PubMed:32457377
Annnotations
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 710-713 | Disease | denotes | STD | http://purl.obolibrary.org/obo/MONDO_0021681 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 758-761 | Glycan | denotes | GD3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 179-188 | Cell | denotes | monocytes | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 179-188 | Body_part | denotes | monocytes | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-70 | Sentence | denotes | Discovery of a new sialic acid binding region that regulates Siglec-7. |
| T2 | 71-189 | Sentence | denotes | Siglec-7 is a human CD33-like siglec, and is localised predominantly on human natural killer (NK) cells and monocytes. |
| T3 | 190-280 | Sentence | denotes | Siglec-7 is considered to function as an immunoreceptor in a sialic acid-dependent manner. |
| T4 | 281-372 | Sentence | denotes | However, the underlying mechanisms linking sialic acid-binding and function remain unknown. |
| T5 | 373-665 | Sentence | denotes | Here, to gain new insights into the ligand-binding properties of Siglec-7, we carried out in silico analysis and site-directed mutagenesis, and found a new sialic acid-binding region (site 2 containing R67) in addition to the well-known primary ligand-binding region (site 1 containing R124). |
| T6 | 666-884 | Sentence | denotes | This was supported by equilibrium dialysis, STD-NMR experiments, and inhibition analysis of GD3-binding toward Siglec-7 using synthetic sialoglycoconjugates and a comprehensive set of ganglioside-based glycoconjugates. |
| T7 | 885-1042 | Sentence | denotes | Our results suggest that the two ligand-binding sites are potentially controlled by each other due to the flexible conformation of the C-C' loop of Siglec-7. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 758-761 | Glycan | denotes | GD3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G98544DH |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 85-90 | OrganismTaxon | denotes | human | 9606 |
| T2 | 143-148 | OrganismTaxon | denotes | human | 9606 |
| T3 | 700-708 | OrganismTaxon | denotes | dialysis | 124307 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 85-90 | OrganismTaxon | denotes | human | 9606 |
| T2 | 143-148 | OrganismTaxon | denotes | human | 9606 |
| T3 | 700-708 | OrganismTaxon | denotes | dialysis | 124307 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 179-188 | Body_part | denotes | monocytes | http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 179-188 | Cell | denotes | monocytes | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |