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LitCovid-OGER-BB

Id Subject Object Predicate Lexical cue
T1 3-8 PR:000008288 denotes GSK3β
T2 31-42 CHEBI:3638 denotes chloroquine
T3 31-42 DG_10 denotes chloroquine
T4 31-42 CHEBI:3638 denotes chloroquine
T5 61-69 SP_7 denotes COVID-19
T6 135-146 CHEBI:3638 denotes chloroquine
T7 135-146 DG_10 denotes chloroquine
T8 135-146 CHEBI:3638 denotes chloroquine
T9 151-169 CHEBI:5801 denotes hydroxychloroquine
T10 151-169 DG_20 denotes hydroxychloroquine
T11 151-169 CHEBI:5801 denotes hydroxychloroquine
T12 178-186 SP_7 denotes COVID-19
T13 304-308 CHEBI:67079 denotes anti
T14 304-308 CHEBI:67079 denotes anti
T15 318-322 CHEBI:23888 denotes drug
T16 318-322 CHEBI:23888 denotes drug
T17 362-370 SP_7 denotes COVID-19
T18 396-401 NCBITaxon:10239 denotes viral
T19 446-457 CHEBI:3638 denotes chloroquine
T20 446-457 DG_10 denotes chloroquine
T21 446-457 CHEBI:3638 denotes chloroquine
T22 530-536 NCBITaxon:33208 denotes animal
T23 593-601 NCBITaxon:2 denotes bacteria
T24 602-627 NCBITaxon:28450 denotes Burkholderia pseudomallei
T25 645-656 CHEBI:3638 denotes chloroquine
T26 645-656 DG_10 denotes chloroquine
T27 645-656 CHEBI:3638 denotes chloroquine
T28 720-728 CHEBI:24384 denotes glycogen
T29 720-728 CHEBI:24384 denotes glycogen
T30 720-747 PR:000008288 denotes glycogen synthase kinase-3β
T31 749-754 PR:000008288 denotes GSK3β
T32 958-969 CHEBI:3638 denotes chloroquine
T33 958-969 DG_10 denotes chloroquine
T34 958-969 CHEBI:3638 denotes chloroquine
T35 978-986 SP_7 denotes COVID-19
T36 1015-1020 PR:000008288 denotes GSK3β

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 720-728 Body_part denotes glycogen http://purl.org/sig/ont/fma/fma82747
T2 762-768 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T3 769-778 Body_part denotes threonine http://purl.org/sig/ont/fma/fma82765
T4 779-786 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 61-69 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T2 178-186 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T3 362-370 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T4 537-546 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T5 556-567 Disease denotes melioidosis http://purl.obolibrary.org/obo/MONDO_0017775
T6 978-986 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 9-10 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T2 402-410 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T3 434-442 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T4 530-536 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T5 569-570 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T6 593-601 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T7 815-816 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 31-42 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T2 135-146 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T3 151-169 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T4 318-322 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T5 446-457 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T6 645-656 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638
T7 720-728 Chemical denotes glycogen http://purl.obolibrary.org/obo/CHEBI_28087
T8 762-768 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T9 769-778 Chemical denotes threonine http://purl.obolibrary.org/obo/CHEBI_26986
T10 779-786 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T11 958-969 Chemical denotes chloroquine http://purl.obolibrary.org/obo/CHEBI_3638

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 675-690 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T2 847-868 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-70 Sentence denotes Is GSK3β a molecular target of chloroquine treatment against COVID-19?
T2 71-371 Sentence denotes The recent clinical trial reports pertaining to the efficacy of chloroquine and hydroxychloroquine against COVID-19 albeit yet to be validated with larger clinical trials, have sparked much interest globally to evaluate whether this anti-malarial drug can be repurposed for the treatment of COVID-19.
T3 372-494 Sentence denotes In addition to its anti-viral activity, the anti-inflammatory activity of chloroquine may also contribute to its efficacy.
T4 495-756 Sentence denotes Based on our data obtained from an animal infection model of melioidosis (a disease caused by the bacteria Burkholderia pseudomallei), treatment with chloroquine can result in the phosphorylation and consequent inhibition of glycogen synthase kinase-3β (GSK3β).
T5 757-869 Sentence denotes This serine/threonine protein kinase is now recognised as a point of convergence for host inflammatory response.
T6 870-1021 Sentence denotes In view of this, it is plausible that the mechanism for the anti-inflammatory effect of chloroquine against COVID-19 involves inhibition of host GSK3β.
T1 0-70 Sentence denotes Is GSK3β a molecular target of chloroquine treatment against COVID-19?
T2 71-371 Sentence denotes The recent clinical trial reports pertaining to the efficacy of chloroquine and hydroxychloroquine against COVID-19 albeit yet to be validated with larger clinical trials, have sparked much interest globally to evaluate whether this anti-malarial drug can be repurposed for the treatment of COVID-19.
T3 372-494 Sentence denotes In addition to its anti-viral activity, the anti-inflammatory activity of chloroquine may also contribute to its efficacy.
T4 495-756 Sentence denotes Based on our data obtained from an animal infection model of melioidosis (a disease caused by the bacteria Burkholderia pseudomallei), treatment with chloroquine can result in the phosphorylation and consequent inhibition of glycogen synthase kinase-3β (GSK3β).
T5 757-869 Sentence denotes This serine/threonine protein kinase is now recognised as a point of convergence for host inflammatory response.
T6 870-1021 Sentence denotes In view of this, it is plausible that the mechanism for the anti-inflammatory effect of chloroquine against COVID-19 involves inhibition of host GSK3β.

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-70 Sentence denotes Is GSK3β a molecular target of chloroquine treatment against COVID-19?
T2 71-371 Sentence denotes The recent clinical trial reports pertaining to the efficacy of chloroquine and hydroxychloroquine against COVID-19 albeit yet to be validated with larger clinical trials, have sparked much interest globally to evaluate whether this anti-malarial drug can be repurposed for the treatment of COVID-19.
T3 372-494 Sentence denotes In addition to its anti-viral activity, the anti-inflammatory activity of chloroquine may also contribute to its efficacy.
T4 495-756 Sentence denotes Based on our data obtained from an animal infection model of melioidosis (a disease caused by the bacteria Burkholderia pseudomallei), treatment with chloroquine can result in the phosphorylation and consequent inhibition of glycogen synthase kinase-3β (GSK3β).
T5 757-869 Sentence denotes This serine/threonine protein kinase is now recognised as a point of convergence for host inflammatory response.
T6 870-1021 Sentence denotes In view of this, it is plausible that the mechanism for the anti-inflammatory effect of chloroquine against COVID-19 involves inhibition of host GSK3β.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2 31-42 Chemical denotes chloroquine MESH:D002738
3 61-69 Disease denotes COVID-19 MESH:C000657245
16 135-146 Chemical denotes chloroquine MESH:D002738
17 151-169 Chemical denotes hydroxychloroquine MESH:D006886
18 178-186 Disease denotes COVID-19 MESH:C000657245
19 362-370 Disease denotes COVID-19 MESH:C000657245
20 446-457 Chemical denotes chloroquine MESH:D002738
21 537-546 Disease denotes infection MESH:D007239
22 556-567 Disease denotes melioidosis MESH:D008554
23 602-627 Species denotes Burkholderia pseudomallei Tax:28450
24 645-656 Chemical denotes chloroquine MESH:D002738
25 762-768 Chemical denotes serine MESH:D012694
26 958-969 Chemical denotes chloroquine MESH:D002738
27 978-986 Disease denotes COVID-19 MESH:C000657245