PubMed:32342252 JSONTXT

{"project":"LitCovid-OGER-BB","denotations":[{"id":"T1","span":{"begin":83,"end":93},"obj":"SP_7"},{"id":"T2","span":{"begin":203,"end":221},"obj":"CHEBI:5801"},{"id":"T3","span":{"begin":203,"end":221},"obj":"DG_20"},{"id":"T4","span":{"begin":203,"end":221},"obj":"CHEBI:5801"},{"id":"T5","span":{"begin":226,"end":238},"obj":"CHEBI:2955"},{"id":"T6","span":{"begin":226,"end":238},"obj":"DG_6"},{"id":"T7","span":{"begin":226,"end":238},"obj":"CHEBI:2955"},{"id":"T8","span":{"begin":261,"end":271},"obj":"SP_7"},{"id":"T9","span":{"begin":302,"end":307},"obj":"NCBITaxon:10239"},{"id":"T10","span":{"begin":316,"end":324},"obj":"SP_7"},{"id":"T11","span":{"begin":485,"end":490},"obj":"NCBITaxon:10239"},{"id":"T12","span":{"begin":555,"end":559},"obj":"SO:0000704"}],"namespaces":[{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"}],"text":"Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards.\nIn a preliminary clinical study, we observed that the combination of hydroxychloroquine and azithromycin was effective against SARS-CoV-2 by shortening the duration of viral load in Covid-19 patients. It is of paramount importance to define when a treated patient can be considered as no longer contagious. Correlation between successful isolation of virus in cell culture and Ct value of quantitative RT-PCR targeting E gene suggests that patients with Ct above 33-34 using our RT-PCR system are not contagious and thus can be discharged from hospital care or strict confinement for non-hospitalized patients."}