PubMed:32330343 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/32330343","sourcedb":"PubMed","sourceid":"32330343","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/32330343","text":"COVID-19 in Solid Organ Transplant Recipients: Initial Report from the US Epicenter.\nSolid organ transplant recipients may be at a high risk for SARS-CoV2 infection and poor associated outcomes. We herein report our initial experience with solid organ transplant recipients with SARS-CoV2 infection at two centers during the first 3 weeks of the outbreak in New York City. Baseline characteristics, clinical presentation, antiviral and immunosuppressive management were compared between patients with mild/moderate and severe disease (defined as ICU admission, intubation or death). 90 patients were analyzed with a median age of 57 years. 46 were kidney recipients, 17 lung, 13 liver, 9 heart and 5 dual-organ transplants. The most common presenting symptoms were fever (70%), cough (59%) and dyspnea (43%). 22 (24%) had mild, 41 (46%) moderate and 27 (30%) severe disease. Among the 68 hospitalized patients, 12% required non-rebreather and 35% required intubation. 91% received hydroxychloroquine, 66% azithromycin, 3% remdesivir, 21% tocilizumab and 24% bolus steroids. Sixteen patients died (18% overall, 24% of hospitalized, 52% of ICU) and 37 (54%) were discharged. In this initial cohort, transplant recipients with COVID-19 appear to have more severe outcomes, although testing limitations likely led to undercounting of mild/asymptomatic cases. As this outbreak unfolds, COVID-19 has the potential to severely impact solid organ transplant recipients.","tracks":[{"project":"LitCovid-OGER-BB","denotations":[{"id":"T1","span":{"begin":0,"end":8},"obj":"SP_7"},{"id":"T2","span":{"begin":18,"end":23},"obj":"UBERON:0000062"},{"id":"T3","span":{"begin":91,"end":96},"obj":"UBERON:0000062"},{"id":"T4","span":{"begin":145,"end":154},"obj":"SP_7"},{"id":"T5","span":{"begin":246,"end":251},"obj":"UBERON:0000062"},{"id":"T6","span":{"begin":279,"end":288},"obj":"SP_7"},{"id":"T7","span":{"begin":436,"end":453},"obj":"CHEBI:35705"},{"id":"T8","span":{"begin":436,"end":453},"obj":"CHEBI:35705"},{"id":"T9","span":{"begin":575,"end":580},"obj":"GO:0016265"},{"id":"T10","span":{"begin":648,"end":654},"obj":"UBERON:0002113"},{"id":"T11","span":{"begin":670,"end":674},"obj":"UBERON:0002048"},{"id":"T12","span":{"begin":679,"end":684},"obj":"UBERON:0002107"},{"id":"T13","span":{"begin":688,"end":693},"obj":"UBERON:0000948"},{"id":"T14","span":{"begin":705,"end":710},"obj":"UBERON:0000062"},{"id":"T15","span":{"begin":778,"end":783},"obj":"UBERON:0002048"},{"id":"T16","span":{"begin":981,"end":999},"obj":"CHEBI:5801"},{"id":"T17","span":{"begin":981,"end":999},"obj":"DG_20"},{"id":"T18","span":{"begin":981,"end":999},"obj":"CHEBI:5801"},{"id":"T19","span":{"begin":1005,"end":1017},"obj":"CHEBI:2955"},{"id":"T20","span":{"begin":1005,"end":1017},"obj":"DG_6"},{"id":"T21","span":{"begin":1005,"end":1017},"obj":"CHEBI:2955"},{"id":"T22","span":{"begin":1022,"end":1032},"obj":"DG_28"},{"id":"T23","span":{"begin":1038,"end":1049},"obj":"DG_35"},{"id":"T24","span":{"begin":1064,"end":1072},"obj":"CHEBI:35341"},{"id":"T25","span":{"begin":1064,"end":1072},"obj":"CHEBI:35341"},{"id":"T26","span":{"begin":1091,"end":1095},"obj":"GO:0016265"},{"id":"T27","span":{"begin":1224,"end":1232},"obj":"SP_7"},{"id":"T28","span":{"begin":1372,"end":1379},"obj":"GO:0043335"},{"id":"T29","span":{"begin":1381,"end":1389},"obj":"SP_7"},{"id":"T30","span":{"begin":1433,"end":1438},"obj":"UBERON:0000062"}],"namespaces":[{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T2","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T3","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T4","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T5","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T6","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T7","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T8","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T9","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T10","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T11","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T12","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T13","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T14","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T15","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T16","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T17","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T18","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T19","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T20","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T21","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T22","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T23","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T24","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T25","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T26","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T27","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T28","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T29","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T30","pred":"source","obj":"LitCovid-OGER-BB"}]},{"project":"hydroxychloroquine","denotations":[{"id":"T1","span":{"begin":765,"end":770},"obj":"Phenotype"},{"id":"T2","span":{"begin":778,"end":783},"obj":"Phenotype"},{"id":"T3","span":{"begin":794,"end":801},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0001945"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0012735"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0002094"},{"subj":"T1","pred":"source","obj":"hydroxychloroquine"},{"subj":"T2","pred":"source","obj":"hydroxychloroquine"},{"subj":"T3","pred":"source","obj":"hydroxychloroquine"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-OGER-BB","color":"#a493ec","default":true},{"id":"hydroxychloroquine","color":"#9cec93"}]}]}}