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A Storm is Raging.\nThe pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunologic characteristics between moderate versus severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10 and TNFα), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFNγ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T1","span":{"begin":447,"end":455},"obj":"Body_part"},{"id":"T2","span":{"begin":519,"end":524},"obj":"Body_part"},{"id":"T3","span":{"begin":567,"end":572},"obj":"Body_part"},{"id":"T4","span":{"begin":648,"end":656},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma84050"}],"text":"SARS-CoV-2: A Storm is Raging.\nThe pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunologic characteristics between moderate versus severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10 and TNFα), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFNγ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design."}

{"project":"LitCovid_AGAC","denotations":[{"id":"p118490s0","span":{"begin":437,"end":446},"obj":"PosReg"},{"id":"p118490s1","span":{"begin":447,"end":455},"obj":"MPA"},{"id":"p118490s28","span":{"begin":531,"end":540},"obj":"NegReg"},{"id":"p118490s29","span":{"begin":541,"end":545},"obj":"Protein"},{"id":"p118490s30","span":{"begin":546,"end":556},"obj":"MPA"}],"text":"SARS-CoV-2: A Storm is Raging.\nThe pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunologic characteristics between moderate versus severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10 and TNFα), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFNγ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T1","span":{"begin":0,"end":8},"obj":"Disease"},{"id":"T2","span":{"begin":56,"end":74},"obj":"Disease"},{"id":"T3","span":{"begin":76,"end":84},"obj":"Disease"},{"id":"T4","span":{"begin":97,"end":144},"obj":"Disease"},{"id":"T5","span":{"begin":97,"end":130},"obj":"Disease"},{"id":"T6","span":{"begin":146,"end":154},"obj":"Disease"},{"id":"T7","span":{"begin":329,"end":337},"obj":"Disease"},{"id":"T8","span":{"begin":487,"end":498},"obj":"Disease"},{"id":"T9","span":{"begin":600,"end":608},"obj":"Disease"},{"id":"T10","span":{"begin":673,"end":681},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0003783"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"SARS-CoV-2: A Storm is Raging.\nThe pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunologic characteristics between moderate versus severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10 and TNFα), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFNγ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1","span":{"begin":9,"end":13},"obj":"http://purl.obolibrary.org/obo/CLO_0001236"},{"id":"T2","span":{"begin":503,"end":506},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T3","span":{"begin":512,"end":515},"obj":"http://purl.obolibrary.org/obo/CLO_0053438"},{"id":"T4","span":{"begin":517,"end":524},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T5","span":{"begin":560,"end":563},"obj":"http://purl.obolibrary.org/obo/PR_000001004"},{"id":"T6","span":{"begin":565,"end":572},"obj":"http://purl.obolibrary.org/obo/CL_0000084"}],"text":"SARS-CoV-2: A Storm is Raging.\nThe pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunologic characteristics between moderate versus severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10 and TNFα), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFNγ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T1","span":{"begin":464,"end":466},"obj":"Chemical"},{"id":"T3","span":{"begin":470,"end":472},"obj":"Chemical"}],"attributes":[{"id":"A1","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A2","pred":"chebi_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A3","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A4","pred":"chebi_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"}],"text":"SARS-CoV-2: A Storm is Raging.\nThe pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunologic characteristics between moderate versus severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10 and TNFα), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFNγ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1","span":{"begin":0,"end":10},"obj":"Species"},{"id":"19","span":{"begin":44,"end":66},"obj":"Disease"},{"id":"20","span":{"begin":67,"end":74},"obj":"Disease"},{"id":"21","span":{"begin":76,"end":84},"obj":"Disease"},{"id":"22","span":{"begin":97,"end":144},"obj":"Species"},{"id":"23","span":{"begin":146,"end":156},"obj":"Species"},{"id":"24","span":{"begin":329,"end":337},"obj":"Disease"},{"id":"25","span":{"begin":362,"end":382},"obj":"Disease"},{"id":"26","span":{"begin":464,"end":468},"obj":"Gene"},{"id":"27","span":{"begin":470,"end":475},"obj":"Gene"},{"id":"29","span":{"begin":487,"end":498},"obj":"Disease"},{"id":"30","span":{"begin":503,"end":506},"obj":"Gene"},{"id":"31","span":{"begin":512,"end":515},"obj":"Gene"},{"id":"32","span":{"begin":541,"end":545},"obj":"Gene"},{"id":"33","span":{"begin":560,"end":563},"obj":"Gene"},{"id":"34","span":{"begin":600,"end":608},"obj":"Disease"},{"id":"35","span":{"begin":673,"end":681},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"tao:has_database_id","subj":"1","obj":"Tax:2697049"},{"id":"A19","pred":"tao:has_database_id","subj":"19","obj":"MESH:D018352"},{"id":"A20","pred":"tao:has_database_id","subj":"20","obj":"MESH:D003141"},{"id":"A21","pred":"tao:has_database_id","subj":"21","obj":"MESH:C000657245"},{"id":"A22","pred":"tao:has_database_id","subj":"22","obj":"Tax:2697049"},{"id":"A23","pred":"tao:has_database_id","subj":"23","obj":"Tax:2697049"},{"id":"A24","pred":"tao:has_database_id","subj":"24","obj":"MESH:C000657245"},{"id":"A25","pred":"tao:has_database_id","subj":"25","obj":"MESH:D012128"},{"id":"A26","pred":"tao:has_database_id","subj":"26","obj":"Gene:3569"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"Gene:3586"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"MESH:D008231"},{"id":"A30","pred":"tao:has_database_id","subj":"30","obj":"Gene:920"},{"id":"A31","pred":"tao:has_database_id","subj":"31","obj":"Gene:925"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"Gene:3458"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"Gene:920"},{"id":"A34","pred":"tao:has_database_id","subj":"34","obj":"MESH:C000657245"},{"id":"A35","pred":"tao:has_database_id","subj":"35","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"SARS-CoV-2: A Storm is Raging.\nThe pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunologic characteristics between moderate versus severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10 and TNFα), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFNγ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T1","span":{"begin":362,"end":382},"obj":"Phenotype"},{"id":"T2","span":{"begin":487,"end":498},"obj":"Phenotype"},{"id":"T3","span":{"begin":648,"end":662},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0001888"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0033041"}],"text":"SARS-CoV-2: A Storm is Raging.\nThe pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunologic characteristics between moderate versus severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10 and TNFα), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFNγ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design."}

{"project":"LitCovid-sentences","denotations":[{"id":"T1","span":{"begin":0,"end":11},"obj":"Sentence"},{"id":"T2","span":{"begin":12,"end":30},"obj":"Sentence"},{"id":"T3","span":{"begin":31,"end":197},"obj":"Sentence"},{"id":"T4","span":{"begin":198,"end":338},"obj":"Sentence"},{"id":"T5","span":{"begin":339,"end":436},"obj":"Sentence"},{"id":"T6","span":{"begin":437,"end":609},"obj":"Sentence"},{"id":"T7","span":{"begin":610,"end":748},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"SARS-CoV-2: A Storm is Raging.\nThe pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunologic characteristics between moderate versus severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10 and TNFα), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFNγ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design."}

{"project":"LitCovid_AGAC_only","denotations":[{"id":"p3694s1","span":{"begin":35,"end":55},"obj":"Disease"},{"id":"p3694s11","span":{"begin":87,"end":96},"obj":"Reg"},{"id":"p3698s28","span":{"begin":531,"end":540},"obj":"NegReg"},{"id":"p3698s29","span":{"begin":541,"end":545},"obj":"Protein"},{"id":"p3698s30","span":{"begin":546,"end":556},"obj":"MPA"}],"text":"SARS-CoV-2: A Storm is Raging.\nThe pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunologic characteristics between moderate versus severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10 and TNFα), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFNγ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design."}