PubMed:32325124
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/32325124","sourcedb":"PubMed","sourceid":"32325124","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/32325124","text":"Vaporization, bioactive formulations and a marine natural product: different perspectives on antivirals.\nThis article examines three aspects of antivirals, such as hydroxychloroquine, chloroquine, and remdesvir, as they might relate to the treatment of a viral infection such as COVID-19: (i) the use of vaporization for the delivery of antivirals, with the bulk constituents having mild antiviral efficacy; (ii) the application of a marine natural product extract as opposed to a single molecule as an antiviral agent; and (iii) a counter intuitive approach to formulation that is, in part, based on delivering multiple species that fall into three categories: building blocks for the virus to accelerate replication; an energy source for the infected cell to boost its immune response; and the species that antagonize or provide toxicity to the virus.","tracks":[{"project":"LitCovid-OGER-BB","denotations":[{"id":"T1","span":{"begin":164,"end":182},"obj":"CHEBI:5801"},{"id":"T2","span":{"begin":164,"end":182},"obj":"DG_20"},{"id":"T3","span":{"begin":164,"end":182},"obj":"CHEBI:5801"},{"id":"T4","span":{"begin":184,"end":195},"obj":"CHEBI:3638"},{"id":"T5","span":{"begin":184,"end":195},"obj":"DG_10"},{"id":"T6","span":{"begin":184,"end":195},"obj":"CHEBI:3638"},{"id":"T7","span":{"begin":201,"end":210},"obj":"NCBITaxon:11632"},{"id":"T8","span":{"begin":255,"end":260},"obj":"NCBITaxon:10239"},{"id":"T9","span":{"begin":279,"end":287},"obj":"SP_7"},{"id":"T10","span":{"begin":488,"end":496},"obj":"CHEBI:36357"},{"id":"T11","span":{"begin":488,"end":496},"obj":"CHEBI:36357"},{"id":"T12","span":{"begin":686,"end":691},"obj":"NCBITaxon:10239"},{"id":"T13","span":{"begin":706,"end":717},"obj":"GO:0006260"},{"id":"T14","span":{"begin":771,"end":777},"obj":"UBERON:0002405"},{"id":"T15","span":{"begin":771,"end":786},"obj":"GO:0006955"},{"id":"T16","span":{"begin":796,"end":803},"obj":"NCBITaxon:species"},{"id":"T17","span":{"begin":847,"end":852},"obj":"NCBITaxon:10239"}],"namespaces":[{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T2","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T3","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T4","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T5","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T6","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T7","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T8","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T9","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T10","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T11","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T12","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T13","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T14","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T15","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T16","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T17","pred":"source","obj":"LitCovid-OGER-BB"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-OGER-BB","color":"#ecc693","default":true}]}]}}