> top > docs > PubMed:32676695 > annotations

PubMed:32676695 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 114-122 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T2 125-134 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T3 224-232 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T4 235-244 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T5 429-431 Disease denotes RD http://purl.obolibrary.org/obo/MONDO_0009973
T6 501-509 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T7 601-603 Disease denotes RD http://purl.obolibrary.org/obo/MONDO_0009973
T8 823-825 Disease denotes RD http://purl.obolibrary.org/obo/MONDO_0009973
T9 984-986 Disease denotes RD http://purl.obolibrary.org/obo/MONDO_0009973
T10 1480-1490 Disease denotes arrhythmia http://purl.obolibrary.org/obo/MONDO_0007263
T11 1662-1673 Disease denotes arrhythmias http://purl.obolibrary.org/obo/MONDO_0007263

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 315-324 http://purl.obolibrary.org/obo/BFO_0000030 denotes OBJECTIVE
T2 429-431 http://purl.obolibrary.org/obo/CLO_0008770 denotes RD
T3 601-603 http://purl.obolibrary.org/obo/CLO_0008770 denotes RD
T4 823-825 http://purl.obolibrary.org/obo/CLO_0008770 denotes RD
T5 832-834 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T6 865-866 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T7 975-977 http://purl.obolibrary.org/obo/CLO_0007874 denotes ms
T8 984-986 http://purl.obolibrary.org/obo/CLO_0008770 denotes RD
T9 1013-1015 http://purl.obolibrary.org/obo/CLO_0007874 denotes ms
T10 1080-1081 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11 1092-1094 http://purl.obolibrary.org/obo/CLO_0007874 denotes ms
T12 1129-1130 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T13 1141-1143 http://purl.obolibrary.org/obo/CLO_0007874 denotes ms
T14 1210-1212 http://purl.obolibrary.org/obo/CLO_0007874 denotes ms
T15 1217-1223 http://purl.obolibrary.org/obo/UBERON_0003100 denotes female
T16 1234-1236 http://purl.obolibrary.org/obo/CLO_0007874 denotes ms
T17 1241-1245 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T18 1241-1245 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T19 1346-1348 http://purl.obolibrary.org/obo/CLO_0007874 denotes ms
T20 1456-1457 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T21 1737-1738 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 26-44 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T2 61-70 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T3 71-80 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T4 84-96 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T5 162-167 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T6 379-397 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T7 399-401 Chemical denotes HY http://purl.obolibrary.org/obo/CHEBI_74059|http://purl.obolibrary.org/obo/CHEBI_5801
T9 408-417 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T10 418-427 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T11 429-431 Chemical denotes RD http://purl.obolibrary.org/obo/CHEBI_73812
T12 436-448 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T13 450-452 Chemical denotes AZ http://purl.obolibrary.org/obo/CHEBI_2955
T14 598-600 Chemical denotes HY http://purl.obolibrary.org/obo/CHEBI_74059|http://purl.obolibrary.org/obo/CHEBI_5801
T16 601-603 Chemical denotes RD http://purl.obolibrary.org/obo/CHEBI_73812
T17 682-684 Chemical denotes HY http://purl.obolibrary.org/obo/CHEBI_74059|http://purl.obolibrary.org/obo/CHEBI_5801
T19 685-687 Chemical denotes AZ http://purl.obolibrary.org/obo/CHEBI_2955
T20 711-714 Chemical denotes ECG http://purl.obolibrary.org/obo/CHEBI_70255
T21 820-822 Chemical denotes HY http://purl.obolibrary.org/obo/CHEBI_74059|http://purl.obolibrary.org/obo/CHEBI_5801
T23 823-825 Chemical denotes RD http://purl.obolibrary.org/obo/CHEBI_73812
T24 826-831 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T25 842-844 Chemical denotes HY http://purl.obolibrary.org/obo/CHEBI_74059|http://purl.obolibrary.org/obo/CHEBI_5801
T27 845-847 Chemical denotes AZ http://purl.obolibrary.org/obo/CHEBI_2955
T28 848-853 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T29 981-983 Chemical denotes HY http://purl.obolibrary.org/obo/CHEBI_74059|http://purl.obolibrary.org/obo/CHEBI_5801
T31 984-986 Chemical denotes RD http://purl.obolibrary.org/obo/CHEBI_73812
T32 1019-1021 Chemical denotes HY http://purl.obolibrary.org/obo/CHEBI_74059|http://purl.obolibrary.org/obo/CHEBI_5801
T34 1022-1024 Chemical denotes AZ http://purl.obolibrary.org/obo/CHEBI_2955
T35 1241-1245 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T36 1441-1446 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T37 1533-1542 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T38 1543-1552 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T39 1556-1568 Chemical denotes azithromycin http://purl.obolibrary.org/obo/CHEBI_2955
T40 1709-1714 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1468-1490 Phenotype denotes ventricular arrhythmia http://purl.obolibrary.org/obo/HP_0004308
T2 1662-1673 Phenotype denotes arrhythmias http://purl.obolibrary.org/obo/HP_0011675

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-135 Sentence denotes Effects on QT interval of hydroxychloroquine associated with ritonavir/darunavir or azithromycin in patients with SARS-CoV-2 infection.
T2 136-149 Sentence denotes INTRODUCTION:
T3 150-314 Sentence denotes Most of the drugs associations that have been used to treat patients with SARS-CoV-2 infection increase the risk of prolongation of the corrected QT interval (QTc).
T4 315-325 Sentence denotes OBJECTIVE:
T5 326-471 Sentence denotes To evaluate the effects of an association therapy of hydroxychloroquine (HY) plus ritonavir/darunavir (RD) or azithromycin (AZ) on QTc intervals.
T6 472-480 Sentence denotes METHODS:
T7 481-688 Sentence denotes At the beginning of COVID-19 pandemic patients admitted to our hospital were treated with the empiric association of HY/RD; one week later the therapeutic protocol was modified with the combination of HY/AZ.
T8 689-769 Sentence denotes Patients underwent an ECG at baseline, then 3 and 7 days after starting therapy.
T9 770-855 Sentence denotes We prospectively enrolled 113 patients (61 in the HY/RD group-52 in the HY/AZ group).
T10 856-864 Sentence denotes RESULTS:
T11 865-1055 Sentence denotes A significant increase in median QTc was reported after seven days of therapy in both groups: from 438 to 452 ms in HY/RD patients; from 433 to 440 ms in HY/AZ patients (p = 0.001 for both).
T12 1056-1105 Sentence denotes 23 patients (21.2%) had a QTc > 500 ms at 7 days.
T13 1106-1424 Sentence denotes The risk of developing a QTc > 500 ms was greater in patients with prolonged baseline QTc values (≥ 440 ms for female and ≥ 460 ms for male patients) (OR 7.10 (95% IC 1.88-26.81); p = 0.004) and in patients with an increase in the QTc > 40 ms 3 days after onset of treatment (OR 30.15 (95% IC 6.96-130.55); p = 0.001).
T14 1425-1491 Sentence denotes One patient per group suffered a malignant ventricular arrhythmia.
T15 1492-1503 Sentence denotes CONCLUSION:
T16 1504-1628 Sentence denotes Hydroxychloroquine with both ritonavir/darunavir or azithromycin therapy significantly increased the QTc-interval at 7 days.
T17 1629-1762 Sentence denotes The risk of developing malignant arrhythmias remained relatively low when these drugs were administered for a limited period of time.

hydroxychloroquine

Id Subject Object Predicate Lexical cue hp_id
T1 1468-1490 Phenotype denotes ventricular arrhythmia http://purl.obolibrary.org/obo/HP_0004308
T2 1662-1673 Phenotype denotes arrhythmias http://purl.obolibrary.org/obo/HP_0011675