PubMed:32179651
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 17-38 | Glycan_Motif | denotes | globotriaosylceramide | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO |
| T2 | 238-259 | Glycan_Motif | denotes | globotriaosylceramide | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO |
| T3 | 261-264 | Glycan_Motif | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO |
| T4 | 326-329 | Glycan_Motif | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO |
| T5 | 358-361 | Glycan_Motif | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO |
| T6 | 402-405 | Glycan_Motif | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO |
| T7 | 469-472 | Glycan_Motif | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO |
| T8 | 521-524 | Glycan_Motif | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO |
| T9 | 568-571 | Glycan_Motif | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO |
| T10 | 640-643 | Glycan_Motif | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO |
| T11 | 708-711 | Glycan_Motif | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO |
| T12 | 842-845 | Glycan_Motif | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO |
| T13 | 999-1002 | Glycan_Motif | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO |
| T14 | 1135-1138 | Glycan_Motif | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO |
| T15 | 1156-1159 | Glycan_Motif | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO |
| T16 | 1177-1180 | Glycan_Motif | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO |
| T17 | 1206-1209 | Glycan_Motif | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO |
| T18 | 1226-1229 | Glycan_Motif | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO |
| T19 | 1254-1257 | Glycan_Motif | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO |
| T20 | 1299-1302 | Glycan_Motif | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO |
| T21 | 1371-1374 | Glycan_Motif | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO |
| T22 | 1426-1429 | Glycan_Motif | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO |
| T23 | 1468-1471 | Glycan_Motif | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO |
| T24 | 1569-1572 | Glycan_Motif | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 261-264 | http://www.glycoepitope.jp/epitopes/EP0071 | denotes | Gb3 |
| T2 | 326-329 | http://www.glycoepitope.jp/epitopes/EP0071 | denotes | Gb3 |
| T3 | 358-361 | http://www.glycoepitope.jp/epitopes/EP0071 | denotes | Gb3 |
| T4 | 402-405 | http://www.glycoepitope.jp/epitopes/EP0071 | denotes | Gb3 |
| T5 | 469-472 | http://www.glycoepitope.jp/epitopes/EP0071 | denotes | Gb3 |
| T6 | 521-524 | http://www.glycoepitope.jp/epitopes/EP0071 | denotes | Gb3 |
| T7 | 568-571 | http://www.glycoepitope.jp/epitopes/EP0071 | denotes | Gb3 |
| T8 | 640-643 | http://www.glycoepitope.jp/epitopes/EP0071 | denotes | Gb3 |
| T9 | 708-711 | http://www.glycoepitope.jp/epitopes/EP0071 | denotes | Gb3 |
| T10 | 842-845 | http://www.glycoepitope.jp/epitopes/EP0071 | denotes | Gb3 |
| T11 | 999-1002 | http://www.glycoepitope.jp/epitopes/EP0071 | denotes | Gb3 |
| T12 | 1135-1138 | http://www.glycoepitope.jp/epitopes/EP0071 | denotes | Gb3 |
| T13 | 1156-1159 | http://www.glycoepitope.jp/epitopes/EP0071 | denotes | Gb3 |
| T14 | 1177-1180 | http://www.glycoepitope.jp/epitopes/EP0071 | denotes | Gb3 |
| T15 | 1206-1209 | http://www.glycoepitope.jp/epitopes/EP0071 | denotes | Gb3 |
| T16 | 1226-1229 | http://www.glycoepitope.jp/epitopes/EP0071 | denotes | Gb3 |
| T17 | 1254-1257 | http://www.glycoepitope.jp/epitopes/EP0071 | denotes | Gb3 |
| T18 | 1299-1302 | http://www.glycoepitope.jp/epitopes/EP0071 | denotes | Gb3 |
| T19 | 1371-1374 | http://www.glycoepitope.jp/epitopes/EP0071 | denotes | Gb3 |
| T20 | 1426-1429 | http://www.glycoepitope.jp/epitopes/EP0071 | denotes | Gb3 |
| T21 | 1468-1471 | http://www.glycoepitope.jp/epitopes/EP0071 | denotes | Gb3 |
| T22 | 1569-1572 | http://www.glycoepitope.jp/epitopes/EP0071 | denotes | Gb3 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-95 | Sentence | denotes | Determination of globotriaosylceramide analogs in the organs of a mouse model of Fabry disease. |
| T2 | 96-266 | Sentence | denotes | Fabry disease is a heritable lipid disorder caused by the low activity of α-galactosidase A and characterized by the systemic accumulation of globotriaosylceramide (Gb3). |
| T3 | 267-459 | Sentence | denotes | Recent studies have reported a structural heterogeneity of Gb3 in Fabry disease, including Gb3 isoforms with different fatty acids and Gb3 analogs with modifications on the sphingosine moiety. |
| T4 | 460-534 | Sentence | denotes | However, Gb3 assays are often performed only on the selected Gb3 isoforms. |
| T5 | 535-665 | Sentence | denotes | To precisely determine the total Gb3 concentration, here we established two methods for determining both Gb3 isoforms and analogs. |
| T6 | 666-922 | Sentence | denotes | One was the deacylation method, involving Gb3 treatment with sphingolipid ceramide N-deacylase, followed by an assay of the deacylated products, globotriaosylsphingosine (lyso-Gb3) and its analogs, by ultra-performance LC coupled to tandem MS (UPLC-MS/MS). |
| T7 | 923-1047 | Sentence | denotes | The other method was a direct assay established in the present study for 37 Gb3 isoforms and analogs/isoforms by UPLC-MS/MS. |
| T8 | 1048-1269 | Sentence | denotes | Gb3s from the organs of symptomatic animals of a Fabry disease mouse model were mainly Gb3 isoforms and two Gb3 analogs, such as Gb3(+18) containing the lyso-Gb3(+18) moiety and Gb3(-2) containing the lyso-Gb3(-2) moiety. |
| T9 | 1270-1370 | Sentence | denotes | The total concentrations and Gb3 analog distributions determined by the two methods were comparable. |
| T10 | 1371-1516 | Sentence | denotes | Gb3(+18) levels were high in the kidneys (24% of total Gb3) and the liver (13%), and we observed Gb3(-2) in the heart (10%) and the kidneys (5%). |
| T11 | 1517-1671 | Sentence | denotes | These results indicate organ-specific expression of Gb3 analogs, insights that may lead to a deeper understanding of the pathophysiology of Fabry disease. |
| T1 | 0-95 | Sentence | denotes | Determination of globotriaosylceramide analogs in the organs of a mouse model of Fabry disease. |
| T2 | 96-266 | Sentence | denotes | Fabry disease is a heritable lipid disorder caused by the low activity of α-galactosidase A and characterized by the systemic accumulation of globotriaosylceramide (Gb3). |
| T3 | 267-459 | Sentence | denotes | Recent studies have reported a structural heterogeneity of Gb3 in Fabry disease, including Gb3 isoforms with different fatty acids and Gb3 analogs with modifications on the sphingosine moiety. |
| T4 | 460-534 | Sentence | denotes | However, Gb3 assays are often performed only on the selected Gb3 isoforms. |
| T5 | 535-665 | Sentence | denotes | To precisely determine the total Gb3 concentration, here we established two methods for determining both Gb3 isoforms and analogs. |
| T6 | 666-922 | Sentence | denotes | One was the deacylation method, involving Gb3 treatment with sphingolipid ceramide N-deacylase, followed by an assay of the deacylated products, globotriaosylsphingosine (lyso-Gb3) and its analogs, by ultra-performance LC coupled to tandem MS (UPLC-MS/MS). |
| T7 | 923-1047 | Sentence | denotes | The other method was a direct assay established in the present study for 37 Gb3 isoforms and analogs/isoforms by UPLC-MS/MS. |
| T8 | 1048-1269 | Sentence | denotes | Gb3s from the organs of symptomatic animals of a Fabry disease mouse model were mainly Gb3 isoforms and two Gb3 analogs, such as Gb3(+18) containing the lyso-Gb3(+18) moiety and Gb3(-2) containing the lyso-Gb3(-2) moiety. |
| T9 | 1270-1370 | Sentence | denotes | The total concentrations and Gb3 analog distributions determined by the two methods were comparable. |
| T10 | 1371-1516 | Sentence | denotes | Gb3(+18) levels were high in the kidneys (24% of total Gb3) and the liver (13%), and we observed Gb3(-2) in the heart (10%) and the kidneys (5%). |
| T11 | 1517-1671 | Sentence | denotes | These results indicate organ-specific expression of Gb3 analogs, insights that may lead to a deeper understanding of the pathophysiology of Fabry disease. |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1404-1411 | http://purl.obolibrary.org/obo/MAT_0000119 | denotes | kidneys |
| T2 | 1439-1444 | http://purl.obolibrary.org/obo/MAT_0000097 | denotes | liver |
| T3 | 1483-1488 | http://purl.obolibrary.org/obo/MAT_0000036 | denotes | heart |
| T4 | 1503-1510 | http://purl.obolibrary.org/obo/MAT_0000119 | denotes | kidneys |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 17-38 | https://glytoucan.org/Structures/Glycans/G00059MO | denotes | globotriaosylceramide |
| T2 | 238-259 | https://glytoucan.org/Structures/Glycans/G00059MO | denotes | globotriaosylceramide |
| T3 | 261-264 | https://glytoucan.org/Structures/Glycans/G00059MO | denotes | Gb3 |
| T4 | 326-329 | https://glytoucan.org/Structures/Glycans/G00059MO | denotes | Gb3 |
| T5 | 358-361 | https://glytoucan.org/Structures/Glycans/G00059MO | denotes | Gb3 |
| T6 | 402-405 | https://glytoucan.org/Structures/Glycans/G00059MO | denotes | Gb3 |
| T7 | 469-472 | https://glytoucan.org/Structures/Glycans/G00059MO | denotes | Gb3 |
| T8 | 521-524 | https://glytoucan.org/Structures/Glycans/G00059MO | denotes | Gb3 |
| T9 | 568-571 | https://glytoucan.org/Structures/Glycans/G00059MO | denotes | Gb3 |
| T10 | 640-643 | https://glytoucan.org/Structures/Glycans/G00059MO | denotes | Gb3 |
| T11 | 708-711 | https://glytoucan.org/Structures/Glycans/G00059MO | denotes | Gb3 |
| T12 | 842-845 | https://glytoucan.org/Structures/Glycans/G00059MO | denotes | Gb3 |
| T13 | 999-1002 | https://glytoucan.org/Structures/Glycans/G00059MO | denotes | Gb3 |
| T14 | 1135-1138 | https://glytoucan.org/Structures/Glycans/G00059MO | denotes | Gb3 |
| T15 | 1156-1159 | https://glytoucan.org/Structures/Glycans/G00059MO | denotes | Gb3 |
| T16 | 1177-1180 | https://glytoucan.org/Structures/Glycans/G00059MO | denotes | Gb3 |
| T17 | 1206-1209 | https://glytoucan.org/Structures/Glycans/G00059MO | denotes | Gb3 |
| T18 | 1226-1229 | https://glytoucan.org/Structures/Glycans/G00059MO | denotes | Gb3 |
| T19 | 1254-1257 | https://glytoucan.org/Structures/Glycans/G00059MO | denotes | Gb3 |
| T20 | 1299-1302 | https://glytoucan.org/Structures/Glycans/G00059MO | denotes | Gb3 |
| T21 | 1371-1374 | https://glytoucan.org/Structures/Glycans/G00059MO | denotes | Gb3 |
| T22 | 1426-1429 | https://glytoucan.org/Structures/Glycans/G00059MO | denotes | Gb3 |
| T23 | 1468-1471 | https://glytoucan.org/Structures/Glycans/G00059MO | denotes | Gb3 |
| T24 | 1569-1572 | https://glytoucan.org/Structures/Glycans/G00059MO | denotes | Gb3 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 1404-1411 | Body_part | denotes | kidneys | http://purl.obolibrary.org/obo/MAT_0000119 |
| T2 | 1439-1444 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T3 | 1483-1488 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/MAT_0000036 |
| T4 | 1503-1510 | Body_part | denotes | kidneys | http://purl.obolibrary.org/obo/MAT_0000119 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 81-94 | Disease | denotes | Fabry disease | http://purl.obolibrary.org/obo/MONDO_0010526 |
| T2 | 96-109 | Disease | denotes | Fabry disease | http://purl.obolibrary.org/obo/MONDO_0010526 |
| T3 | 333-346 | Disease | denotes | Fabry disease | http://purl.obolibrary.org/obo/MONDO_0010526 |
| T4 | 1097-1110 | Disease | denotes | Fabry disease | http://purl.obolibrary.org/obo/MONDO_0010526 |
| T5 | 1657-1670 | Disease | denotes | Fabry disease | http://purl.obolibrary.org/obo/MONDO_0010526 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 261-264 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T2 | 326-329 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T3 | 358-361 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T4 | 402-405 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T5 | 469-472 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T6 | 521-524 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T7 | 568-571 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T8 | 640-643 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T9 | 708-711 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T10 | 842-845 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T11 | 999-1002 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T12 | 1135-1138 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T13 | 1156-1159 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T14 | 1177-1180 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T15 | 1206-1209 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T16 | 1226-1229 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T17 | 1254-1257 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T18 | 1299-1302 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T19 | 1371-1374 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T20 | 1426-1429 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T21 | 1468-1471 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T22 | 1569-1572 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 261-264 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T2 | 326-329 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T3 | 358-361 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T4 | 402-405 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T5 | 469-472 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T6 | 521-524 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T7 | 568-571 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T8 | 640-643 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T9 | 708-711 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T10 | 842-845 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T11 | 999-1002 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T12 | 1135-1138 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T13 | 1156-1159 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T14 | 1177-1180 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T15 | 1206-1209 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T16 | 1226-1229 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T17 | 1254-1257 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T18 | 1299-1302 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T19 | 1371-1374 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T20 | 1426-1429 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T21 | 1468-1471 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T22 | 1569-1572 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 81-94 | Disease | denotes | Fabry disease | http://purl.obolibrary.org/obo/MONDO_0010526 |
| T2 | 96-109 | Disease | denotes | Fabry disease | http://purl.obolibrary.org/obo/MONDO_0010526 |
| T3 | 333-346 | Disease | denotes | Fabry disease | http://purl.obolibrary.org/obo/MONDO_0010526 |
| T4 | 1097-1110 | Disease | denotes | Fabry disease | http://purl.obolibrary.org/obo/MONDO_0010526 |
| T5 | 1657-1670 | Disease | denotes | Fabry disease | http://purl.obolibrary.org/obo/MONDO_0010526 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 66-71 | OrganismTaxon | denotes | mouse | 10088|10090 |
| T3 | 1111-1116 | OrganismTaxon | denotes | mouse | 10088|10090 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 1439-1444 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T2 | 1483-1488 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230 |
| T6 | 1540-1545 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062|http://purl.obolibrary.org/obo/UBERON_0003103 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 1404-1411 | Body_part | denotes | kidneys | http://purl.obolibrary.org/obo/MAT_0000119 |
| T2 | 1439-1444 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/MAT_0000097 |
| T3 | 1483-1488 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/MAT_0000036 |
| T4 | 1503-1510 | Body_part | denotes | kidneys | http://purl.obolibrary.org/obo/MAT_0000119 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-95 | Sentence | denotes | Determination of globotriaosylceramide analogs in the organs of a mouse model of Fabry disease. |
| T2 | 96-266 | Sentence | denotes | Fabry disease is a heritable lipid disorder caused by the low activity of α-galactosidase A and characterized by the systemic accumulation of globotriaosylceramide (Gb3). |
| T3 | 267-459 | Sentence | denotes | Recent studies have reported a structural heterogeneity of Gb3 in Fabry disease, including Gb3 isoforms with different fatty acids and Gb3 analogs with modifications on the sphingosine moiety. |
| T4 | 460-534 | Sentence | denotes | However, Gb3 assays are often performed only on the selected Gb3 isoforms. |
| T5 | 535-665 | Sentence | denotes | To precisely determine the total Gb3 concentration, here we established two methods for determining both Gb3 isoforms and analogs. |
| T6 | 666-922 | Sentence | denotes | One was the deacylation method, involving Gb3 treatment with sphingolipid ceramide N-deacylase, followed by an assay of the deacylated products, globotriaosylsphingosine (lyso-Gb3) and its analogs, by ultra-performance LC coupled to tandem MS (UPLC-MS/MS). |
| T7 | 923-1047 | Sentence | denotes | The other method was a direct assay established in the present study for 37 Gb3 isoforms and analogs/isoforms by UPLC-MS/MS. |
| T8 | 1048-1269 | Sentence | denotes | Gb3s from the organs of symptomatic animals of a Fabry disease mouse model were mainly Gb3 isoforms and two Gb3 analogs, such as Gb3(+18) containing the lyso-Gb3(+18) moiety and Gb3(-2) containing the lyso-Gb3(-2) moiety. |
| T9 | 1270-1370 | Sentence | denotes | The total concentrations and Gb3 analog distributions determined by the two methods were comparable. |
| T10 | 1371-1516 | Sentence | denotes | Gb3(+18) levels were high in the kidneys (24% of total Gb3) and the liver (13%), and we observed Gb3(-2) in the heart (10%) and the kidneys (5%). |
| T11 | 1517-1671 | Sentence | denotes | These results indicate organ-specific expression of Gb3 analogs, insights that may lead to a deeper understanding of the pathophysiology of Fabry disease. |
| T1 | 0-95 | Sentence | denotes | Determination of globotriaosylceramide analogs in the organs of a mouse model of Fabry disease. |
| T2 | 96-266 | Sentence | denotes | Fabry disease is a heritable lipid disorder caused by the low activity of α-galactosidase A and characterized by the systemic accumulation of globotriaosylceramide (Gb3). |
| T3 | 267-459 | Sentence | denotes | Recent studies have reported a structural heterogeneity of Gb3 in Fabry disease, including Gb3 isoforms with different fatty acids and Gb3 analogs with modifications on the sphingosine moiety. |
| T4 | 460-534 | Sentence | denotes | However, Gb3 assays are often performed only on the selected Gb3 isoforms. |
| T5 | 535-665 | Sentence | denotes | To precisely determine the total Gb3 concentration, here we established two methods for determining both Gb3 isoforms and analogs. |
| T6 | 666-922 | Sentence | denotes | One was the deacylation method, involving Gb3 treatment with sphingolipid ceramide N-deacylase, followed by an assay of the deacylated products, globotriaosylsphingosine (lyso-Gb3) and its analogs, by ultra-performance LC coupled to tandem MS (UPLC-MS/MS). |
| T7 | 923-1047 | Sentence | denotes | The other method was a direct assay established in the present study for 37 Gb3 isoforms and analogs/isoforms by UPLC-MS/MS. |
| T8 | 1048-1269 | Sentence | denotes | Gb3s from the organs of symptomatic animals of a Fabry disease mouse model were mainly Gb3 isoforms and two Gb3 analogs, such as Gb3(+18) containing the lyso-Gb3(+18) moiety and Gb3(-2) containing the lyso-Gb3(-2) moiety. |
| T9 | 1270-1370 | Sentence | denotes | The total concentrations and Gb3 analog distributions determined by the two methods were comparable. |
| T10 | 1371-1516 | Sentence | denotes | Gb3(+18) levels were high in the kidneys (24% of total Gb3) and the liver (13%), and we observed Gb3(-2) in the heart (10%) and the kidneys (5%). |
| T11 | 1517-1671 | Sentence | denotes | These results indicate organ-specific expression of Gb3 analogs, insights that may lead to a deeper understanding of the pathophysiology of Fabry disease. |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-95 | Sentence | denotes | Determination of globotriaosylceramide analogs in the organs of a mouse model of Fabry disease. |
| T2 | 96-266 | Sentence | denotes | Fabry disease is a heritable lipid disorder caused by the low activity of α-galactosidase A and characterized by the systemic accumulation of globotriaosylceramide (Gb3). |
| T3 | 267-459 | Sentence | denotes | Recent studies have reported a structural heterogeneity of Gb3 in Fabry disease, including Gb3 isoforms with different fatty acids and Gb3 analogs with modifications on the sphingosine moiety. |
| T4 | 460-534 | Sentence | denotes | However, Gb3 assays are often performed only on the selected Gb3 isoforms. |
| T5 | 535-665 | Sentence | denotes | To precisely determine the total Gb3 concentration, here we established two methods for determining both Gb3 isoforms and analogs. |
| T6 | 666-922 | Sentence | denotes | One was the deacylation method, involving Gb3 treatment with sphingolipid ceramide N-deacylase, followed by an assay of the deacylated products, globotriaosylsphingosine (lyso-Gb3) and its analogs, by ultra-performance LC coupled to tandem MS (UPLC-MS/MS). |
| T7 | 923-1047 | Sentence | denotes | The other method was a direct assay established in the present study for 37 Gb3 isoforms and analogs/isoforms by UPLC-MS/MS. |
| T8 | 1048-1269 | Sentence | denotes | Gb3s from the organs of symptomatic animals of a Fabry disease mouse model were mainly Gb3 isoforms and two Gb3 analogs, such as Gb3(+18) containing the lyso-Gb3(+18) moiety and Gb3(-2) containing the lyso-Gb3(-2) moiety. |
| T9 | 1270-1370 | Sentence | denotes | The total concentrations and Gb3 analog distributions determined by the two methods were comparable. |
| T10 | 1371-1516 | Sentence | denotes | Gb3(+18) levels were high in the kidneys (24% of total Gb3) and the liver (13%), and we observed Gb3(-2) in the heart (10%) and the kidneys (5%). |
| T11 | 1517-1671 | Sentence | denotes | These results indicate organ-specific expression of Gb3 analogs, insights that may lead to a deeper understanding of the pathophysiology of Fabry disease. |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 261-264 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T2 | 326-329 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T3 | 358-361 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T4 | 402-405 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T5 | 469-472 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T6 | 521-524 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T7 | 568-571 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T8 | 640-643 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T9 | 708-711 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T10 | 842-845 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T11 | 999-1002 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T12 | 1135-1138 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T13 | 1156-1159 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T14 | 1177-1180 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T15 | 1206-1209 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T16 | 1226-1229 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T17 | 1254-1257 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T18 | 1299-1302 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T19 | 1371-1374 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T20 | 1426-1429 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T21 | 1468-1471 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
| T22 | 1569-1572 | Glycan | denotes | Gb3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 261-264 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T2 | 326-329 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T3 | 358-361 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T4 | 402-405 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T5 | 469-472 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T6 | 521-524 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T7 | 568-571 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T8 | 640-643 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T9 | 708-711 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T10 | 842-845 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T11 | 999-1002 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T12 | 1135-1138 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T13 | 1156-1159 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T14 | 1177-1180 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T15 | 1206-1209 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T16 | 1226-1229 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T17 | 1254-1257 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T18 | 1299-1302 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T19 | 1371-1374 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T20 | 1426-1429 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T21 | 1468-1471 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
| T22 | 1569-1572 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | Gb3 | http://www.glycoepitope.jp/epitopes/EP0071 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 66-71 | OrganismTaxon | denotes | mouse | 10088|10090 |
| T3 | 1111-1116 | OrganismTaxon | denotes | mouse | 10088|10090 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 1439-1444 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T2 | 1483-1488 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948|http://purl.obolibrary.org/obo/UBERON_0007100|http://purl.obolibrary.org/obo/UBERON_0015228|http://purl.obolibrary.org/obo/UBERON_0015230 |
| T6 | 1540-1545 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062|http://purl.obolibrary.org/obo/UBERON_0003103 |