PubMed:32573711
Annnotations
sonoma2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T89 | 1945-1955 | REG | denotes | contribute |
| T90 | 1959-1967 | DISEASE | denotes | COVID-19 |
| T91 | 1968-1983 | MPA | denotes | pathophysiology |
| T45 | 968-990 | MPA | denotes | protein ubiquitination |
| T46 | 992-1012 | MPA | denotes | antigen presentation |
| T47 | 1017-1042 | MPA | denotes | mitochondrial dysfunction |
| T48 | 1024-1028 | GENE | denotes | ndri |
| T49 | 1081-1085 | GENE | denotes | ACE2 |
| T51 | 1113-1121 | DISEASE | denotes | r protei |
| T52 | 1151-1155 | MPA | denotes | mRNA |
| T53 | 1165-1178 | GENE | denotes | SARS-CoV-2 N1 |
| T54 | 1188-1196 | REG | denotes | detected |
| T55 | 1196-1200 | GENE | denotes | in |
| T56 | 1220-1228 | DISEASE | denotes | COVID-19 |
| T57 | 1222-1230 | DISEASE | denotes | VID-19 p |
| T59 | 1264-1271 | POSREG | denotes | take-up |
| T60 | 1272-1282 | GENE | denotes | SARS-COV-2 |
| T61 | 1283-1287 | MPA | denotes | mRNA |
| T62 | 1303-1307 | GENE | denotes | ACE2 |
| T63 | 1332-1340 | DISEASE | denotes | COVID-19 |
| T64 | 1354-1363 | POSREG | denotes | increased |
| T65 | 1364-1374 | GENE | denotes | P-selectin |
| T66 | 1375-1385 | MPA | denotes | expression |
| T67 | 1402-1410 | DISEASE | denotes | activat |
| T68 | 1403-1413 | MPA | denotes | activation |
| T69 | 1471-1481 | MPA | denotes | aggregates |
| T70 | 1476-1484 | DISEASE | denotes | gates we |
| T71 | 1505-1513 | POSREG | denotes | elevated |
| T72 | 1517-1525 | DISEASE | denotes | COVID-19 |
| T73 | 1591-1599 | DISEASE | denotes | COVID-19 |
| T74 | 1620-1626 | POSREG | denotes | faster |
| T75 | 1638-1647 | POSREG | denotes | increased |
| T76 | 1648-1657 | CPA | denotes | spreading |
| T77 | 1666-1676 | GENE | denotes | fibrinogen |
| T78 | 1681-1689 | GENE | denotes | collagen |
| T79 | 1695-1703 | POSREG | denotes | increase |
| T80 | 1707-1726 | CPA | denotes | platelet activation |
| T81 | 1731-1742 | CPA | denotes | aggregation |
| T82 | 1753-1773 | DISEASE | denotes | ially be attributed |
| T83 | 1786-1798 | PATHWAY | denotes | MAPK pathway |
| T84 | 1799-1809 | MPA | denotes | activation |
| T85 | 1814-1836 | MPA | denotes | thromboxane generation |
| T86 | 1842-1850 | DISEASE | denotes | e findin |
| T87 | 1894-1904 | REG | denotes | associated |
| T88 | 1919-1934 | MPA | denotes | hyperreactivity |
| T0 | 14-24 | MPA | denotes | Expression |
| T1 | 29-37 | MPA | denotes | Function |
| T3 | 41-49 | DISEASE | denotes | COVID-19 |
| T4 | 113-137 | DISEASE | denotes | s of coronavirus disease |
| T5 | 118-142 | DISEASE | denotes | coronavirus disease 2019 |
| T6 | 139-147 | DISEASE | denotes | 019 (COV |
| T7 | 144-152 | DISEASE | denotes | COVID-19 |
| T8 | 165-189 | DISEASE | denotes | lar, thrombotic complica |
| T9 | 170-180 | CPA | denotes | thrombotic |
| T10 | 181-194 | CPA | denotes | complications |
| T11 | 207-215 | DISEASE | denotes | with COV |
| T12 | 212-220 | DISEASE | denotes | COVID-19 |
| T13 | 225-231 | REG | denotes | common |
| T14 | 236-246 | REG | denotes | contribute |
| T15 | 245-258 | DISEASE | denotes | e to organ fa |
| T16 | 250-263 | CPA | denotes | organ failure |
| T17 | 263-272 | DISEASE | denotes | and mort |
| T18 | 295-303 | DISEASE | denotes | vere COV |
| T19 | 300-308 | DISEASE | denotes | COVID-19 |
| T20 | 309-316 | REG | denotes | present |
| T21 | 317-341 | DISEASE | denotes | with hemostatic abnormal |
| T22 | 322-332 | CPA | denotes | hemostatic |
| T23 | 333-346 | MPA | denotes | abnormalities |
| T24 | 353-392 | DISEASE | denotes | imic disseminated intravascular coagulo |
| T25 | 358-397 | CPA | denotes | disseminated intravascular coagulopathy |
| T26 | 409-415 | DISEASE | denotes | with s |
| T27 | 414-420 | DISEASE | denotes | sepsis |
| T28 | 453-462 | POSREG | denotes | increased |
| T29 | 465-475 | DISEASE | denotes | sk of thro |
| T30 | 471-481 | CPA | denotes | thrombosis |
| T31 | 488-496 | DISEASE | denotes | than bl |
| T32 | 494-502 | CPA | denotes | bleeding |
| T34 | 542-548 | REG | denotes | alters |
| T35 | 549-566 | CPA | denotes | platelet function |
| T36 | 551-559 | DISEASE | denotes | atelet f |
| T37 | 570-580 | REG | denotes | contribute |
| T38 | 607-615 | DISEASE | denotes | COVID-19 |
| T39 | 672-680 | DISEASE | denotes | et gene |
| T40 | 742-752 | GENE | denotes | SARS-CoV-2 |
| T41 | 802-810 | DISEASE | denotes | the gene |
| T42 | 858-866 | DISEASE | denotes | COVID-19 |
| T43 | 952-962 | REG | denotes | associated |
| T44 | 961-986 | DISEASE | denotes | d with protein ubiquitina |
| R43 | T73 | T74 | ThemeOf | COVID-19,faster |
| R44 | T73 | T75 | ThemeOf | COVID-19,increased |
| R45 | T76 | T75 | ThemeOf | spreading,increased |
| R46 | T77 | T75 | ThemeOf | fibrinogen,increased |
| R47 | T78 | T75 | ThemeOf | collagen,increased |
| R48 | T80 | T79 | ThemeOf | platelet activation,increase |
| R49 | T81 | T79 | ThemeOf | aggregation,increase |
| R50 | T83 | T84 | ThemeOf | MAPK pathway,activation |
| R51 | T88 | T87 | ThemeOf | hyperreactivity,associated |
| R52 | T91 | T89 | ThemeOf | pathophysiology,contribute |
| R53 | T90 | T87 | ThemeOf | COVID-19,associated |
| R0 | T3 | T0 | ThemeOf | COVID-19,Expression |
| R1 | T3 | T1 | ThemeOf | COVID-19,Function |
| R2 | T7 | T13 | ThemeOf | COVID-19,common |
| R3 | T7 | T14 | ThemeOf | COVID-19,contribute |
| R4 | T9 | T10 | ThemeOf | thrombotic,complications |
| R5 | T9 | T13 | ThemeOf | thrombotic,common |
| R6 | T9 | T14 | ThemeOf | thrombotic,contribute |
| R7 | T10 | T13 | ThemeOf | complications,common |
| R8 | T10 | T14 | ThemeOf | complications,contribute |
| R9 | T12 | T9 | ThemeOf | COVID-19,thrombotic |
| R10 | T12 | T10 | ThemeOf | COVID-19,complications |
| R11 | T12 | T13 | ThemeOf | COVID-19,common |
| R12 | T12 | T14 | ThemeOf | COVID-19,contribute |
| R13 | T16 | T14 | ThemeOf | organ failure,contribute |
| R14 | T19 | T20 | ThemeOf | COVID-19,present |
| R15 | T19 | T23 | ThemeOf | COVID-19,abnormalities |
| R16 | T22 | T20 | ThemeOf | hemostatic,present |
| R17 | T22 | T23 | ThemeOf | hemostatic,abnormalities |
| R18 | T23 | T20 | ThemeOf | abnormalities,present |
| R19 | T27 | T20 | ThemeOf | sepsis,present |
| R20 | T27 | T23 | ThemeOf | sepsis,abnormalities |
| R21 | T30 | T28 | ThemeOf | thrombosis,increased |
| R22 | T32 | T28 | ThemeOf | bleeding,increased |
| R23 | T35 | T34 | ThemeOf | platelet function,alters |
| R24 | T35 | T37 | ThemeOf | platelet function,contribute |
| R25 | T38 | T34 | ThemeOf | COVID-19,alters |
| R26 | T38 | T37 | ThemeOf | COVID-19,contribute |
| R27 | T45 | T43 | ThemeOf | protein ubiquitination,associated |
| R28 | T46 | T43 | ThemeOf | antigen presentation,associated |
| R29 | T47 | T43 | ThemeOf | mitochondrial dysfunction,associated |
| R30 | T52 | T54 | ThemeOf | mRNA,detected |
| R31 | T56 | T54 | ThemeOf | COVID-19,detected |
| R32 | T56 | T59 | ThemeOf | COVID-19,take-up |
| R33 | T60 | T61 | ThemeOf | SARS-COV-2,mRNA |
| R34 | T61 | T59 | ThemeOf | mRNA,take-up |
| R35 | T63 | T64 | ThemeOf | COVID-19,increased |
| R36 | T63 | T71 | ThemeOf | COVID-19,elevated |
| R37 | T66 | T64 | ThemeOf | expression,increased |
| R38 | T65 | T64 | ThemeOf | P-selectin,increased |
| R39 | T65 | T66 | ThemeOf | P-selectin,expression |
| R40 | T69 | T71 | ThemeOf | aggregates,elevated |
| R41 | T72 | T71 | ThemeOf | COVID-19,elevated |
| R42 | T73 | T71 | ThemeOf | COVID-19,elevated |
| R54 | T90 | T89 | ThemeOf | COVID-19,contribute |
| R55 | T90 | T91 | ThemeOf | COVID-19,pathophysiology |
| R56 | T91 | T87 | ThemeOf | pathophysiology,associated |
| R57 | T91 | T88 | ThemeOf | pathophysiology,hyperreactivity |
LitCovid-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-8 | CL:0000233 | denotes | Platelet |
| T2 | 9-13 | SO:0000704 | denotes | Gene |
| T3 | 9-24 | GO:0010467 | denotes | Gene Expression |
| T4 | 41-49 | SP_7 | denotes | COVID-19 |
| T5 | 118-129 | NCBITaxon:11118 | denotes | coronavirus |
| T6 | 144-152 | SP_7 | denotes | COVID-19 |
| T7 | 170-180 | GO:0007596 | denotes | thrombotic |
| T8 | 212-220 | SP_7 | denotes | COVID-19 |
| T9 | 250-255 | UBERON:0000062 | denotes | organ |
| T10 | 300-308 | SP_7 | denotes | COVID-19 |
| T11 | 322-332 | GO:0007599 | denotes | hemostatic |
| T12 | 385-397 | GO:0050817 | denotes | coagulopathy |
| T13 | 471-481 | GO:0007596 | denotes | thrombosis |
| T14 | 521-531 | SP_7 | denotes | SARS-CoV-2 |
| T15 | 549-557 | CL:0000233 | denotes | platelet |
| T16 | 607-615 | SP_7 | denotes | COVID-19 |
| T17 | 666-674 | CL:0000233 | denotes | platelet |
| T18 | 675-679 | SO:0000704 | denotes | gene |
| T19 | 675-690 | GO:0010467 | denotes | gene expression |
| T20 | 742-752 | SP_7 | denotes | SARS-CoV-2 |
| T21 | 806-810 | SO:0000704 | denotes | gene |
| T22 | 806-821 | GO:0010467 | denotes | gene expression |
| T23 | 833-844 | CL:0000080 | denotes | circulating |
| T24 | 845-854 | CL:0000233 | denotes | platelets |
| T25 | 858-866 | SP_7 | denotes | COVID-19 |
| T26 | 916-920 | SO:0000704 | denotes | gene |
| T27 | 916-931 | GO:0010467 | denotes | gene expression |
| T28 | 968-990 | GO:0016567 | denotes | protein ubiquitination |
| T29 | 992-999 | CHEBI:59132 | denotes | antigen |
| T30 | 992-999 | CHEBI:59132 | denotes | antigen |
| T31 | 1017-1030 | GO:0005739 | denotes | mitochondrial |
| T32 | 1061-1071 | SP_7 | denotes | SARS-CoV-2 |
| T33 | 1081-1085 | G_3 | denotes | ACE2 |
| T34 | 1081-1085 | PG_10 | denotes | ACE2 |
| T35 | 1081-1085 | PR:000003622 | denotes | ACE2 |
| T36 | 1126-1135 | CL:0000233 | denotes | platelets |
| T37 | 1165-1175 | SP_7 | denotes | SARS-CoV-2 |
| T38 | 1179-1183 | SO:0000704 | denotes | gene |
| T39 | 1200-1209 | CL:0000233 | denotes | platelets |
| T40 | 1220-1228 | SP_7 | denotes | COVID-19 |
| T41 | 1250-1259 | CL:0000233 | denotes | platelets |
| T42 | 1272-1282 | SP_7 | denotes | SARS-COV-2 |
| T43 | 1303-1307 | G_3 | denotes | ACE2 |
| T44 | 1303-1307 | PG_10 | denotes | ACE2 |
| T45 | 1303-1307 | PR:000003622 | denotes | ACE2 |
| T46 | 1317-1326 | CL:0000233 | denotes | platelets |
| T47 | 1332-1340 | SP_7 | denotes | COVID-19 |
| T48 | 1364-1374 | PR:000001432 | denotes | P-selectin |
| T49 | 1375-1385 | GO:0010467 | denotes | expression |
| T50 | 1427-1435 | CL:0000233 | denotes | platelet |
| T51 | 1436-1446 | CL:0000775 | denotes | neutrophil |
| T52 | 1449-1457 | CL:0000576 | denotes | monocyte |
| T53 | 1464-1470 | CL:0000084 | denotes | T-cell |
| T54 | 1517-1525 | SP_7 | denotes | COVID-19 |
| T55 | 1576-1585 | CL:0000233 | denotes | platelets |
| T56 | 1591-1599 | SP_7 | denotes | COVID-19 |
| T57 | 1666-1676 | GO:0005577 | denotes | fibrinogen |
| T58 | 1707-1715 | CL:0000233 | denotes | platelet |
| T59 | 1707-1726 | GO:0030168 | denotes | platelet activation |
| T60 | 1786-1809 | GO:0000187 | denotes | MAPK pathway activation |
| T61 | 1814-1825 | CHEBI:26995 | denotes | thromboxane |
| T62 | 1814-1825 | CHEBI:26995 | denotes | thromboxane |
| T63 | 1870-1880 | SP_7 | denotes | SARS-CoV-2 |
| T64 | 1910-1918 | CL:0000233 | denotes | platelet |
| T65 | 1959-1967 | SP_7 | denotes | COVID-19 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T1 | 0-8 | Body_part | denotes | Platelet | http://purl.org/sig/ont/fma/fma62851 |
| T2 | 9-13 | Body_part | denotes | Gene | http://purl.org/sig/ont/fma/fma74402 |
| T3 | 250-255 | Body_part | denotes | organ | http://purl.org/sig/ont/fma/fma67498 |
| T4 | 549-557 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
| T5 | 666-674 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
| T6 | 675-679 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T7 | 754-757 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T8 | 806-810 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T9 | 845-854 | Body_part | denotes | platelets | http://purl.org/sig/ont/fma/fma62851 |
| T10 | 916-920 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T11 | 968-975 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T12 | 1107-1111 | Body_part | denotes | mRNA | http://purl.org/sig/ont/fma/fma67122 |
| T13 | 1115-1122 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T14 | 1126-1135 | Body_part | denotes | platelets | http://purl.org/sig/ont/fma/fma62851 |
| T15 | 1151-1155 | Body_part | denotes | mRNA | http://purl.org/sig/ont/fma/fma67122 |
| T16 | 1179-1183 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T17 | 1200-1209 | Body_part | denotes | platelets | http://purl.org/sig/ont/fma/fma62851 |
| T18 | 1250-1259 | Body_part | denotes | platelets | http://purl.org/sig/ont/fma/fma62851 |
| T19 | 1283-1287 | Body_part | denotes | mRNA | http://purl.org/sig/ont/fma/fma67122 |
| T20 | 1317-1326 | Body_part | denotes | platelets | http://purl.org/sig/ont/fma/fma62851 |
| T21 | 1364-1374 | Body_part | denotes | P-selectin | http://purl.org/sig/ont/fma/fma62933 |
| T22 | 1427-1435 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
| T23 | 1436-1446 | Body_part | denotes | neutrophil | http://purl.org/sig/ont/fma/fma62860 |
| T24 | 1449-1457 | Body_part | denotes | monocyte | http://purl.org/sig/ont/fma/fma62864 |
| T25 | 1466-1470 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T26 | 1576-1585 | Body_part | denotes | platelets | http://purl.org/sig/ont/fma/fma62851 |
| T27 | 1681-1689 | Body_part | denotes | collagen | http://purl.org/sig/ont/fma/fma63891 |
| T28 | 1707-1715 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
| T29 | 1910-1918 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 250-255 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 41-49 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T2 | 118-142 | Disease | denotes | coronavirus disease 2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T3 | 144-152 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T4 | 212-220 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T5 | 300-308 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T6 | 385-397 | Disease | denotes | coagulopathy | http://purl.obolibrary.org/obo/MONDO_0001531 |
| T7 | 471-481 | Disease | denotes | thrombosis | http://purl.obolibrary.org/obo/MONDO_0000831 |
| T8 | 521-529 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T9 | 532-541 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T10 | 607-615 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T11 | 742-750 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T12 | 858-866 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T13 | 1061-1069 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T14 | 1165-1173 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T15 | 1220-1228 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T16 | 1272-1276 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T17 | 1332-1340 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T18 | 1517-1525 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T19 | 1591-1599 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T20 | 1870-1878 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T21 | 1881-1890 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T22 | 1959-1967 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 9-13 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | Gene |
| T2 | 250-255 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organ |
| T3 | 675-679 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T4 | 806-810 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T5 | 916-920 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T6 | 1179-1183 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T7 | 1215-1219 | http://purl.obolibrary.org/obo/CLO_0001196 | denotes | 2/25 |
| T8 | 1403-1413 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T9 | 1449-1457 | http://purl.obolibrary.org/obo/CL_0000576 | denotes | monocyte |
| T10 | 1464-1470 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T-cell |
| T11 | 1681-1689 | http://purl.obolibrary.org/obo/CHEBI_3815 | denotes | collagen |
| T12 | 1716-1726 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T13 | 1799-1809 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T1 | 877-884 | Chemical | denotes | Pathway | http://purl.obolibrary.org/obo/CHEBI_34922 |
| T2 | 968-975 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T3 | 992-999 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
| T4 | 1115-1122 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T5 | 1814-1825 | Chemical | denotes | thromboxane | http://purl.obolibrary.org/obo/CHEBI_26995 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 9-24 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | Gene Expression |
| T2 | 102-114 | http://purl.obolibrary.org/obo/GO_0009405 | denotes | pathogenesis |
| T3 | 675-690 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
| T4 | 806-821 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
| T5 | 916-931 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
| T6 | 968-990 | http://purl.obolibrary.org/obo/GO_0016567 | denotes | protein ubiquitination |
| T7 | 992-1012 | http://purl.obolibrary.org/obo/GO_0019882 | denotes | antigen presentation |
| T8 | 1464-1481 | http://purl.obolibrary.org/obo/GO_0070489 | denotes | T-cell aggregates |
| T9 | 1707-1726 | http://purl.obolibrary.org/obo/GO_0030168 | denotes | platelet activation |
| T10 | 1786-1790 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | MAPK |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 2 | 41-49 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 3 | 50-58 | Species | denotes | Patients | Tax:9606 |
| 43 | 118-142 | Disease | denotes | coronavirus disease 2019 | MESH:C000657245 |
| 44 | 144-152 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 45 | 170-194 | Disease | denotes | thrombotic complications | MESH:D013927 |
| 46 | 198-206 | Species | denotes | patients | Tax:9606 |
| 47 | 212-220 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 48 | 250-263 | Disease | denotes | organ failure | MESH:D009102 |
| 49 | 268-277 | Disease | denotes | mortality | MESH:D003643 |
| 50 | 279-287 | Species | denotes | Patients | Tax:9606 |
| 51 | 300-308 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 52 | 322-346 | Disease | denotes | hemostatic abnormalities | MESH:D020141 |
| 53 | 358-397 | Disease | denotes | disseminated intravascular coagulopathy | MESH:D004211 |
| 54 | 414-420 | Disease | denotes | sepsis | MESH:D018805 |
| 55 | 471-481 | Disease | denotes | thrombosis | MESH:D013927 |
| 56 | 494-502 | Disease | denotes | bleeding | MESH:D006470 |
| 57 | 521-541 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
| 58 | 607-615 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 59 | 719-727 | Species | denotes | patients | Tax:9606 |
| 60 | 728-736 | Disease | denotes | infected | MESH:D007239 |
| 61 | 742-752 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 62 | 858-866 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 63 | 867-875 | Species | denotes | patients | Tax:9606 |
| 64 | 1017-1042 | Disease | denotes | mitochondrial dysfunction | MESH:D028361 |
| 65 | 1061-1071 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 66 | 1081-1085 | Gene | denotes | ACE2 | Gene:59272 |
| 67 | 1165-1175 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 68 | 1220-1228 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 69 | 1229-1237 | Species | denotes | patients | Tax:9606 |
| 70 | 1272-1282 | Species | denotes | SARS-COV-2 | Tax:2697049 |
| 71 | 1303-1307 | Gene | denotes | ACE2 | Gene:59272 |
| 72 | 1332-1340 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 73 | 1341-1349 | Species | denotes | patients | Tax:9606 |
| 74 | 1364-1374 | Gene | denotes | P-selectin | Gene:6403 |
| 75 | 1517-1525 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 76 | 1526-1534 | Species | denotes | patients | Tax:9606 |
| 77 | 1591-1599 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 78 | 1600-1608 | Species | denotes | patients | Tax:9606 |
| 79 | 1814-1825 | Chemical | denotes | thromboxane | MESH:D013931 |
| 80 | 1870-1890 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
| 81 | 1959-1967 | Disease | denotes | COVID-19 | MESH:C000657245 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-59 | Sentence | denotes | Platelet Gene Expression and Function in COVID-19 Patients. |
| T2 | 60-154 | Sentence | denotes | There is an urgent need to understand the pathogenesis of coronavirus disease 2019 (COVID-19). |
| T3 | 155-278 | Sentence | denotes | In particular, thrombotic complications in patients with COVID-19 are common and contribute to organ failure and mortality. |
| T4 | 279-503 | Sentence | denotes | Patients with severe COVID-19 present with hemostatic abnormalities that mimic disseminated intravascular coagulopathy associated with sepsis with the major difference being increased risk of thrombosis rather than bleeding. |
| T5 | 504-632 | Sentence | denotes | However, whether SARS-CoV-2 infection alters platelet function to contribute to the pathophysiology of COVID-19 remains unknown. |
| T6 | 633-753 | Sentence | denotes | In this study, we report altered platelet gene expression and functional responses in patients infected with SARS-CoV-2. |
| T7 | 754-876 | Sentence | denotes | RNA sequencing demonstrated distinct changes in the gene expression profile of circulating platelets of COVID-19 patients. |
| T8 | 877-1043 | Sentence | denotes | Pathway analysis revealed differential gene expression changes in pathways associated with protein ubiquitination, antigen presentation and mitochondrial dysfunction. |
| T9 | 1044-1136 | Sentence | denotes | The receptor for SARS-CoV-2 binding, ACE2, was not detected by mRNA or protein in platelets. |
| T10 | 1137-1308 | Sentence | denotes | Surprisingly, mRNA from the SARS-CoV-2 N1 gene was detected in platelets from 2/25 COVID-19 patients, suggesting platelets may take-up SARS-COV-2 mRNA independent of ACE2. |
| T11 | 1309-1414 | Sentence | denotes | Resting platelets from COVID-19 patients had increased P-selectin expression basally and upon activation. |
| T12 | 1415-1562 | Sentence | denotes | Circulating platelet-neutrophil, -monocyte, and -T-cell aggregates were all significantly elevated in COVID-19 patients compared to healthy donors. |
| T13 | 1563-1690 | Sentence | denotes | Furthermore, platelets from COVID-19 patients aggregated faster and showed increased spreading on both fibrinogen and collagen. |
| T14 | 1691-1837 | Sentence | denotes | The increase in platelet activation and aggregation could partially be attributed to increased MAPK pathway activation and thromboxane generation. |
| T15 | 1838-1984 | Sentence | denotes | These findings demonstrate that SARS-CoV-2 infection is associated with platelet hyperreactivity which may contribute to COVID-19 pathophysiology. |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 385-397 | Phenotype | denotes | coagulopathy | http://purl.obolibrary.org/obo/HP_0003256 |
| T2 | 414-420 | Phenotype | denotes | sepsis | http://purl.obolibrary.org/obo/HP_0100806 |
| T3 | 1017-1042 | Phenotype | denotes | mitochondrial dysfunction | http://purl.obolibrary.org/obo/HP_0003287 |