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PubMed:32038240 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-212 Sentence denotes Anti-Inflammatory Effects of Huangqin Decoction on Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice Through Regulation of the Gut Microbiota and Suppression of the Ras-PI3K-Akt-HIF-1α and NF-κB Pathways.
T2 213-223 Sentence denotes OBJECTIVE:
T3 224-382 Sentence denotes Huangqin decoction (HQD), a classical traditional Chinese medicinal formula, has been commonly used to treat gastrointestinal diseases for thousands of years.
T4 383-526 Sentence denotes We investigated the anti-inflammatory effects and underlying mechanisms of HQD on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC).
T5 527-535 Sentence denotes METHODS:
T6 536-658 Sentence denotes Experimental mice were given 3% DSS, and HQD (2.275, 4.55, and 9.1 g/kg), or mesalazine (ME, 200 mg/kg) orally for 7 days.
T7 659-825 Sentence denotes Body weight loss, disease activity index (DAI), colon length, histology, and levels of inflammatory cytokines were measured to evaluate the effects of HQD on colitis.
T8 826-1019 Sentence denotes The effects of HQD on the Ras-phosphoinositide-3-kinase (PI3K)-Akt-hypoxia inducible factor 1 alpha (HIF-1α) and nuclear factor-kappa B (NF-κB) pathways were evaluated by Western blot analysis.
T9 1020-1118 Sentence denotes In addition, the gut microbiota was characterized using high-throughput Illumina MiSeq sequencing.
T10 1119-1127 Sentence denotes RESULTS:
T11 1128-1325 Sentence denotes The results showed that HQD significantly reduced the body weight loss, ameliorated DAI, restored colon length, and improved the intestinal epithelial cell barrier in mice with DSS-induced colitis.
T12 1326-1434 Sentence denotes The messenger RNA (mRNA) expression levels of inflammatory mediators were decreased following HQD treatment.
T13 1435-1527 Sentence denotes Furthermore, the Ras-PI3K-Akt-HIF-1α and NF-κB pathways were significantly inhibited by HQD.
T14 1528-1605 Sentence denotes Finally, treatment with HQD resulted in recovery of gut microbiota diversity.
T15 1606-1755 Sentence denotes CONCLUSIONS: HQD ameliorates DSS-induced colitis through regulation of the gut microbiota, and suppression of Ras-PI3K-Akt-HIF-1α and NF-κB pathways.
T16 1756-1836 Sentence denotes Our results suggested that HQD may be a potential candidate for treatment of UC.
T1 0-212 Sentence denotes Anti-Inflammatory Effects of Huangqin Decoction on Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice Through Regulation of the Gut Microbiota and Suppression of the Ras-PI3K-Akt-HIF-1α and NF-κB Pathways.
T2 213-223 Sentence denotes OBJECTIVE:
T3 224-382 Sentence denotes Huangqin decoction (HQD), a classical traditional Chinese medicinal formula, has been commonly used to treat gastrointestinal diseases for thousands of years.
T4 383-526 Sentence denotes We investigated the anti-inflammatory effects and underlying mechanisms of HQD on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC).
T5 527-535 Sentence denotes METHODS:
T6 536-658 Sentence denotes Experimental mice were given 3% DSS, and HQD (2.275, 4.55, and 9.1 g/kg), or mesalazine (ME, 200 mg/kg) orally for 7 days.
T7 659-825 Sentence denotes Body weight loss, disease activity index (DAI), colon length, histology, and levels of inflammatory cytokines were measured to evaluate the effects of HQD on colitis.
T8 826-1019 Sentence denotes The effects of HQD on the Ras-phosphoinositide-3-kinase (PI3K)-Akt-hypoxia inducible factor 1 alpha (HIF-1α) and nuclear factor-kappa B (NF-κB) pathways were evaluated by Western blot analysis.
T9 1020-1118 Sentence denotes In addition, the gut microbiota was characterized using high-throughput Illumina MiSeq sequencing.
T10 1119-1127 Sentence denotes RESULTS:
T11 1128-1325 Sentence denotes The results showed that HQD significantly reduced the body weight loss, ameliorated DAI, restored colon length, and improved the intestinal epithelial cell barrier in mice with DSS-induced colitis.
T12 1326-1434 Sentence denotes The messenger RNA (mRNA) expression levels of inflammatory mediators were decreased following HQD treatment.
T13 1435-1527 Sentence denotes Furthermore, the Ras-PI3K-Akt-HIF-1α and NF-κB pathways were significantly inhibited by HQD.
T14 1528-1605 Sentence denotes Finally, treatment with HQD resulted in recovery of gut microbiota diversity.
T15 1606-1755 Sentence denotes CONCLUSIONS: HQD ameliorates DSS-induced colitis through regulation of the gut microbiota, and suppression of Ras-PI3K-Akt-HIF-1α and NF-κB pathways.
T16 1756-1836 Sentence denotes Our results suggested that HQD may be a potential candidate for treatment of UC.