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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 327-350 Cell denotes airway epithelial cells http://purl.obolibrary.org/obo/CL:0002368

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 78-84 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T2 117-123 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T3 334-350 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T4 345-350 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T5 402-410 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T6 703-709 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T7 738-742 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T8 769-774 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T9 987-994 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T10 1007-1019 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T11 1007-1011 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T12 1078-1090 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T13 1078-1082 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T14 1091-1099 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T15 1116-1120 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T16 1121-1130 Body_part denotes organelle http://purl.org/sig/ont/fma/fma63832
T17 1172-1179 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T18 1341-1348 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 703-709 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T2 738-742 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 262-277 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T2 268-277 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T3 418-451 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T4 453-457 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T5 1324-1332 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T6 1324-1328 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 46-52 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T2 53-63 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T3 146-147 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4 292-293 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 327-333 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T6 334-344 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T7 345-350 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8 358-361 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T9 387-395 http://purl.obolibrary.org/obo/CLO_0001658 denotes activate
T10 578-588 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T11 650-651 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T12 687-692 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T13 693-709 http://www.ebi.ac.uk/efo/EFO_0000927 denotes embryonic kidney
T14 710-713 http://purl.obolibrary.org/obo/CLO_0001230 denotes 293
T15 710-713 http://purl.obolibrary.org/obo/CLO_0037237 denotes 293
T16 710-713 http://purl.obolibrary.org/obo/CLO_0050903 denotes 293
T17 710-713 http://purl.obolibrary.org/obo/CLO_0054249 denotes 293
T18 710-713 http://purl.obolibrary.org/obo/CLO_0054250 denotes 293
T19 710-713 http://purl.obolibrary.org/obo/CLO_0054251 denotes 293
T20 710-713 http://purl.obolibrary.org/obo/CLO_0054252 denotes 293
T21 738-742 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T22 738-742 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T23 743-753 http://purl.obolibrary.org/obo/CL_0000066 denotes epithelial
T24 754-758 http://purl.obolibrary.org/obo/CLO_0001601 denotes A549
T25 754-758 http://purl.obolibrary.org/obo/CLO_0050025 denotes A549
T26 754-758 http://purl.obolibrary.org/obo/CLO_0054264 denotes A549
T27 754-758 http://purl.obolibrary.org/obo/CLO_0054265 denotes A549
T28 754-758 http://purl.obolibrary.org/obo/CLO_0054266 denotes A549
T29 754-758 http://purl.obolibrary.org/obo/CLO_0054267 denotes A549
T30 754-758 http://purl.obolibrary.org/obo/CLO_0054268 denotes A549
T31 754-758 http://purl.obolibrary.org/obo/CLO_0054269 denotes A549
T32 769-774 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T33 843-853 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T34 866-871 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T35 947-957 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T36 1007-1011 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T37 1078-1082 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T38 1116-1120 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T39 1209-1210 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T40 1432-1442 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T41 1489-1499 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T42 1608-1618 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 78-84 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T2 100-102 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T3 117-123 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T4 148-153 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T5 402-410 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T6 987-994 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T7 1091-1099 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T8 1172-1179 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T9 1341-1348 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 262-277 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T2 1058-1067 http://purl.obolibrary.org/obo/GO_0007586 denotes digestion
T3 1424-1442 http://purl.obolibrary.org/obo/GO_0031638 denotes zymogen activation
T4 1481-1499 http://purl.obolibrary.org/obo/GO_0031638 denotes zymogen activation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-94 Sentence denotes Intracellular autoactivation of TMPRSS11A, an airway epithelial transmembrane serine protease.
T2 95-211 Sentence denotes Type II transmembrane serine proteases (TTSPs) are a group of enzymes participating in diverse biological processes.
T3 212-278 Sentence denotes Some members of the TTSP family are implicated in viral infection.
T4 279-521 Sentence denotes TMPRSS11A is a TTSP expressed on the surface of airway epithelial cells, which has been shown to cleave and activate spike proteins of the severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome coronaviruses (CoVs).
T5 522-669 Sentence denotes In this study, we examined the mechanism underlying the activation cleavage of TMPRSS11A that converts the one-chain zymogen to a two-chain enzyme.
T6 670-912 Sentence denotes By expression in human embryonic kidney 293, esophageal EC9706, and lung epithelial A549 and 16HBE cells, Western blotting, and site-directed mutagenesis, we found that the activation cleavage of human TMPRSS11A was mediated by autocatalysis.
T7 913-1270 Sentence denotes Moreover, we found that TMPRSS11A activation cleavage occurred before the protein reached the cell surface, as indicated by studies with trypsin digestion to remove cell surface proteins, treatment with cell organelle-disturbing agents to block intracellular protein trafficking, and analysis of a soluble form of TMPRSS11A without the transmembrane domain.
T8 1271-1349 Sentence denotes We also showed that TMPRSS11A was able to cleave the SARS-CoV-2 spike protein.
T9 1350-1524 Sentence denotes These results reveal an intracellular autocleavage mechanism in TMPRSS11A zymogen activation, which differs from the extracellular zymogen activation reported in other TTSPs.
T10 1525-1619 Sentence denotes These findings provide new insights into the diverse mechanisms in regulating TTSP activation.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2 32-41 Gene denotes TMPRSS11A Gene:339967
3 78-84 Chemical denotes serine MESH:D012694
26 117-123 Chemical denotes serine MESH:D012694
27 262-277 Disease denotes viral infection MESH:D001102
28 279-288 Gene denotes TMPRSS11A Gene:339967
29 396-401 Gene denotes spike Gene:43740568
30 425-451 Disease denotes acute respiratory syndrome MESH:D012120
31 453-457 Disease denotes SARS MESH:D045169
32 500-513 Species denotes coronaviruses Tax:11118
33 515-519 Species denotes CoVs Tax:11118
34 601-610 Gene denotes TMPRSS11A Gene:339967
35 687-692 Species denotes human Tax:9606
36 693-709 Disease denotes embryonic kidney MESH:D007674
37 726-732 CellLine denotes EC9706 CVCL:E307
38 754-758 CellLine denotes A549 CVCL:0023
39 763-768 CellLine denotes 16HBE CVCL:0112
40 866-871 Species denotes human Tax:9606
41 872-881 Gene denotes TMPRSS11A Gene:339967
42 937-946 Gene denotes TMPRSS11A Gene:339967
43 1227-1236 Gene denotes TMPRSS11A Gene:339967
44 1291-1300 Gene denotes TMPRSS11A Gene:339967
45 1324-1334 Species denotes SARS-CoV-2 Tax:2697049
46 1335-1340 Gene denotes spike Gene:43740568
47 1414-1423 Gene denotes TMPRSS11A Gene:339967

sentences

Id Subject Object Predicate Lexical cue
T1 0-94 Sentence denotes Intracellular autoactivation of TMPRSS11A, an airway epithelial transmembrane serine protease.
T2 95-211 Sentence denotes Type II transmembrane serine proteases (TTSPs) are a group of enzymes participating in diverse biological processes.
T3 212-278 Sentence denotes Some members of the TTSP family are implicated in viral infection.
T4 279-521 Sentence denotes TMPRSS11A is a TTSP expressed on the surface of airway epithelial cells, which has been shown to cleave and activate spike proteins of the severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome coronaviruses (CoVs).
T5 522-669 Sentence denotes In this study, we examined the mechanism underlying the activation cleavage of TMPRSS11A that converts the one-chain zymogen to a two-chain enzyme.
T6 670-912 Sentence denotes By expression in human embryonic kidney 293, esophageal EC9706, and lung epithelial A549 and 16HBE cells, Western blotting, and site-directed mutagenesis, we found that the activation cleavage of human TMPRSS11A was mediated by autocatalysis.
T7 913-1270 Sentence denotes Moreover, we found that TMPRSS11A activation cleavage occurred before the protein reached the cell surface, as indicated by studies with trypsin digestion to remove cell surface proteins, treatment with cell organelle-disturbing agents to block intracellular protein trafficking, and analysis of a soluble form of TMPRSS11A without the transmembrane domain.
T8 1271-1349 Sentence denotes We also showed that TMPRSS11A was able to cleave the SARS-CoV-2 spike protein.
T9 1350-1524 Sentence denotes These results reveal an intracellular autocleavage mechanism in TMPRSS11A zymogen activation, which differs from the extracellular zymogen activation reported in other TTSPs.
T10 1525-1619 Sentence denotes These findings provide new insights into the diverse mechanisms in regulating TTSP activation.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 703-709 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T2 738-742 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 703-709 Body_part denotes kidney http://purl.obolibrary.org/obo/MAT_0000119
T2 738-742 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 262-277 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T2 418-451 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T3 453-457 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T4 1324-1334 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T5 1324-1328 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 418-451 OrganismTaxon denotes severe acute respiratory syndrome 694009
T2 453-457 OrganismTaxon denotes SARS 694009
T3 467-513 OrganismTaxon denotes Middle East respiratory syndrome coronaviruses 1335626
T4 687-692 OrganismTaxon denotes human 9606
T5 866-871 OrganismTaxon denotes human 9606
T6 1324-1332 OrganismTaxon denotes SARS-CoV 694009
T7 1324-1328 OrganismTaxon denotes SARS 694009

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 0-13 Body_part denotes Intracellular http://purl.obolibrary.org/obo/GO_0005622
T2 46-52 Body_part denotes airway http://purl.obolibrary.org/obo/UBERON_0000117|http://purl.obolibrary.org/obo/UBERON_0001005
T4 64-77 Body_part denotes transmembrane http://purl.obolibrary.org/obo/GO_0016020
T5 103-116 Body_part denotes transmembrane http://purl.obolibrary.org/obo/GO_0016020
T6 327-350 Body_part denotes airway epithelial cells http://purl.obolibrary.org/obo/CL_0002368
T7 693-709 Body_part denotes embryonic kidney http://purl.obolibrary.org/obo/UBERON_0002120
T8 738-742 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T9 1121-1130 Body_part denotes organelle http://purl.obolibrary.org/obo/GO_0043226
T10 1158-1171 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T11 1249-1262 Body_part denotes transmembrane http://purl.obolibrary.org/obo/GO_0016020
T12 1374-1387 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T13 1467-1480 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576