"MESH:D009154"},{"id":"A46","pred":"tao:has_database_id","subj":"T76","obj":"Gene:59272"},{"id":"A29","pred":"tao:has_database_id","subj":"T52","obj":"MESH:D000804"},{"id":"A22","pred":"tao:has_standard_notation","subj":"T43","obj":"p.R273Q"},{"id":"A23","pred":"tao:has_standard_notation","subj":"T44","obj":"p.T445G"},{"id":"A12","pred":"tao:has_database_id","subj":"T12","obj":"Gene:59272"}],"text":"The obtained resulted revealed that the Arg273Gln and Thr445Gly mutation have drastically reduced the binding affinity of the angiotensin-II into the active site of ACE2."}

{"project":"LitCovid_AGAC_only","denotations":[{"id":"p75930s6","span":{"begin":40,"end":49},"obj":"Var"},{"id":"p75930s8","span":{"begin":54,"end":63},"obj":"Var"},{"id":"p75930s12","span":{"begin":90,"end":97},"obj":"NegReg"},{"id":"p75930s14","span":{"begin":102,"end":109},"obj":"MPA"},{"id":"p75930s15","span":{"begin":110,"end":118},"obj":"MPA"},{"id":"p75930s26","span":{"begin":165,"end":169},"obj":"Gene"}],"text":"The obtained resulted revealed that the Arg273Gln and Thr445Gly mutation have drastically reduced the binding affinity of the angiotensin-II into the active site of ACE2."}