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PubMed:32360480 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 49-154 DRI_FutureWork denotes Outbreak and pandemic of coronavirus SARS-CoV-2 in 2019/2020 will challenge global health for the future.
T2 155-303 DRI_Approach denotes Because a vaccine against the virus will not be available in the near future, we herein try to offer a pharmacological strategy to combat the virus.
T3 304-407 DRI_Outcome denotes There exists a number of candidate drugs that may inhibit infection with and replication of SARS-CoV-2.
T4 408-523 DRI_Background denotes Such drugs comprise inhibitors of TMPRSS2 serine protease and inhibitors of angiotensin-converting enzyme 2 (ACE2).
T5 524-701 DRI_Outcome denotes Blockade of ACE2, the host cell receptor for the S protein of SARS-CoV-2 and inhibition of TMPRSS2, which is required for S protein priming may prevent cell entry of SARS-CoV-2.
T6 702-1062 DRI_Background denotes Further, chloroquine and hydroxychloroquine, and off-label antiviral drugs, such as the nucleotide analogue remdesivir, HIV protease inhibitors lopinavir and ritonavir, broad-spectrum antiviral drugs arbidol and favipiravir as well as antiviral phytochemicals available to date may prevent spread of SARS-CoV-2 and morbidity and mortality of COVID-19 pandemic.

LitCovid-OGER-BB

Id Subject Object Predicate Lexical cue
T1 10-15 CHEBI:23888 denotes drugs
T2 10-15 CHEBI:23888 denotes drugs
T3 24-34 SP_7 denotes SARS-CoV-2
T4 39-47 SP_7 denotes COVID-19
T5 74-85 NCBITaxon:11118 denotes coronavirus
T6 86-96 SP_7 denotes SARS-CoV-2
T7 185-190 NCBITaxon:10239 denotes virus
T8 258-273 CHEBI:52217 denotes pharmacological
T9 258-273 CHEBI:52217 denotes pharmacological
T10 297-302 NCBITaxon:10239 denotes virus
T11 339-344 CHEBI:23888 denotes drugs
T12 339-344 CHEBI:23888 denotes drugs
T13 381-392 GO:0006260 denotes replication
T14 396-406 SP_7 denotes SARS-CoV-2
T15 413-418 CHEBI:23888 denotes drugs
T16 413-418 CHEBI:23888 denotes drugs
T17 428-438 CHEBI:35222 denotes inhibitors
T18 428-438 CHEBI:35222 denotes inhibitors
T19 442-449 G_2 denotes TMPRSS2
T20 442-449 PR:000016456 denotes TMPRSS2
T21 470-480 CHEBI:35222 denotes inhibitors
T22 470-480 CHEBI:35222 denotes inhibitors
T23 484-515 PG_10 denotes angiotensin-converting enzyme 2
T24 484-515 PR:000003622 denotes angiotensin-converting enzyme 2
T25 517-521 G_3 denotes ACE2
T26 517-521 PG_10 denotes ACE2
T27 517-521 PR:000003622 denotes ACE2
T28 536-540 G_3 denotes ACE2
T29 536-540 PG_10 denotes ACE2
T30 536-540 PR:000003622 denotes ACE2
T31 573-582 PG_1 denotes S protein
T32 586-590 PR:000014459 denotes SARS
T33 586-596 SP_7 denotes SARS-CoV-2
T34 615-622 G_2 denotes TMPRSS2
T35 615-622 PR:000016456 denotes TMPRSS2
T36 646-655 PG_1 denotes S protein
T37 676-686 GO:0035376 denotes cell entry
T38 690-700 SP_7 denotes SARS-CoV-2
T39 711-722 CHEBI:3638 denotes chloroquine
T40 711-722 DG_10 denotes chloroquine
T41 711-722 CHEBI:3638 denotes chloroquine
T42 727-745 CHEBI:5801 denotes hydroxychloroquine
T43 727-745 DG_20 denotes hydroxychloroquine
T44 727-745 CHEBI:5801 denotes hydroxychloroquine
T45 771-776 CHEBI:36044 denotes drugs
T46 771-776 CHEBI:36044 denotes drugs
T47 810-820 DG_28 denotes remdesivir
T48 846-855 CHEBI:31781 denotes lopinavir
T49 846-855 DG_23 denotes lopinavir
T50 846-855 CHEBI:31781 denotes lopinavir
T51 860-869 DG_30 denotes ritonavir
T52 896-901 CHEBI:36044 denotes drugs
T53 896-901 CHEBI:36044 denotes drugs
T54 902-909 DG_49 denotes arbidol
T55 914-925 CHEBI:119915 denotes favipiravir
T56 914-925 DG_17 denotes favipiravir
T57 914-925 CHEBI:119915 denotes favipiravir
T58 914-925 NCBITaxon:31032 denotes favipiravir
T59 1002-1012 SP_7 denotes SARS-CoV-2
T60 1044-1052 SP_7 denotes COVID-19