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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 171-314 DRI_Challenge denotes The emergence of SARS-coronavirus-2 (SARS-CoV-2) is responsible for a global pandemic disease referred to as coronavirus disease 19 (Covid-19).
T2 315-431 DRI_Background denotes Hydroxychloroquine/azithromycin combination therapy is currently tested for curing Covid-19, with promising results.
T3 432-518 DRI_Background denotes However, the molecular mechanism of action of this combination is not established yet.
T4 519-685 DRI_Approach denotes Using molecular dynamics (MD) simulations we show that both drugs act in synergy to prevent any close contact between the virus and the plasma membrane of host cells.
T5 686-864 DRI_Challenge denotes We reveal unexpected molecular similarity between azithromycin and the sugar moiety of GM1, a lipid raft ganglioside acting as a host attachment cofactor for respiratory viruses.
T6 865-973 DRI_Background denotes Due to this mimicry, azithromycin interacts with the ganglioside-binding domain of SARS-CoV-2 spike protein.
T7 974-1119 DRI_Background denotes This binding site shared by azithromycin and GM1 displays a conserved amino acid triad Q-134/F-135/N-137 located at the tip of the spike protein.
T8 1120-1277 DRI_Outcome denotes We also show that hydroxychloroquine molecules can saturate virus attachment sites on gangliosides in the vicinity of the primary coronavirus receptor ACE-2.
T9 1278-1436 DRI_Background denotes Taken together, these data show that azithromycin is directed against the virus, whereas hydroxychloroquine is directed against cellular attachment cofactors.
T10 1437-1546 DRI_Outcome denotes We conclude that both drugs act as competitive inhibitors of SARS-CoV-2 attachment to the host cell membrane.
T11 1547-1701 DRI_Outcome denotes This is consistent with a synergistic antiviral mechanism at the plasma membrane level, where the most efficient therapeutic intervention probably stands.
T12 1702-1843 DRI_Outcome denotes This molecular mechanism may explain the beneficial effects of hydroxychloroquine/azithromycin combination therapy in patients with Covid-19.
T13 1844-1973 DRI_Outcome denotes Incidentally, our data suggest that the conserved Q-134/F-135/N-137 triad could be considered as a target for vaccine strategies.

LitCovid-OGER-BB

Id Subject Object Predicate Lexical cue
T1 33-51 CHEBI:5801;DG_20;CHEBI:5801 denotes hydroxychloroquine
T2 56-68 CHEBI:2955;DG_6;CHEBI:2955 denotes azithromycin
T3 92-102 SP_7 denotes SARS-CoV-2
T4 139-144 NCBITaxon:10239 denotes virus
T5 145-149 GO:0018995 denotes host
T6 188-192 SP_10 denotes SARS
T7 193-204 NCBITaxon:11118 denotes coronavirus
T8 208-218 SP_7 denotes SARS-CoV-2
T9 280-291 NCBITaxon:11118 denotes coronavirus
T10 304-312 SP_7 denotes Covid-19
T11 315-333 CHEBI:5801;DG_20;CHEBI:5801 denotes Hydroxychloroquine
T12 334-346 CHEBI:2955;DG_6;CHEBI:2955 denotes azithromycin
T13 398-406 SP_7 denotes Covid-19
T14 579-584 CHEBI:23888;CHEBI:23888 denotes drugs
T15 641-646 NCBITaxon:10239 denotes virus
T16 655-670 GO:0005886 denotes plasma membrane
T17 736-748 CHEBI:2955;DG_6;CHEBI:2955 denotes azithromycin
T18 780-785 CHEBI:18059;CHEBI:18059;GO:0045121 denotes lipid
T19 786-790 GO:0045121 denotes raft
T20 791-802 CHEBI:5386;CHEBI:5386 denotes ganglioside
T21 831-839 CHEBI:23357;CHEBI:23357 denotes cofactor
T22 844-855 GO:0045333 denotes respiratory
T23 856-863 NCBITaxon:10239 denotes viruses
T24 886-898 CHEBI:2955;DG_6;CHEBI:2955 denotes azithromycin
T25 918-929 CHEBI:28892;CHEBI:28892 denotes ganglioside
T26 938-944 SO:0000417 denotes domain
T27 948-958 SP_7 denotes SARS-CoV-2
T28 979-991 SO:0000409 denotes binding site
T29 1002-1014 CHEBI:2955;DG_6;CHEBI:2955 denotes azithromycin
T30 1138-1156 CHEBI:5801;DG_20;CHEBI:5801 denotes hydroxychloroquine
T31 1157-1166 CHEBI:36357;CHEBI:36357 denotes molecules
T32 1180-1185 NCBITaxon:10239 denotes virus
T33 1186-1202 SO:0000366 denotes attachment sites
T34 1206-1218 CHEBI:5386;CHEBI:5386 denotes gangliosides
T35 1250-1261 NCBITaxon:11118 denotes coronavirus
T36 1271-1276 G_3;PG_10;PR:000003622 denotes ACE-2
T37 1315-1327 CHEBI:2955;DG_6;CHEBI:2955 denotes azithromycin
T38 1352-1357 NCBITaxon:10239 denotes virus
T39 1367-1385 CHEBI:5801;DG_20;CHEBI:5801 denotes hydroxychloroquine
T40 1426-1435 CHEBI:23357;CHEBI:23357 denotes cofactors
T41 1459-1464 CHEBI:23888;CHEBI:23888 denotes drugs
T42 1484-1494 CHEBI:35222;CHEBI:35222 denotes inhibitors
T43 1498-1508 SP_7 denotes SARS-CoV-2
T44 1527-1545 GO:0033644 denotes host cell membrane
T45 1612-1627 GO:0005886 denotes plasma membrane
T46 1765-1783 CHEBI:5801;DG_20;CHEBI:5801 denotes hydroxychloroquine
T47 1784-1796 CHEBI:2955;DG_6;CHEBI:2955 denotes azithromycin
T48 1834-1842 SP_7 denotes Covid-19