PubMed:32359771 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/32359771","sourcedb":"PubMed","sourceid":"32359771","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/32359771","text":"Urgent Guidance for Navigating and Circumventing the QTc-Prolonging and Torsadogenic Potential of Possible Pharmacotherapies for Coronavirus Disease 19 (COVID-19).\nAs the coronavirus disease 19 (COVID-19) global pandemic rages across the globe, the race to prevent and treat this deadly disease has led to the \"off-label\" repurposing of drugs such as hydroxychloroquine and lopinavir/ritonavir, which have the potential for unwanted QT-interval prolongation and a risk of drug-induced sudden cardiac death. With the possibility that a considerable proportion of the world's population soon could receive COVID-19 pharmacotherapies with torsadogenic potential for therapy or postexposure prophylaxis, this document serves to help health care professionals mitigate the risk of drug-induced ventricular arrhythmias while minimizing risk of COVID-19 exposure to personnel and conserving the limited supply of personal protective equipment.","tracks":[{"project":"LitCovid-OGER-BB","denotations":[{"id":"T1","span":{"begin":107,"end":124},"obj":"CHEBI:52217"},{"id":"T2","span":{"begin":107,"end":124},"obj":"CHEBI:52217"},{"id":"T3","span":{"begin":129,"end":140},"obj":"NCBITaxon:11118"},{"id":"T4","span":{"begin":153,"end":161},"obj":"SP_7"},{"id":"T5","span":{"begin":171,"end":182},"obj":"NCBITaxon:11118"},{"id":"T6","span":{"begin":195,"end":203},"obj":"SP_7"},{"id":"T7","span":{"begin":238,"end":243},"obj":"UBERON:0010230"},{"id":"T8","span":{"begin":337,"end":342},"obj":"CHEBI:23888"},{"id":"T9","span":{"begin":337,"end":342},"obj":"CHEBI:23888"},{"id":"T10","span":{"begin":351,"end":369},"obj":"CHEBI:5801"},{"id":"T11","span":{"begin":351,"end":369},"obj":"CHEBI:5801"},{"id":"T12","span":{"begin":351,"end":369},"obj":"DG_20"},{"id":"T13","span":{"begin":374,"end":383},"obj":"CHEBI:31781"},{"id":"T14","span":{"begin":374,"end":383},"obj":"CHEBI:31781"},{"id":"T15","span":{"begin":374,"end":383},"obj":"DG_23"},{"id":"T16","span":{"begin":384,"end":393},"obj":"CHEBI:45409"},{"id":"T17","span":{"begin":384,"end":393},"obj":"CHEBI:45409"},{"id":"T18","span":{"begin":384,"end":393},"obj":"DG_30"},{"id":"T19","span":{"begin":472,"end":476},"obj":"CHEBI:23888"},{"id":"T20","span":{"begin":472,"end":476},"obj":"CHEBI:23888"},{"id":"T21","span":{"begin":492,"end":499},"obj":"UBERON:0000948"},{"id":"T22","span":{"begin":500,"end":505},"obj":"GO:0016265"},{"id":"T23","span":{"begin":604,"end":612},"obj":"SP_7"},{"id":"T24","span":{"begin":613,"end":630},"obj":"CHEBI:52217"},{"id":"T25","span":{"begin":613,"end":630},"obj":"CHEBI:52217"},{"id":"T26","span":{"begin":776,"end":780},"obj":"CHEBI:23888"},{"id":"T27","span":{"begin":776,"end":780},"obj":"CHEBI:23888"},{"id":"T28","span":{"begin":789,"end":800},"obj":"UBERON:0002082"},{"id":"T29","span":{"begin":838,"end":846},"obj":"SP_7"}],"namespaces":[{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T2","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T3","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T4","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T5","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T6","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T7","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T8","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T9","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T10","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T11","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T12","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T13","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T14","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T15","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T16","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T17","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T18","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T19","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T20","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T21","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T22","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T23","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T24","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T25","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T26","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T27","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T28","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T29","pred":"source","obj":"LitCovid-OGER-BB"}]},{"project":"hydroxychloroquine","denotations":[{"id":"T1","span":{"begin":485,"end":505},"obj":"Phenotype"},{"id":"T2","span":{"begin":789,"end":812},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0001645"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0004308"},{"subj":"T1","pred":"source","obj":"hydroxychloroquine"},{"subj":"T2","pred":"source","obj":"hydroxychloroquine"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-OGER-BB","color":"#93ec9f","default":true},{"id":"hydroxychloroquine","color":"#ec93a0"}]}]}}