PubMed:32565792 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/32565792","sourcedb":"PubMed","sourceid":"32565792","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/32565792","text":"Selenium Supplementation, Body Mass Composition, and Leptin Levels in Patients with Obesity on a Balanced Mildly Hypocaloric Diet: A Pilot Study.\nBACKGROUND: Adequate levels of selenium (Se) have protective effects against several chronic diseases, such as obesity. The aim of this study was to assess the effect of Se supplementation in a selected group of patients with obesity.\nMETHODS: This randomized prospective study included 37 overweight/obese individuals aged 18-65 years, who adopted a slightly hypocaloric diet for 3 months. An intervention group received 240 μg/day of L-selenomethionine for 3 months; a control group received a placebo. Clinical and biochemical parameters, body composition measurements, and the Psychological General Well-Being Index (PGWBI) questionnaire were tested at the beginning and end of the treatment.\nRESULTS: A comparison of the two groups showed a significant change in body composition, involving a decrease in body fat mass, between the baseline and the end of the follow-up, in the intervention group. Unlike the placebo group, the group given Se had a significant increase in lean body and muscle mass and a significant decrease in leptin levels after 3 months on diet. At the end of the follow-up, the group given Se scored higher on the PGWBI than those who did not.\nCONCLUSION: Se could reinforce the effects of diet for overweight and obesity. This work was registered in the ISRCTN registry with study ID ISRCTN6106073.","tracks":[{"project":"maxiaofeng52_800_3","denotations":[{"id":"T1","span":{"begin":0,"end":8},"obj":"CI"},{"id":"T10","span":{"begin":1060,"end":1067},"obj":"CI"},{"id":"T2","span":{"begin":177,"end":185},"obj":"CI"},{"id":"T3","span":{"begin":187,"end":189},"obj":"CI"},{"id":"T4","span":{"begin":582,"end":600},"obj":"CI"},{"id":"T5","span":{"begin":316,"end":318},"obj":"CI"},{"id":"T6","span":{"begin":1091,"end":1093},"obj":"CI"},{"id":"T7","span":{"begin":1263,"end":1265},"obj":"CI"},{"id":"T8","span":{"begin":1329,"end":1331},"obj":"CI"},{"id":"T9","span":{"begin":642,"end":649},"obj":"CI"}],"attributes":[{"subj":"T1","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T10","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T2","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T3","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T4","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T5","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T6","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T7","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T8","pred":"source","obj":"maxiaofeng52_800_3"},{"subj":"T9","pred":"source","obj":"maxiaofeng52_800_3"}]},{"project":"wangzhuo19_800_3","denotations":[{"id":"T1","span":{"begin":187,"end":189},"obj":"CI"},{"id":"T2","span":{"begin":316,"end":318},"obj":"CI"},{"id":"T3","span":{"begin":1091,"end":1093},"obj":"CI"},{"id":"T4","span":{"begin":1263,"end":1265},"obj":"CI"},{"id":"T5","span":{"begin":1329,"end":1331},"obj":"CI"},{"id":"T6","span":{"begin":582,"end":600},"obj":"CI"},{"id":"T7","span":{"begin":177,"end":185},"obj":"CI"},{"id":"T8","span":{"begin":0,"end":8},"obj":"CI"},{"id":"T9","span":{"begin":642,"end":649},"obj":"CI"},{"id":"T10","span":{"begin":1060,"end":1067},"obj":"CI"}],"attributes":[{"subj":"T1","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T2","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T3","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T4","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T5","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T6","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T7","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T8","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T9","pred":"source","obj":"wangzhuo19_800_3"},{"subj":"T10","pred":"source","obj":"wangzhuo19_800_3"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"maxiaofeng52_800_3","color":"#b893ec","default":true},{"id":"wangzhuo19_800_3","color":"#93ec9e"}]}]}}