PubMed:32275259 JSONTXT

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    LitCovid-OGER-BB

    {"project":"LitCovid-OGER-BB","denotations":[{"id":"T1","span":{"begin":0,"end":10},"obj":"SP_7"},{"id":"T2","span":{"begin":12,"end":20},"obj":"SP_10"},{"id":"T3","span":{"begin":26,"end":34},"obj":"SP_9"},{"id":"T4","span":{"begin":82,"end":92},"obj":"SP_7"},{"id":"T5","span":{"begin":238,"end":246},"obj":"SP_10"},{"id":"T6","span":{"begin":361,"end":372},"obj":"NCBITaxon:11118"},{"id":"T7","span":{"begin":392,"end":400},"obj":"SP_10"},{"id":"T8","span":{"begin":409,"end":417},"obj":"SP_9"},{"id":"T9","span":{"begin":493,"end":503},"obj":"SP_7"},{"id":"T10","span":{"begin":537,"end":545},"obj":"SP_10"},{"id":"T11","span":{"begin":550,"end":558},"obj":"SP_9"},{"id":"T12","span":{"begin":651,"end":661},"obj":"SP_7"},{"id":"T13","span":{"begin":752,"end":765},"obj":"NCBITaxon:11118"},{"id":"T14","span":{"begin":787,"end":797},"obj":"SP_7"},{"id":"T15","span":{"begin":831,"end":844},"obj":"BV_19"},{"id":"T16","span":{"begin":850,"end":858},"obj":"SP_10"},{"id":"T17","span":{"begin":963,"end":970},"obj":"NCBITaxon:10239"},{"id":"T18","span":{"begin":990,"end":995},"obj":"PR:000003137"},{"id":"T19","span":{"begin":1001,"end":1009},"obj":"MOP:0000780"},{"id":"T20","span":{"begin":1018,"end":1028},"obj":"SP_7"},{"id":"T21","span":{"begin":1045,"end":1054},"obj":"PG_1"},{"id":"T22","span":{"begin":1114,"end":1124},"obj":"SP_7"},{"id":"T23","span":{"begin":1151,"end":1164},"obj":"NCBITaxon:11118"},{"id":"T24","span":{"begin":1170,"end":1175},"obj":"PR:000003137"},{"id":"T25","span":{"begin":1176,"end":1186},"obj":"CHEBI:35222"},{"id":"T26","span":{"begin":1176,"end":1186},"obj":"CHEBI:35222"},{"id":"T27","span":{"begin":1216,"end":1220},"obj":"CHEBI:23888"},{"id":"T28","span":{"begin":1216,"end":1220},"obj":"CHEBI:23888"},{"id":"T29","span":{"begin":1235,"end":1243},"obj":"SP_10"}],"namespaces":[{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"}],"text":"SARS-CoV-2, SARS-CoV, and MERS-COV: A comparative overview\nThe recent outbreak of SARS-CoV-2 that started in Wuhan, China, has now spread to several other countries and is in its exponential phase of spread. Although less pathogenic than SARS-CoV, it has taken several lives and taken down the economies of many countries. Before this outbreak, the most recent coronavirus outbreaks were the SARS-CoV and the MERS-CoV outbreaks that happened in China and Saudi Arabia, respectively. Since the SARS-CoV-2 belongs to the same family as of SARS-CoV and MERS-CoV, they share several similarities. So, this review aims at understanding the new scenario of SARS-CoV-2 outbreak and compares the epidemiology, clinical presentations, and the genetics of these coronaviruses. Studies reveal that SARS-CoV-2 is very similar in structure and pathogenicity with SARS-CoV, but the most important structural protein, i.e., the spike protein (S), is slightly different in these viruses. The presence of a furin-like cleavage site in SARS-CoV-2 facilitates the S protein priming and might increase the efficiency of the spread of SARS-CoV-2 as compared to other beta coronaviruses. So, furin inhibitors can be targeted as potential drug therapies for SARS-CoV."}

    LitCovid-PD-FMA-UBERON

    {"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":894,"end":901},"obj":"Body_part"},{"id":"T2","span":{"begin":919,"end":926},"obj":"Body_part"},{"id":"T3","span":{"begin":1047,"end":1054},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"SARS-CoV-2, SARS-CoV, and MERS-COV: A comparative overview\nThe recent outbreak of SARS-CoV-2 that started in Wuhan, China, has now spread to several other countries and is in its exponential phase of spread. Although less pathogenic than SARS-CoV, it has taken several lives and taken down the economies of many countries. Before this outbreak, the most recent coronavirus outbreaks were the SARS-CoV and the MERS-CoV outbreaks that happened in China and Saudi Arabia, respectively. Since the SARS-CoV-2 belongs to the same family as of SARS-CoV and MERS-CoV, they share several similarities. So, this review aims at understanding the new scenario of SARS-CoV-2 outbreak and compares the epidemiology, clinical presentations, and the genetics of these coronaviruses. Studies reveal that SARS-CoV-2 is very similar in structure and pathogenicity with SARS-CoV, but the most important structural protein, i.e., the spike protein (S), is slightly different in these viruses. The presence of a furin-like cleavage site in SARS-CoV-2 facilitates the S protein priming and might increase the efficiency of the spread of SARS-CoV-2 as compared to other beta coronaviruses. So, furin inhibitors can be targeted as potential drug therapies for SARS-CoV."}

    LitCovid_AGAC

    {"project":"LitCovid_AGAC","denotations":[{"id":"p127652s17","span":{"begin":1045,"end":1062},"obj":"MPA"},{"id":"p127652s22","span":{"begin":1073,"end":1081},"obj":"PosReg"},{"id":"p127652s24","span":{"begin":1086,"end":1096},"obj":"MPA"}],"text":"SARS-CoV-2, SARS-CoV, and MERS-COV: A comparative overview\nThe recent outbreak of SARS-CoV-2 that started in Wuhan, China, has now spread to several other countries and is in its exponential phase of spread. Although less pathogenic than SARS-CoV, it has taken several lives and taken down the economies of many countries. Before this outbreak, the most recent coronavirus outbreaks were the SARS-CoV and the MERS-CoV outbreaks that happened in China and Saudi Arabia, respectively. Since the SARS-CoV-2 belongs to the same family as of SARS-CoV and MERS-CoV, they share several similarities. So, this review aims at understanding the new scenario of SARS-CoV-2 outbreak and compares the epidemiology, clinical presentations, and the genetics of these coronaviruses. Studies reveal that SARS-CoV-2 is very similar in structure and pathogenicity with SARS-CoV, but the most important structural protein, i.e., the spike protein (S), is slightly different in these viruses. The presence of a furin-like cleavage site in SARS-CoV-2 facilitates the S protein priming and might increase the efficiency of the spread of SARS-CoV-2 as compared to other beta coronaviruses. So, furin inhibitors can be targeted as potential drug therapies for SARS-CoV."}

    LitCovid-PD-MONDO

    {"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":0,"end":8},"obj":"Disease"},{"id":"T2","span":{"begin":12,"end":20},"obj":"Disease"},{"id":"T3","span":{"begin":82,"end":90},"obj":"Disease"},{"id":"T4","span":{"begin":238,"end":246},"obj":"Disease"},{"id":"T5","span":{"begin":392,"end":400},"obj":"Disease"},{"id":"T6","span":{"begin":493,"end":501},"obj":"Disease"},{"id":"T7","span":{"begin":537,"end":545},"obj":"Disease"},{"id":"T8","span":{"begin":651,"end":659},"obj":"Disease"},{"id":"T9","span":{"begin":787,"end":795},"obj":"Disease"},{"id":"T10","span":{"begin":850,"end":858},"obj":"Disease"},{"id":"T11","span":{"begin":1018,"end":1026},"obj":"Disease"},{"id":"T12","span":{"begin":1114,"end":1122},"obj":"Disease"},{"id":"T13","span":{"begin":1235,"end":1243},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A12","pred":"mondo_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"SARS-CoV-2, SARS-CoV, and MERS-COV: A comparative overview\nThe recent outbreak of SARS-CoV-2 that started in Wuhan, China, has now spread to several other countries and is in its exponential phase of spread. Although less pathogenic than SARS-CoV, it has taken several lives and taken down the economies of many countries. Before this outbreak, the most recent coronavirus outbreaks were the SARS-CoV and the MERS-CoV outbreaks that happened in China and Saudi Arabia, respectively. Since the SARS-CoV-2 belongs to the same family as of SARS-CoV and MERS-CoV, they share several similarities. So, this review aims at understanding the new scenario of SARS-CoV-2 outbreak and compares the epidemiology, clinical presentations, and the genetics of these coronaviruses. Studies reveal that SARS-CoV-2 is very similar in structure and pathogenicity with SARS-CoV, but the most important structural protein, i.e., the spike protein (S), is slightly different in these viruses. The presence of a furin-like cleavage site in SARS-CoV-2 facilitates the S protein priming and might increase the efficiency of the spread of SARS-CoV-2 as compared to other beta coronaviruses. So, furin inhibitors can be targeted as potential drug therapies for SARS-CoV."}

    LitCovid-PD-CLO

    {"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":36,"end":37},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T2","span":{"begin":123,"end":126},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T3","span":{"begin":251,"end":254},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T4","span":{"begin":963,"end":970},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T5","span":{"begin":988,"end":989},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"SARS-CoV-2, SARS-CoV, and MERS-COV: A comparative overview\nThe recent outbreak of SARS-CoV-2 that started in Wuhan, China, has now spread to several other countries and is in its exponential phase of spread. Although less pathogenic than SARS-CoV, it has taken several lives and taken down the economies of many countries. Before this outbreak, the most recent coronavirus outbreaks were the SARS-CoV and the MERS-CoV outbreaks that happened in China and Saudi Arabia, respectively. Since the SARS-CoV-2 belongs to the same family as of SARS-CoV and MERS-CoV, they share several similarities. So, this review aims at understanding the new scenario of SARS-CoV-2 outbreak and compares the epidemiology, clinical presentations, and the genetics of these coronaviruses. Studies reveal that SARS-CoV-2 is very similar in structure and pathogenicity with SARS-CoV, but the most important structural protein, i.e., the spike protein (S), is slightly different in these viruses. The presence of a furin-like cleavage site in SARS-CoV-2 facilitates the S protein priming and might increase the efficiency of the spread of SARS-CoV-2 as compared to other beta coronaviruses. So, furin inhibitors can be targeted as potential drug therapies for SARS-CoV."}

    LitCovid-PD-CHEBI

    {"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":894,"end":901},"obj":"Chemical"},{"id":"T2","span":{"begin":919,"end":926},"obj":"Chemical"},{"id":"T3","span":{"begin":1047,"end":1054},"obj":"Chemical"},{"id":"T4","span":{"begin":1146,"end":1150},"obj":"Chemical"},{"id":"T5","span":{"begin":1176,"end":1186},"obj":"Chemical"},{"id":"T6","span":{"begin":1216,"end":1220},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A2","pred":"chebi_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A4","pred":"chebi_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CHEBI_10545"},{"id":"A5","pred":"chebi_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A6","pred":"chebi_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"SARS-CoV-2, SARS-CoV, and MERS-COV: A comparative overview\nThe recent outbreak of SARS-CoV-2 that started in Wuhan, China, has now spread to several other countries and is in its exponential phase of spread. Although less pathogenic than SARS-CoV, it has taken several lives and taken down the economies of many countries. Before this outbreak, the most recent coronavirus outbreaks were the SARS-CoV and the MERS-CoV outbreaks that happened in China and Saudi Arabia, respectively. Since the SARS-CoV-2 belongs to the same family as of SARS-CoV and MERS-CoV, they share several similarities. So, this review aims at understanding the new scenario of SARS-CoV-2 outbreak and compares the epidemiology, clinical presentations, and the genetics of these coronaviruses. Studies reveal that SARS-CoV-2 is very similar in structure and pathogenicity with SARS-CoV, but the most important structural protein, i.e., the spike protein (S), is slightly different in these viruses. The presence of a furin-like cleavage site in SARS-CoV-2 facilitates the S protein priming and might increase the efficiency of the spread of SARS-CoV-2 as compared to other beta coronaviruses. So, furin inhibitors can be targeted as potential drug therapies for SARS-CoV."}

    LitCovid-sentences

    {"project":"LitCovid-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":35},"obj":"Sentence"},{"id":"T2","span":{"begin":36,"end":58},"obj":"Sentence"},{"id":"T3","span":{"begin":59,"end":207},"obj":"Sentence"},{"id":"T4","span":{"begin":208,"end":322},"obj":"Sentence"},{"id":"T5","span":{"begin":323,"end":482},"obj":"Sentence"},{"id":"T6","span":{"begin":483,"end":592},"obj":"Sentence"},{"id":"T7","span":{"begin":593,"end":766},"obj":"Sentence"},{"id":"T8","span":{"begin":767,"end":971},"obj":"Sentence"},{"id":"T9","span":{"begin":972,"end":1165},"obj":"Sentence"},{"id":"T10","span":{"begin":1166,"end":1244},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"SARS-CoV-2, SARS-CoV, and MERS-COV: A comparative overview\nThe recent outbreak of SARS-CoV-2 that started in Wuhan, China, has now spread to several other countries and is in its exponential phase of spread. Although less pathogenic than SARS-CoV, it has taken several lives and taken down the economies of many countries. Before this outbreak, the most recent coronavirus outbreaks were the SARS-CoV and the MERS-CoV outbreaks that happened in China and Saudi Arabia, respectively. Since the SARS-CoV-2 belongs to the same family as of SARS-CoV and MERS-CoV, they share several similarities. So, this review aims at understanding the new scenario of SARS-CoV-2 outbreak and compares the epidemiology, clinical presentations, and the genetics of these coronaviruses. Studies reveal that SARS-CoV-2 is very similar in structure and pathogenicity with SARS-CoV, but the most important structural protein, i.e., the spike protein (S), is slightly different in these viruses. The presence of a furin-like cleavage site in SARS-CoV-2 facilitates the S protein priming and might increase the efficiency of the spread of SARS-CoV-2 as compared to other beta coronaviruses. So, furin inhibitors can be targeted as potential drug therapies for SARS-CoV."}

    LitCovid-PubTator

    {"project":"LitCovid-PubTator","denotations":[{"id":"3","span":{"begin":0,"end":10},"obj":"Species"},{"id":"4","span":{"begin":12,"end":20},"obj":"Species"},{"id":"5","span":{"begin":26,"end":34},"obj":"Species"},{"id":"25","span":{"begin":82,"end":92},"obj":"Species"},{"id":"26","span":{"begin":238,"end":246},"obj":"Species"},{"id":"27","span":{"begin":361,"end":372},"obj":"Species"},{"id":"28","span":{"begin":392,"end":400},"obj":"Species"},{"id":"29","span":{"begin":409,"end":417},"obj":"Species"},{"id":"30","span":{"begin":493,"end":503},"obj":"Species"},{"id":"31","span":{"begin":537,"end":545},"obj":"Species"},{"id":"32","span":{"begin":550,"end":558},"obj":"Species"},{"id":"33","span":{"begin":651,"end":661},"obj":"Species"},{"id":"34","span":{"begin":752,"end":765},"obj":"Species"},{"id":"35","span":{"begin":787,"end":797},"obj":"Species"},{"id":"36","span":{"begin":850,"end":858},"obj":"Species"},{"id":"37","span":{"begin":990,"end":995},"obj":"Gene"},{"id":"38","span":{"begin":1018,"end":1028},"obj":"Species"},{"id":"39","span":{"begin":1045,"end":1046},"obj":"Gene"},{"id":"40","span":{"begin":1114,"end":1124},"obj":"Species"},{"id":"41","span":{"begin":1146,"end":1164},"obj":"Species"},{"id":"42","span":{"begin":1170,"end":1175},"obj":"Gene"},{"id":"43","span":{"begin":1235,"end":1243},"obj":"Species"}],"attributes":[{"id":"A3","pred":"tao:has_database_id","subj":"3","obj":"Tax:2697049"},{"id":"A4","pred":"tao:has_database_id","subj":"4","obj":"Tax:694009"},{"id":"A5","pred":"tao:has_database_id","subj":"5","obj":"Tax:1335626"},{"id":"A25","pred":"tao:has_database_id","subj":"25","obj":"Tax:2697049"},{"id":"A26","pred":"tao:has_database_id","subj":"26","obj":"Tax:694009"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"Tax:11118"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"Tax:694009"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"Tax:1335626"},{"id":"A30","pred":"tao:has_database_id","subj":"30","obj":"Tax:2697049"},{"id":"A31","pred":"tao:has_database_id","subj":"31","obj":"Tax:694009"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"Tax:1335626"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"Tax:2697049"},{"id":"A34","pred":"tao:has_database_id","subj":"34","obj":"Tax:11118"},{"id":"A35","pred":"tao:has_database_id","subj":"35","obj":"Tax:2697049"},{"id":"A36","pred":"tao:has_database_id","subj":"36","obj":"Tax:694009"},{"id":"A37","pred":"tao:has_database_id","subj":"37","obj":"Gene:5045"},{"id":"A38","pred":"tao:has_database_id","subj":"38","obj":"Tax:2697049"},{"id":"A39","pred":"tao:has_database_id","subj":"39","obj":"Gene:43740568"},{"id":"A40","pred":"tao:has_database_id","subj":"40","obj":"Tax:2697049"},{"id":"A41","pred":"tao:has_database_id","subj":"41","obj":"Tax:694002"},{"id":"A42","pred":"tao:has_database_id","subj":"42","obj":"Gene:5045"},{"id":"A43","pred":"tao:has_database_id","subj":"43","obj":"Tax:694009"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"SARS-CoV-2, SARS-CoV, and MERS-COV: A comparative overview\nThe recent outbreak of SARS-CoV-2 that started in Wuhan, China, has now spread to several other countries and is in its exponential phase of spread. Although less pathogenic than SARS-CoV, it has taken several lives and taken down the economies of many countries. Before this outbreak, the most recent coronavirus outbreaks were the SARS-CoV and the MERS-CoV outbreaks that happened in China and Saudi Arabia, respectively. Since the SARS-CoV-2 belongs to the same family as of SARS-CoV and MERS-CoV, they share several similarities. So, this review aims at understanding the new scenario of SARS-CoV-2 outbreak and compares the epidemiology, clinical presentations, and the genetics of these coronaviruses. Studies reveal that SARS-CoV-2 is very similar in structure and pathogenicity with SARS-CoV, but the most important structural protein, i.e., the spike protein (S), is slightly different in these viruses. The presence of a furin-like cleavage site in SARS-CoV-2 facilitates the S protein priming and might increase the efficiency of the spread of SARS-CoV-2 as compared to other beta coronaviruses. So, furin inhibitors can be targeted as potential drug therapies for SARS-CoV."}

    Covid19_manual_annotation_v2

    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So, furin inhibitors can be targeted as potential drug therapies for SARS-CoV."}

    Zoonoses

    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SARS-CoV, and MERS-COV: A comparative overview\nThe recent outbreak of SARS-CoV-2 that started in Wuhan, China, has now spread to several other countries and is in its exponential phase of spread. Although less pathogenic than SARS-CoV, it has taken several lives and taken down the economies of many countries. Before this outbreak, the most recent coronavirus outbreaks were the SARS-CoV and the MERS-CoV outbreaks that happened in China and Saudi Arabia, respectively. Since the SARS-CoV-2 belongs to the same family as of SARS-CoV and MERS-CoV, they share several similarities. So, this review aims at understanding the new scenario of SARS-CoV-2 outbreak and compares the epidemiology, clinical presentations, and the genetics of these coronaviruses. Studies reveal that SARS-CoV-2 is very similar in structure and pathogenicity with SARS-CoV, but the most important structural protein, i.e., the spike protein (S), is slightly different in these viruses. The presence of a furin-like cleavage site in SARS-CoV-2 facilitates the S protein priming and might increase the efficiency of the spread of SARS-CoV-2 as compared to other beta coronaviruses. So, furin inhibitors can be targeted as potential drug therapies for SARS-CoV."}