PubMed:32651954
Annnotations
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 172-187 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 83-87 | http://purl.obolibrary.org/obo/MAT_0000135 | denotes | lung |
| T2 | 306-319 | http://purl.obolibrary.org/obo/MAT_0000393 | denotes | blood vessels |
| T3 | 306-311 | http://purl.obolibrary.org/obo/MAT_0000083 | denotes | blood |
| T4 | 306-311 | http://purl.obolibrary.org/obo/MAT_0000315 | denotes | blood |
| T5 | 436-440 | http://purl.obolibrary.org/obo/MAT_0000135 | denotes | lung |
| T6 | 527-531 | http://purl.obolibrary.org/obo/MAT_0000135 | denotes | lung |
| T7 | 574-579 | http://purl.obolibrary.org/obo/MAT_0000135 | denotes | lungs |
| T8 | 585-592 | http://purl.obolibrary.org/obo/MAT_0000226 | denotes | embryos |
| T9 | 749-753 | http://purl.obolibrary.org/obo/MAT_0000135 | denotes | lung |
| T10 | 754-764 | http://purl.obolibrary.org/obo/MAT_0000482 | denotes | primordium |
| T11 | 832-836 | http://purl.obolibrary.org/obo/MAT_0000135 | denotes | lung |
| T12 | 974-978 | http://purl.obolibrary.org/obo/MAT_0000135 | denotes | lung |
| T13 | 1085-1090 | http://purl.obolibrary.org/obo/MAT_0000135 | denotes | lungs |
| T14 | 1318-1323 | http://purl.obolibrary.org/obo/MAT_0000135 | denotes | lungs |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-100 | Sentence | denotes | Glucuronyl C5-epimerase is crucial for epithelial cell maturation during embryonic lung development. |
| T2 | 101-320 | Sentence | denotes | Glucuronyl C5-epimerase (Hsepi) is a key enzyme in the biosynthesis of heparan sulfate that is a sulfated polysaccharide expressed on the cell surface and in the extracellular matrix of alveolar walls and blood vessels. |
| T3 | 321-453 | Sentence | denotes | Targeted interruption of the Hsepi gene, Glce, in mice resulted in neonatal lethality, which is most likely due to lung atelectasis. |
| T4 | 454-544 | Sentence | denotes | In this study, we examined the potential mechanisms behind the defect in lung development. |
| T5 | 545-682 | Sentence | denotes | Histological analysis of the lungs from embryos revealed no difference in the morphology between wildtype and mutant animals up to E16.5. |
| T6 | 683-811 | Sentence | denotes | This suggests that the initial events leading to formation of the lung primordium and branching morphogenesis are not disturbed. |
| T7 | 812-979 | Sentence | denotes | However, the distal lung of E17.5-18.5 mutants is still populated by epithelial tubules, lacking the typical saccular structural characteristic of a normal E17.5 lung. |
| T8 | 980-1205 | Sentence | denotes | Immunostaining revealed strong signals of surfactant protein-C, but a weaker signal of T1α in the mutant lungs in comparison to WT littermates, suggesting differentiation of type I alveolar epithelial cells (AT1) is impaired. |
| T9 | 1206-1324 | Sentence | denotes | One of the parameters contributed to the failure of AT1 maturation is reduced vascularization in the developing lungs. |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 83-87 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/MAT_0000135 |
| T2 | 306-319 | Body_part | denotes | blood vessels | http://purl.obolibrary.org/obo/MAT_0000393 |
| T3 | 436-440 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/MAT_0000135 |
| T4 | 527-531 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/MAT_0000135 |
| T5 | 574-579 | Body_part | denotes | lungs | http://purl.obolibrary.org/obo/MAT_0000135 |
| T6 | 585-592 | Body_part | denotes | embryos | http://purl.obolibrary.org/obo/MAT_0000226 |
| T7 | 749-753 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/MAT_0000135 |
| T8 | 754-764 | Body_part | denotes | primordium | http://purl.obolibrary.org/obo/MAT_0000482 |
| T9 | 832-836 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/MAT_0000135 |
| T10 | 974-978 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/MAT_0000135 |
| T11 | 1085-1090 | Body_part | denotes | lungs | http://purl.obolibrary.org/obo/MAT_0000135 |
| T12 | 1318-1323 | Body_part | denotes | lungs | http://purl.obolibrary.org/obo/MAT_0000135 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 441-452 | Phenotype | denotes | atelectasis | HP:0100750 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 1188-1191 | Disease | denotes | AT1 | http://purl.obolibrary.org/obo/MONDO_0008840 |
| T2 | 1258-1261 | Disease | denotes | AT1 | http://purl.obolibrary.org/obo/MONDO_0008840 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 371-375 | OrganismTaxon | denotes | mice | 10088 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 39-54 | Body_part | denotes | epithelial cell | http://purl.obolibrary.org/obo/CL_0000066 |
| T2 | 83-87 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T3 | 263-283 | Body_part | denotes | extracellular matrix | http://purl.obolibrary.org/obo/GO_0031012 |
| T4 | 287-301 | Body_part | denotes | alveolar walls | http://purl.obolibrary.org/obo/UBERON_0004894 |
| T5 | 306-319 | Body_part | denotes | blood vessels | http://purl.obolibrary.org/obo/UBERON_0004537 |
| T6 | 436-440 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T7 | 527-531 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T8 | 574-579 | Body_part | denotes | lungs | http://purl.obolibrary.org/obo/UBERON_0000170 |
| T9 | 749-764 | Body_part | denotes | lung primordium | http://purl.obolibrary.org/obo/UBERON_0005597 |
| T10 | 832-836 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T11 | 974-978 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T12 | 1085-1090 | Body_part | denotes | lungs | http://purl.obolibrary.org/obo/UBERON_0000170 |
| T13 | 1154-1186 | Body_part | denotes | type I alveolar epithelial cells | http://purl.obolibrary.org/obo/CL_0002062 |
| T14 | 1318-1323 | Body_part | denotes | lungs | http://purl.obolibrary.org/obo/UBERON_0000170 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 39-54 | Cell | denotes | epithelial cell | http://purl.obolibrary.org/obo/CL:0000066 |
| T2 | 1154-1186 | Cell | denotes | type I alveolar epithelial cells | http://purl.obolibrary.org/obo/CL:0002062 |
| T3 | 1154-1160 | Cell | denotes | type I | http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138 |