PubMed:32282982 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/32282982","sourcedb":"PubMed","sourceid":"32282982","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/32282982","text":"Early Impact of COVID-19 on Transplant Center Practices and Policies in the United States.\nCOVID-19 is a novel, rapidly-changing pandemic: consequently, evidence-based recommendations in solid organ transplantation (SOT) remain challenging and unclear. To understand the impact on transplant activity across the US, and center-level variation in testing, clinical practice, and policies, we conducted a national survey between March 24-31, 2020 and linked responses to the COVID-19 incidence map. Response rate was a very high 79.3%, reflecting a strong national priority to better understand COVID-19. Complete suspension of live donor kidney transplantation was reported by 71.8% and live donor liver by 67.7%. While complete suspension of deceased donor transplantation was less frequent, some restrictions to deceased donor kidney transplantation were reported by 84.0% and deceased donor liver by 73.3%; more stringent restrictions were associated with higher regional incidence of COVID-19. Shortage of COVID-19 tests was reported by 42.5%. Respondents reported a total of 148 COVID-19 recipients from \u003c1y to \u003e10y post-transplant: 69.6% were kidney recipients, and 25.0% were critically ill. Hydroxychloroquine (HCQ) was used by 78.1% of respondents; azithromycin by 46.9%; tocilizumab by 31.3%, and remdesivir by 25.0%. There is wide heterogeneity in center-level response across the US; ongoing national data collection, expert discussion, and clinical studies are critical to informing evidence-based practices.","tracks":[{"project":"LitCovid-OGER-BB","denotations":[{"id":"T1","span":{"begin":16,"end":24},"obj":"SP_7"},{"id":"T2","span":{"begin":91,"end":99},"obj":"SP_7"},{"id":"T3","span":{"begin":193,"end":198},"obj":"UBERON:0000062"},{"id":"T4","span":{"begin":473,"end":481},"obj":"SP_7"},{"id":"T5","span":{"begin":593,"end":601},"obj":"SP_7"},{"id":"T6","span":{"begin":637,"end":643},"obj":"UBERON:0002113"},{"id":"T7","span":{"begin":697,"end":702},"obj":"UBERON:0002107"},{"id":"T8","span":{"begin":828,"end":834},"obj":"UBERON:0002113"},{"id":"T9","span":{"begin":893,"end":898},"obj":"UBERON:0002107"},{"id":"T10","span":{"begin":987,"end":995},"obj":"SP_7"},{"id":"T11","span":{"begin":1009,"end":1017},"obj":"SP_7"},{"id":"T12","span":{"begin":1083,"end":1091},"obj":"SP_7"},{"id":"T13","span":{"begin":1148,"end":1154},"obj":"UBERON:0002113"},{"id":"T14","span":{"begin":1198,"end":1216},"obj":"CHEBI:5801"},{"id":"T15","span":{"begin":1198,"end":1216},"obj":"DG_20"},{"id":"T16","span":{"begin":1198,"end":1216},"obj":"CHEBI:5801"},{"id":"T17","span":{"begin":1257,"end":1269},"obj":"CHEBI:2955"},{"id":"T18","span":{"begin":1257,"end":1269},"obj":"DG_6"},{"id":"T19","span":{"begin":1257,"end":1269},"obj":"CHEBI:2955"},{"id":"T20","span":{"begin":1280,"end":1291},"obj":"DG_35"},{"id":"T21","span":{"begin":1306,"end":1316},"obj":"DG_28"}],"namespaces":[{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"}],"attributes":[{"subj":"T1","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T2","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T3","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T4","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T5","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T6","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T7","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T8","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T9","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T10","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T11","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T12","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T13","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T14","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T15","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T16","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T17","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T18","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T19","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T20","pred":"source","obj":"LitCovid-OGER-BB"},{"subj":"T21","pred":"source","obj":"LitCovid-OGER-BB"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-OGER-BB","color":"#93ecb3","default":true}]}]}}