PubMed:32277065 JSONTXT

{"project":"LitCovid-OGER-BB","denotations":[{"id":"T1","span":{"begin":8,"end":19},"obj":"NCBITaxon:11118"},{"id":"T2","span":{"begin":56,"end":66},"obj":"DG_28"},{"id":"T3","span":{"begin":89,"end":93},"obj":"CHEBI:23888"},{"id":"T4","span":{"begin":89,"end":93},"obj":"CHEBI:23888"},{"id":"T5","span":{"begin":115,"end":120},"obj":"SP_6"},{"id":"T6","span":{"begin":115,"end":120},"obj":"NCBITaxon:9606"},{"id":"T7","span":{"begin":121,"end":132},"obj":"NCBITaxon:11118"},{"id":"T8","span":{"begin":144,"end":154},"obj":"DG_28"},{"id":"T9","span":{"begin":160,"end":175},"obj":"CHEBI:17102"},{"id":"T10","span":{"begin":160,"end":175},"obj":"CHEBI:17102"},{"id":"T11","span":{"begin":207,"end":212},"obj":"NCBITaxon:10239"},{"id":"T12","span":{"begin":287,"end":297},"obj":"DG_28"},{"id":"T13","span":{"begin":341,"end":349},"obj":"SP_9"},{"id":"T14","span":{"begin":361,"end":370},"obj":"GO:0032991"}],"namespaces":[{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"}],"text":"Halting coronavirus polymerase.\nThe nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon et al. identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":36,"end":46},"obj":"Body_part"},{"id":"T2","span":{"begin":213,"end":216},"obj":"Body_part"},{"id":"T3","span":{"begin":227,"end":230},"obj":"Body_part"},{"id":"T4","span":{"begin":316,"end":319},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma82740"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma67095"}],"text":"Halting coronavirus polymerase.\nThe nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon et al. identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":133,"end":142},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Halting coronavirus polymerase.\nThe nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon et al. identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":115,"end":120},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T2","span":{"begin":158,"end":159},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T3","span":{"begin":306,"end":307},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Halting coronavirus polymerase.\nThe nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon et al. identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":36,"end":46},"obj":"Chemical"},{"id":"T2","span":{"begin":56,"end":66},"obj":"Chemical"},{"id":"T3","span":{"begin":89,"end":93},"obj":"Chemical"},{"id":"T4","span":{"begin":160,"end":175},"obj":"Chemical"},{"id":"T5","span":{"begin":176,"end":183},"obj":"Chemical"},{"id":"T6","span":{"begin":287,"end":297},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_36976"},{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_145994"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_29920"},{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_50266"},{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_145994"}],"text":"Halting coronavirus polymerase.\nThe nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon et al. identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes."}

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{"project":"sentences","denotations":[{"id":"T1","span":{"begin":0,"end":31},"obj":"Sentence"},{"id":"T2","span":{"begin":32,"end":143},"obj":"Sentence"},{"id":"T3","span":{"begin":144,"end":243},"obj":"Sentence"},{"id":"T4","span":{"begin":244,"end":371},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Halting coronavirus polymerase.\nThe nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon et al. identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes."}

{"project":"LitCovid-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":31},"obj":"Sentence"},{"id":"T2","span":{"begin":32,"end":143},"obj":"Sentence"},{"id":"T3","span":{"begin":144,"end":243},"obj":"Sentence"},{"id":"T4","span":{"begin":244,"end":371},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Halting coronavirus polymerase.\nThe nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon et al. identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes."}

{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":133,"end":142},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Halting coronavirus polymerase.\nThe nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon et al. identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes."}

{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":115,"end":120},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":341,"end":349},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"9606"},{"id":"A2","pred":"db_id","subj":"T2","obj":"1335626"}],"text":"Halting coronavirus polymerase.\nThe nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon et al. identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes."}