PubMed:32464098 JSONTXT

{"project":"LitCovid-OGER-BB","denotations":[{"id":"T1","span":{"begin":11,"end":24},"obj":"UBERON:0002405"},{"id":"T2","span":{"begin":79,"end":87},"obj":"SP_7"},{"id":"T3","span":{"begin":93,"end":104},"obj":"NCBITaxon:11118"},{"id":"T4","span":{"begin":119,"end":127},"obj":"SP_7"},{"id":"T5","span":{"begin":148,"end":158},"obj":"SP_7"},{"id":"T6","span":{"begin":303,"end":309},"obj":"UBERON:0002405"},{"id":"T7","span":{"begin":303,"end":318},"obj":"GO:0006955"},{"id":"T8","span":{"begin":322,"end":332},"obj":"SP_7"},{"id":"T9","span":{"begin":427,"end":449},"obj":"GO:0045087"},{"id":"T10","span":{"begin":434,"end":440},"obj":"UBERON:0002405"},{"id":"T11","span":{"begin":503,"end":515},"obj":"GO:0065007"},{"id":"T12","span":{"begin":516,"end":522},"obj":"UBERON:0002405"},{"id":"T13","span":{"begin":516,"end":531},"obj":"GO:0006955"},{"id":"T14","span":{"begin":619,"end":632},"obj":"UBERON:0002405"},{"id":"T15","span":{"begin":640,"end":650},"obj":"SP_7"},{"id":"T16","span":{"begin":723,"end":731},"obj":"SP_7"}],"namespaces":[{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"}],"text":"The Innate Immune System: Fighting on the Front Lines or Fanning the Flames of COVID-19?\nThe coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has had devastating global impacts and will continue to have dramatic effects on public health for years to come. A better understanding of the immune response to SARS-CoV-2 will be critical for the application and development of therapeutics. The degree to which the innate immune response confers protection or induces pathogenesis through a dysregulated immune response remains unclear. In this review, we discuss what is known about the role of the innate immune system during SARS-CoV-2 infection, suggest directions for future studies, and evaluate proposed COVID-19 immunomodulating therapeutics."}