PubMed:32188728 / 1565-2000 JSONTXT

{"project":"LitCovid-OGER","denotations":[{"id":"T8","span":{"begin":226,"end":238},"obj":"GO:0009405"},{"id":"T9","span":{"begin":412,"end":434},"obj":"GO:0045087"},{"id":"T13","span":{"begin":343,"end":348},"obj":"GO:0019012"},{"id":"T14","span":{"begin":381,"end":385},"obj":"GO:0018995"},{"id":"T18","span":{"begin":119,"end":123},"obj":"PR:000012880"},{"id":"T19","span":{"begin":124,"end":133},"obj":"PR:000035728"},{"id":"T20","span":{"begin":152,"end":156},"obj":"PR:000012880"},{"id":"T21","span":{"begin":157,"end":160},"obj":"PR:000022507;PR:Q9V877"},{"id":"T5","span":{"begin":55,"end":66},"obj":"SO:0001148"}],"namespaces":[{"prefix":"PR","uri":"http://purl.obolibrary.org/obo/PR_"},{"prefix":"UBERON","uri":"http://purl.obolibrary.org/obo/UBERON_"}],"text":"Overall, this study demonstrates that structure-guided mutagenesis aids the identification of critical determinants of PLP2-ubiquitin complex, and that PLP2 DUB activity plays a role as an interferon antagonist in coronavirus pathogenesis.IMPORTANCE Coronaviruses employ a genetic economy by encoding multifunctional proteins that function in viral replication and also modify the host environment to disarm the innate immune response."}

{"project":"LitCovid-sentences-v1","denotations":[{"id":"TextSentencer_T9","span":{"begin":0,"end":435},"obj":"Sentence"}],"text":"Overall, this study demonstrates that structure-guided mutagenesis aids the identification of critical determinants of PLP2-ubiquitin complex, and that PLP2 DUB activity plays a role as an interferon antagonist in coronavirus pathogenesis.IMPORTANCE Coronaviruses employ a genetic economy by encoding multifunctional proteins that function in viral replication and also modify the host environment to disarm the innate immune response."}

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this study demonstrates that structure-guided mutagenesis aids the identification of critical determinants of PLP2-ubiquitin complex, and that PLP2 DUB activity plays a role as an interferon antagonist in coronavirus pathogenesis.IMPORTANCE Coronaviruses employ a genetic economy by encoding multifunctional proteins that function in viral replication and also modify the host environment to disarm the innate immune response."}

{"project":"LitCovid-PD-FMA-UBERON-v1","denotations":[{"id":"T8","span":{"begin":317,"end":325},"obj":"Body_part"}],"attributes":[{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Overall, this study demonstrates that structure-guided mutagenesis aids the identification of critical determinants of PLP2-ubiquitin complex, and that PLP2 DUB activity plays a role as an interferon antagonist in coronavirus pathogenesis.IMPORTANCE Coronaviruses employ a genetic economy by encoding multifunctional proteins that function in viral replication and also modify the host environment to disarm the innate immune response."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T8","span":{"begin":317,"end":325},"obj":"Body_part"}],"attributes":[{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Overall, this study demonstrates that structure-guided mutagenesis aids the identification of critical determinants of PLP2-ubiquitin complex, and that PLP2 DUB activity plays a role as an interferon antagonist in coronavirus pathogenesis.IMPORTANCE Coronaviruses employ a genetic economy by encoding multifunctional proteins that function in viral replication and also modify the host environment to disarm the innate immune response."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T31","span":{"begin":161,"end":169},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T32","span":{"begin":176,"end":177},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T33","span":{"begin":271,"end":272},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Overall, this study demonstrates that structure-guided mutagenesis aids the identification of critical determinants of PLP2-ubiquitin complex, and that PLP2 DUB activity plays a role as an interferon antagonist in coronavirus pathogenesis.IMPORTANCE Coronaviruses employ a genetic economy by encoding multifunctional proteins that function in viral replication and also modify the host environment to disarm the innate immune response."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T12","span":{"begin":189,"end":199},"obj":"Chemical"},{"id":"T13","span":{"begin":200,"end":210},"obj":"Chemical"},{"id":"T14","span":{"begin":317,"end":325},"obj":"Chemical"}],"attributes":[{"id":"A12","pred":"chebi_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CHEBI_52999"},{"id":"A13","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_48706"},{"id":"A14","pred":"chebi_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Overall, this study demonstrates that structure-guided mutagenesis aids the identification of critical determinants of PLP2-ubiquitin complex, and that PLP2 DUB activity plays a role as an interferon antagonist in coronavirus pathogenesis.IMPORTANCE Coronaviruses employ a genetic economy by encoding multifunctional proteins that function in viral replication and also modify the host environment to disarm the innate immune response."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T13","span":{"begin":157,"end":160},"obj":"http://purl.obolibrary.org/obo/GO_0016579"},{"id":"T14","span":{"begin":343,"end":360},"obj":"http://purl.obolibrary.org/obo/GO_0019079"},{"id":"T15","span":{"begin":343,"end":360},"obj":"http://purl.obolibrary.org/obo/GO_0019058"},{"id":"T16","span":{"begin":412,"end":434},"obj":"http://purl.obolibrary.org/obo/GO_0045087"},{"id":"T17","span":{"begin":419,"end":434},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"text":"Overall, this study demonstrates that structure-guided mutagenesis aids the identification of critical determinants of PLP2-ubiquitin complex, and that PLP2 DUB activity plays a role as an interferon antagonist in coronavirus pathogenesis.IMPORTANCE Coronaviruses employ a genetic economy by encoding multifunctional proteins that function in viral replication and also modify the host environment to disarm the innate immune response."}

{"project":"LitCovid-sentences","denotations":[{"id":"T9","span":{"begin":0,"end":435},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Overall, this study demonstrates that structure-guided mutagenesis aids the identification of critical determinants of PLP2-ubiquitin complex, and that PLP2 DUB activity plays a role as an interferon antagonist in coronavirus pathogenesis.IMPORTANCE Coronaviruses employ a genetic economy by encoding multifunctional proteins that function in viral replication and also modify the host environment to disarm the innate immune response."}