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    week10

    {"project":"week10","denotations":[{"id":"T2","span":{"begin":7,"end":10},"obj":"P00299"},{"id":"T5","span":{"begin":7,"end":10},"obj":"UBERON:0001628"},{"id":"T1","span":{"begin":7,"end":10},"obj":"C562643"},{"id":"T3","span":{"begin":7,"end":10},"obj":"CHEBI:62248"},{"id":"T4","span":{"begin":7,"end":10},"obj":"CHEBI:36751"},{"id":"T6","span":{"begin":134,"end":140},"obj":"SO:0001026"},{"id":"T8","span":{"begin":245,"end":275},"obj":"SO:0000694"},{"id":"T9","span":{"begin":252,"end":262},"obj":"CHEBI:7656"},{"id":"T10","span":{"begin":252,"end":262},"obj":"CHEBI:36976"},{"id":"T12","span":{"begin":472,"end":475},"obj":"P00299"},{"id":"T15","span":{"begin":472,"end":475},"obj":"UBERON:0001628"},{"id":"T11","span":{"begin":472,"end":475},"obj":"C562643"},{"id":"T13","span":{"begin":472,"end":475},"obj":"CHEBI:62248"},{"id":"T14","span":{"begin":472,"end":475},"obj":"CHEBI:36751"},{"id":"T16","span":{"begin":530,"end":536},"obj":"PR:Q811X5"},{"id":"T17","span":{"begin":530,"end":536},"obj":"PR:000006862"},{"id":"T18","span":{"begin":530,"end":536},"obj":"PR:Q96CJ1"},{"id":"T19","span":{"begin":530,"end":536},"obj":"PR:Q91ZD6"},{"id":"T21","span":{"begin":545,"end":548},"obj":"P00299"},{"id":"T24","span":{"begin":545,"end":548},"obj":"UBERON:0001628"},{"id":"T20","span":{"begin":545,"end":548},"obj":"C562643"},{"id":"T22","span":{"begin":545,"end":548},"obj":"CHEBI:62248"},{"id":"T23","span":{"begin":545,"end":548},"obj":"CHEBI:36751"},{"id":"T26","span":{"begin":591,"end":594},"obj":"P00299"},{"id":"T29","span":{"begin":591,"end":594},"obj":"UBERON:0001628"},{"id":"T25","span":{"begin":591,"end":594},"obj":"C562643"},{"id":"T27","span":{"begin":591,"end":594},"obj":"CHEBI:62248"},{"id":"T28","span":{"begin":591,"end":594},"obj":"CHEBI:36751"},{"id":"T30","span":{"begin":612,"end":621},"obj":"MOP:0000569"},{"id":"T31","span":{"begin":625,"end":631},"obj":"SO:0000984"},{"id":"T32","span":{"begin":632,"end":642},"obj":"CHEBI:7656"},{"id":"T33","span":{"begin":632,"end":642},"obj":"CHEBI:36976"},{"id":"T34","span":{"begin":665,"end":669},"obj":"SO:0000704"},{"id":"T36","span":{"begin":745,"end":748},"obj":"P00299"},{"id":"T39","span":{"begin":745,"end":748},"obj":"UBERON:0001628"},{"id":"T35","span":{"begin":745,"end":748},"obj":"C562643"},{"id":"T37","span":{"begin":745,"end":748},"obj":"CHEBI:62248"},{"id":"T38","span":{"begin":745,"end":748},"obj":"CHEBI:36751"},{"id":"T41","span":{"begin":823,"end":826},"obj":"P00299"},{"id":"T44","span":{"begin":823,"end":826},"obj":"UBERON:0001628"},{"id":"T40","span":{"begin":823,"end":826},"obj":"C562643"},{"id":"T42","span":{"begin":823,"end":826},"obj":"CHEBI:62248"},{"id":"T43","span":{"begin":823,"end":826},"obj":"CHEBI:36751"},{"id":"T46","span":{"begin":915,"end":918},"obj":"P00299"},{"id":"T49","span":{"begin":915,"end":918},"obj":"UBERON:0001628"},{"id":"T45","span":{"begin":915,"end":918},"obj":"C562643"},{"id":"T47","span":{"begin":915,"end":918},"obj":"CHEBI:62248"},{"id":"T48","span":{"begin":915,"end":918},"obj":"CHEBI:36751"},{"id":"T50","span":{"begin":924,"end":927},"obj":"PR:000034449"},{"id":"T51","span":{"begin":950,"end":953},"obj":"PR:O01367"},{"id":"T52","span":{"begin":996,"end":1000},"obj":"SO:0000704"},{"id":"T53","span":{"begin":1120,"end":1123},"obj":"PR:000034449"},{"id":"T55","span":{"begin":1183,"end":1186},"obj":"P00299"},{"id":"T58","span":{"begin":1183,"end":1186},"obj":"UBERON:0001628"},{"id":"T54","span":{"begin":1183,"end":1186},"obj":"C562643"},{"id":"T56","span":{"begin":1183,"end":1186},"obj":"CHEBI:62248"},{"id":"T57","span":{"begin":1183,"end":1186},"obj":"CHEBI:36751"}],"text":"HisCoM-PCA: software for hierarchical structural component analysis for pathway analysis based using principal component analysis.\nIn genome-wide association studies, pathway-based analysis has been widely performed to enhance interpretation of single-nucleotide polymorphism association results. We proposed a novel method of hierarchical structural component model (HisCoM) for pathway analysis of common variants (HisCoM for pathway analysis of common variants [HisCoM-PCA]) which was used to identify pathways associated with traits. HisCoM-PCA is based on principal component analysis (PCA) for dimensional reduction of single nucleotide polymorphisms in each gene, and the HisCoM for pathway analysis. In this study, we developed a HisCoM-PCA software for the hierarchical pathway analysis of common variants. HisCoM-PCA software has several features. Various principle component scores selection criteria in PCA step can be specified by users who want to summarize common variants at each gene-level by different threshold values. In addition, multiple public pathway databases and customized pathway information can be used to perform pathway analysis. We expect that HisCoM-PCA software will be useful for users to perform powerful pathway analysis."}