PubMed:32254064
Annnotations
LitCovid-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 27-33 | UBERON:0001969 | denotes | plasma |
| T2 | 70-78 | SP_7 | denotes | COVID-19 |
| T3 | 80-127 | SP_7 | denotes | Severe Acute Respiratory Syndrome Coronavirus 2 |
| T4 | 93-104 | UBERON:0001004 | denotes | Respiratory |
| T5 | 129-139 | SP_7 | denotes | SARS-CoV-2 |
| T6 | 155-166 | NCBITaxon:11118 | denotes | coronavirus |
| T7 | 176-184 | SP_7 | denotes | COVID-19 |
| T8 | 311-321 | SP_7 | denotes | SARS-CoV-2 |
| T9 | 357-365 | SP_7 | denotes | COVID-19 |
| T10 | 396-402 | UBERON:0001969 | denotes | plasma |
| T11 | 413-419 | UBERON:0001969 | denotes | plasma |
| T12 | 443-454 | NCBITaxon:1 | denotes | individuals |
| T13 | 509-519 | GO:0042571 | denotes | antibodies |
| T14 | 529-537 | GO:0042571 | denotes | antibody |
| T15 | 589-595 | UBERON:0001969 | denotes | plasma |
| T16 | 679-690 | NCBITaxon:1 | denotes | individuals |
| T17 | 740-746 | UBERON:0001969 | denotes | plasma |
| T18 | 873-886 | NCBITaxon:11118 | denotes | coronaviruses |
| T19 | 894-898 | SP_10 | denotes | SARS |
| T20 | 894-900 | PR:000014459 | denotes | SARS-1 |
| T21 | 914-925 | UBERON:0001004 | denotes | Respiratory |
| T22 | 936-940 | SP_9 | denotes | MERS |
| T23 | 957-963 | UBERON:0001969 | denotes | plasma |
| T24 | 990-998 | SP_7 | denotes | COVID-19 |
| T25 | 1107-1112 | NCBITaxon:10239 | denotes | viral |
| T26 | 1152-1157 | UBERON:0000178 | denotes | blood |
| T27 | 1260-1266 | UBERON:0001969 | denotes | plasma |
| T28 | 1343-1353 | GO:0065007 | denotes | regulatory |
| T29 | 1517-1523 | UBERON:0001969 | denotes | plasma |
| T30 | 1745-1751 | UBERON:0001969 | denotes | plasma |
| T31 | 1779-1789 | GO:0065007 | denotes | regulatory |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T1 | 27-33 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T2 | 396-402 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T3 | 413-419 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T4 | 529-537 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
| T5 | 589-595 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T6 | 740-746 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T7 | 957-963 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T8 | 1152-1157 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T9 | 1260-1266 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T10 | 1517-1523 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T11 | 1745-1751 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 1152-1157 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T2 | 1860-1865 | Body_part | denotes | scale | http://purl.obolibrary.org/obo/UBERON_0002542 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 70-78 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T2 | 80-127 | Disease | denotes | Severe Acute Respiratory Syndrome Coronavirus 2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T3 | 129-137 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T4 | 176-184 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T5 | 311-319 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T6 | 357-365 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T7 | 480-489 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T8 | 823-833 | Disease | denotes | infectious | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T9 | 894-898 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T10 | 990-998 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 27-33 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T2 | 187-190 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T3 | 199-200 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T4 | 396-402 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T5 | 413-419 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T6 | 589-595 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T7 | 740-746 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T8 | 747-750 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T9 | 957-963 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T10 | 964-967 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T11 | 1152-1157 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T12 | 1152-1157 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T13 | 1260-1266 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T14 | 1517-1523 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T15 | 1580-1591 | http://purl.obolibrary.org/obo/BFO_0000030 | denotes | objectively |
| T16 | 1596-1597 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T17 | 1745-1751 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T1 | 1379-1384 | Chemical | denotes | donor | http://purl.obolibrary.org/obo/CHEBI_17891 |
| T2 | 1398-1403 | Chemical | denotes | donor | http://purl.obolibrary.org/obo/CHEBI_17891 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1 | 70-78 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 15 | 80-127 | Species | denotes | Severe Acute Respiratory Syndrome Coronavirus 2 | Tax:2697049 |
| 16 | 129-139 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 18 | 176-184 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 19 | 311-321 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 20 | 357-365 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 21 | 480-489 | Disease | denotes | infection | MESH:D007239 |
| 22 | 823-842 | Disease | denotes | infectious diseases | MESH:D003141 |
| 23 | 873-886 | Species | denotes | coronaviruses | Tax:11118 |
| 24 | 902-934 | Disease | denotes | Middle East Respiratory Syndrome | MESH:D018352 |
| 25 | 936-940 | Disease | denotes | MERS | MESH:D018352 |
| 26 | 990-998 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 27 | 1655-1662 | Species | denotes | patient | Tax:9606 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-79 | Sentence | denotes | Deployment of convalescent plasma for the prevention and treatment of COVID-19. |
| T2 | 80-222 | Sentence | denotes | Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease (COVID-19), has spurred a global health crisis. |
| T3 | 223-366 | Sentence | denotes | To date, there are no proven options for prophylaxis for those who have been exposed to SARS-CoV-2, nor therapy for those who develop COVID-19. |
| T4 | 367-520 | Sentence | denotes | Immune (i.e. "convalescent") plasma refers to plasma that is collected from individuals, following resolution of infection and development of antibodies. |
| T5 | 521-691 | Sentence | denotes | Passive antibody administration through transfusion of convalescent plasma may offer the only short-term strategy to confer immediate immunity to susceptible individuals. |
| T6 | 692-943 | Sentence | denotes | There are numerous examples, where convalescent plasma has been used successfully as post-exposure prophylaxis and/or treatment of infectious diseases, including other outbreaks of coronaviruses (e.g., SARS-1, Middle East Respiratory Syndrome [MERS]). |
| T7 | 944-1141 | Sentence | denotes | Convalescent plasma has also been used in the COVID-19 pandemic; limited data from China suggest clinical benefit, including radiological resolution, reduction in viral loads and improved survival. |
| T8 | 1142-1294 | Sentence | denotes | Globally, blood centers have robust infrastructure to undertake collections and construct inventories of convalescent plasma to meet the growing demand. |
| T9 | 1295-1452 | Sentence | denotes | Nonetheless, there are nuanced challenges, both regulatory and logistical, spanning donor eligibility, donor recruitment, collections and transfusion itself. |
| T10 | 1453-1705 | Sentence | denotes | Data from rigorously controlled clinical trials of convalescent plasma are also few, underscoring the need to evaluate its use objectively for a range of indications (e.g., prevention vs treatment) and patient populations (e.g., age, comorbid disease). |
| T11 | 1706-1927 | Sentence | denotes | We provide an overview of convalescent plasma, from evidence of benefit, regulatory considerations, logistical work flow and proposed clinical trials, as scale up is brought underway to mobilize this critical resource. . |