PubMed:32344177 JSONTXT

{"project":"LitCovid-OGER-BB","denotations":[{"id":"T1","span":{"begin":29,"end":47},"obj":"CHEBI:5801"},{"id":"T2","span":{"begin":29,"end":47},"obj":"DG_20"},{"id":"T3","span":{"begin":29,"end":47},"obj":"CHEBI:5801"},{"id":"T4","span":{"begin":52,"end":64},"obj":"CHEBI:2955"},{"id":"T5","span":{"begin":52,"end":64},"obj":"DG_6"},{"id":"T6","span":{"begin":52,"end":64},"obj":"CHEBI:2955"},{"id":"T7","span":{"begin":68,"end":78},"obj":"SP_7"},{"id":"T8","span":{"begin":105,"end":110},"obj":"SP_6"},{"id":"T9","span":{"begin":105,"end":110},"obj":"NCBITaxon:9606"},{"id":"T10","span":{"begin":111,"end":124},"obj":"NCBITaxon:11118"},{"id":"T11","span":{"begin":125,"end":135},"obj":"SP_7"},{"id":"T12","span":{"begin":257,"end":262},"obj":"CHEBI:23888"},{"id":"T13","span":{"begin":257,"end":262},"obj":"CHEBI:23888"},{"id":"T14","span":{"begin":278,"end":283},"obj":"NCBITaxon:10239"},{"id":"T15","span":{"begin":285,"end":289},"obj":"CHEBI:23888"},{"id":"T16","span":{"begin":285,"end":289},"obj":"CHEBI:23888"},{"id":"T17","span":{"begin":388,"end":406},"obj":"CHEBI:5801"},{"id":"T18","span":{"begin":388,"end":406},"obj":"DG_20"},{"id":"T19","span":{"begin":388,"end":406},"obj":"CHEBI:5801"},{"id":"T20","span":{"begin":502,"end":514},"obj":"CHEBI:2955"},{"id":"T21","span":{"begin":502,"end":514},"obj":"DG_6"},{"id":"T22","span":{"begin":502,"end":514},"obj":"CHEBI:2955"},{"id":"T23","span":{"begin":592,"end":610},"obj":"CHEBI:5801"},{"id":"T24","span":{"begin":592,"end":610},"obj":"DG_20"},{"id":"T25","span":{"begin":592,"end":610},"obj":"CHEBI:5801"},{"id":"T26","span":{"begin":615,"end":627},"obj":"CHEBI:2955"},{"id":"T27","span":{"begin":615,"end":627},"obj":"DG_6"},{"id":"T28","span":{"begin":615,"end":627},"obj":"CHEBI:2955"},{"id":"T29","span":{"begin":665,"end":675},"obj":"SP_7"},{"id":"T30","span":{"begin":727,"end":732},"obj":"SP_6"},{"id":"T31","span":{"begin":727,"end":732},"obj":"NCBITaxon:9606"},{"id":"T32","span":{"begin":733,"end":737},"obj":"UBERON:0002048"}],"namespaces":[{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"}],"text":"In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect.\nHuman coronaviruses SARS-CoV-2 appeared at the end of 2019 and led to a pandemic with high morbidity and mortality. As there are currently no effective drugs targeting this virus, drug repurposing represents a short-term strategy to treat millions of infected patients at low costs. Hydroxychloroquine showed an antiviral effect in vitro. In vivo it showed efficacy, especially when combined with azithromycin in a preliminary clinical trial. Here we demonstrate that the combination of hydroxychloroquine and azithromycin has a synergistic effect in vitro on SARS-CoV-2 at concentrations compatible with that obtained in human lung."}