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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-66 Sentence denotes Lessons from dermatology about inflammatory responses in Covid-19.
T2 67-219 Sentence denotes The SARS-Cov-2 is a single-stranded RNA virus composed of 16 non-structural proteins (NSP 1-16) with specific roles in the replication of coronaviruses.
T3 220-314 Sentence denotes NSP3 has the property to block host innate immune response and to promote cytokine expression.
T4 315-428 Sentence denotes NSP5 can inhibit interferon (IFN) signalling and NSP16 prevents MAD5 recognition, depressing the innate immunity.
T5 429-528 Sentence denotes Dendritic cells, monocytes, and macrophages are the first cell lineage against viruses' infections.
T6 529-613 Sentence denotes The IFN type I is the danger signal for the human body during this clinical setting.
T7 614-776 Sentence denotes Protective immune responses to viral infection are initiated by innate immune sensors that survey extracellular and intracellular space for foreign nucleic acids.
T8 777-886 Sentence denotes In Covid-19 the pathogenesis is not yet fully understood, but viral and host factors seem to play a key role.
T9 887-1191 Sentence denotes Important points in severe Covid-19 are characterized by an upregulated innate immune response, hypercoagulopathy state, pulmonary tissue damage, neurological and/or gastrointestinal tract involvement, and fatal outcome in severe cases of macrophage activation syndrome, which produce a 'cytokine storm'.
T10 1192-1505 Sentence denotes These systemic conditions share polymorphous cutaneous lesions where innate immune system is involved in the histopathological findings with acute respiratory distress syndrome, hypercoagulability, hyperferritinemia, increased serum levels of D-dimer, lactic dehydrogenase, reactive-C-protein and serum A amyloid.
T11 1506-1843 Sentence denotes It is described that several polymorphous cutaneous lesions similar to erythema pernio, urticarial rashes, diffuse or disseminated erythema, livedo racemosa, blue toe syndrome, retiform purpura, vesicles lesions, and purpuric exanthema or exanthema with clinical aspects of symmetrical drug-related intertriginous and flexural exanthema.
T12 1844-1938 Sentence denotes This review describes the complexity of Covid-19, its pathophysiological and clinical aspects.
T1 0-66 Sentence denotes Lessons from dermatology about inflammatory responses in Covid-19.
T2 67-219 Sentence denotes The SARS-Cov-2 is a single-stranded RNA virus composed of 16 non-structural proteins (NSP 1-16) with specific roles in the replication of coronaviruses.
T3 220-314 Sentence denotes NSP3 has the property to block host innate immune response and to promote cytokine expression.
T4 315-428 Sentence denotes NSP5 can inhibit interferon (IFN) signalling and NSP16 prevents MAD5 recognition, depressing the innate immunity.
T5 429-528 Sentence denotes Dendritic cells, monocytes, and macrophages are the first cell lineage against viruses' infections.
T6 529-613 Sentence denotes The IFN type I is the danger signal for the human body during this clinical setting.
T7 614-776 Sentence denotes Protective immune responses to viral infection are initiated by innate immune sensors that survey extracellular and intracellular space for foreign nucleic acids.
T8 777-886 Sentence denotes In Covid-19 the pathogenesis is not yet fully understood, but viral and host factors seem to play a key role.
T9 887-1191 Sentence denotes Important points in severe Covid-19 are characterized by an upregulated innate immune response, hypercoagulopathy state, pulmonary tissue damage, neurological and/or gastrointestinal tract involvement, and fatal outcome in severe cases of macrophage activation syndrome, which produce a 'cytokine storm'.
T10 1192-1505 Sentence denotes These systemic conditions share polymorphous cutaneous lesions where innate immune system is involved in the histopathological findings with acute respiratory distress syndrome, hypercoagulability, hyperferritinemia, increased serum levels of D-dimer, lactic dehydrogenase, reactive-C-protein and serum A amyloid.
T11 1506-1843 Sentence denotes It is described that several polymorphous cutaneous lesions similar to erythema pernio, urticarial rashes, diffuse or disseminated erythema, livedo racemosa, blue toe syndrome, retiform purpura, vesicles lesions, and purpuric exanthema or exanthema with clinical aspects of symmetrical drug-related intertriginous and flexural exanthema.
T12 1844-1938 Sentence denotes This review describes the complexity of Covid-19, its pathophysiological and clinical aspects.

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 103-106 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T2 143-151 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T3 294-302 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T4 429-444 Body_part denotes Dendritic cells http://purl.org/sig/ont/fma/fma273565
T5 439-444 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T6 446-455 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T7 461-472 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T8 487-491 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T9 573-583 Body_part denotes human body http://purl.org/sig/ont/fma/fma305853
T10 1018-1024 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T11 1053-1075 Body_part denotes gastrointestinal tract http://purl.org/sig/ont/fma/fma71132
T12 1126-1136 Body_part denotes macrophage http://purl.org/sig/ont/fma/fma63261
T13 1175-1183 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T14 1268-1281 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T15 1419-1424 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T16 1477-1484 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T17 1489-1494 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T18 1669-1672 Body_part denotes toe http://purl.org/sig/ont/fma/fma25046

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 1018-1024 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T2 1268-1281 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T3 1419-1424 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T4 1489-1494 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 71-75 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T2 508-527 Disease denotes viruses' infections http://purl.obolibrary.org/obo/MONDO_0005108
T3 645-660 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T4 651-660 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T5 1126-1156 Disease denotes macrophage activation syndrome http://purl.obolibrary.org/obo/MONDO_0015545
T6 1333-1368 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T7 1339-1368 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T8 1370-1388 Disease denotes hypercoagulability http://purl.obolibrary.org/obo/MONDO_0002305
T9 1497-1504 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T10 1647-1662 Disease denotes livedo racemosa http://purl.obolibrary.org/obo/MONDO_0044037
T11 1664-1681 Disease denotes blue toe syndrome http://purl.obolibrary.org/obo/MONDO_0001883
T12 1692-1699 Disease denotes purpura http://purl.obolibrary.org/obo/MONDO_0002610
T13 1732-1741 Disease denotes exanthema http://purl.obolibrary.org/obo/MONDO_0006547
T14 1745-1754 Disease denotes exanthema http://purl.obolibrary.org/obo/MONDO_0006547
T15 1833-1842 Disease denotes exanthema http://purl.obolibrary.org/obo/MONDO_0006547

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 85-86 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T2 107-112 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T3 157-161 http://purl.obolibrary.org/obo/CLO_0001046 denotes 1-16
T4 225-228 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T5 349-359 http://purl.obolibrary.org/obo/SO_0000418 denotes signalling
T6 429-444 http://purl.obolibrary.org/obo/CL_0000451 denotes Dendritic cells
T7 446-455 http://purl.obolibrary.org/obo/CL_0000576 denotes monocytes
T8 487-491 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T9 508-515 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T10 533-543 http://purl.obolibrary.org/obo/PR_000024990 denotes IFN type I
T11 558-564 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T12 573-578 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T13 875-876 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14 1053-1075 http://purl.obolibrary.org/obo/UBERON_0005409 denotes gastrointestinal tract
T15 1137-1147 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T16 1172-1173 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T17 1268-1281 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T18 1495-1496 http://purl.obolibrary.org/obo/CLO_0001020 denotes A

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 143-151 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T2 332-342 Chemical denotes interferon http://purl.obolibrary.org/obo/CHEBI_52999
T3 344-347 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T4 533-536 Chemical denotes IFN http://purl.obolibrary.org/obo/CHEBI_52999
T5 762-775 Chemical denotes nucleic acids http://purl.obolibrary.org/obo/CHEBI_33696
T6 770-775 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T7 1477-1484 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T8 1792-1796 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 31-53 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses
T2 256-278 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T3 263-278 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T4 349-359 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T5 412-427 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immunity
T6 625-641 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T7 645-660 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T8 678-691 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T9 793-805 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T10 947-981 http://purl.obolibrary.org/obo/GO_0045089 denotes upregulated innate immune response
T11 959-981 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T12 966-981 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T13 1126-1147 http://purl.obolibrary.org/obo/GO_0042116 denotes macrophage activation
T14 1261-1274 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1175-1189 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T2 1339-1359 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T3 1370-1388 Phenotype denotes hypercoagulability http://purl.obolibrary.org/obo/HP_0100724
T4 1390-1407 Phenotype denotes hyperferritinemia http://purl.obolibrary.org/obo/HP_0003281
T5 1577-1585 Phenotype denotes erythema http://purl.obolibrary.org/obo/HP_0010783
T6 1637-1645 Phenotype denotes erythema http://purl.obolibrary.org/obo/HP_0010783
T7 1647-1662 Phenotype denotes livedo racemosa http://purl.obolibrary.org/obo/HP_0033260
T8 1692-1699 Phenotype denotes purpura http://purl.obolibrary.org/obo/HP_0000979

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-66 Sentence denotes Lessons from dermatology about inflammatory responses in Covid-19.
T2 67-219 Sentence denotes The SARS-Cov-2 is a single-stranded RNA virus composed of 16 non-structural proteins (NSP 1-16) with specific roles in the replication of coronaviruses.
T3 220-314 Sentence denotes NSP3 has the property to block host innate immune response and to promote cytokine expression.
T4 315-428 Sentence denotes NSP5 can inhibit interferon (IFN) signalling and NSP16 prevents MAD5 recognition, depressing the innate immunity.
T5 429-528 Sentence denotes Dendritic cells, monocytes, and macrophages are the first cell lineage against viruses' infections.
T6 529-613 Sentence denotes The IFN type I is the danger signal for the human body during this clinical setting.
T7 614-776 Sentence denotes Protective immune responses to viral infection are initiated by innate immune sensors that survey extracellular and intracellular space for foreign nucleic acids.
T8 777-886 Sentence denotes In Covid-19 the pathogenesis is not yet fully understood, but viral and host factors seem to play a key role.
T9 887-1191 Sentence denotes Important points in severe Covid-19 are characterized by an upregulated innate immune response, hypercoagulopathy state, pulmonary tissue damage, neurological and/or gastrointestinal tract involvement, and fatal outcome in severe cases of macrophage activation syndrome, which produce a 'cytokine storm'.
T10 1192-1505 Sentence denotes These systemic conditions share polymorphous cutaneous lesions where innate immune system is involved in the histopathological findings with acute respiratory distress syndrome, hypercoagulability, hyperferritinemia, increased serum levels of D-dimer, lactic dehydrogenase, reactive-C-protein and serum A amyloid.
T11 1506-1843 Sentence denotes It is described that several polymorphous cutaneous lesions similar to erythema pernio, urticarial rashes, diffuse or disseminated erythema, livedo racemosa, blue toe syndrome, retiform purpura, vesicles lesions, and purpuric exanthema or exanthema with clinical aspects of symmetrical drug-related intertriginous and flexural exanthema.
T12 1844-1938 Sentence denotes This review describes the complexity of Covid-19, its pathophysiological and clinical aspects.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1 57-65 Disease denotes Covid-19 MESH:C000657245
25 71-81 Species denotes SARS-Cov-2 Tax:2697049
26 85-112 Species denotes a single-stranded RNA virus Tax:674971
27 153-161 Gene denotes NSP 1-16 Gene:10045
28 205-218 Species denotes coronaviruses Tax:11118
29 315-319 Gene denotes NSP5 Gene:92521
30 379-383 Gene denotes MAD5 Gene:23269
31 517-527 Disease denotes infections MESH:D007239
32 573-578 Species denotes human Tax:9606
33 645-660 Disease denotes viral infection MESH:D001102
34 780-788 Disease denotes Covid-19 MESH:C000657245
35 914-922 Disease denotes Covid-19 MESH:C000657245
36 983-1000 Disease denotes hypercoagulopathy
37 1333-1368 Disease denotes acute respiratory distress syndrome MESH:D012128
38 1370-1388 Disease denotes hypercoagulability MESH:D019851
39 1390-1407 Disease denotes hyperferritinemia MESH:C538137
40 1577-1585 Disease denotes erythema MESH:D004890
41 1594-1611 Disease denotes urticarial rashes MESH:D005076
42 1637-1645 Disease denotes erythema MESH:D004890
43 1664-1681 Disease denotes blue toe syndrome MESH:D018438
44 1683-1699 Disease denotes retiform purpura MESH:D011693
45 1723-1754 Disease denotes purpuric exanthema or exanthema MESH:D005076
46 1824-1842 Disease denotes flexural exanthema MESH:D005076
47 1884-1892 Disease denotes Covid-19 MESH:C000657245