PubMed:32330817 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/32330817","sourcedb":"PubMed","sourceid":"32330817","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/32330817","text":"Clinical presentation and initial management critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Brescia, Italy.\nPURPOSE: An ongoing pandemic of COVID-19 that started in Hubei, China has resulted in massive strain on the healthcare infrastructure in Lombardy, Italy. The management of these patients is still evolving.\nMATERIALS AND METHODS: This is a single-center observational cohort study of critically ill patients infected with COVID-19. Bedside clinicians abstracted daily patient data on history, treatment, and short-term course. We describe management and a proposed severity scale for treatment used in this hospital.\nRESULTS: 44 patients were enrolled; with incomplete information on 11. Of the 33 studied patients, 91% were male, median age 64; 88% were overweight or obese. 45% were hypertensive, 12% had been taking an ACE-inhibitor. Noninvasive ventilation was performed on 39% of patients for part or all or their ICU stay with no provider infection. Most patients received antibiotics for pneumonia. Patients also received lopinivir/ritonavir (82%), hydroxychloroquine (79%), and tocilizumab (12%) according to this treatment algorithm. Nine of 10 patients survived their ICU course and were transferred to the floor, with one dying in the ICU.\nCONCLUSIONS: ICU patients with COVID-19 frequently have hypertension. Many could be managed with noninvasive ventilation, despite the risk of aerosolization. The use of a severity scale augmented clinician management.","tracks":[{"project":"LitCovid-OGER-BB","denotations":[{"id":"T1","span":{"begin":74,"end":121},"obj":"SP_7"},{"id":"T2","span":{"begin":87,"end":98},"obj":"UBERON:0001004"},{"id":"T3","span":{"begin":123,"end":133},"obj":"SP_7"},{"id":"T4","span":{"begin":196,"end":204},"obj":"SP_7"},{"id":"T5","span":{"begin":485,"end":493},"obj":"SP_7"},{"id":"T6","span":{"begin":889,"end":898},"obj":"CHEBI:35222"},{"id":"T7","span":{"begin":889,"end":898},"obj":"CHEBI:35222"},{"id":"T8","span":{"begin":1042,"end":1053},"obj":"CHEBI:33282"},{"id":"T9","span":{"begin":1042,"end":1053},"obj":"CHEBI:33282"},{"id":"T10","span":{"begin":1102,"end":1111},"obj":"DG_30"},{"id":"T11","span":{"begin":1119,"end":1137},"obj":"DG_20"},{"id":"T12","span":{"begin":1119,"end":1137},"obj":"CHEBI:5801"},{"id":"T13","span":{"begin":1119,"end":1137},"obj":"CHEBI:5801"},{"id":"T14","span":{"begin":1149,"end":1160},"obj":"DG_35"},{"id":"T15","span":{"begin":1296,"end":1301},"obj":"GO:0016265"},{"id":"T16","span":{"begin":1345,"end":1353},"obj":"SP_7"}],"namespaces":[{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T2","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T3","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T4","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T5","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T6","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T7","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T8","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T9","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T10","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T11","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T12","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T13","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T14","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T15","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T16","pred":"source","obj":"LitCovid-OGER-BB"}]},{"project":"hydroxychloroquine","denotations":[{"id":"T1","span":{"begin":818,"end":828},"obj":"Phenotype"},{"id":"T2","span":{"begin":1058,"end":1067},"obj":"Phenotype"},{"id":"T3","span":{"begin":1370,"end":1382},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0025502"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0000822"},{"subj":"T1","pred":"source","obj":"hydroxychloroquine"},{"subj":"T2","pred":"source","obj":"hydroxychloroquine"},{"subj":"T3","pred":"source","obj":"hydroxychloroquine"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-OGER-BB","color":"#93b1ec","default":true},{"id":"hydroxychloroquine","color":"#cbec93"}]}]}}