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LitCovid-OGER-BB

Id Subject Object Predicate Lexical cue
T1 36-47 CHEBI:3638 denotes chloroquine
T2 36-47 DG_10 denotes chloroquine
T3 36-47 CHEBI:3638 denotes chloroquine
T4 51-69 CHEBI:5801 denotes hydroxychloroquine
T5 51-69 DG_20 denotes hydroxychloroquine
T6 51-69 CHEBI:5801 denotes hydroxychloroquine
T7 82-90 SP_7 denotes COVID-19
T8 94-101 NCBITaxon:1 denotes persons
T9 224-235 CHEBI:3638 denotes chloroquine
T10 224-235 DG_10 denotes chloroquine
T11 224-235 CHEBI:3638 denotes chloroquine
T12 239-257 CHEBI:5801 denotes hydroxychloroquine
T13 239-257 DG_20 denotes hydroxychloroquine
T14 239-257 CHEBI:5801 denotes hydroxychloroquine
T15 269-276 NCBITaxon:1 denotes persons
T16 313-321 SP_7 denotes COVID-19
T17 384-394 SP_7 denotes SARS CoV-2
T18 395-400 NCBITaxon:10239 denotes virus
T19 402-413 CHEBI:3638 denotes Chloroquine
T20 402-413 DG_10 denotes Chloroquine
T21 402-413 CHEBI:3638 denotes Chloroquine
T22 417-435 CHEBI:5801 denotes hydroxychloroquine
T23 417-435 DG_20 denotes hydroxychloroquine
T24 417-435 CHEBI:5801 denotes hydroxychloroquine
T25 532-538 SO:0000667 denotes insert
T26 557-568 CHEBI:23888 denotes medications
T27 557-568 CHEBI:23888 denotes medications
T28 811-822 CHEBI:3638 denotes chloroquine
T29 811-822 DG_10 denotes chloroquine
T30 811-822 CHEBI:3638 denotes chloroquine
T31 826-844 CHEBI:5801 denotes hydroxychloroquine
T32 826-844 DG_20 denotes hydroxychloroquine
T33 826-844 CHEBI:5801 denotes hydroxychloroquine
T34 954-958 CHEBI:23888 denotes drug
T35 954-958 CHEBI:23888 denotes drug
T36 1073-1084 CHEBI:3638 denotes chloroquine
T37 1073-1084 DG_10 denotes chloroquine
T38 1073-1084 CHEBI:3638 denotes chloroquine
T39 1199-1210 CHEBI:3638 denotes chloroquine
T40 1199-1210 DG_10 denotes chloroquine
T41 1199-1210 CHEBI:3638 denotes chloroquine
T42 1314-1332 CHEBI:5801 denotes hydroxychloroquine
T43 1314-1332 DG_20 denotes hydroxychloroquine
T44 1314-1332 CHEBI:5801 denotes hydroxychloroquine
T45 1491-1502 CHEBI:3638 denotes chloroquine
T46 1491-1502 DG_10 denotes chloroquine
T47 1491-1502 CHEBI:3638 denotes chloroquine
T48 1506-1524 CHEBI:5801 denotes hydroxychloroquine
T49 1506-1524 DG_20 denotes hydroxychloroquine
T50 1506-1524 CHEBI:5801 denotes hydroxychloroquine
T51 1559-1565 SO:0000667 denotes insert
T52 1880-1891 CHEBI:23888 denotes medications
T53 1880-1891 CHEBI:23888 denotes medications

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 82-90 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T2 107-115 Disease denotes epilepsy http://purl.obolibrary.org/obo/MONDO_0005027
T3 294-302 Disease denotes epilepsy http://purl.obolibrary.org/obo/MONDO_0005027
T4 313-321 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T5 384-388 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T6 607-615 Disease denotes epilepsy http://purl.obolibrary.org/obo/MONDO_0005027
T7 666-673 Disease denotes anxiety http://purl.obolibrary.org/obo/MONDO_0005618|http://purl.obolibrary.org/obo/MONDO_0011918
T9 681-689 Disease denotes epilepsy http://purl.obolibrary.org/obo/MONDO_0005027
T10 860-868 Disease denotes epilepsy http://purl.obolibrary.org/obo/MONDO_0005027
T11 886-904 Disease denotes status epilepticus http://purl.obolibrary.org/obo/MONDO_0002125

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 341-342 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T2 395-400 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T3 468-471 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T4 626-629 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T5 732-734 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T6 772-774 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T7 1269-1270 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 1649-1650 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 36-47 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T2 51-69 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T3 224-235 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T4 239-257 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T5 402-413 Chemical denotes Chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T6 417-435 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T7 811-822 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T8 826-844 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T9 954-958 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T10 1073-1084 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T11 1199-1210 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T12 1314-1332 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T13 1491-1502 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T14 1506-1524 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-116 Sentence denotes Assessing the risk of seizures with chloroquine or hydroxychloroquine therapy for COVID-19 in persons with epilepsy.
T2 117-128 Sentence denotes BACKGROUND:
T3 129-303 Sentence denotes The goal of this systematic review is to assess the published literature for seizure risk with chloroquine or hydroxychloroquine therapy in persons with and without epilepsy.
T4 304-401 Sentence denotes With the COVID-19 pandemic, there is a desperate need for treatment against the SARS CoV-2 virus.
T5 402-510 Sentence denotes Chloroquine or hydroxychloroquine is one proposed medication that has received substantial public attention.
T6 511-700 Sentence denotes However, the package insert states that these medications may provoke seizures in patients with epilepsy, and this has resulted in increased questions and anxiety in the epilepsy community.
T7 701-709 Sentence denotes METHODS:
T8 710-905 Sentence denotes PubMed (1970 to March 27, 2020) and the Embase (1970 to March 27, 2020) were searched with the terms chloroquine or hydroxychloroquine and seizure or epilepsy, convulsions, or status epilepticus.
T9 906-983 Sentence denotes Selected studies were reviewed, and the adverse drug reaction was classified.
T10 984-992 Sentence denotes RESULTS:
T11 993-1068 Sentence denotes Only eleven out of 31 studies were deemed eligible for systematic analysis.
T12 1069-1186 Sentence denotes For chloroquine, eligible studies were- one prospective study(n = 109), two case series(n = 6), and six case reports.
T13 1187-1309 Sentence denotes The dose of chloroquine ranged between 100-500 mg/day, except in one patient with a seizure, who was after taking 1000 mg.
T14 1310-1409 Sentence denotes For hydroxychloroquine, there was one prospective observational study(n = 631) and one case report.
T15 1410-1525 Sentence denotes The clinical trials failed to find any significant relation between seizures and chloroquine or hydroxychloroquine.
T16 1526-1537 Sentence denotes CONCLUSION:
T17 1538-1698 Sentence denotes Although the package insert describes an increased risk of seizure, the systematic review highlights that such a statement is not supported by class I evidence.
T18 1699-1824 Sentence denotes Clinicians, therefore, need to understand that data regarding this specific topic is limited to case series and case reports.
T19 1825-1918 Sentence denotes There is no substantial evidence to suggest that these medications can increase seizure risk.

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 22-30 Phenotype denotes seizures http://purl.obolibrary.org/obo/HP_0001250
T2 107-115 Phenotype denotes epilepsy http://purl.obolibrary.org/obo/HP_0001250
T3 206-213 Phenotype denotes seizure http://purl.obolibrary.org/obo/HP_0001250
T4 294-302 Phenotype denotes epilepsy http://purl.obolibrary.org/obo/HP_0001250
T5 581-589 Phenotype denotes seizures http://purl.obolibrary.org/obo/HP_0001250
T6 607-615 Phenotype denotes epilepsy http://purl.obolibrary.org/obo/HP_0001250
T7 666-673 Phenotype denotes anxiety http://purl.obolibrary.org/obo/HP_0000739
T8 681-689 Phenotype denotes epilepsy http://purl.obolibrary.org/obo/HP_0001250
T9 849-856 Phenotype denotes seizure http://purl.obolibrary.org/obo/HP_0001250
T10 860-868 Phenotype denotes epilepsy http://purl.obolibrary.org/obo/HP_0001250
T11 870-904 Phenotype denotes convulsions, or status epilepticus http://purl.obolibrary.org/obo/HP_0032660
T12 946-967 Phenotype denotes adverse drug reaction http://purl.obolibrary.org/obo/HP_0020172
T13 1271-1278 Phenotype denotes seizure http://purl.obolibrary.org/obo/HP_0001250
T14 1478-1486 Phenotype denotes seizures http://purl.obolibrary.org/obo/HP_0001250
T15 1597-1604 Phenotype denotes seizure http://purl.obolibrary.org/obo/HP_0001250
T16 1905-1912 Phenotype denotes seizure http://purl.obolibrary.org/obo/HP_0001250

hydroxychloroquine

Id Subject Object Predicate Lexical cue hp_id
T1 22-30 Phenotype denotes seizures http://purl.obolibrary.org/obo/HP_0001250
T2 107-115 Phenotype denotes epilepsy http://purl.obolibrary.org/obo/HP_0001250
T3 206-213 Phenotype denotes seizure http://purl.obolibrary.org/obo/HP_0001250
T4 294-302 Phenotype denotes epilepsy http://purl.obolibrary.org/obo/HP_0001250
T5 581-589 Phenotype denotes seizures http://purl.obolibrary.org/obo/HP_0001250
T6 607-615 Phenotype denotes epilepsy http://purl.obolibrary.org/obo/HP_0001250
T7 666-673 Phenotype denotes anxiety http://purl.obolibrary.org/obo/HP_0000739
T8 681-689 Phenotype denotes epilepsy http://purl.obolibrary.org/obo/HP_0001250
T9 849-856 Phenotype denotes seizure http://purl.obolibrary.org/obo/HP_0001250
T10 860-868 Phenotype denotes epilepsy http://purl.obolibrary.org/obo/HP_0001250
T11 870-904 Phenotype denotes convulsions, or status epilepticus http://purl.obolibrary.org/obo/HP_0032660
T12 946-967 Phenotype denotes adverse drug reaction http://purl.obolibrary.org/obo/HP_0020172
T13 1271-1278 Phenotype denotes seizure http://purl.obolibrary.org/obo/HP_0001250
T14 1478-1486 Phenotype denotes seizures http://purl.obolibrary.org/obo/HP_0001250
T15 1597-1604 Phenotype denotes seizure http://purl.obolibrary.org/obo/HP_0001250
T16 1905-1912 Phenotype denotes seizure http://purl.obolibrary.org/obo/HP_0001250