PubMed:32571880 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/32571880","sourcedb":"PubMed","sourceid":"32571880","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/32571880","text":"Structural and functional conservation of the programmed -1 ribosomal frameshift signal of SARS coronavirus 2 (SARS-CoV-2).\nAbout 17 years after the severe acute respiratory syndrome coronavirus (SARS-CoV) epidemic, the world is currently facing the COVID-19 pandemic caused by SARS coronavirus 2 (SARS-CoV-2). According to the most optimistic projections, it will take more than a year to develop a vaccine, so the best short-term strategy may lie in identifying virus-specific targets for small molecule-based interventions. All coronaviruses utilize a molecular mechanism called programmed -1 ribosomal frameshift (-1 PRF) to control the relative expression of their proteins. Previous analyses of SARS-CoV have revealed that it employs a structurally unique three-stemmed mRNA pseudoknot that stimulates high -1 PRF rates and that it also harbors a -1 PRF attenuation element. Altering -1 PRF activity impairs virus replication, suggesting that this activity may be therapeutically targeted. Here, we comparatively analyzed the SARS-CoV and SARS-CoV-2 frameshift signals. Structural and functional analyses revealed that both elements promote similar -1 PRF rates and that silent coding mutations in the slippery sites and in all three stems of the pseudoknot strongly ablate -1 PRF activity. We noted that the upstream attenuator hairpin activity is also functionally retained in both viruses, despite differences in the primary sequence in this region. Small-angle X-ray scattering analyses indicated that the pseudoknots in SARS-CoV and SARS-CoV-2 have the same conformation. Finally, a small molecule previously shown to bind the SARS-CoV pseudoknot and inhibit -1 PRF was similarly effective against -1 PRF in SARS-CoV-2, suggesting that such frameshift inhibitors may be promising lead compounds to combat the current COVID-19 pandemic.","tracks":[{"project":"LitCovid-OGER-BB","denotations":[{"id":"T1","span":{"begin":60,"end":69},"obj":"GO:0005840"},{"id":"T2","span":{"begin":70,"end":87},"obj":"SO:0001532"},{"id":"T3","span":{"begin":91,"end":95},"obj":"SP_10"},{"id":"T4","span":{"begin":91,"end":95},"obj":"PR:000014459"},{"id":"T5","span":{"begin":96,"end":107},"obj":"NCBITaxon:11118"},{"id":"T6","span":{"begin":111,"end":115},"obj":"PR:000014459"},{"id":"T7","span":{"begin":111,"end":121},"obj":"SP_7"},{"id":"T8","span":{"begin":149,"end":194},"obj":"SP_10"},{"id":"T9","span":{"begin":162,"end":173},"obj":"UBERON:0001004"},{"id":"T10","span":{"begin":196,"end":204},"obj":"SP_10"},{"id":"T11","span":{"begin":250,"end":258},"obj":"SP_7"},{"id":"T12","span":{"begin":278,"end":282},"obj":"SP_10"},{"id":"T13","span":{"begin":283,"end":294},"obj":"NCBITaxon:11118"},{"id":"T14","span":{"begin":298,"end":308},"obj":"SP_7"},{"id":"T15","span":{"begin":344,"end":355},"obj":"GO:0042995"},{"id":"T16","span":{"begin":464,"end":469},"obj":"NCBITaxon:10239"},{"id":"T17","span":{"begin":497,"end":505},"obj":"CHEBI:36357"},{"id":"T18","span":{"begin":497,"end":505},"obj":"CHEBI:36357"},{"id":"T19","span":{"begin":531,"end":544},"obj":"NCBITaxon:11118"},{"id":"T20","span":{"begin":596,"end":605},"obj":"GO:0005840"},{"id":"T21","span":{"begin":629,"end":636},"obj":"GO:0065007"},{"id":"T22","span":{"begin":650,"end":660},"obj":"GO:0010467"},{"id":"T23","span":{"begin":701,"end":709},"obj":"SP_10"},{"id":"T24","span":{"begin":856,"end":859},"obj":"GO:0035098"},{"id":"T25","span":{"begin":893,"end":896},"obj":"GO:0035098"},{"id":"T26","span":{"begin":914,"end":919},"obj":"NCBITaxon:10239"},{"id":"T27","span":{"begin":914,"end":919},"obj":"GO:0006260"},{"id":"T28","span":{"begin":920,"end":931},"obj":"GO:0006260"},{"id":"T29","span":{"begin":1032,"end":1040},"obj":"SP_10"},{"id":"T30","span":{"begin":1045,"end":1055},"obj":"SP_7"},{"id":"T31","span":{"begin":1253,"end":1263},"obj":"SO:0000591"},{"id":"T32","span":{"begin":1335,"end":1342},"obj":"SO:0000313"},{"id":"T33","span":{"begin":1390,"end":1397},"obj":"NCBITaxon:10239"},{"id":"T34","span":{"begin":1516,"end":1527},"obj":"SO:0000591"},{"id":"T35","span":{"begin":1531,"end":1539},"obj":"SP_10"},{"id":"T36","span":{"begin":1544,"end":1554},"obj":"SP_7"},{"id":"T37","span":{"begin":1600,"end":1608},"obj":"CHEBI:36357"},{"id":"T38","span":{"begin":1600,"end":1608},"obj":"CHEBI:36357"},{"id":"T39","span":{"begin":1638,"end":1646},"obj":"SP_10"},{"id":"T40","span":{"begin":1719,"end":1729},"obj":"SP_7"},{"id":"T41","span":{"begin":1763,"end":1773},"obj":"CHEBI:35222"},{"id":"T42","span":{"begin":1763,"end":1773},"obj":"CHEBI:35222"},{"id":"T43","span":{"begin":1796,"end":1805},"obj":"CHEBI:36357"},{"id":"T44","span":{"begin":1796,"end":1805},"obj":"CHEBI:36357"},{"id":"T45","span":{"begin":1828,"end":1836},"obj":"SP_7"}],"namespaces":[{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T2","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T3","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T4","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T5","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T6","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T7","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T8","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T9","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T10","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T11","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T12","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T13","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T14","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T15","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T16","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T17","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T18","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T19","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T20","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T21","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T22","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T23","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T24","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T25","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T26","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T27","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T28","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T29","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T30","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T31","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T32","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T33","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T34","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T35","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T36","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T37","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T38","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T39","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T40","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T41","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T42","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T43","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T44","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T45","pred":"source","obj":"LitCovid-OGER-BB"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":60,"end":69},"obj":"Body_part"},{"id":"T2","span":{"begin":596,"end":605},"obj":"Body_part"},{"id":"T3","span":{"begin":670,"end":678},"obj":"Body_part"},{"id":"T4","span":{"begin":776,"end":780},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma66867"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma66867"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma67122"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":91,"end":95},"obj":"Disease"},{"id":"T2","span":{"begin":111,"end":119},"obj":"Disease"},{"id":"T3","span":{"begin":149,"end":182},"obj":"Disease"},{"id":"T4","span":{"begin":196,"end":204},"obj":"Disease"},{"id":"T5","span":{"begin":250,"end":258},"obj":"Disease"},{"id":"T6","span":{"begin":278,"end":282},"obj":"Disease"},{"id":"T7","span":{"begin":298,"end":306},"obj":"Disease"},{"id":"T8","span":{"begin":701,"end":709},"obj":"Disease"},{"id":"T9","span":{"begin":1032,"end":1040},"obj":"Disease"},{"id":"T10","span":{"begin":1045,"end":1053},"obj":"Disease"},{"id":"T11","span":{"begin":1531,"end":1539},"obj":"Disease"},{"id":"T12","span":{"begin":1544,"end":1552},"obj":"Disease"},{"id":"T13","span":{"begin":1638,"end":1646},"obj":"Disease"},{"id":"T14","span":{"begin":1719,"end":1727},"obj":"Disease"},{"id":"T15","span":{"begin":1828,"end":1836},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":81,"end":87},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T2","span":{"begin":239,"end":249},"obj":"http://purl.obolibrary.org/obo/UBERON_0001456"},{"id":"T3","span":{"begin":380,"end":381},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T4","span":{"begin":398,"end":399},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T5","span":{"begin":464,"end":469},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T6","span":{"begin":553,"end":554},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T7","span":{"begin":740,"end":741},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T8","span":{"begin":851,"end":852},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T9","span":{"begin":897,"end":905},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T10","span":{"begin":914,"end":919},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T11","span":{"begin":954,"end":962},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T12","span":{"begin":1067,"end":1074},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T13","span":{"begin":1287,"end":1295},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T14","span":{"begin":1343,"end":1351},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T15","span":{"begin":1390,"end":1397},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T16","span":{"begin":1592,"end":1593},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T12","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":497,"end":505},"obj":"Chemical"},{"id":"T2","span":{"begin":670,"end":678},"obj":"Chemical"},{"id":"T3","span":{"begin":1600,"end":1608},"obj":"Chemical"},{"id":"T4","span":{"begin":1763,"end":1773},"obj":"Chemical"},{"id":"T5","span":{"begin":1791,"end":1805},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_33585"},{"subj":"T1","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"2","span":{"begin":91,"end":109},"obj":"Species"},{"id":"3","span":{"begin":111,"end":121},"obj":"Species"},{"id":"18","span":{"begin":149,"end":194},"obj":"Species"},{"id":"19","span":{"begin":196,"end":204},"obj":"Species"},{"id":"20","span":{"begin":250,"end":258},"obj":"Disease"},{"id":"21","span":{"begin":283,"end":294},"obj":"Species"},{"id":"22","span":{"begin":298,"end":308},"obj":"Species"},{"id":"23","span":{"begin":531,"end":544},"obj":"Species"},{"id":"24","span":{"begin":701,"end":709},"obj":"Species"},{"id":"25","span":{"begin":1032,"end":1040},"obj":"Species"},{"id":"26","span":{"begin":1045,"end":1055},"obj":"Species"},{"id":"27","span":{"begin":1531,"end":1539},"obj":"Species"},{"id":"28","span":{"begin":1544,"end":1554},"obj":"Species"},{"id":"29","span":{"begin":1638,"end":1646},"obj":"Species"},{"id":"30","span":{"begin":1719,"end":1729},"obj":"Species"},{"id":"31","span":{"begin":1828,"end":1836},"obj":"Disease"}],"attributes":[{"id":"A2","pred":"tao:has_database_id","subj":"2","obj":"Tax:2697049"},{"id":"A3","pred":"tao:has_database_id","subj":"3","obj":"Tax:2697049"},{"id":"A18","pred":"tao:has_database_id","subj":"18","obj":"Tax:694009"},{"id":"A19","pred":"tao:has_database_id","subj":"19","obj":"Tax:694009"},{"id":"A20","pred":"tao:has_database_id","subj":"20","obj":"MESH:C000657245"},{"id":"A21","pred":"tao:has_database_id","subj":"21","obj":"Tax:11118"},{"id":"A22","pred":"tao:has_database_id","subj":"22","obj":"Tax:2697049"},{"id":"A23","pred":"tao:has_database_id","subj":"23","obj":"Tax:11118"},{"id":"A24","pred":"tao:has_database_id","subj":"24","obj":"Tax:694009"},{"id":"A25","pred":"tao:has_database_id","subj":"25","obj":"Tax:694009"},{"id":"A26","pred":"tao:has_database_id","subj":"26","obj":"Tax:2697049"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"Tax:694009"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"Tax:2697049"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"Tax:694009"},{"id":"A30","pred":"tao:has_database_id","subj":"30","obj":"Tax:2697049"},{"id":"A31","pred":"tao:has_database_id","subj":"31","obj":"MESH:C000657245"},{"subj":"2","pred":"source","obj":"LitCovid-PubTator"},{"subj":"3","pred":"source","obj":"LitCovid-PubTator"},{"subj":"18","pred":"source","obj":"LitCovid-PubTator"},{"subj":"19","pred":"source","obj":"LitCovid-PubTator"},{"subj":"20","pred":"source","obj":"LitCovid-PubTator"},{"subj":"21","pred":"source","obj":"LitCovid-PubTator"},{"subj":"22","pred":"source","obj":"LitCovid-PubTator"},{"subj":"23","pred":"source","obj":"LitCovid-PubTator"},{"subj":"24","pred":"source","obj":"LitCovid-PubTator"},{"subj":"25","pred":"source","obj":"LitCovid-PubTator"},{"subj":"26","pred":"source","obj":"LitCovid-PubTator"},{"subj":"27","pred":"source","obj":"LitCovid-PubTator"},{"subj":"28","pred":"source","obj":"LitCovid-PubTator"},{"subj":"29","pred":"source","obj":"LitCovid-PubTator"},{"subj":"30","pred":"source","obj":"LitCovid-PubTator"},{"subj":"31","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":123},"obj":"Sentence"},{"id":"T2","span":{"begin":124,"end":310},"obj":"Sentence"},{"id":"T3","span":{"begin":311,"end":526},"obj":"Sentence"},{"id":"T4","span":{"begin":527,"end":679},"obj":"Sentence"},{"id":"T5","span":{"begin":680,"end":880},"obj":"Sentence"},{"id":"T6","span":{"begin":881,"end":995},"obj":"Sentence"},{"id":"T7","span":{"begin":996,"end":1075},"obj":"Sentence"},{"id":"T8","span":{"begin":1076,"end":1296},"obj":"Sentence"},{"id":"T9","span":{"begin":1297,"end":1458},"obj":"Sentence"},{"id":"T10","span":{"begin":1459,"end":1582},"obj":"Sentence"},{"id":"T11","span":{"begin":1583,"end":1846},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-sentences"},{"subj":"T2","pred":"source","obj":"LitCovid-sentences"},{"subj":"T3","pred":"source","obj":"LitCovid-sentences"},{"subj":"T4","pred":"source","obj":"LitCovid-sentences"},{"subj":"T5","pred":"source","obj":"LitCovid-sentences"},{"subj":"T6","pred":"source","obj":"LitCovid-sentences"},{"subj":"T7","pred":"source","obj":"LitCovid-sentences"},{"subj":"T8","pred":"source","obj":"LitCovid-sentences"},{"subj":"T9","pred":"source","obj":"LitCovid-sentences"},{"subj":"T10","pred":"source","obj":"LitCovid-sentences"},{"subj":"T11","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid_AGAC_only","denotations":[{"id":"p40518s0","span":{"begin":881,"end":889},"obj":"Var"},{"id":"p40518s5","span":{"begin":906,"end":913},"obj":"NegReg"},{"id":"p40518s6","span":{"begin":914,"end":919},"obj":"Protein"},{"id":"p40518s7","span":{"begin":920,"end":931},"obj":"MPA"}],"attributes":[{"subj":"p40518s0","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p40518s5","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p40518s6","pred":"source","obj":"LitCovid_AGAC_only"},{"subj":"p40518s7","pred":"source","obj":"LitCovid_AGAC_only"}]},{"project":"sentences","denotations":[{"id":"T1","span":{"begin":0,"end":123},"obj":"Sentence"},{"id":"T2","span":{"begin":124,"end":310},"obj":"Sentence"},{"id":"T3","span":{"begin":311,"end":526},"obj":"Sentence"},{"id":"T4","span":{"begin":527,"end":679},"obj":"Sentence"},{"id":"T5","span":{"begin":680,"end":880},"obj":"Sentence"},{"id":"T6","span":{"begin":881,"end":995},"obj":"Sentence"},{"id":"T7","span":{"begin":996,"end":1075},"obj":"Sentence"},{"id":"T8","span":{"begin":1076,"end":1296},"obj":"Sentence"},{"id":"T9","span":{"begin":1297,"end":1458},"obj":"Sentence"},{"id":"T10","span":{"begin":1459,"end":1582},"obj":"Sentence"},{"id":"T11","span":{"begin":1583,"end":1846},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"},{"subj":"T10","pred":"source","obj":"sentences"},{"subj":"T11","pred":"source","obj":"sentences"}]},{"project":"Glycosmos6-MAT","denotations":[{"id":"T1","span":{"begin":768,"end":775},"obj":"http://purl.obolibrary.org/obo/MAT_0000239"},{"id":"T2","span":{"begin":1240,"end":1245},"obj":"http://purl.obolibrary.org/obo/MAT_0000239"}],"attributes":[{"subj":"T1","pred":"source","obj":"Glycosmos6-MAT"},{"subj":"T2","pred":"source","obj":"Glycosmos6-MAT"}]},{"project":"Anatomy-MAT","denotations":[{"id":"T1","span":{"begin":768,"end":775},"obj":"Body_part"},{"id":"T2","span":{"begin":1240,"end":1245},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"mat_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MAT_0000239"},{"id":"A2","pred":"mat_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MAT_0000239"},{"subj":"T1","pred":"source","obj":"Anatomy-MAT"},{"subj":"T2","pred":"source","obj":"Anatomy-MAT"}]},{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":91,"end":95},"obj":"Disease"},{"id":"T2","span":{"begin":111,"end":121},"obj":"Disease"},{"id":"T3","span":{"begin":149,"end":182},"obj":"Disease"},{"id":"T4","span":{"begin":196,"end":204},"obj":"Disease"},{"id":"T5","span":{"begin":250,"end":258},"obj":"Disease"},{"id":"T6","span":{"begin":278,"end":282},"obj":"Disease"},{"id":"T7","span":{"begin":298,"end":308},"obj":"Disease"},{"id":"T8","span":{"begin":701,"end":709},"obj":"Disease"},{"id":"T9","span":{"begin":1032,"end":1040},"obj":"Disease"},{"id":"T10","span":{"begin":1045,"end":1055},"obj":"Disease"},{"id":"T11","span":{"begin":1531,"end":1539},"obj":"Disease"},{"id":"T12","span":{"begin":1544,"end":1554},"obj":"Disease"},{"id":"T13","span":{"begin":1638,"end":1646},"obj":"Disease"},{"id":"T14","span":{"begin":1719,"end":1729},"obj":"Disease"},{"id":"T15","span":{"begin":1828,"end":1836},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T1","pred":"source","obj":"mondo_disease"},{"subj":"T2","pred":"source","obj":"mondo_disease"},{"subj":"T3","pred":"source","obj":"mondo_disease"},{"subj":"T4","pred":"source","obj":"mondo_disease"},{"subj":"T5","pred":"source","obj":"mondo_disease"},{"subj":"T6","pred":"source","obj":"mondo_disease"},{"subj":"T7","pred":"source","obj":"mondo_disease"},{"subj":"T8","pred":"source","obj":"mondo_disease"},{"subj":"T9","pred":"source","obj":"mondo_disease"},{"subj":"T10","pred":"source","obj":"mondo_disease"},{"subj":"T11","pred":"source","obj":"mondo_disease"},{"subj":"T12","pred":"source","obj":"mondo_disease"},{"subj":"T13","pred":"source","obj":"mondo_disease"},{"subj":"T14","pred":"source","obj":"mondo_disease"},{"subj":"T15","pred":"source","obj":"mondo_disease"}]},{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":111,"end":119},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":149,"end":182},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":196,"end":204},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":298,"end":306},"obj":"OrganismTaxon"},{"id":"T5","span":{"begin":701,"end":709},"obj":"OrganismTaxon"},{"id":"T6","span":{"begin":1032,"end":1040},"obj":"OrganismTaxon"},{"id":"T7","span":{"begin":1045,"end":1053},"obj":"OrganismTaxon"},{"id":"T8","span":{"begin":1531,"end":1539},"obj":"OrganismTaxon"},{"id":"T9","span":{"begin":1544,"end":1552},"obj":"OrganismTaxon"},{"id":"T10","span":{"begin":1638,"end":1646},"obj":"OrganismTaxon"},{"id":"T11","span":{"begin":1719,"end":1727},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"694009"},{"id":"A2","pred":"db_id","subj":"T2","obj":"694009"},{"id":"A3","pred":"db_id","subj":"T3","obj":"694009"},{"id":"A4","pred":"db_id","subj":"T4","obj":"694009"},{"id":"A5","pred":"db_id","subj":"T5","obj":"694009"},{"id":"A6","pred":"db_id","subj":"T6","obj":"694009"},{"id":"A7","pred":"db_id","subj":"T7","obj":"694009"},{"id":"A8","pred":"db_id","subj":"T8","obj":"694009"},{"id":"A9","pred":"db_id","subj":"T9","obj":"694009"},{"id":"A10","pred":"db_id","subj":"T10","obj":"694009"},{"id":"A11","pred":"db_id","subj":"T11","obj":"694009"},{"subj":"T1","pred":"source","obj":"NCBITAXON"},{"subj":"T2","pred":"source","obj":"NCBITAXON"},{"subj":"T3","pred":"source","obj":"NCBITAXON"},{"subj":"T4","pred":"source","obj":"NCBITAXON"},{"subj":"T5","pred":"source","obj":"NCBITAXON"},{"subj":"T6","pred":"source","obj":"NCBITAXON"},{"subj":"T7","pred":"source","obj":"NCBITAXON"},{"subj":"T8","pred":"source","obj":"NCBITAXON"},{"subj":"T9","pred":"source","obj":"NCBITAXON"},{"subj":"T10","pred":"source","obj":"NCBITAXON"},{"subj":"T11","pred":"source","obj":"NCBITAXON"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-OGER-BB","color":"#c193ec","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#93eca7"},{"id":"LitCovid-PD-MONDO","color":"#ec9399"},{"id":"LitCovid-PD-CLO","color":"#93b3ec"},{"id":"LitCovid-PD-CHEBI","color":"#cdec93"},{"id":"LitCovid-PubTator","color":"#ec93e7"},{"id":"LitCovid-sentences","color":"#93ecd7"},{"id":"LitCovid_AGAC_only","color":"#ecbd93"},{"id":"sentences","color":"#a393ec"},{"id":"Glycosmos6-MAT","color":"#9cec93"},{"id":"Anatomy-MAT","color":"#ec93b6"},{"id":"mondo_disease","color":"#93d0ec"},{"id":"NCBITAXON","color":"#ebec93"}]}]}}