PubMed:32245784 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/32245784","sourcedb":"PubMed","sourceid":"32245784","source_url":"https://www.ncbi.nlm.nih.gov/pubmed/32245784","text":"A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV.\nThe outbreak of COVID-19 caused by SARS-CoV-2 virus has now become a pandemic, but there is currently very little understanding of the antigenicity of the virus. We therefore determined the crystal structure of CR3022, a neutralizing antibody previously isolated from a convalescent SARS patient, in complex with the receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein to 3.1 Å. CR3022 targets a highly conserved epitope, distal from the receptor-binding site, that enables cross-reactive binding between SARS-CoV-2 and SARS-CoV. 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