PubMed:32216698 JSONTXT

{"project":"LitCovid-OGER-BB","denotations":[{"id":"T1","span":{"begin":51,"end":59},"obj":"SP_7"},{"id":"T2","span":{"begin":114,"end":122},"obj":"UBERON:0001621"},{"id":"T3","span":{"begin":123,"end":128},"obj":"UBERON:0000948"},{"id":"T4","span":{"begin":138,"end":153},"obj":"UBERON:0002037"},{"id":"T5","span":{"begin":165,"end":166},"obj":"UBERON:0002048"},{"id":"T6","span":{"begin":173,"end":179},"obj":"UBERON:0002113"},{"id":"T7","span":{"begin":240,"end":250},"obj":"SP_7"},{"id":"T8","span":{"begin":376,"end":384},"obj":"SP_7"},{"id":"T9","span":{"begin":460,"end":466},"obj":"MOP:0000780"},{"id":"T10","span":{"begin":484,"end":489},"obj":"PR:000003137"},{"id":"T11","span":{"begin":502,"end":511},"obj":"PG_1"},{"id":"T12","span":{"begin":515,"end":525},"obj":"SP_7"},{"id":"T13","span":{"begin":527,"end":542},"obj":"GO:0005576"},{"id":"T14","span":{"begin":591,"end":609},"obj":"GO:0042730"},{"id":"T15","span":{"begin":760,"end":768},"obj":"SP_7"}],"namespaces":[{"prefix":"NCBITaxon","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"}],"text":"Elevated plasmin(ogen) as a common risk factor for COVID-19 susceptibility.\nPatients with hypertension, diabetes, coronary heart disease, cerebrovascular illness, COPD, and kidney dysfunction have worse clinical outcomes when infected with SARS-CoV-2, for unknown reasons. The purpose of this review is to summarize the evidence for the existence of elevated plasmin(ogen) in COVID-19 patients with these comorbid conditions. Plasmin, and other proteases, may cleave a newly inserted furin site in the S protein of SARS-CoV-2, extracellularly, which increases its infectivity and virulence. Hyper-fibrinolysis associated with plasmin leads to elevated D-dimer in severe patients. The plasmin(ogen) system may prove a promising therapeutic target for combating COVID-19."}

{"project":"LitCovid-sentences-v1","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":75},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":76,"end":272},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":273,"end":425},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":426,"end":590},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":591,"end":679},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":680,"end":769},"obj":"Sentence"}],"text":"Elevated plasmin(ogen) as a common risk factor for COVID-19 susceptibility.\nPatients with hypertension, diabetes, coronary heart disease, cerebrovascular illness, COPD, and kidney dysfunction have worse clinical outcomes when infected with SARS-CoV-2, for unknown reasons. The purpose of this review is to summarize the evidence for the existence of elevated plasmin(ogen) in COVID-19 patients with these comorbid conditions. Plasmin, and other proteases, may cleave a newly inserted furin site in the S protein of SARS-CoV-2, extracellularly, which increases its infectivity and virulence. Hyper-fibrinolysis associated with plasmin leads to elevated D-dimer in severe patients. The plasmin(ogen) system may prove a promising therapeutic target for combating COVID-19."}

{"project":"LitCovid-TimeML","denotations":[{"id":"tok1","span":{"begin":0,"end":8},"obj":"NNP"},{"id":"tok2","span":{"begin":9,"end":16},"obj":"NN"},{"id":"tok3","span":{"begin":16,"end":17},"obj":"("},{"id":"tok4","span":{"begin":17,"end":21},"obj":"NN"},{"id":"tok5","span":{"begin":21,"end":22},"obj":")"},{"id":"tok6","span":{"begin":23,"end":25},"obj":"IN"},{"id":"tok7","span":{"begin":26,"end":27},"obj":"DT"},{"id":"tok8","span":{"begin":28,"end":34},"obj":"JJ"},{"id":"tok9","span":{"begin":35,"end":39},"obj":"NN"},{"id":"tok10","span":{"begin":40,"end":46},"obj":"NN"},{"id":"tok11","span":{"begin":47,"end":50},"obj":"IN"},{"id":"tok12","span":{"begin":51,"end":57},"obj":"NNP"},{"id":"tok13","span":{"begin":57,"end":59},"obj":"CD"},{"id":"tok14","span":{"begin":60,"end":74},"obj":"NN"},{"id":"tok15","span":{"begin":74,"end":75},"obj":"."},{"id":"tok16","span":{"begin":76,"end":84},"obj":"NNS"},{"id":"tok17","span":{"begin":85,"end":89},"obj":"IN"},{"id":"tok18","span":{"begin":90,"end":102},"obj":"NN"},{"id":"tok19","span":{"begin":102,"end":103},"obj":","},{"id":"tok20","span":{"begin":104,"end":112},"obj":"NN"},{"id":"tok21","span":{"begin":112,"end":113},"obj":","},{"id":"tok22","span":{"begin":114,"end":122},"obj":"JJ"},{"id":"tok23","span":{"begin":123,"end":128},"obj":"NN"},{"id":"tok24","span":{"begin":129,"end":136},"obj":"NN"},{"id":"tok25","span":{"begin":136,"end":137},"obj":","},{"id":"tok26","span":{"begin":138,"end":153},"obj":"NN"},{"id":"tok27","span":{"begin":154,"end":161},"obj":"NN"},{"id":"tok28","span":{"begin":161,"end":162},"obj":","},{"id":"tok29","span":{"begin":163,"end":167},"obj":"NNP"},{"id":"tok30","span":{"begin":167,"end":168},"obj":","},{"id":"tok31","span":{"begin":169,"end":172},"obj":"CC"},{"id":"tok32","span":{"begin":173,"end":179},"obj":"NN"},{"id":"tok33","span":{"begin":180,"end":191},"obj":"NN"},{"id":"tok34","span":{"begin":192,"end":196},"obj":"VBP"},{"id":"tok35","span":{"begin":197,"end":202},"obj":"RBR"},{"id":"tok36","span":{"begin":203,"end":211},"obj":"JJ"},{"id":"tok37","span":{"begin":212,"end":220},"obj":"NNS"},{"id":"tok38","span":{"begin":221,"end":225},"obj":"WRB"},{"id":"tok39","span":{"begin":226,"end":234},"obj":"VBN"},{"id":"tok40","span":{"begin":235,"end":239},"obj":"IN"},{"id":"tok41","span":{"begin":240,"end":249},"obj":"NNP"},{"id":"tok42","span":{"begin":249,"end":250},"obj":"CD"},{"id":"tok43","span":{"begin":250,"end":251},"obj":","},{"id":"tok44","span":{"begin":252,"end":255},"obj":"IN"},{"id":"tok45","span":{"begin":256,"end":263},"obj":"JJ"},{"id":"tok46","span":{"begin":264,"end":271},"obj":"NNS"},{"id":"tok47","span":{"begin":271,"end":272},"obj":"."},{"id":"tok48","span":{"begin":273,"end":276},"obj":"DT"},{"id":"tok49","span":{"begin":277,"end":284},"obj":"NN"},{"id":"tok50","span":{"begin":285,"end":287},"obj":"IN"},{"id":"tok51","span":{"begin":288,"end":292},"obj":"DT"},{"id":"tok52","span":{"begin":293,"end":299},"obj":"NN"},{"id":"tok53","span":{"begin":300,"end":302},"obj":"VBZ"},{"id":"tok54","span":{"begin":303,"end":305},"obj":"TO"},{"id":"tok55","span":{"begin":306,"end":315},"obj":"VB"},{"id":"tok56","span":{"begin":316,"end":319},"obj":"DT"},{"id":"tok57","span":{"begin":320,"end":328},"obj":"NN"},{"id":"tok58","span":{"begin":329,"end":332},"obj":"IN"},{"id":"tok59","span":{"begin":333,"end":336},"obj":"DT"},{"id":"tok60","span":{"begin":337,"end":346},"obj":"NN"},{"id":"tok61","span":{"begin":347,"end":349},"obj":"IN"},{"id":"tok62","span":{"begin":350,"end":358},"obj":"JJ"},{"id":"tok63","span":{"begin":359,"end":366},"obj":"NN"},{"id":"tok64","span":{"begin":366,"end":367},"obj":"("},{"id":"tok65","span":{"begin":367,"end":371},"obj":"NN"},{"id":"tok66","span":{"begin":371,"end":372},"obj":")"},{"id":"tok67","span":{"begin":373,"end":375},"obj":"IN"},{"id":"tok68","span":{"begin":376,"end":382},"obj":"NNP"},{"id":"tok69","span":{"begin":382,"end":384},"obj":"CD"},{"id":"tok70","span":{"begin":385,"end":393},"obj":"NNS"},{"id":"tok71","span":{"begin":394,"end":398},"obj":"IN"},{"id":"tok72","span":{"begin":399,"end":404},"obj":"DT"},{"id":"tok73","span":{"begin":405,"end":413},"obj":"NN"},{"id":"tok74","span":{"begin":414,"end":424},"obj":"NNS"},{"id":"tok75","span":{"begin":424,"end":425},"obj":"."},{"id":"tok76","span":{"begin":426,"end":433},"obj":"NNP"},{"id":"tok77","span":{"begin":433,"end":434},"obj":","},{"id":"tok78","span":{"begin":435,"end":438},"obj":"CC"},{"id":"tok79","span":{"begin":439,"end":444},"obj":"JJ"},{"id":"tok80","span":{"begin":445,"end":454},"obj":"NNS"},{"id":"tok81","span":{"begin":454,"end":455},"obj":","},{"id":"tok82","span":{"begin":456,"end":459},"obj":"MD"},{"id":"tok83","span":{"begin":460,"end":466},"obj":"NN"},{"id":"tok84","span":{"begin":467,"end":468},"obj":"DT"},{"id":"tok85","span":{"begin":469,"end":474},"obj":"RB"},{"id":"tok86","span":{"begin":475,"end":483},"obj":"VBN"},{"id":"tok87","span":{"begin":484,"end":489},"obj":"NN"},{"id":"tok88","span":{"begin":490,"end":494},"obj":"NN"},{"id":"tok89","span":{"begin":495,"end":497},"obj":"IN"},{"id":"tok90","span":{"begin":498,"end":501},"obj":"DT"},{"id":"tok91","span":{"begin":502,"end":503},"obj":"NNP"},{"id":"tok92","span":{"begin":504,"end":511},"obj":"NN"},{"id":"tok93","span":{"begin":512,"end":514},"obj":"IN"},{"id":"tok94","span":{"begin":515,"end":524},"obj":"NNP"},{"id":"tok95","span":{"begin":524,"end":525},"obj":"CD"},{"id":"tok96","span":{"begin":525,"end":526},"obj":","},{"id":"tok97","span":{"begin":527,"end":542},"obj":"RB"},{"id":"tok98","span":{"begin":542,"end":543},"obj":","},{"id":"tok99","span":{"begin":544,"end":549},"obj":"WDT"},{"id":"tok100","span":{"begin":550,"end":559},"obj":"VBZ"},{"id":"tok101","span":{"begin":560,"end":563},"obj":"PRP$"},{"id":"tok102","span":{"begin":564,"end":575},"obj":"NN"},{"id":"tok103","span":{"begin":576,"end":579},"obj":"CC"},{"id":"tok104","span":{"begin":580,"end":589},"obj":"NN"},{"id":"tok105","span":{"begin":589,"end":590},"obj":"."},{"id":"tok106","span":{"begin":591,"end":609},"obj":"NNP"},{"id":"tok107","span":{"begin":610,"end":620},"obj":"VBN"},{"id":"tok108","span":{"begin":621,"end":625},"obj":"IN"},{"id":"tok109","span":{"begin":626,"end":633},"obj":"NN"},{"id":"tok110","span":{"begin":634,"end":639},"obj":"VBZ"},{"id":"tok111","span":{"begin":640,"end":642},"obj":"TO"},{"id":"tok112","span":{"begin":643,"end":651},"obj":"VBD"},{"id":"tok113","span":{"begin":652,"end":654},"obj":"NNP"},{"id":"tok114","span":{"begin":654,"end":659},"obj":"NN"},{"id":"tok115","span":{"begin":660,"end":662},"obj":"IN"},{"id":"tok116","span":{"begin":663,"end":669},"obj":"JJ"},{"id":"tok117","span":{"begin":670,"end":678},"obj":"NNS"},{"id":"tok118","span":{"begin":678,"end":679},"obj":"."},{"id":"tok119","span":{"begin":680,"end":683},"obj":"DT"},{"id":"tok120","span":{"begin":684,"end":691},"obj":"NN"},{"id":"tok121","span":{"begin":691,"end":692},"obj":"("},{"id":"tok122","span":{"begin":692,"end":696},"obj":"NN"},{"id":"tok123","span":{"begin":696,"end":697},"obj":")"},{"id":"tok124","span":{"begin":698,"end":704},"obj":"NN"},{"id":"tok125","span":{"begin":705,"end":708},"obj":"MD"},{"id":"tok126","span":{"begin":709,"end":714},"obj":"VB"},{"id":"tok127","span":{"begin":715,"end":716},"obj":"DT"},{"id":"tok128","span":{"begin":717,"end":726},"obj":"JJ"},{"id":"tok129","span":{"begin":727,"end":738},"obj":"JJ"},{"id":"tok130","span":{"begin":739,"end":745},"obj":"NN"},{"id":"tok131","span":{"begin":746,"end":749},"obj":"IN"},{"id":"tok132","span":{"begin":750,"end":759},"obj":"VBG"},{"id":"tok133","span":{"begin":760,"end":766},"obj":"NNP"},{"id":"tok134","span":{"begin":766,"end":768},"obj":"CD"},{"id":"tok135","span":{"begin":768,"end":769},"obj":"."},{"id":"lookup1","span":{"begin":23,"end":25},"obj":"country_code"},{"id":"lookup2","span":{"begin":288,"end":292},"obj":"time_modifier"},{"id":"lookup3","span":{"begin":300,"end":302},"obj":"country_code"},{"id":"lookup4","span":{"begin":303,"end":305},"obj":"country_code"},{"id":"lookup5","span":{"begin":373,"end":375},"obj":"country_code"},{"id":"lookup6","span":{"begin":495,"end":497},"obj":"country_code"},{"id":"lookup7","span":{"begin":640,"end":642},"obj":"country_code"},{"id":"lookup8","span":{"begin":660,"end":662},"obj":"country_code"},{"id":"event1","span":{"begin":550,"end":559},"obj":"OCCURRENCE"},{"id":"event2","span":{"begin":643,"end":651},"obj":"OCCURRENCE"},{"id":"event3","span":{"begin":306,"end":315},"obj":"OCCURRENCE"},{"id":"event4","span":{"begin":226,"end":234},"obj":"OCCURRENCE"},{"id":"event5","span":{"begin":709,"end":714},"obj":"OCCURRENCE"}],"text":"Elevated plasmin(ogen) as a common risk factor for COVID-19 susceptibility.\nPatients with hypertension, diabetes, coronary heart disease, cerebrovascular illness, COPD, and kidney dysfunction have worse clinical outcomes when infected with SARS-CoV-2, for unknown reasons. The purpose of this review is to summarize the evidence for the existence of elevated plasmin(ogen) in COVID-19 patients with these comorbid conditions. Plasmin, and other proteases, may cleave a newly inserted furin site in the S protein of SARS-CoV-2, extracellularly, which increases its infectivity and virulence. Hyper-fibrinolysis associated with plasmin leads to elevated D-dimer in severe patients. The plasmin(ogen) system may prove a promising therapeutic target for combating COVID-19."}

{"project":"LitCovid-PD-MONDO-v1","denotations":[{"id":"T1","span":{"begin":51,"end":59},"obj":"Disease"},{"id":"T2","span":{"begin":90,"end":102},"obj":"Disease"},{"id":"T3","span":{"begin":104,"end":112},"obj":"Disease"},{"id":"T4","span":{"begin":114,"end":136},"obj":"Disease"},{"id":"T5","span":{"begin":123,"end":136},"obj":"Disease"},{"id":"T6","span":{"begin":163,"end":167},"obj":"Disease"},{"id":"T7","span":{"begin":240,"end":248},"obj":"Disease"},{"id":"T8","span":{"begin":376,"end":384},"obj":"Disease"},{"id":"T9","span":{"begin":515,"end":523},"obj":"Disease"},{"id":"T10","span":{"begin":760,"end":768},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005044"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0005015"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005010"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0005267"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0005002"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Elevated plasmin(ogen) as a common risk factor for COVID-19 susceptibility.\nPatients with hypertension, diabetes, coronary heart disease, cerebrovascular illness, COPD, and kidney dysfunction have worse clinical outcomes when infected with SARS-CoV-2, for unknown reasons. The purpose of this review is to summarize the evidence for the existence of elevated plasmin(ogen) in COVID-19 patients with these comorbid conditions. Plasmin, and other proteases, may cleave a newly inserted furin site in the S protein of SARS-CoV-2, extracellularly, which increases its infectivity and virulence. Hyper-fibrinolysis associated with plasmin leads to elevated D-dimer in severe patients. The plasmin(ogen) system may prove a promising therapeutic target for combating COVID-19."}

{"project":"LitCovid-PD-HP-v1","denotations":[{"id":"T1","span":{"begin":90,"end":102},"obj":"Phenotype"},{"id":"T2","span":{"begin":163,"end":167},"obj":"Phenotype"},{"id":"T3","span":{"begin":591,"end":609},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/HP_0000822"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/HP_0006510"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/HP_0040236"}],"text":"Elevated plasmin(ogen) as a common risk factor for COVID-19 susceptibility.\nPatients with hypertension, diabetes, coronary heart disease, cerebrovascular illness, COPD, and kidney dysfunction have worse clinical outcomes when infected with SARS-CoV-2, for unknown reasons. The purpose of this review is to summarize the evidence for the existence of elevated plasmin(ogen) in COVID-19 patients with these comorbid conditions. Plasmin, and other proteases, may cleave a newly inserted furin site in the S protein of SARS-CoV-2, extracellularly, which increases its infectivity and virulence. Hyper-fibrinolysis associated with plasmin leads to elevated D-dimer in severe patients. The plasmin(ogen) system may prove a promising therapeutic target for combating COVID-19."}

{"project":"LitCovid-PD-FMA-UBERON-v1","denotations":[{"id":"T1","span":{"begin":123,"end":128},"obj":"Body_part"},{"id":"T2","span":{"begin":173,"end":179},"obj":"Body_part"},{"id":"T3","span":{"begin":504,"end":511},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma7088"},{"id":"A58338","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma7203"},{"id":"A15442","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Elevated plasmin(ogen) as a common risk factor for COVID-19 susceptibility.\nPatients with hypertension, diabetes, coronary heart disease, cerebrovascular illness, COPD, and kidney dysfunction have worse clinical outcomes when infected with SARS-CoV-2, for unknown reasons. The purpose of this review is to summarize the evidence for the existence of elevated plasmin(ogen) in COVID-19 patients with these comorbid conditions. Plasmin, and other proteases, may cleave a newly inserted furin site in the S protein of SARS-CoV-2, extracellularly, which increases its infectivity and virulence. Hyper-fibrinolysis associated with plasmin leads to elevated D-dimer in severe patients. The plasmin(ogen) system may prove a promising therapeutic target for combating COVID-19."}

{"project":"LitCovid_AGAC","denotations":[{"id":"p118374s27","span":{"begin":550,"end":559},"obj":"PosReg"},{"id":"p118374s29","span":{"begin":564,"end":575},"obj":"MPA"},{"id":"p118374s31","span":{"begin":580,"end":589},"obj":"MPA"},{"id":"p118375s9","span":{"begin":652,"end":659},"obj":"MPA"}],"text":"Elevated plasmin(ogen) as a common risk factor for COVID-19 susceptibility.\nPatients with hypertension, diabetes, coronary heart disease, cerebrovascular illness, COPD, and kidney dysfunction have worse clinical outcomes when infected with SARS-CoV-2, for unknown reasons. The purpose of this review is to summarize the evidence for the existence of elevated plasmin(ogen) in COVID-19 patients with these comorbid conditions. Plasmin, and other proteases, may cleave a newly inserted furin site in the S protein of SARS-CoV-2, extracellularly, which increases its infectivity and virulence. Hyper-fibrinolysis associated with plasmin leads to elevated D-dimer in severe patients. The plasmin(ogen) system may prove a promising therapeutic target for combating COVID-19."}