PubMed:3203384 JSONTXT

{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":142,"end":152},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"trans-activation of RNA polymerase II and III promoters by SV40 small t antigen.\nA biochemical role for SV40 small t antigen (t) in the viral infectious cycle that would explain the strong conservation of t structure among papovaviruses and its role as a helper of SV40 large T antigen function in the viral transforming process is not understood. Here, we report an intracellular biochemical function of the protein--the capacity to trans-activate selected RNA polymerase II and III-requiring promoters. Since t has failed in the past to bind to DNA and did not stimulate all polymerase II-requiring promoters tested, it likely trans-activates, at least in part, by modifying the activity of selected transcription factors."}

{"project":"Glycan-GlyCosmos","denotations":[{"id":"T1","span":{"begin":276,"end":285},"obj":"Glycan"}],"attributes":[{"id":"A1","pred":"glycosmos_id","subj":"T1","obj":"https://glycosmos.org/glycans/show/G00031MO"},{"id":"A2","pred":"image","subj":"T1","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO"}],"text":"trans-activation of RNA polymerase II and III promoters by SV40 small t antigen.\nA biochemical role for SV40 small t antigen (t) in the viral infectious cycle that would explain the strong conservation of t structure among papovaviruses and its role as a helper of SV40 large T antigen function in the viral transforming process is not understood. Here, we report an intracellular biochemical function of the protein--the capacity to trans-activate selected RNA polymerase II and III-requiring promoters. Since t has failed in the past to bind to DNA and did not stimulate all polymerase II-requiring promoters tested, it likely trans-activates, at least in part, by modifying the activity of selected transcription factors."}

{"project":"GlyCosmos-GlycoEpitope","denotations":[{"id":"T1","span":{"begin":70,"end":79},"obj":"http://purl.jp/bio/12/glyco/glycan#Glycan_epitope"},{"id":"T2","span":{"begin":115,"end":124},"obj":"http://purl.jp/bio/12/glyco/glycan#Glycan_epitope"},{"id":"T3","span":{"begin":276,"end":285},"obj":"http://purl.jp/bio/12/glyco/glycan#Glycan_epitope"}],"attributes":[{"id":"A1","pred":"glycoepitope_id","subj":"T1","obj":"http://www.glycoepitope.jp/epitopes/EP0020"},{"id":"A2","pred":"glycoepitope_id","subj":"T2","obj":"http://www.glycoepitope.jp/epitopes/EP0020"},{"id":"A3","pred":"glycoepitope_id","subj":"T3","obj":"http://www.glycoepitope.jp/epitopes/EP0020"}],"text":"trans-activation of RNA polymerase II and III promoters by SV40 small t antigen.\nA biochemical role for SV40 small t antigen (t) in the viral infectious cycle that would explain the strong conservation of t structure among papovaviruses and its role as a helper of SV40 large T antigen function in the viral transforming process is not understood. Here, we report an intracellular biochemical function of the protein--the capacity to trans-activate selected RNA polymerase II and III-requiring promoters. Since t has failed in the past to bind to DNA and did not stimulate all polymerase II-requiring promoters tested, it likely trans-activates, at least in part, by modifying the activity of selected transcription factors."}

{"project":"GlyCosmos15-UBERON","denotations":[{"id":"T1","span":{"begin":367,"end":380},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/GO_0005622"}],"text":"trans-activation of RNA polymerase II and III promoters by SV40 small t antigen.\nA biochemical role for SV40 small t antigen (t) in the viral infectious cycle that would explain the strong conservation of t structure among papovaviruses and its role as a helper of SV40 large T antigen function in the viral transforming process is not understood. Here, we report an intracellular biochemical function of the protein--the capacity to trans-activate selected RNA polymerase II and III-requiring promoters. Since t has failed in the past to bind to DNA and did not stimulate all polymerase II-requiring promoters tested, it likely trans-activates, at least in part, by modifying the activity of selected transcription factors."}

{"project":"GlyCosmos15-Sentences","blocks":[{"id":"T1","span":{"begin":0,"end":80},"obj":"Sentence"},{"id":"T2","span":{"begin":81,"end":347},"obj":"Sentence"},{"id":"T3","span":{"begin":348,"end":504},"obj":"Sentence"},{"id":"T4","span":{"begin":505,"end":724},"obj":"Sentence"}],"text":"trans-activation of RNA polymerase II and III promoters by SV40 small t antigen.\nA biochemical role for SV40 small t antigen (t) in the viral infectious cycle that would explain the strong conservation of t structure among papovaviruses and its role as a helper of SV40 large T antigen function in the viral transforming process is not understood. Here, we report an intracellular biochemical function of the protein--the capacity to trans-activate selected RNA polymerase II and III-requiring promoters. Since t has failed in the past to bind to DNA and did not stimulate all polymerase II-requiring promoters tested, it likely trans-activates, at least in part, by modifying the activity of selected transcription factors."}

{"project":"GlyCosmos15-GlycoEpitope","denotations":[{"id":"T1","span":{"begin":70,"end":79},"obj":"http://purl.jp/bio/12/glyco/glycan#Glycan_epitope"},{"id":"T2","span":{"begin":115,"end":124},"obj":"http://purl.jp/bio/12/glyco/glycan#Glycan_epitope"},{"id":"T3","span":{"begin":276,"end":285},"obj":"http://purl.jp/bio/12/glyco/glycan#Glycan_epitope"}],"attributes":[{"id":"A1","pred":"glycoepitope_id","subj":"T1","obj":"http://www.glycoepitope.jp/epitopes/EP0020"},{"id":"A2","pred":"glycoepitope_id","subj":"T2","obj":"http://www.glycoepitope.jp/epitopes/EP0020"},{"id":"A3","pred":"glycoepitope_id","subj":"T3","obj":"http://www.glycoepitope.jp/epitopes/EP0020"}],"text":"trans-activation of RNA polymerase II and III promoters by SV40 small t antigen.\nA biochemical role for SV40 small t antigen (t) in the viral infectious cycle that would explain the strong conservation of t structure among papovaviruses and its role as a helper of SV40 large T antigen function in the viral transforming process is not understood. Here, we report an intracellular biochemical function of the protein--the capacity to trans-activate selected RNA polymerase II and III-requiring promoters. Since t has failed in the past to bind to DNA and did not stimulate all polymerase II-requiring promoters tested, it likely trans-activates, at least in part, by modifying the activity of selected transcription factors."}

{"project":"GlyCosmos15-Glycan","denotations":[{"id":"T1","span":{"begin":70,"end":79},"obj":"Glycan"},{"id":"T2","span":{"begin":70,"end":71},"obj":"Glycan"},{"id":"T3","span":{"begin":115,"end":124},"obj":"Glycan"},{"id":"T4","span":{"begin":115,"end":116},"obj":"Glycan"},{"id":"T5","span":{"begin":126,"end":127},"obj":"Glycan"},{"id":"T6","span":{"begin":205,"end":206},"obj":"Glycan"},{"id":"T7","span":{"begin":276,"end":285},"obj":"Glycan"},{"id":"T8","span":{"begin":511,"end":512},"obj":"Glycan"}],"attributes":[{"id":"A1","pred":"glycosmos_id","subj":"T1","obj":"https://glycosmos.org/glycans/show/G00031MO"},{"id":"A9","pred":"image","subj":"T1","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO"},{"id":"A2","pred":"glycosmos_id","subj":"T2","obj":"https://glycosmos.org/glycans/show/G00031MO"},{"id":"A10","pred":"image","subj":"T2","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO"},{"id":"A3","pred":"glycosmos_id","subj":"T3","obj":"https://glycosmos.org/glycans/show/G00031MO"},{"id":"A11","pred":"image","subj":"T3","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO"},{"id":"A4","pred":"glycosmos_id","subj":"T4","obj":"https://glycosmos.org/glycans/show/G00031MO"},{"id":"A12","pred":"image","subj":"T4","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO"},{"id":"A5","pred":"glycosmos_id","subj":"T5","obj":"https://glycosmos.org/glycans/show/G00031MO"},{"id":"A13","pred":"image","subj":"T5","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO"},{"id":"A6","pred":"glycosmos_id","subj":"T6","obj":"https://glycosmos.org/glycans/show/G00031MO"},{"id":"A14","pred":"image","subj":"T6","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO"},{"id":"A7","pred":"glycosmos_id","subj":"T7","obj":"https://glycosmos.org/glycans/show/G00031MO"},{"id":"A15","pred":"image","subj":"T7","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO"},{"id":"A8","pred":"glycosmos_id","subj":"T8","obj":"https://glycosmos.org/glycans/show/G00031MO"},{"id":"A16","pred":"image","subj":"T8","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO"}],"text":"trans-activation of RNA polymerase II and III promoters by SV40 small t antigen.\nA biochemical role for SV40 small t antigen (t) in the viral infectious cycle that would explain the strong conservation of t structure among papovaviruses and its role as a helper of SV40 large T antigen function in the viral transforming process is not understood. Here, we report an intracellular biochemical function of the protein--the capacity to trans-activate selected RNA polymerase II and III-requiring promoters. Since t has failed in the past to bind to DNA and did not stimulate all polymerase II-requiring promoters tested, it likely trans-activates, at least in part, by modifying the activity of selected transcription factors."}

{"project":"GlyCosmos15-MONDO","denotations":[{"id":"T1","span":{"begin":142,"end":152},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"MONDO:0005550"}],"namespaces":[{"prefix":"MONDO","uri":"http://purl.obolibrary.org/obo/MONDO_"}],"text":"trans-activation of RNA polymerase II and III promoters by SV40 small t antigen.\nA biochemical role for SV40 small t antigen (t) in the viral infectious cycle that would explain the strong conservation of t structure among papovaviruses and its role as a helper of SV40 large T antigen function in the viral transforming process is not understood. Here, we report an intracellular biochemical function of the protein--the capacity to trans-activate selected RNA polymerase II and III-requiring promoters. Since t has failed in the past to bind to DNA and did not stimulate all polymerase II-requiring promoters tested, it likely trans-activates, at least in part, by modifying the activity of selected transcription factors."}

{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":367,"end":380},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/GO_0005622"}],"text":"trans-activation of RNA polymerase II and III promoters by SV40 small t antigen.\nA biochemical role for SV40 small t antigen (t) in the viral infectious cycle that would explain the strong conservation of t structure among papovaviruses and its role as a helper of SV40 large T antigen function in the viral transforming process is not understood. Here, we report an intracellular biochemical function of the protein--the capacity to trans-activate selected RNA polymerase II and III-requiring promoters. Since t has failed in the past to bind to DNA and did not stimulate all polymerase II-requiring promoters tested, it likely trans-activates, at least in part, by modifying the activity of selected transcription factors."}