PubMed:32716836 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/32716836","sourcedb":"PubMed","sourceid":"32716836","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/32716836","text":"Immunotherapy for ANCA-associated vasculitis during the COVID-19 pandemic.\nSince the first description of infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China in December 2019, it has evolved into a pandemic and emerged as an unprecedented worldwide crisis overwhelming healthcare systems globally. Analysis of the available literature to date suggests that, in addition to older age, patients with underlying co-morbidities including hypertension, diabetes, heart disease are at higher risk for severe disease with increased mortality. Practitioners around the world also have become increasingly concerned that immunosuppressed patients including those with autoimmune diseases may be at increased risk for developing Coronavirus Disease 2019 (COVID-19) with serious complications. Very little is known about how anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis modifies the susceptibility, clinical presentation and disease course of COVID-19. In this review, we discuss the mechanism of action and challenges of the current therapeutic armamentarium of ANCA-associated vasculitis and outline approaches to management of ANCA-associated vasculitis during the COVID-19 pandemic.","tracks":[{"project":"LitCovid-OGER-BB","denotations":[{"id":"T1","span":{"begin":56,"end":64},"obj":"SP_7"},{"id":"T2","span":{"begin":122,"end":169},"obj":"SP_7"},{"id":"T3","span":{"begin":135,"end":146},"obj":"UBERON:0001004"},{"id":"T4","span":{"begin":171,"end":181},"obj":"SP_7"},{"id":"T5","span":{"begin":492,"end":497},"obj":"UBERON:0000948"},{"id":"T6","span":{"begin":646,"end":662},"obj":"CHEBI:35705"},{"id":"T7","span":{"begin":646,"end":662},"obj":"CHEBI:35705"},{"id":"T8","span":{"begin":693,"end":703},"obj":"UBERON:0002405"},{"id":"T9","span":{"begin":753,"end":764},"obj":"NCBITaxon:11118"},{"id":"T10","span":{"begin":779,"end":787},"obj":"SP_7"},{"id":"T11","span":{"begin":853,"end":863},"obj":"CL:0000775"},{"id":"T12","span":{"begin":864,"end":875},"obj":"GO:0005737"},{"id":"T13","span":{"begin":876,"end":884},"obj":"GO:0042571"},{"id":"T14","span":{"begin":987,"end":995},"obj":"SP_7"},{"id":"T15","span":{"begin":1212,"end":1220},"obj":"SP_7"}],"namespaces":[{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T2","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T3","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T4","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T5","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T6","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T7","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T8","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T9","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T10","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T11","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T12","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T13","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T14","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T15","pred":"source","obj":"LitCovid-OGER-BB"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":492,"end":497},"obj":"Body_part"},{"id":"T2","span":{"begin":853,"end":863},"obj":"Body_part"},{"id":"T3","span":{"begin":864,"end":875},"obj":"Body_part"},{"id":"T4","span":{"begin":876,"end":884},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma7088"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma66835"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma62871"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T1","span":{"begin":492,"end":497},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":18,"end":44},"obj":"Disease"},{"id":"T3","span":{"begin":34,"end":44},"obj":"Disease"},{"id":"T4","span":{"begin":56,"end":64},"obj":"Disease"},{"id":"T5","span":{"begin":106,"end":116},"obj":"Disease"},{"id":"T6","span":{"begin":122,"end":169},"obj":"Disease"},{"id":"T7","span":{"begin":122,"end":155},"obj":"Disease"},{"id":"T8","span":{"begin":171,"end":179},"obj":"Disease"},{"id":"T9","span":{"begin":468,"end":480},"obj":"Disease"},{"id":"T10","span":{"begin":482,"end":490},"obj":"Disease"},{"id":"T11","span":{"begin":492,"end":505},"obj":"Disease"},{"id":"T12","span":{"begin":693,"end":712},"obj":"Disease"},{"id":"T13","span":{"begin":753,"end":777},"obj":"Disease"},{"id":"T14","span":{"begin":779,"end":787},"obj":"Disease"},{"id":"T15","span":{"begin":885,"end":913},"obj":"Disease"},{"id":"T17","span":{"begin":903,"end":913},"obj":"Disease"},{"id":"T18","span":{"begin":987,"end":995},"obj":"Disease"},{"id":"T19","span":{"begin":1107,"end":1133},"obj":"Disease"},{"id":"T21","span":{"begin":1123,"end":1133},"obj":"Disease"},{"id":"T22","span":{"begin":1174,"end":1200},"obj":"Disease"},{"id":"T24","span":{"begin":1190,"end":1200},"obj":"Disease"},{"id":"T25","span":{"begin":1212,"end":1220},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0012105"},{"id":"A2","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0015492"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0018882"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0005044"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0005015"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0005267"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0007179"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0012105"},{"id":"A16","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0015492"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/MONDO_0018882"},{"id":"A18","pred":"mondo_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A19","pred":"mondo_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/MONDO_0012105"},{"id":"A20","pred":"mondo_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/MONDO_0015492"},{"id":"A21","pred":"mondo_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/MONDO_0018882"},{"id":"A22","pred":"mondo_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/MONDO_0012105"},{"id":"A23","pred":"mondo_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/MONDO_0015492"},{"id":"A24","pred":"mondo_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/MONDO_0018882"},{"id":"A25","pred":"mondo_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":213,"end":216},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T2","span":{"begin":230,"end":231},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T3","span":{"begin":492,"end":497},"obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"T4","span":{"begin":492,"end":497},"obj":"http://purl.obolibrary.org/obo/UBERON_0007100"},{"id":"T5","span":{"begin":492,"end":497},"obj":"http://purl.obolibrary.org/obo/UBERON_0015228"},{"id":"T6","span":{"begin":492,"end":497},"obj":"http://www.ebi.ac.uk/efo/EFO_0000815"},{"id":"T7","span":{"begin":853,"end":875},"obj":"http://purl.obolibrary.org/obo/CP_0000000"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":18,"end":22},"obj":"Chemical"},{"id":"T2","span":{"begin":886,"end":890},"obj":"Chemical"},{"id":"T3","span":{"begin":1107,"end":1111},"obj":"Chemical"},{"id":"T4","span":{"begin":1174,"end":1178},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_34507"},{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_34507"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_34507"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_34507"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T1","span":{"begin":34,"end":44},"obj":"Phenotype"},{"id":"T2","span":{"begin":468,"end":480},"obj":"Phenotype"},{"id":"T3","span":{"begin":693,"end":712},"obj":"Phenotype"},{"id":"T4","span":{"begin":903,"end":913},"obj":"Phenotype"},{"id":"T5","span":{"begin":1123,"end":1133},"obj":"Phenotype"},{"id":"T6","span":{"begin":1190,"end":1200},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0002633"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0000822"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0002960"},{"id":"A4","pred":"hp_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/HP_0002633"},{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0002633"},{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0002633"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"2","span":{"begin":34,"end":44},"obj":"Disease"},{"id":"3","span":{"begin":56,"end":64},"obj":"Disease"},{"id":"21","span":{"begin":106,"end":116},"obj":"Disease"},{"id":"22","span":{"begin":122,"end":169},"obj":"Species"},{"id":"23","span":{"begin":171,"end":181},"obj":"Species"},{"id":"24","span":{"begin":418,"end":426},"obj":"Species"},{"id":"25","span":{"begin":468,"end":480},"obj":"Disease"},{"id":"26","span":{"begin":482,"end":490},"obj":"Disease"},{"id":"27","span":{"begin":492,"end":505},"obj":"Disease"},{"id":"28","span":{"begin":559,"end":568},"obj":"Disease"},{"id":"29","span":{"begin":663,"end":671},"obj":"Species"},{"id":"30","span":{"begin":693,"end":712},"obj":"Disease"},{"id":"31","span":{"begin":753,"end":777},"obj":"Disease"},{"id":"32","span":{"begin":779,"end":787},"obj":"Disease"},{"id":"33","span":{"begin":903,"end":913},"obj":"Disease"},{"id":"34","span":{"begin":987,"end":995},"obj":"Disease"},{"id":"35","span":{"begin":1123,"end":1133},"obj":"Disease"},{"id":"36","span":{"begin":1190,"end":1200},"obj":"Disease"},{"id":"37","span":{"begin":1212,"end":1220},"obj":"Disease"}],"attributes":[{"id":"A2","pred":"tao:has_database_id","subj":"2","obj":"MESH:D014657"},{"id":"A3","pred":"tao:has_database_id","subj":"3","obj":"MESH:C000657245"},{"id":"A21","pred":"tao:has_database_id","subj":"21","obj":"MESH:D007239"},{"id":"A22","pred":"tao:has_database_id","subj":"22","obj":"Tax:2697049"},{"id":"A23","pred":"tao:has_database_id","subj":"23","obj":"Tax:2697049"},{"id":"A24","pred":"tao:has_database_id","subj":"24","obj":"Tax:9606"},{"id":"A25","pred":"tao:has_database_id","subj":"25","obj":"MESH:D006973"},{"id":"A26","pred":"tao:has_database_id","subj":"26","obj":"MESH:D003920"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"MESH:D006331"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"MESH:D003643"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"Tax:9606"},{"id":"A30","pred":"tao:has_database_id","subj":"30","obj":"MESH:D001327"},{"id":"A31","pred":"tao:has_database_id","subj":"31","obj":"MESH:C000657245"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"MESH:C000657245"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"MESH:D014657"},{"id":"A34","pred":"tao:has_database_id","subj":"34","obj":"MESH:C000657245"},{"id":"A35","pred":"tao:has_database_id","subj":"35","obj":"MESH:D014657"},{"id":"A36","pred":"tao:has_database_id","subj":"36","obj":"MESH:D014657"},{"id":"A37","pred":"tao:has_database_id","subj":"37","obj":"MESH:C000657245"},{"subj":"2","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3","pred":"source","obj":"LitCovid-PubTator"},{"subj":"21","pred":"source","obj":"LitCovid-PubTator"},{"subj":"22","pred":"source","obj":"LitCovid-PubTator"},{"subj":"23","pred":"source","obj":"LitCovid-PubTator"},{"subj":"24","pred":"source","obj":"LitCovid-PubTator"},{"subj":"25","pred":"source","obj":"LitCovid-PubTator"},{"subj":"26","pred":"source","obj":"LitCovid-PubTator"},{"subj":"27","pred":"source","obj":"LitCovid-PubTator"},{"subj":"28","pred":"source","obj":"LitCovid-PubTator"},{"subj":"29","pred":"source","obj":"LitCovid-PubTator"},{"subj":"30","pred":"source","obj":"LitCovid-PubTator"},{"subj":"31","pred":"source","obj":"LitCovid-PubTator"},{"subj":"32","pred":"source","obj":"LitCovid-PubTator"},{"subj":"33","pred":"source","obj":"LitCovid-PubTator"},{"subj":"34","pred":"source","obj":"LitCovid-PubTator"},{"subj":"35","pred":"source","obj":"LitCovid-PubTator"},{"subj":"36","pred":"source","obj":"LitCovid-PubTator"},{"subj":"37","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":74},"obj":"Sentence"},{"id":"T2","span":{"begin":75,"end":331},"obj":"Sentence"},{"id":"T3","span":{"begin":332,"end":569},"obj":"Sentence"},{"id":"T4","span":{"begin":570,"end":816},"obj":"Sentence"},{"id":"T5","span":{"begin":817,"end":996},"obj":"Sentence"},{"id":"T6","span":{"begin":997,"end":1230},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-sentences"},{"subj":"T2","pred":"source","obj":"LitCovid-sentences"},{"subj":"T3","pred":"source","obj":"LitCovid-sentences"},{"subj":"T4","pred":"source","obj":"LitCovid-sentences"},{"subj":"T5","pred":"source","obj":"LitCovid-sentences"},{"subj":"T6","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-OGER-BB","color":"#9396ec","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#b0ec93"},{"id":"LitCovid-PD-UBERON","color":"#ec93ca"},{"id":"LitCovid-PD-MONDO","color":"#93e4ec"},{"id":"LitCovid-PD-CLO","color":"#ecd993"},{"id":"LitCovid-PD-CHEBI","color":"#bf93ec"},{"id":"LitCovid-PD-HP","color":"#93eca5"},{"id":"LitCovid-PubTator","color":"#ec939a"},{"id":"LitCovid-sentences","color":"#93b4ec"}]}]}}