PubMed:32691370 / 1206-1447 JSONTXT

{"project":"LitCovid-OGER-BB","denotations":[{"id":"T59","span":{"begin":53,"end":58},"obj":"SP_6"},{"id":"T60","span":{"begin":53,"end":58},"obj":"NCBITaxon:9606"},{"id":"T61","span":{"begin":98,"end":102},"obj":"G_3"},{"id":"T62","span":{"begin":98,"end":102},"obj":"PG_10"},{"id":"T63","span":{"begin":98,"end":102},"obj":"PR:000003622"},{"id":"T64","span":{"begin":121,"end":125},"obj":"PR:000014459"},{"id":"T65","span":{"begin":121,"end":131},"obj":"SP_7"},{"id":"T66","span":{"begin":160,"end":165},"obj":"PR:000011271"},{"id":"T67","span":{"begin":216,"end":226},"obj":"GO:0008219"},{"id":"T68","span":{"begin":230,"end":240},"obj":"GO:0070269"}],"namespaces":[{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"}],"text":"Moreover, we demonstrate for the first time that, in human VSELs and HSCs, the interaction of the ACE2 receptor with the SARS-CoV-2 spike protein activates the Nlrp3 inflammasome, which if hyperactivated may lead to cell death by pyroptosis."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T17","span":{"begin":138,"end":145},"obj":"Body_part"},{"id":"T18","span":{"begin":216,"end":220},"obj":"Body_part"}],"attributes":[{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Moreover, we demonstrate for the first time that, in human VSELs and HSCs, the interaction of the ACE2 receptor with the SARS-CoV-2 spike protein activates the Nlrp3 inflammasome, which if hyperactivated may lead to cell death by pyroptosis."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T3","span":{"begin":121,"end":129},"obj":"Disease"}],"attributes":[{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Moreover, we demonstrate for the first time that, in human VSELs and HSCs, the interaction of the ACE2 receptor with the SARS-CoV-2 spike protein activates the Nlrp3 inflammasome, which if hyperactivated may lead to cell death by pyroptosis."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T24","span":{"begin":53,"end":58},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T25","span":{"begin":146,"end":155},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T26","span":{"begin":216,"end":220},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Moreover, we demonstrate for the first time that, in human VSELs and HSCs, the interaction of the ACE2 receptor with the SARS-CoV-2 spike protein activates the Nlrp3 inflammasome, which if hyperactivated may lead to cell death by pyroptosis."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T14","span":{"begin":138,"end":145},"obj":"Chemical"}],"attributes":[{"id":"A14","pred":"chebi_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Moreover, we demonstrate for the first time that, in human VSELs and HSCs, the interaction of the ACE2 receptor with the SARS-CoV-2 spike protein activates the Nlrp3 inflammasome, which if hyperactivated may lead to cell death by pyroptosis."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T2","span":{"begin":216,"end":226},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T3","span":{"begin":230,"end":240},"obj":"http://purl.obolibrary.org/obo/GO_0070269"}],"text":"Moreover, we demonstrate for the first time that, in human VSELs and HSCs, the interaction of the ACE2 receptor with the SARS-CoV-2 spike protein activates the Nlrp3 inflammasome, which if hyperactivated may lead to cell death by pyroptosis."}

{"project":"LitCovid-sentences","denotations":[{"id":"T7","span":{"begin":0,"end":241},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Moreover, we demonstrate for the first time that, in human VSELs and HSCs, the interaction of the ACE2 receptor with the SARS-CoV-2 spike protein activates the Nlrp3 inflammasome, which if hyperactivated may lead to cell death by pyroptosis."}