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LitCovid-OGER-BB

Id Subject Object Predicate Lexical cue
T1 35-46 CHEBI:3638 denotes chloroquine
T2 35-46 DG_10 denotes chloroquine
T3 35-46 CHEBI:3638 denotes chloroquine
T4 61-78 CHEBI:52217 denotes pharmacovigilance
T5 61-78 CHEBI:52217 denotes pharmacovigilance
T6 188-200 CHEBI:35718 denotes antimalarial
T7 188-200 CHEBI:35718 denotes antimalarial
T8 201-205 CHEBI:23888 denotes drug
T9 201-205 CHEBI:23888 denotes drug
T10 207-218 CHEBI:3638 denotes chloroquine
T11 207-218 CHEBI:3638 denotes chloroquine
T12 207-218 DG_10 denotes chloroquine
T13 272-283 NCBITaxon:11118 denotes coronavirus
T14 298-306 SP_7 denotes COVID-19
T15 435-446 CHEBI:3638 denotes chloroquine
T16 435-446 DG_10 denotes chloroquine
T17 435-446 CHEBI:3638 denotes chloroquine
T18 479-489 UBERON:0002405 denotes autoimmune
T19 722-733 CHEBI:3638 denotes chloroquine
T20 722-733 DG_10 denotes chloroquine
T21 722-733 CHEBI:3638 denotes chloroquine
T22 738-756 CHEBI:5801 denotes hydroxychloroquine
T23 738-756 DG_20 denotes hydroxychloroquine
T24 738-756 CHEBI:5801 denotes hydroxychloroquine
T25 995-1006 CHEBI:3638 denotes chloroquine
T26 995-1006 DG_10 denotes chloroquine
T27 995-1006 CHEBI:3638 denotes chloroquine
T28 1121-1132 CHEBI:3638 denotes chloroquine
T29 1121-1132 DG_10 denotes chloroquine
T30 1121-1132 CHEBI:3638 denotes chloroquine
T31 1186-1197 CHEBI:3638 denotes chloroquine
T32 1186-1197 DG_10 denotes chloroquine
T33 1186-1197 CHEBI:3638 denotes chloroquine
T34 1605-1622 CHEBI:52217 denotes pharmacovigilance
T35 1605-1622 CHEBI:52217 denotes pharmacovigilance
T36 1691-1702 CHEBI:3638 denotes chloroquine
T37 1691-1702 CHEBI:3638 denotes chloroquine
T38 1691-1702 DG_10 denotes chloroquine
T39 1829-1840 CHEBI:3638 denotes chloroquine
T40 1829-1840 CHEBI:3638 denotes chloroquine
T41 1829-1840 DG_10 denotes chloroquine
T42 1862-1870 SP_7 denotes COVID-19

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 272-296 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T2 298-306 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T3 468-475 Disease denotes malaria http://purl.obolibrary.org/obo/MONDO_0005136
T4 479-498 Disease denotes autoimmune diseases http://purl.obolibrary.org/obo/MONDO_0007179
T5 1264-1271 Disease denotes amnesia http://purl.obolibrary.org/obo/MONDO_0001152
T6 1273-1281 Disease denotes delirium http://purl.obolibrary.org/obo/MONDO_0045057
T7 1299-1309 Disease denotes depression http://purl.obolibrary.org/obo/MONDO_0002050
T8 1560-1569 Disease denotes psychosis http://purl.obolibrary.org/obo/MONDO_0005485
T9 1737-1746 Disease denotes psychosis http://purl.obolibrary.org/obo/MONDO_0005485
T10 1862-1870 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 48-49 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T2 220-223 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T3 570-571 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4 616-617 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 684-686 http://purl.obolibrary.org/obo/CLO_0051456 denotes AE
T6 687-694 http://purl.obolibrary.org/obo/SO_0000418 denotes signals
T7 912-914 http://purl.obolibrary.org/obo/CLO_0051456 denotes AE
T8 971-973 http://purl.obolibrary.org/obo/CLO_0051456 denotes AE
T9 1154-1155 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T10 1218-1219 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11 1537-1539 http://purl.obolibrary.org/obo/CLO_0051456 denotes AE

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 35-46 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T2 188-200 Chemical denotes antimalarial http://purl.obolibrary.org/obo/CHEBI_38068
T3 201-205 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T4 207-218 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T5 435-446 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T6 684-686 Chemical denotes AE http://purl.obolibrary.org/obo/CHEBI_61565
T7 722-733 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T8 738-756 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T9 912-914 Chemical denotes AE http://purl.obolibrary.org/obo/CHEBI_61565
T10 971-973 Chemical denotes AE http://purl.obolibrary.org/obo/CHEBI_61565
T11 995-1006 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T12 1121-1132 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T13 1186-1197 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T14 1537-1539 Chemical denotes AE http://purl.obolibrary.org/obo/CHEBI_61565
T15 1691-1702 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T16 1829-1840 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-147 Sentence denotes Neuropsychiatric adverse events of chloroquine: a real-world pharmacovigilance study using the FDA Adverse Event Reporting System (FAERS) database.
T2 148-343 Sentence denotes In late March and early April 2020, the antimalarial drug, chloroquine, has been approved as an emergency treatment for the coronavirus disease 2019 (COVID-19) in the United States and in Europe.
T3 344-499 Sentence denotes Although infrequent, neuropsychiatric symptoms have been reported in patients who received chloroquine for the treatment of malaria or autoimmune diseases.
T4 500-889 Sentence denotes In this study, aiming to investigate these adverse events (AEs) using a large self-reporting database, we conducted a disproportionality analysis for the detection of neuropsychiatric AE signals associated with the use of chloroquine (or hydroxychloroquine), reported to FDA Adverse Event Reporting System (FAERS) database between the fourth quarter of 2012 and the fourth quarter of 2019.
T5 890-1007 Sentence denotes We included 2,389,474 AE cases, among which 520 cases developed neuropsychiatric AE following the use of chloroquine.
T6 1008-1452 Sentence denotes Adjusted reporting odds ratio (ROR) for the development of each of the neuropsychiatric AEs following the use of chloroquine was calculated using a multilevel model: exposure to chloroquine was associated with a statistically significant high reporting of amnesia, delirium, hallucinations, depression, and loss of consciousness, (lower 95% confidence interval of the adjusted ROR > 1), although the degree of increase in their ROR was limited.
T7 1453-1596 Sentence denotes There was no statistically significant high reporting of any other neuropsychiatric AE, including suicide, psychosis, confusion, and agitation.
T8 1597-1871 Sentence denotes Current pharmacovigilance study results did not suggest any potential link between the use of chloroquine and an increased risk of suicide, psychosis, confusion, and agitation, which would be informative during the emergency use of chloroquine for the treatment of COVID-19.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1 35-46 Chemical denotes chloroquine MESH:D002738
27 207-218 Chemical denotes chloroquine MESH:D002738
28 272-296 Disease denotes coronavirus disease 2019 MESH:C000657245
29 298-306 Disease denotes COVID-19 MESH:C000657245
30 413-421 Species denotes patients Tax:9606
31 435-446 Chemical denotes chloroquine MESH:D002738
32 468-475 Disease denotes malaria MESH:D008288
33 479-498 Disease denotes autoimmune diseases MESH:D001327
34 722-733 Chemical denotes chloroquine MESH:D002738
35 738-756 Chemical denotes hydroxychloroquine MESH:D006886
36 995-1006 Chemical denotes chloroquine MESH:D002738
37 1079-1099 Disease denotes neuropsychiatric AEs MESH:D001523
38 1121-1132 Chemical denotes chloroquine MESH:D002738
39 1186-1197 Chemical denotes chloroquine MESH:D002738
40 1264-1271 Disease denotes amnesia MESH:D000647
41 1273-1281 Disease denotes delirium MESH:D003693
42 1283-1297 Disease denotes hallucinations MESH:D006212
43 1299-1309 Disease denotes depression MESH:D000275
44 1315-1336 Disease denotes loss of consciousness MESH:D014474
45 1560-1569 Disease denotes psychosis MESH:D011605
46 1586-1595 Disease denotes agitation MESH:D011595
47 1691-1702 Chemical denotes chloroquine MESH:D002738
48 1737-1746 Disease denotes psychosis MESH:D011605
49 1763-1772 Disease denotes agitation MESH:D011595
50 1829-1840 Chemical denotes chloroquine MESH:D002738
51 1862-1870 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 479-498 Phenotype denotes autoimmune diseases http://purl.obolibrary.org/obo/HP_0002960
T2 1273-1281 Phenotype denotes delirium http://purl.obolibrary.org/obo/HP_0031258
T3 1283-1297 Phenotype denotes hallucinations http://purl.obolibrary.org/obo/HP_0000738
T4 1299-1309 Phenotype denotes depression http://purl.obolibrary.org/obo/HP_0000716
T5 1315-1336 Phenotype denotes loss of consciousness http://purl.obolibrary.org/obo/HP_0007185
T6 1560-1569 Phenotype denotes psychosis http://purl.obolibrary.org/obo/HP_0000709
T7 1586-1595 Phenotype denotes agitation http://purl.obolibrary.org/obo/HP_0000713
T8 1737-1746 Phenotype denotes psychosis http://purl.obolibrary.org/obo/HP_0000709
T9 1763-1772 Phenotype denotes agitation http://purl.obolibrary.org/obo/HP_0000713

hydroxychloroquine

Id Subject Object Predicate Lexical cue hp_id
T1 479-498 Phenotype denotes autoimmune diseases http://purl.obolibrary.org/obo/HP_0002960
T2 1273-1281 Phenotype denotes delirium http://purl.obolibrary.org/obo/HP_0031258
T3 1283-1297 Phenotype denotes hallucinations http://purl.obolibrary.org/obo/HP_0000738
T4 1299-1309 Phenotype denotes depression http://purl.obolibrary.org/obo/HP_0000716
T5 1315-1336 Phenotype denotes loss of consciousness http://purl.obolibrary.org/obo/HP_0007185
T6 1560-1569 Phenotype denotes psychosis http://purl.obolibrary.org/obo/HP_0000709
T7 1586-1595 Phenotype denotes agitation http://purl.obolibrary.org/obo/HP_0000713
T8 1737-1746 Phenotype denotes psychosis http://purl.obolibrary.org/obo/HP_0000709
T9 1763-1772 Phenotype denotes agitation http://purl.obolibrary.org/obo/HP_0000713