> top > docs > PubMed:32633661 > annotations

PubMed:32633661 JSONTXT

Annnotations TAB JSON ListView MergeView

PubMed_Structured_Abstracts

Id Subject Object Predicate Lexical cue
T1 263-923 BACKGROUND denotes Chemotherapy-induced nausea and vomiting (CINV) can be a serious and debilitating adverse effect that is highly feared by cancer patients. For patients receiving moderately emetogenic chemotherapy regimens at our institution in the ambulatory infusion center, palonosetron was selected as the preferred serotonin (5-HT3) antagonist for CINV prophylaxis per the 2016 NCCN Guidelines, when a neurokinin1 antagonist was not included in the prophylactic regimen. The purpose of this study was to evaluate the efficacy of dexamethasone and palonosetron versus granisetron for the prevention of CINV in patients receiving moderately emetogenic chemotherapy regimens.
T2 933-1207 METHODS denotes This study is an Institutional Review Board-approved, single-center retrospective review of electronic health records including patients who received moderately emetogenic chemotherapy regimens with CINV prophylaxis with dexamethasone and either palonosetron or granisetron.
T3 1217-1779 RESULTS denotes A total of 268 eligible patients were included in the study. Eighty-eight patients received palonosetron and 180 patients received granisetron as their 5-HT3 receptor antagonist between October 31, 2014 and October 31, 2016. There were no statistically significant differences between the two antiemetic groups for the primary outcome of presence of any change in day 1 intravenous prophylactic antiemetics. Nine (10.23%) palonosetron patients and 15 (8.33%) granisetron patients required a change in their day 1 intravenous prophylactic antiemetics (P = 0.610).
T4 1793-2182 CONCLUSIONS denotes Despite palonosetron's better efficacy, longer half-life, and higher binding affinity, the results of this retrospective review demonstrates that the choice of serotonin antagonist, palonosetron or granisetron, did not result in a change in day 1 intravenous prophylactic antiemetics or antiemetic outpatient medications for patients undergoing moderately emetogenic chemotherapy regimens.

SMAFIRA_OGER_TEXT

Id Subject Object Predicate Lexical cue
T5 40-61 CHEBI:48279 denotes serotonin antagonists
T6 40-61 D012702 denotes serotonin antagonists
T7 40-61 D012702 denotes serotonin antagonists
T9 92-98 D009325 denotes nausea
T10 92-98 D009325 denotes nausea
T11 103-111 D014839 denotes vomiting
T12 103-111 D014839 denotes vomiting
T13 241-247 CVCL_E031 denotes center
T14 284-290 D009325 denotes nausea
T15 284-290 D009325 denotes nausea
T16 295-303 D014839 denotes vomiting
T17 295-303 D014839 denotes vomiting
T18 515-521 CVCL_E031 denotes center
T21 523-535 70561 denotes palonosetron
T19 523-535 D000077924 denotes palonosetron
T20 523-535 CHEBI:85161 denotes palonosetron
T22 523-535 D000077924 denotes palonosetron
T23 566-575 CHEBI:28790 denotes serotonin
T24 566-575 D012701 denotes serotonin
T25 566-575 CHEBI:350546 denotes serotonin
T26 566-575 D012701 denotes serotonin
T30 577-582 P46098 denotes 5-HT3
T31 577-582 O70212 denotes 5-HT3
T32 577-582 PR:P35563 denotes 5-HT3
T33 577-582 PR:P23979 denotes 5-HT3
T34 577-582 PR:000008833 denotes 5-HT3
T35 577-582 P23979 denotes 5-HT3
T36 577-582 P35563 denotes 5-HT3
T37 577-594 D058831 denotes 5-HT3) antagonist
T38 577-594 D058831 denotes 5-HT3) antagonist
T39 579-582 CVCL_1293 denotes HT3
T43 629-633 CHEBI:29819 denotes NCCN
T44 629-633 CHEBI:29308 denotes NCCN
T45 665-675 CHEBI:48706 denotes antagonist
T47 780-793 3264 denotes dexamethasone
T46 780-793 D003907 denotes dexamethasone
T48 780-793 CHEBI:41879 denotes dexamethasone
T49 780-793 D003907 denotes dexamethasone
T52 798-810 70561 denotes palonosetron
T50 798-810 D000077924 denotes palonosetron
T51 798-810 CHEBI:85161 denotes palonosetron
T53 798-810 D000077924 denotes palonosetron
T54 818-829 26237 denotes granisetron
T55 818-829 D017829 denotes granisetron
T56 818-829 D017829 denotes granisetron
T57 818-829 CHEBI:5537 denotes granisetron
T58 994-1000 CVCL_E031 denotes center
T60 1154-1167 3264 denotes dexamethasone
T59 1154-1167 D003907 denotes dexamethasone
T61 1154-1167 CHEBI:41879 denotes dexamethasone
T62 1154-1167 D003907 denotes dexamethasone
T65 1179-1191 70561 denotes palonosetron
T63 1179-1191 D000077924 denotes palonosetron
T64 1179-1191 CHEBI:85161 denotes palonosetron
T66 1179-1191 D000077924 denotes palonosetron
T67 1195-1206 26237 denotes granisetron
T68 1195-1206 D017829 denotes granisetron
T69 1195-1206 D017829 denotes granisetron
T70 1195-1206 CHEBI:5537 denotes granisetron
T73 1309-1321 70561 denotes palonosetron
T71 1309-1321 D000077924 denotes palonosetron
T72 1309-1321 CHEBI:85161 denotes palonosetron
T74 1309-1321 D000077924 denotes palonosetron
T75 1348-1359 26237 denotes granisetron
T76 1348-1359 D017829 denotes granisetron
T77 1348-1359 D017829 denotes granisetron
T78 1348-1359 CHEBI:5537 denotes granisetron
T82 1369-1374 P46098 denotes 5-HT3
T83 1369-1374 O70212 denotes 5-HT3
T84 1369-1374 PR:P35563 denotes 5-HT3
T85 1369-1374 PR:P23979 denotes 5-HT3
T86 1369-1374 PR:000008833 denotes 5-HT3
T87 1369-1374 P23979 denotes 5-HT3
T88 1369-1374 P35563 denotes 5-HT3
T89 1369-1383 D044406 denotes 5-HT3 receptor
T90 1371-1374 CVCL_1293 denotes HT3
T93 1384-1394 CHEBI:48706 denotes antagonist
T94 1510-1520 CHEBI:50919 denotes antiemetic
T95 1612-1623 CHEBI:50919 denotes antiemetics
T96 1612-1623 D000932 denotes antiemetics
T97 1612-1623 D000932 denotes antiemetics
T100 1639-1651 70561 denotes palonosetron
T98 1639-1651 D000077924 denotes palonosetron
T99 1639-1651 CHEBI:85161 denotes palonosetron
T101 1639-1651 D000077924 denotes palonosetron
T102 1676-1687 26237 denotes granisetron
T103 1676-1687 D017829 denotes granisetron
T104 1676-1687 D017829 denotes granisetron
T105 1676-1687 CHEBI:5537 denotes granisetron
T106 1755-1766 CHEBI:50919 denotes antiemetics
T107 1755-1766 D000932 denotes antiemetics
T108 1755-1766 D000932 denotes antiemetics
T111 1801-1813 70561 denotes palonosetron
T109 1801-1813 D000077924 denotes palonosetron
T110 1801-1813 CHEBI:85161 denotes palonosetron
T112 1801-1813 D000077924 denotes palonosetron
T113 1862-1869 SO:0100018 denotes binding
T114 1862-1869 SO:0001091 denotes binding
T115 1862-1869 GO:0005488 denotes binding
T116 1953-1962 CHEBI:28790 denotes serotonin
T117 1953-1962 D012701 denotes serotonin
T118 1953-1962 CHEBI:350546 denotes serotonin
T119 1953-1962 D012701 denotes serotonin
T120 1963-1973 CHEBI:48706 denotes antagonist
T123 1975-1987 70561 denotes palonosetron
T121 1975-1987 D000077924 denotes palonosetron
T122 1975-1987 CHEBI:85161 denotes palonosetron
T124 1975-1987 D000077924 denotes palonosetron
T125 1991-2002 26237 denotes granisetron
T126 1991-2002 D017829 denotes granisetron
T127 1991-2002 D017829 denotes granisetron
T128 1991-2002 CHEBI:5537 denotes granisetron
T129 2065-2076 CHEBI:50919 denotes antiemetics
T130 2065-2076 D000932 denotes antiemetics
T131 2065-2076 D000932 denotes antiemetics
T132 2080-2090 CHEBI:50919 denotes antiemetic