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LitCovid-OGER-BB

Id Subject Object Predicate Lexical cue
T1 0-11 NCBITaxon:11118 denotes Coronavirus
T2 19-29 SP_7 denotes SARS-CoV-2
T3 80-85 NCBITaxon:10239 denotes viral
T4 104-114 SP_7 denotes SARS-CoV-2
T5 138-143 NCBITaxon:10239 denotes virus
T6 156-167 NCBITaxon:11118 denotes coronavirus
T7 180-188 SP_7 denotes COVID-19
T8 199-210 UBERON:0001004 denotes respiratory
T9 357-363 UBERON:0002405 denotes immune
T10 357-372 GO:0006955 denotes immune response
T11 468-473 NCBITaxon:10239 denotes viral
T12 506-521 GO:0045087 denotes innate immunity
T13 513-521 UBERON:0002405 denotes immunity
T14 523-539 CHEBI:26764 denotes steroid hormones
T15 523-539 CHEBI:26764 denotes steroid hormones
T16 563-578 GO:0000803 denotes sex chromosomes
T17 600-613 GO:0000805 denotes X chromosomes
T18 637-650 UBERON:0002405 denotes immune system
T19 680-686 UBERON:0002405 denotes immune
T20 687-697 GO:0065007 denotes regulatory
T21 698-703 SO:0000704 denotes genes
T22 715-727 GO:0000805 denotes X chromosome
T23 758-763 NCBITaxon:10239 denotes viral
T24 807-810 NCBITaxon:9606 denotes man
T25 818-821 PR:000001004 denotes CD4
T26 823-830 CL:0000084 denotes T cells
T27 854-860 UBERON:0002405 denotes immune
T28 854-869 GO:0006955 denotes immune response
T29 925-935 GO:0042571 denotes antibodies
T30 990-1003 GO:0001775 denotes activation of
T31 1008-1014 UBERON:0002405 denotes immune
T32 1008-1020 CL:0000738 denotes immune cells
T33 1095-1099 PR:000001158 denotes TLR7
T34 1127-1131 PR:000001158 denotes TLR7
T35 1171-1180 SO:0001023 denotes biallelic
T36 1181-1191 GO:0010467 denotes expression
T37 1208-1214 UBERON:0002405 denotes immune
T38 1208-1224 GO:0006955 denotes immune responses
T39 1257-1262 NCBITaxon:10239 denotes viral
T40 1275-1279 PR:000001158 denotes TLR7
T41 1283-1292 GO:0010467 denotes expressed
T42 1296-1315 CL:0000738 denotes innate immune cells
T43 1303-1309 UBERON:0002405 denotes immune
T44 1333-1346 SO:0001199 denotes single strand
T45 1347-1356 BV_22 denotes RNA virus
T46 1351-1356 NCBITaxon:10239 denotes virus
T47 1388-1398 GO:0042571 denotes antibodies
T48 1411-1416 NCBITaxon:10239 denotes virus
T49 1476-1480 PR:000001393 denotes IL-6
T50 1556-1560 PR:000001393 denotes IL-6
T51 1567-1572 NCBITaxon:10239 denotes viral
T52 1675-1687 GO:0000805 denotes X chromosome
T53 1721-1726 SO:0000704 denotes genes
T54 1743-1753 GO:0065007 denotes regulation
T55 1757-1763 UBERON:0002405 denotes immune
T56 1757-1769 CL:0000738 denotes immune cells
T57 1778-1783 PR:000001350 denotes FOXP3
T58 1831-1836 NCBITaxon:10239 denotes virus
T59 1855-1867 GO:0000805 denotes X chromosome
T60 1883-1896 UBERON:0002405 denotes immune system
T61 1941-1945 PR:000001159 denotes TLR8
T62 1947-1952 PR:000001950 denotes CD40L
T63 1957-1962 PR:000001207 denotes CXCR3
T64 1981-1990 GO:0010467 denotes expressed
T65 2031-2036 NCBITaxon:10239 denotes viral
T66 2079-2088 SO:0001023 denotes biallelic
T67 2089-2099 GO:0010467 denotes expression
T68 2107-2108 GO:0000805 denotes X
T69 2116-2121 SO:0000704 denotes genes
T70 2142-2152 UBERON:0002405 denotes autoimmune
T71 2181-2195 UBERON:0004535 denotes Cardiovascular
T72 2253-2267 UBERON:0004535 denotes cardiovascular
T73 2391-2396 CHEBI:23888 denotes drugs
T74 2391-2396 CHEBI:23888 denotes drugs
T75 2432-2451 CHEBI:67079 denotes anti-inflammatories
T76 2432-2451 CHEBI:67079 denotes anti-inflammatories
T77 2493-2503 GO:0042571 denotes antibodies
T78 2524-2528 PR:000001393 denotes IL-6
T79 2545-2549 CHEBI:23888 denotes drug
T80 2545-2549 CHEBI:23888 denotes drug
T81 2560-2569 CHEBI:22260 denotes adenosine
T82 2560-2569 CHEBI:22260 denotes adenosine
T83 2597-2615 CHEBI:5801 denotes hydroxychloroquine
T84 2597-2615 CHEBI:5801 denotes hydroxychloroquine
T85 2597-2615 DG_20 denotes hydroxychloroquine
T86 2738-2743 NCBITaxon:10239 denotes virus

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 637-650 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T2 1883-1896 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p124602s13 758-775 MPA denotes viral load levels
p124605s14 1201-1207 PosReg denotes higher
p124605s15 1208-1224 MPA denotes immune responses
p124605s18 1229-1238 PosReg denotes increases
p124605s20 1243-1273 MPA denotes resistance to viral infections

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 523-539 Body_part denotes steroid hormones http://purl.org/sig/ont/fma/fma83353
T2 563-578 Body_part denotes sex chromosomes http://purl.org/sig/ont/fma/fma74407
T3 600-613 Body_part denotes X chromosomes http://purl.org/sig/ont/fma/fma84055
T4 637-650 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T5 715-727 Body_part denotes X chromosome http://purl.org/sig/ont/fma/fma84055
T6 825-830 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T7 1015-1020 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T8 1310-1315 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T9 1347-1350 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T10 1456-1465 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T11 1485-1489 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T12 1675-1687 Body_part denotes X chromosome http://purl.org/sig/ont/fma/fma84055
T13 1764-1769 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T14 1855-1867 Body_part denotes X chromosome http://purl.org/sig/ont/fma/fma84055
T15 1883-1896 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T16 1921-1929 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T17 2510-2514 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 19-27 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T2 80-95 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T3 86-95 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T4 104-112 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T5 180-188 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T6 193-228 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T7 199-228 Disease denotes respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0009971
T8 383-392 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T9 397-418 Disease denotes inflammatory diseases http://purl.obolibrary.org/obo/MONDO_0021166
T10 468-484 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T11 786-798 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T12 1257-1273 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T13 1567-1582 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T14 1573-1582 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T15 2031-2047 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T16 2181-2204 Disease denotes Cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0004995
T17 2461-2479 Disease denotes rheumatic diseases http://purl.obolibrary.org/obo/MONDO_0005554
T18 2589-2594 Disease denotes ebola http://purl.obolibrary.org/obo/MONDO_0005737
T19 2638-2645 Disease denotes malaria http://purl.obolibrary.org/obo/MONDO_0005136

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 118-119 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T2 138-143 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T3 494-495 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T4 637-650 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T5 698-703 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T6 731-737 http://purl.obolibrary.org/obo/UBERON_0003100 denotes female
T7 818-821 http://purl.obolibrary.org/obo/PR_000001004 denotes CD4
T8 823-830 http://purl.obolibrary.org/obo/CL_0000084 denotes T cells
T9 990-1000 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T10 1015-1020 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T11 1310-1315 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12 1351-1356 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T13 1411-1416 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T14 1600-1605 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T15 1600-1605 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T16 1635-1636 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T17 1721-1726 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T18 1764-1769 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T19 1778-1783 http://purl.obolibrary.org/obo/PR_000001350 denotes FOXP3
T20 1814-1818 http://purl.obolibrary.org/obo/CL_0000792 denotes Treg
T21 1831-1836 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T22 1883-1896 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T23 2116-2121 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T24 2226-2231 http://purl.obolibrary.org/obo/UBERON_0003101 denotes males
T25 2226-2231 http://www.ebi.ac.uk/efo/EFO_0000970 denotes males
T26 2305-2306 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T27 2738-2743 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 523-539 Chemical denotes steroid hormones http://purl.obolibrary.org/obo/CHEBI_26764
T2 523-530 Chemical denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341
T3 531-539 Chemical denotes hormones http://purl.obolibrary.org/obo/CHEBI_24621
T4 1476-1478 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T6 1485-1487 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T8 1556-1558 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T10 1921-1929 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T11 2391-2396 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T12 2510-2512 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T14 2524-2526 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T16 2545-2549 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T17 2560-2569 Chemical denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T18 2597-2615 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 199-219 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T2 2181-2204 Phenotype denotes Cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 80-95 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T2 357-372 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T3 468-484 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T4 506-521 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immunity
T5 786-798 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T6 854-869 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T7 1208-1224 http://purl.obolibrary.org/obo/GO_0006955 denotes immune responses
T8 1257-1273 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T9 1296-1309 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T10 1567-1582 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T11 1743-1753 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T12 1789-1809 http://purl.obolibrary.org/obo/GO_0000981 denotes transcription factor
T13 1789-1802 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T14 1837-1849 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T15 2031-2047 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T16 2157-2179 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory responses

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-96 Sentence denotes Coronavirus COV-19/SARS-CoV-2 affects women less than men: clinical response to viral infection.
T2 97-279 Sentence denotes CoV-19/SARS-CoV-2 is a highly pathogenic virus that causes coronavirus-19 disease (COVID-19) an acute respiratory distress syndrome which provokes serious problems for global health.
T3 280-419 Sentence denotes Studies suggest that there are many differences between men and women in the immune response to CoV-19 infection and inflammatory diseases.
T4 420-579 Sentence denotes Women, compared to men, are less susceptible to viral infections based on a different innate immunity, steroid hormones and factors related to sex chromosomes.
T5 580-675 Sentence denotes The presence of two X chromosomes in women emphasize the immune system even if one is inactive.
T6 676-870 Sentence denotes The immune regulatory genes encoded by X chromosome in female gender causes lower viral load levels, and less inflammation than in man, while CD4+ T cells are higher with better immune response.
T7 871-975 Sentence denotes In addition, women generally produce higher levels of antibodies which remain in the circulation longer.
T8 976-1126 Sentence denotes The levels of activation of the immune cells are higher in women than in men, and it is correlated with the trigger of TLR7 and the production of IFN.
T9 1127-1274 Sentence denotes TLR7 is higher in women than in men and its biallelic expression leads to higher immune responses and increases the resistance to viral infections.
T10 1275-1505 Sentence denotes TLR7 is expressed in innate immune cells which recognizes single strand RNA virus by promoting the production of antibodies against the virus and the generation of pro-inflammatory cytokines including IL-6 and IL-1 family members.
T11 1506-1654 Sentence denotes Moreover, in women the production of inflammatory IL-6 after viral infection is lower than in males and is often correlated with a better longevity.
T12 1655-1850 Sentence denotes In addition, on the X chromosome there are loci that code for the genes involved in the regulation of immune cells such as FOXP3, and transcription factor for Treg involved in virus pathogenesis.
T13 1851-2065 Sentence denotes The X chromosome influences the immune system by acting on many other proteins, including TLR8, CD40L and CXCR3 which can be over-expressed in women, and influence the response to viral infections and vaccinations.
T14 2066-2180 Sentence denotes However, the biallelic expression of the X-linked genes can promote harmful autoimmune and inflammatory responses.
T15 2181-2365 Sentence denotes Cardiovascular diseases are more frequent in males and subjects without cardiovascular dysfunctions infected by CoV-19 have a better prognosis, but these effects are still under study.
T16 2366-2744 Sentence denotes It is hoped that certain drugs, such as CoV-19 receptor blockers, anti-inflammatories (against rheumatic diseases), monoclonal antibodies, anti-IL-1 and anti-IL-6, the remdesevir drug (analogue adenosine, effective against ebola), hydroxychloroquine (for the treatment of malaria) and vaccines, will open up new strategies and new therapeutic ways to combat this terrible virus.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
6 0-11 Species denotes Coronavirus Tax:11118
7 12-18 Species denotes COV-19 Tax:2697049
8 19-29 Species denotes SARS-CoV-2 Tax:2697049
9 38-43 Species denotes women Tax:9606
10 54-57 Species denotes men Tax:9606
11 80-95 Disease denotes viral infection MESH:D001102
59 97-103 Species denotes CoV-19 Tax:2697049
60 104-114 Species denotes SARS-CoV-2 Tax:2697049
61 156-170 Species denotes coronavirus-19 Tax:2697049
62 180-188 Disease denotes COVID-19 MESH:C000657245
63 193-228 Disease denotes acute respiratory distress syndrome MESH:D012128
64 336-339 Species denotes men Tax:9606
65 344-349 Species denotes women Tax:9606
66 376-392 Disease denotes CoV-19 infection MESH:D018352
67 420-425 Species denotes Women Tax:9606
68 439-442 Species denotes men Tax:9606
69 468-484 Disease denotes viral infections MESH:D001102
70 523-530 Chemical denotes steroid MESH:D013256
71 617-622 Species denotes women Tax:9606
72 786-798 Disease denotes inflammation MESH:D007249
73 818-821 Gene denotes CD4 Gene:920
74 884-889 Species denotes women Tax:9606
75 1035-1040 Species denotes women Tax:9606
76 1049-1052 Species denotes men Tax:9606
77 1095-1099 Gene denotes TLR7 Gene:51284
78 1122-1125 Gene denotes IFN Gene:3439
79 1127-1131 Gene denotes TLR7 Gene:51284
80 1145-1150 Species denotes women Tax:9606
81 1159-1162 Species denotes men Tax:9606
82 1257-1273 Disease denotes viral infections MESH:D001102
83 1275-1279 Gene denotes TLR7 Gene:51284
84 1476-1480 Gene denotes IL-6 Gene:3569
85 1485-1489 Gene denotes IL-1 Gene:3552
86 1519-1524 Species denotes women Tax:9606
87 1556-1560 Gene denotes IL-6 Gene:3569
88 1567-1582 Disease denotes viral infection MESH:D001102
89 1778-1783 Gene denotes FOXP3 Gene:50943
90 1941-1945 Gene denotes TLR8 Gene:51311
91 1947-1952 Gene denotes CD40L Gene:959
92 1957-1962 Gene denotes CXCR3 Gene:2833
93 1994-1999 Species denotes women Tax:9606
94 2031-2047 Disease denotes viral infections MESH:D001102
95 2181-2204 Disease denotes Cardiovascular diseases MESH:D002318
96 2253-2289 Disease denotes cardiovascular dysfunctions infected MESH:D002318
97 2293-2299 Species denotes CoV-19 Tax:2697049
98 2406-2412 Species denotes CoV-19 Tax:2697049
99 2461-2479 Disease denotes rheumatic diseases MESH:D012216
100 2510-2514 Gene denotes IL-1 Gene:3552
101 2524-2528 Gene denotes IL-6 Gene:3569
102 2560-2569 Chemical denotes adenosine MESH:D000241
103 2589-2594 Species denotes ebola Tax:1570291
104 2597-2615 Chemical denotes hydroxychloroquine MESH:D006886
105 2638-2645 Disease denotes malaria MESH:D008288

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-96 Sentence denotes Coronavirus COV-19/SARS-CoV-2 affects women less than men: clinical response to viral infection.
T2 97-279 Sentence denotes CoV-19/SARS-CoV-2 is a highly pathogenic virus that causes coronavirus-19 disease (COVID-19) an acute respiratory distress syndrome which provokes serious problems for global health.
T3 280-419 Sentence denotes Studies suggest that there are many differences between men and women in the immune response to CoV-19 infection and inflammatory diseases.
T4 420-579 Sentence denotes Women, compared to men, are less susceptible to viral infections based on a different innate immunity, steroid hormones and factors related to sex chromosomes.
T5 580-675 Sentence denotes The presence of two X chromosomes in women emphasize the immune system even if one is inactive.
T6 676-870 Sentence denotes The immune regulatory genes encoded by X chromosome in female gender causes lower viral load levels, and less inflammation than in man, while CD4+ T cells are higher with better immune response.
T7 871-975 Sentence denotes In addition, women generally produce higher levels of antibodies which remain in the circulation longer.
T8 976-1126 Sentence denotes The levels of activation of the immune cells are higher in women than in men, and it is correlated with the trigger of TLR7 and the production of IFN.
T9 1127-1274 Sentence denotes TLR7 is higher in women than in men and its biallelic expression leads to higher immune responses and increases the resistance to viral infections.
T10 1275-1505 Sentence denotes TLR7 is expressed in innate immune cells which recognizes single strand RNA virus by promoting the production of antibodies against the virus and the generation of pro-inflammatory cytokines including IL-6 and IL-1 family members.
T11 1506-1654 Sentence denotes Moreover, in women the production of inflammatory IL-6 after viral infection is lower than in males and is often correlated with a better longevity.
T12 1655-1850 Sentence denotes In addition, on the X chromosome there are loci that code for the genes involved in the regulation of immune cells such as FOXP3, and transcription factor for Treg involved in virus pathogenesis.
T13 1851-2065 Sentence denotes The X chromosome influences the immune system by acting on many other proteins, including TLR8, CD40L and CXCR3 which can be over-expressed in women, and influence the response to viral infections and vaccinations.
T14 2066-2180 Sentence denotes However, the biallelic expression of the X-linked genes can promote harmful autoimmune and inflammatory responses.
T15 2181-2365 Sentence denotes Cardiovascular diseases are more frequent in males and subjects without cardiovascular dysfunctions infected by CoV-19 have a better prognosis, but these effects are still under study.
T16 2366-2744 Sentence denotes It is hoped that certain drugs, such as CoV-19 receptor blockers, anti-inflammatories (against rheumatic diseases), monoclonal antibodies, anti-IL-1 and anti-IL-6, the remdesevir drug (analogue adenosine, effective against ebola), hydroxychloroquine (for the treatment of malaria) and vaccines, will open up new strategies and new therapeutic ways to combat this terrible virus.
T1 0-96 Sentence denotes Coronavirus COV-19/SARS-CoV-2 affects women less than men: clinical response to viral infection.
T2 97-279 Sentence denotes CoV-19/SARS-CoV-2 is a highly pathogenic virus that causes coronavirus-19 disease (COVID-19) an acute respiratory distress syndrome which provokes serious problems for global health.
T3 280-419 Sentence denotes Studies suggest that there are many differences between men and women in the immune response to CoV-19 infection and inflammatory diseases.
T4 420-579 Sentence denotes Women, compared to men, are less susceptible to viral infections based on a different innate immunity, steroid hormones and factors related to sex chromosomes.
T5 580-675 Sentence denotes The presence of two X chromosomes in women emphasize the immune system even if one is inactive.
T6 676-870 Sentence denotes The immune regulatory genes encoded by X chromosome in female gender causes lower viral load levels, and less inflammation than in man, while CD4+ T cells are higher with better immune response.
T7 871-975 Sentence denotes In addition, women generally produce higher levels of antibodies which remain in the circulation longer.
T8 976-1126 Sentence denotes The levels of activation of the immune cells are higher in women than in men, and it is correlated with the trigger of TLR7 and the production of IFN.
T9 1127-1274 Sentence denotes TLR7 is higher in women than in men and its biallelic expression leads to higher immune responses and increases the resistance to viral infections.
T10 1275-1505 Sentence denotes TLR7 is expressed in innate immune cells which recognizes single strand RNA virus by promoting the production of antibodies against the virus and the generation of pro-inflammatory cytokines including IL-6 and IL-1 family members.
T11 1506-1654 Sentence denotes Moreover, in women the production of inflammatory IL-6 after viral infection is lower than in males and is often correlated with a better longevity.
T12 1655-1850 Sentence denotes In addition, on the X chromosome there are loci that code for the genes involved in the regulation of immune cells such as FOXP3, and transcription factor for Treg involved in virus pathogenesis.
T13 1851-2065 Sentence denotes The X chromosome influences the immune system by acting on many other proteins, including TLR8, CD40L and CXCR3 which can be over-expressed in women, and influence the response to viral infections and vaccinations.
T14 2066-2180 Sentence denotes However, the biallelic expression of the X-linked genes can promote harmful autoimmune and inflammatory responses.
T15 2181-2365 Sentence denotes Cardiovascular diseases are more frequent in males and subjects without cardiovascular dysfunctions infected by CoV-19 have a better prognosis, but these effects are still under study.
T16 2366-2744 Sentence denotes It is hoped that certain drugs, such as CoV-19 receptor blockers, anti-inflammatories (against rheumatic diseases), monoclonal antibodies, anti-IL-1 and anti-IL-6, the remdesevir drug (analogue adenosine, effective against ebola), hydroxychloroquine (for the treatment of malaria) and vaccines, will open up new strategies and new therapeutic ways to combat this terrible virus.

hydroxychloroquine

Id Subject Object Predicate Lexical cue hp_id
T1 199-219 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T2 2181-2204 Phenotype denotes Cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626

LitCovid_AGAC_only

Id Subject Object Predicate Lexical cue
p5785s15 149-155 Reg denotes causes
p5785s16 156-167 Disease denotes coronavirus
p5792s14 1201-1207 PosReg denotes higher
p5792s15 1208-1224 MPA denotes immune responses
p5792s18 1229-1238 PosReg denotes increases
p5792s20 1243-1253 MPA denotes resistance