PubMed:32567171
Annnotations
LitCovid-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 4-9 | PR:000013883 | denotes | renin |
| T2 | 71-82 | NCBITaxon:11118 | denotes | coronavirus |
| T3 | 106-117 | NCBITaxon:11118 | denotes | Coronavirus |
| T4 | 132-140 | SP_7 | denotes | COVID-19 |
| T5 | 170-181 | UBERON:0001004 | denotes | respiratory |
| T6 | 191-202 | NCBITaxon:11118 | denotes | coronavirus |
| T7 | 206-215 | SP_7 | denotes | SARS-CoV2 |
| T8 | 341-349 | SP_7 | denotes | COVID-19 |
| T9 | 399-410 | NCBITaxon:1 | denotes | individuals |
| T10 | 460-472 | GO:0065007 | denotes | dysregulated |
| T11 | 473-478 | PR:000013883 | denotes | renin |
| T12 | 491-502 | CHEBI:27584 | denotes | aldosterone |
| T13 | 491-502 | CHEBI:27584 | denotes | aldosterone |
| T14 | 555-559 | UBERON:0002048 | denotes | lung |
| T15 | 578-588 | UBERON:0002349 | denotes | myocardial |
| T16 | 656-664 | SP_7 | denotes | COVID-19 |
| T17 | 787-796 | SP_7 | denotes | SARS-CoV2 |
| T18 | 860-869 | SP_7 | denotes | SARS-CoV2 |
| T19 | 879-887 | GO:0016020 | denotes | membrane |
| T20 | 902-933 | PG_10 | denotes | angiotensin-converting enzyme 2 |
| T21 | 902-933 | PR:000003622 | denotes | angiotensin-converting enzyme 2 |
| T22 | 935-939 | G_3 | denotes | ACE2 |
| T23 | 935-939 | PG_10 | denotes | ACE2 |
| T24 | 935-939 | PR:000003622 | denotes | ACE2 |
| T25 | 981-985 | G_3 | denotes | ACE2 |
| T26 | 981-985 | PG_10 | denotes | ACE2 |
| T27 | 981-985 | PR:000003622 | denotes | ACE2 |
| T28 | 1056-1065 | SP_7 | denotes | SARS-CoV2 |
| T29 | 1132-1140 | SP_7 | denotes | COVID-19 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T1 | 510-514 | Body_part | denotes | axis | http://purl.org/sig/ont/fma/fma12520 |
| T2 | 555-559 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T3 | 959-963 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T4 | 1024-1028 | Body_part | denotes | axis | http://purl.org/sig/ont/fma/fma12520 |
| T5 | 1086-1090 | Body_part | denotes | axis | http://purl.org/sig/ont/fma/fma12520 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 555-559 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 59-66 | Disease | denotes | obesity | http://purl.obolibrary.org/obo/MONDO_0011122 |
| T2 | 71-95 | Disease | denotes | coronavirus disease 2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T3 | 106-130 | Disease | denotes | Coronavirus disease 2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T4 | 132-140 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T5 | 206-210 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T6 | 341-349 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T7 | 416-423 | Disease | denotes | obesity | http://purl.obolibrary.org/obo/MONDO_0011122 |
| T8 | 425-432 | Disease | denotes | Obesity | http://purl.obolibrary.org/obo/MONDO_0011122 |
| T9 | 549-566 | Disease | denotes | acute lung injury | http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796 |
| T11 | 560-566 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T12 | 589-595 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T13 | 656-664 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T14 | 787-791 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T15 | 860-864 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T16 | 1056-1060 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T17 | 1066-1075 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T18 | 1120-1127 | Disease | denotes | obesity | http://purl.obolibrary.org/obo/MONDO_0011122 |
| T19 | 1132-1140 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 44-45 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T2 | 221-222 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T3 | 521-524 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T4 | 555-559 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T5 | 555-559 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T6 | 600-603 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T7 | 631-632 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T8 | 741-742 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T9 | 836-839 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T10 | 879-887 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T11 | 944-945 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T12 | 959-963 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T13 | 989-990 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T14 | 1105-1106 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T1 | 10-21 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T2 | 22-33 | Chemical | denotes | aldosterone | http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834 |
| T4 | 479-490 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T5 | 491-502 | Chemical | denotes | aldosterone | http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834 |
| T7 | 902-913 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-105 | Sentence | denotes | The renin-angiotensin-aldosterone system as a link between obesity and coronavirus disease 2019 severity. |
| T2 | 106-317 | Sentence | denotes | Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory distress coronavirus 2 (SARS-CoV2), is a rapidly evolving pandemic challenging the world and posing unprecedented public health issues. |
| T3 | 318-424 | Sentence | denotes | Current data show that COVID-19 is associated with increased disease severity in individuals with obesity. |
| T4 | 425-515 | Sentence | denotes | Obesity is usually associated with dysregulated renin-angiotensin-aldosterone (RAAS) axis. |
| T5 | 516-674 | Sentence | denotes | RAAS has also been implicated in acute lung injury as well as myocardial injury and has thus attracted interest as a potential regulator of COVID-19 severity. |
| T6 | 675-980 | Sentence | denotes | Whilst research all over the world is still struggling to provide a detailed characterization of the biology of SARS-CoV2 and its associated disease profile, it has become evident that SARS-CoV2 uses the membrane-bound form of angiotensin-converting enzyme 2 (ACE2) as a receptor for cell internalization. |
| T7 | 981-1076 | Sentence | denotes | ACE2 is a protective component of the RAAS axis and is downregulated after SARS-CoV2 infection. |
| T8 | 1077-1298 | Sentence | denotes | The RAAS axis could thus be a link between obesity and COVID-19 severity; therefore, more accurate understanding of the underlying mechanisms would be needed with the hope of proposing efficient therapeutic interventions. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 3 | 22-33 | Chemical | denotes | aldosterone | MESH:D000450 |
| 4 | 59-66 | Disease | denotes | obesity | MESH:D009765 |
| 5 | 71-95 | Disease | denotes | coronavirus disease 2019 | MESH:C000657245 |
| 26 | 106-130 | Disease | denotes | Coronavirus disease 2019 | MESH:C000657245 |
| 27 | 132-140 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 28 | 191-204 | Species | denotes | coronavirus 2 | Tax:2697049 |
| 29 | 206-215 | Species | denotes | SARS-CoV2 | Tax:2697049 |
| 30 | 341-349 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 31 | 416-423 | Disease | denotes | obesity | MESH:D009765 |
| 32 | 425-432 | Disease | denotes | Obesity | MESH:D009765 |
| 33 | 491-502 | Chemical | denotes | aldosterone | MESH:D000450 |
| 34 | 555-566 | Disease | denotes | lung injury | MESH:D055370 |
| 35 | 578-595 | Disease | denotes | myocardial injury | MESH:D009202 |
| 36 | 656-664 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 37 | 787-796 | Species | denotes | SARS-CoV2 | Tax:2697049 |
| 38 | 860-869 | Species | denotes | SARS-CoV2 | Tax:2697049 |
| 39 | 902-933 | Gene | denotes | angiotensin-converting enzyme 2 | Gene:59272 |
| 40 | 935-939 | Gene | denotes | ACE2 | Gene:59272 |
| 41 | 981-985 | Gene | denotes | ACE2 | Gene:59272 |
| 42 | 1056-1065 | Species | denotes | SARS-CoV2 | Tax:2697049 |
| 43 | 1066-1075 | Disease | denotes | infection | MESH:D007239 |
| 44 | 1120-1127 | Disease | denotes | obesity | MESH:D009765 |
| 45 | 1132-1140 | Disease | denotes | COVID-19 | MESH:C000657245 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 59-66 | Phenotype | denotes | obesity | http://purl.obolibrary.org/obo/HP_0001513 |
| T2 | 170-190 | Phenotype | denotes | respiratory distress | http://purl.obolibrary.org/obo/HP_0002098 |
| T3 | 416-423 | Phenotype | denotes | obesity | http://purl.obolibrary.org/obo/HP_0001513 |
| T4 | 425-432 | Phenotype | denotes | Obesity | http://purl.obolibrary.org/obo/HP_0001513 |
| T5 | 549-566 | Phenotype | denotes | acute lung injury | http://www.orpha.net/ORDO/Orphanet_178320 |
| T6 | 1120-1127 | Phenotype | denotes | obesity | http://purl.obolibrary.org/obo/HP_0001513 |
LitCovid_AGAC_only
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| p39845s0 | 106-130 | Disease | denotes | Coronavirus disease 2019 |
| p39845s9 | 143-152 | Reg | denotes | caused by |