PubMed:32316270 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	0-8	SP_7	denotes	COVID-19
T2	10-21	CHEBI:3638	denotes	Chloroquine
T3	10-21	DG_10	denotes	Chloroquine
T4	10-21	CHEBI:3638	denotes	Chloroquine
T5	39-46	UBERON:0000948	denotes	Cardiac
T6	112-117	CHEBI:23888	denotes	drugs
T7	112-117	CHEBI:23888	denotes	drugs
T8	122-130	SP_7	denotes	COVID-19
T9	271-283	CHEBI:35718	denotes	antimalarial
T10	271-283	CHEBI:35718	denotes	antimalarial
T11	284-288	CHEBI:23888	denotes	drug
T12	284-288	CHEBI:23888	denotes	drug
T13	290-301	CHEBI:3638	denotes	chloroquine
T14	290-301	CHEBI:3638	denotes	chloroquine
T15	290-301	DG_10	denotes	chloroquine
T16	319-337	CHEBI:5801	denotes	hydroxychloroquine
T17	319-337	CHEBI:5801	denotes	hydroxychloroquine
T18	319-337	DG_20	denotes	hydroxychloroquine
T19	385-394	CHEBI:51323	denotes	alkaloids
T20	385-394	CHEBI:51323	denotes	alkaloids
T21	402-408	CHEBI:75050	denotes	chiral
T22	402-408	CHEBI:75050	denotes	chiral
T23	409-422	CHEBI:35718	denotes	antimalarials
T24	409-422	CHEBI:35718	denotes	antimalarials
T25	543-548	CHEBI:23888	denotes	drugs
T26	543-548	CHEBI:23888	denotes	drugs
T27	605-612	UBERON:0000948	denotes	cardiac
T28	630-635	CHEBI:23888	denotes	drugs
T29	630-635	CHEBI:23888	denotes	drugs
T30	726-737	CHEBI:3638	denotes	chloroquine
T31	726-737	DG_10	denotes	chloroquine
T32	726-737	CHEBI:3638	denotes	chloroquine
T33	738-756	CHEBI:5801	denotes	hydroxychloroquine
T34	738-756	DG_20	denotes	hydroxychloroquine
T35	738-756	CHEBI:5801	denotes	hydroxychloroquine

Id	Subject	Object	Predicate	Lexical cue
T1	85-220	DRI_FutureWork	denotes	The desperate need to find drugs for COVID-19 has indicated repurposing strategies as our quickest way to obtain efficacious medicines.
T2	221-338	DRI_Background	denotes	One of the options under investigation is the old antimalarial drug, chloroquine, and its analog, hydroxychloroquine.
T3	339-460	DRI_Background	denotes	Developed as synthetic succedanea of cinchona alkaloids, these chiral antimalarials are currently in use as the racemate.
T4	461-662	DRI_Challenge	denotes	Besides the ethical concern related to accelerated large-scale clinical trials of drugs with unproven efficacy, the known potential detrimental cardiac effects of these drugs should also be considered.
T5	663-801	DRI_Approach	denotes	In principle, the safety profile might be ameliorated by using chloroquine/hydroxychloroquine single enantiomers in place of the racemate.