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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-85 Sentence denotes [Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia].
T2 86-96 Sentence denotes Objective:
T3 97-285 Sentence denotes To analyze the clinical characteristics of 2019 novel coronavirus (2019-nCoV) pneumonia and to investigate the correlation between serum inflammatory cytokines and severity of the disease.
T4 286-294 Sentence denotes Methods:
T5 295-510 Sentence denotes 29 patients with 2019-ncov admitted to the isolation ward of Tongji hospital affiliated to Tongji medical college of Huazhong University of Science and Technology in January 2020 were selected as the study subjects.
T6 511-644 Sentence denotes Clinical data were collected and the general information, clinical symptoms, blood test and CT imaging characteristics were analyzed.
T7 645-794 Sentence denotes According to the relevant diagnostic criteria, the patients were divided into three groups: mild (15 cases), severe (9 cases) and critical (5 cases).
T8 795-1065 Sentence denotes The expression levels of inflammatory cytokines and other markers in the serum of each group were detected, and the changes of these indicators of the three groups were compared and analyzed, as well as their relationship with the clinical classification of the disease.
T9 1066-1194 Sentence denotes Results: (1) The main symptoms of 2019-nCoV pneumonia was fever (28/29) with or without respiratory and other systemic symptoms.
T10 1195-1496 Sentence denotes Two patients died with underlying disease and co-bacterial infection, respectively. (2) The blood test of the patients showed normal or decreased white blood cell count (23/29), decreased lymphocyte count (20/29), increased hypersensitive C reactive protein (hs-CRP) (27/29), and normal procalcitonin.
T11 1497-1622 Sentence denotes In most patients, serum lactate dehydrogenase (LDH) was significantly increased (20/29), while albumin was decreased (15/29).
T12 1623-1901 Sentence denotes Alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (Tbil), serum creatinine (Scr) and other items showed no significant changes. (3) CT findings of typical cases were single or multiple patchy ground glass shadows accompanied by septal thickening.
T13 1902-2336 Sentence denotes When the disease progresses, the lesion increases and the scope expands, and the ground glass shadow coexists with the solid shadow or the stripe shadow. (4) There were statistically significant differences in the expression levels of interleukin-2 receptor (IL-2R) and IL-6 in the serum of the three groups (P<0.05), among which the critical group was higher than the severe group and the severe group was higher than the mild group.
T14 2337-2538 Sentence denotes However, there were no statistically significant differences in serum levels of tumor necrosis factor-alpha (TNF-α), IL-1, IL-8, IL-10, hs-CRP, lymphocyte count and LDH among the three groups (P>0.05).
T15 2539-2550 Sentence denotes Conclusion:
T16 2551-2650 Sentence denotes The clinical characteristics of 2019-nCoV pneumonia are similar to those of common viral pneumonia.
T17 2651-2734 Sentence denotes High resolution CT is of great value in the differential diagnosis of this disease.
T18 2735-2880 Sentence denotes The increased expression of IL-2R and IL-6 in serum is expected to predict the severity of the 2019-nCoV pneumonia and the prognosis of patients.
T1 0-85 Sentence denotes [Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia].
T2 86-96 Sentence denotes Objective:
T3 97-285 Sentence denotes To analyze the clinical characteristics of 2019 novel coronavirus (2019-nCoV) pneumonia and to investigate the correlation between serum inflammatory cytokines and severity of the disease.
T4 286-294 Sentence denotes Methods:
T5 295-510 Sentence denotes 29 patients with 2019-ncov admitted to the isolation ward of Tongji hospital affiliated to Tongji medical college of Huazhong University of Science and Technology in January 2020 were selected as the study subjects.
T6 511-644 Sentence denotes Clinical data were collected and the general information, clinical symptoms, blood test and CT imaging characteristics were analyzed.
T7 645-794 Sentence denotes According to the relevant diagnostic criteria, the patients were divided into three groups: mild (15 cases), severe (9 cases) and critical (5 cases).
T8 795-1065 Sentence denotes The expression levels of inflammatory cytokines and other markers in the serum of each group were detected, and the changes of these indicators of the three groups were compared and analyzed, as well as their relationship with the clinical classification of the disease.
T9 1066-1194 Sentence denotes Results: (1) The main symptoms of 2019-nCoV pneumonia was fever (28/29) with or without respiratory and other systemic symptoms.
T10 1195-1496 Sentence denotes Two patients died with underlying disease and co-bacterial infection, respectively. (2) The blood test of the patients showed normal or decreased white blood cell count (23/29), decreased lymphocyte count (20/29), increased hypersensitive C reactive protein (hs-CRP) (27/29), and normal procalcitonin.
T11 1497-1622 Sentence denotes In most patients, serum lactate dehydrogenase (LDH) was significantly increased (20/29), while albumin was decreased (15/29).
T12 1623-1901 Sentence denotes Alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (Tbil), serum creatinine (Scr) and other items showed no significant changes. (3) CT findings of typical cases were single or multiple patchy ground glass shadows accompanied by septal thickening.
T13 1902-2336 Sentence denotes When the disease progresses, the lesion increases and the scope expands, and the ground glass shadow coexists with the solid shadow or the stripe shadow. (4) There were statistically significant differences in the expression levels of interleukin-2 receptor (IL-2R) and IL-6 in the serum of the three groups (P<0.05), among which the critical group was higher than the severe group and the severe group was higher than the mild group.
T14 2337-2538 Sentence denotes However, there were no statistically significant differences in serum levels of tumor necrosis factor-alpha (TNF-α), IL-1, IL-8, IL-10, hs-CRP, lymphocyte count and LDH among the three groups (P>0.05).
T15 2539-2550 Sentence denotes Conclusion:
T16 2551-2650 Sentence denotes The clinical characteristics of 2019-nCoV pneumonia are similar to those of common viral pneumonia.
T17 2651-2734 Sentence denotes High resolution CT is of great value in the differential diagnosis of this disease.
T18 2735-2880 Sentence denotes The increased expression of IL-2R and IL-6 in serum is expected to predict the severity of the 2019-nCoV pneumonia and the prognosis of patients.

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 228-233 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T2 247-256 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T3 588-593 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T4 833-842 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T5 868-873 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T6 1287-1292 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T7 1341-1357 Body_part denotes white blood cell http://purl.org/sig/ont/fma/fma62852
T8 1353-1357 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T9 1383-1393 Body_part denotes lymphocyte http://purl.org/sig/ont/fma/fma62863
T10 1445-1452 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T11 1515-1520 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T12 1623-1630 Body_part denotes Alanine http://purl.org/sig/ont/fma/fma82749
T13 1713-1718 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T14 2137-2150 Body_part denotes interleukin-2 http://purl.org/sig/ont/fma/fma84051
T15 2184-2189 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T16 2401-2406 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T17 2454-2458 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T18 2481-2491 Body_part denotes lymphocyte http://purl.org/sig/ont/fma/fma62863
T19 2781-2786 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 228-233 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T2 588-593 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T3 868-873 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T4 1287-1292 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T5 1347-1352 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T6 1515-1520 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T7 1713-1718 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T8 2184-2189 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T9 2401-2406 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T10 2781-2786 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 74-83 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T2 175-184 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T3 1110-1119 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T4 1244-1263 Disease denotes bacterial infection http://purl.obolibrary.org/obo/MONDO_0005113
T5 1254-1263 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T6 1419-1433 Disease denotes hypersensitive http://purl.obolibrary.org/obo/MONDO_0000605
T7 2417-2422 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T8 2593-2602 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T9 2634-2649 Disease denotes viral pneumonia http://purl.obolibrary.org/obo/MONDO_0006012
T10 2640-2649 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T11 2840-2849 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 86-95 http://purl.obolibrary.org/obo/BFO_0000030 denotes Objective
T2 588-593 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T3 588-593 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T4 594-598 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T5 1287-1292 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T6 1287-1292 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T7 1293-1297 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T8 1347-1352 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T9 1353-1357 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T10 1463-1465 http://purl.obolibrary.org/obo/CLO_0050509 denotes 27
T11 2137-2150 http://purl.obolibrary.org/obo/PR_000001379 denotes interleukin-2
T12 2161-2166 http://purl.obolibrary.org/obo/PR_000001380 denotes IL-2R
T13 2417-2444 http://purl.obolibrary.org/obo/PR_000000134 denotes tumor necrosis factor-alpha
T14 2460-2464 http://purl.obolibrary.org/obo/CLO_0053704 denotes IL-8
T15 2763-2768 http://purl.obolibrary.org/obo/PR_000001380 denotes IL-2R

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 882-887 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T2 1445-1452 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T3 1521-1528 Chemical denotes lactate http://purl.obolibrary.org/obo/CHEBI_24996
T4 1623-1630 Chemical denotes Alanine http://purl.obolibrary.org/obo/CHEBI_16449
T5 1655-1664 Chemical denotes aspartate http://purl.obolibrary.org/obo/CHEBI_132943|http://purl.obolibrary.org/obo/CHEBI_29995|http://purl.obolibrary.org/obo/CHEBI_72314
T8 1683-1686 Chemical denotes AST http://purl.obolibrary.org/obo/CHEBI_76649
T9 1695-1704 Chemical denotes bilirubin http://purl.obolibrary.org/obo/CHEBI_16990
T10 1719-1729 Chemical denotes creatinine http://purl.obolibrary.org/obo/CHEBI_16737
T11 2161-2163 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T13 2172-2174 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T15 2245-2250 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T16 2278-2283 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T17 2299-2304 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T18 2330-2335 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T19 2439-2444 Chemical denotes alpha http://purl.obolibrary.org/obo/CHEBI_30216
T20 2454-2456 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T22 2460-2462 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T24 2466-2468 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T26 2763-2765 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T28 2773-2775 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 74-83 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T2 175-184 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T3 1110-1119 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T4 1124-1129 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T5 1419-1433 Phenotype denotes hypersensitive http://purl.obolibrary.org/obo/HP_0041092
T6 2417-2422 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T7 2593-2602 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T8 2640-2649 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T9 2840-2849 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 1419-1433 http://purl.obolibrary.org/obo/GO_0002524 denotes hypersensitive
T2 2161-2166 http://purl.obolibrary.org/obo/GO_0004911 denotes IL-2R
T3 2423-2431 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T4 2423-2431 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T5 2423-2431 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T6 2423-2431 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T7 2763-2768 http://purl.obolibrary.org/obo/GO_0004911 denotes IL-2R

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2 37-45 Species denotes patients Tax:9606
3 56-83 Disease denotes novel coronavirus pneumonia MESH:C000657245
39 151-184 Disease denotes coronavirus (2019-nCoV) pneumonia MESH:C000657245
40 298-306 Species denotes patients Tax:9606
41 312-321 Species denotes 2019-ncov Tax:2697049
42 696-704 Species denotes patients Tax:9606
43 1100-1119 Disease denotes 2019-nCoV pneumonia MESH:C000657245
44 1124-1129 Disease denotes fever MESH:D005334
45 1199-1207 Species denotes patients Tax:9606
46 1208-1212 Disease denotes died MESH:D003643
47 1241-1263 Disease denotes co-bacterial infection MESH:D060085
48 1305-1313 Species denotes patients Tax:9606
49 1419-1433 Disease denotes hypersensitive MESH:D004342
50 1434-1452 Gene denotes C reactive protein Gene:1401
51 1457-1460 Gene denotes CRP Gene:1401
52 1505-1513 Species denotes patients Tax:9606
53 1623-1647 Gene denotes Alanine aminotransferase Gene:2875
54 1655-1681 Gene denotes aspartate aminotransferase Gene:26503
55 1683-1686 Gene denotes AST Gene:26503
56 1695-1704 Chemical denotes bilirubin MESH:D001663
57 1706-1710 Chemical denotes Tbil MESH:D001663
58 1719-1729 Chemical denotes creatinine MESH:D003404
59 2137-2159 Gene denotes interleukin-2 receptor Gene:3559
60 2161-2166 Gene denotes IL-2R Gene:3559
61 2172-2176 Gene denotes IL-6 Gene:3569
62 2417-2444 Gene denotes tumor necrosis factor-alpha Gene:7124
63 2446-2451 Gene denotes TNF-α Gene:7124
64 2454-2458 Gene denotes IL-1 Gene:3552
65 2460-2464 Gene denotes IL-8 Gene:3576
66 2466-2471 Gene denotes IL-10 Gene:3586
67 2476-2479 Gene denotes CRP Gene:1401
68 2583-2602 Disease denotes 2019-nCoV pneumonia MESH:C000657245
69 2634-2649 Disease denotes viral pneumonia
70 2763-2768 Gene denotes IL-2R Gene:3559
71 2773-2777 Gene denotes IL-6 Gene:3569
72 2830-2849 Disease denotes 2019-nCoV pneumonia MESH:C000657245
73 2871-2879 Species denotes patients Tax:9606

LitCovid_AGAC_only

Id Subject Object Predicate Lexical cue
p2284s21 1383-1393 CPA denotes lymphocyte
p2285s12 1567-1576 PosReg denotes increased
p2285s20 1592-1599 MPA denotes albumin

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-85 Sentence denotes [Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia].
T2 86-96 Sentence denotes Objective:
T3 97-285 Sentence denotes To analyze the clinical characteristics of 2019 novel coronavirus (2019-nCoV) pneumonia and to investigate the correlation between serum inflammatory cytokines and severity of the disease.
T4 286-294 Sentence denotes Methods:
T5 295-510 Sentence denotes 29 patients with 2019-ncov admitted to the isolation ward of Tongji hospital affiliated to Tongji medical college of Huazhong University of Science and Technology in January 2020 were selected as the study subjects.
T6 511-644 Sentence denotes Clinical data were collected and the general information, clinical symptoms, blood test and CT imaging characteristics were analyzed.
T7 645-794 Sentence denotes According to the relevant diagnostic criteria, the patients were divided into three groups: mild (15 cases), severe (9 cases) and critical (5 cases).
T8 795-1065 Sentence denotes The expression levels of inflammatory cytokines and other markers in the serum of each group were detected, and the changes of these indicators of the three groups were compared and analyzed, as well as their relationship with the clinical classification of the disease.
T9 1066-1194 Sentence denotes Results: (1) The main symptoms of 2019-nCoV pneumonia was fever (28/29) with or without respiratory and other systemic symptoms.
T10 1195-1496 Sentence denotes Two patients died with underlying disease and co-bacterial infection, respectively. (2) The blood test of the patients showed normal or decreased white blood cell count (23/29), decreased lymphocyte count (20/29), increased hypersensitive C reactive protein (hs-CRP) (27/29), and normal procalcitonin.
T11 1497-1622 Sentence denotes In most patients, serum lactate dehydrogenase (LDH) was significantly increased (20/29), while albumin was decreased (15/29).
T12 1623-1901 Sentence denotes Alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (Tbil), serum creatinine (Scr) and other items showed no significant changes. (3) CT findings of typical cases were single or multiple patchy ground glass shadows accompanied by septal thickening.
T13 1902-2336 Sentence denotes When the disease progresses, the lesion increases and the scope expands, and the ground glass shadow coexists with the solid shadow or the stripe shadow. (4) There were statistically significant differences in the expression levels of interleukin-2 receptor (IL-2R) and IL-6 in the serum of the three groups (P<0.05), among which the critical group was higher than the severe group and the severe group was higher than the mild group.
T14 2337-2538 Sentence denotes However, there were no statistically significant differences in serum levels of tumor necrosis factor-alpha (TNF-α), IL-1, IL-8, IL-10, hs-CRP, lymphocyte count and LDH among the three groups (P>0.05).
T15 2539-2550 Sentence denotes Conclusion:
T16 2551-2650 Sentence denotes The clinical characteristics of 2019-nCoV pneumonia are similar to those of common viral pneumonia.
T17 2651-2734 Sentence denotes High resolution CT is of great value in the differential diagnosis of this disease.
T18 2735-2880 Sentence denotes The increased expression of IL-2R and IL-6 in serum is expected to predict the severity of the 2019-nCoV pneumonia and the prognosis of patients.