PubMed:32376395 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/32376395","sourcedb":"PubMed","sourceid":"32376395","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/32376395","text":"SARS-CoV-2 infection among patients with systemic autoimmune diseases.\nOBJECTIVES: This study aimed to evaluate the prevalence of clinically overt SARS-CoV-2 infection (COVID-19) among patients with systemic autoimmune diseases residing in Tuscany, and to compare it with that observed in the general Tuscan population.\nMETHODS: In this cross-sectional study, Tuscan outpatients with systemic autoimmune diseases followed at a tertiary referral centre were telephonically interviewed between April 1st-14th 2020 to collect demographic and clinical data, information on ongoing immunomodulating/immunosuppressive treatments, and on the presence of symptoms suspected of SARS-CoV-2 or of a confirmed infection.\nRESULTS: 458 patients were interviewed [74% female, median age 56 years (IQR 43-68)]; 56% of them were receiving corticosteroids, 44% traditional disease-modifying anti-rheumatic drugs (DMARDs), of whom 23% hydroxychloroquine, 5% colchicine, while 41% were on biologic DMARDs (of whom 9% on tocilizumab). Thirteen patients reported symptoms suggesting SARS-CoV-2 infection. Of them, 7 had undergone nasopharyngeal swab and only one was positive and developed severe SARS-CoV-2 complications. Within our cohort, the prevalence of SARS-CoV-2 infection was therefore 0.22% (0.01-1.21%), comparable to that observed in the general population of Tuscany [0.20% (0.20-0.21%), p = .597].\nCONCLUSIONS: Patients with systemic autoimmune diseases do not seem to carry an increased risk of SARS- CoV-2 infection as compared to the general population.","tracks":[{"project":"LitCovid-OGER-BB","denotations":[{"id":"T1","span":{"begin":0,"end":10},"obj":"SP_7"},{"id":"T2","span":{"begin":50,"end":60},"obj":"UBERON:0002405"},{"id":"T3","span":{"begin":147,"end":157},"obj":"SP_7"},{"id":"T4","span":{"begin":169,"end":177},"obj":"SP_7"},{"id":"T5","span":{"begin":208,"end":218},"obj":"UBERON:0002405"},{"id":"T6","span":{"begin":393,"end":403},"obj":"UBERON:0002405"},{"id":"T7","span":{"begin":594,"end":611},"obj":"CHEBI:35705;CHEBI:35705"},{"id":"T8","span":{"begin":669,"end":679},"obj":"SP_7"},{"id":"T9","span":{"begin":822,"end":837},"obj":"CHEBI:50858;CHEBI:50858"},{"id":"T10","span":{"begin":873,"end":877},"obj":"CHEBI:67079;CHEBI:67079"},{"id":"T11","span":{"begin":888,"end":893},"obj":"CHEBI:23888;CHEBI:23888"},{"id":"T12","span":{"begin":916,"end":934},"obj":"CHEBI:5801;CHEBI:5801;DG_20"},{"id":"T13","span":{"begin":939,"end":949},"obj":"CHEBI:23359;CHEBI:23359"},{"id":"T14","span":{"begin":1000,"end":1011},"obj":"DG_35"},{"id":"T15","span":{"begin":1061,"end":1071},"obj":"SP_7"},{"id":"T16","span":{"begin":1108,"end":1122},"obj":"UBERON:0001728"},{"id":"T17","span":{"begin":1175,"end":1185},"obj":"SP_7"},{"id":"T18","span":{"begin":1238,"end":1248},"obj":"SP_7"},{"id":"T19","span":{"begin":1426,"end":1436},"obj":"UBERON:0002405"},{"id":"T20","span":{"begin":1488,"end":1499},"obj":"SP_7"}],"namespaces":[{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T2","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T3","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T4","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T5","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T6","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T7","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T8","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T9","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T10","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T11","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T12","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T13","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T14","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T15","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T16","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T17","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T18","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T19","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T20","pred":"source","obj":"LitCovid-OGER-BB"}]},{"project":"hydroxychloroquine","denotations":[{"id":"T1","span":{"begin":50,"end":69},"obj":"Phenotype"},{"id":"T2","span":{"begin":208,"end":227},"obj":"Phenotype"},{"id":"T3","span":{"begin":393,"end":412},"obj":"Phenotype"},{"id":"T4","span":{"begin":1426,"end":1445},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0002960"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0002960"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0002960"},{"id":"A4","pred":"hp_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/HP_0002960"},{"subj":"T1","pred":"source","obj":"hydroxychloroquine"},{"subj":"T2","pred":"source","obj":"hydroxychloroquine"},{"subj":"T3","pred":"source","obj":"hydroxychloroquine"},{"subj":"T4","pred":"source","obj":"hydroxychloroquine"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-OGER-BB","color":"#93eca2","default":true},{"id":"hydroxychloroquine","color":"#ec939e"}]}]}}