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PubMed:32047578 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-132 Sentence denotes Remote Ischaemic Preconditioning Reduces Kidney Injury Biomarkers in Patients Undergoing Open Surgical Lower Limb Revascularisation:
T2 133-152 Sentence denotes A Randomised Trial.
T3 153-173 Sentence denotes BACKGROUND AND AIMS:
T4 174-276 Sentence denotes Perioperative kidney injury affects 12.7% of patients undergoing lower limb revascularisation surgery.
T5 277-430 Sentence denotes Remote ischaemic preconditioning (RIPC) is a potentially protective procedure against organ damage and consists of short nonlethal episodes of ischaemia.
T6 431-623 Sentence denotes The main objective of this substudy was to evaluate the effect of RIPC on kidney function, inflammation, and oxidative stress in patients undergoing open surgical lower limb revascularisation.
T7 624-646 Sentence denotes Materials and Methods.
T8 647-745 Sentence denotes This is a subgroup analysis of a randomised, sham-controlled, double-blinded, single-centre study.
T9 746-906 Sentence denotes A RIPC or a sham procedure was performed noninvasively along with preparation for anaesthesia in patients undergoing open surgical lower limb revascularisation.
T10 907-1026 Sentence denotes The RIPC protocol consisted of 4 cycles of 5 minutes of ischaemia, with 5 minutes of reperfusion between every episode.
T11 1027-1176 Sentence denotes Blood was collected for analysis preoperatively, 2, 8, and 24 hours after surgery, and urine was collected preoperatively and 24 hours after surgery.
T12 1177-1185 Sentence denotes RESULTS:
T13 1186-1236 Sentence denotes Data of 56 patients were included in the analysis.
T14 1237-1460 Sentence denotes Serum creatinine, cystatin C, and beta-2 microglobulin increased, and eGFR decreased across all time points significantly more in the sham group than in the RIPC group (p = 0.021, p = 0.021, p = 0.021, p = 0.021, p = 0.021.
T15 1461-1473 Sentence denotes CONCLUSIONS:
T16 1474-1646 Sentence denotes Our finding of reduced release of kidney injury biomarkers may indicate the renoprotective effect of RIPC in patients undergoing open surgical lower limb revascularisation.
T17 1647-1707 Sentence denotes The trial is registered with ClinicalTrials.gov NCT02689414.
T1 0-132 Sentence denotes Remote Ischaemic Preconditioning Reduces Kidney Injury Biomarkers in Patients Undergoing Open Surgical Lower Limb Revascularisation:
T2 133-152 Sentence denotes A Randomised Trial.
T3 153-173 Sentence denotes BACKGROUND AND AIMS:
T4 174-276 Sentence denotes Perioperative kidney injury affects 12.7% of patients undergoing lower limb revascularisation surgery.
T5 277-430 Sentence denotes Remote ischaemic preconditioning (RIPC) is a potentially protective procedure against organ damage and consists of short nonlethal episodes of ischaemia.
T6 431-623 Sentence denotes The main objective of this substudy was to evaluate the effect of RIPC on kidney function, inflammation, and oxidative stress in patients undergoing open surgical lower limb revascularisation.
T7 624-646 Sentence denotes Materials and Methods.
T8 647-745 Sentence denotes This is a subgroup analysis of a randomised, sham-controlled, double-blinded, single-centre study.
T9 746-906 Sentence denotes A RIPC or a sham procedure was performed noninvasively along with preparation for anaesthesia in patients undergoing open surgical lower limb revascularisation.
T10 907-1026 Sentence denotes The RIPC protocol consisted of 4 cycles of 5 minutes of ischaemia, with 5 minutes of reperfusion between every episode.
T11 1027-1176 Sentence denotes Blood was collected for analysis preoperatively, 2, 8, and 24 hours after surgery, and urine was collected preoperatively and 24 hours after surgery.
T12 1177-1185 Sentence denotes RESULTS:
T13 1186-1236 Sentence denotes Data of 56 patients were included in the analysis.
T14 1237-1460 Sentence denotes Serum creatinine, cystatin C, and beta-2 microglobulin increased, and eGFR decreased across all time points significantly more in the sham group than in the RIPC group (p = 0.021, p = 0.021, p = 0.021, p = 0.021, p = 0.021.
T15 1461-1473 Sentence denotes CONCLUSIONS:
T16 1474-1646 Sentence denotes Our finding of reduced release of kidney injury biomarkers may indicate the renoprotective effect of RIPC in patients undergoing open surgical lower limb revascularisation.
T17 1647-1707 Sentence denotes The trial is registered with ClinicalTrials.gov NCT02689414.