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PubMed:31972345 JSONTXT

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Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 6-11 http://purl.obolibrary.org/obo/MAT_0000131 denotes sperm
T2 6-11 http://purl.obolibrary.org/obo/MAT_0000218 denotes sperm
T3 95-100 http://purl.obolibrary.org/obo/MAT_0000131 denotes sperm
T4 95-100 http://purl.obolibrary.org/obo/MAT_0000218 denotes sperm
T5 117-122 http://purl.obolibrary.org/obo/MAT_0000131 denotes sperm
T6 117-122 http://purl.obolibrary.org/obo/MAT_0000218 denotes sperm
T7 196-200 http://purl.obolibrary.org/obo/MAT_0000029 denotes male
T8 271-276 http://purl.obolibrary.org/obo/MAT_0000131 denotes sperm
T9 271-276 http://purl.obolibrary.org/obo/MAT_0000218 denotes sperm
T10 372-377 http://purl.obolibrary.org/obo/MAT_0000131 denotes sperm
T11 372-377 http://purl.obolibrary.org/obo/MAT_0000218 denotes sperm
T12 439-444 http://purl.obolibrary.org/obo/MAT_0000131 denotes sperm
T13 439-444 http://purl.obolibrary.org/obo/MAT_0000218 denotes sperm
T14 712-717 http://purl.obolibrary.org/obo/MAT_0000131 denotes sperm
T15 712-717 http://purl.obolibrary.org/obo/MAT_0000218 denotes sperm
T16 898-903 http://purl.obolibrary.org/obo/MAT_0000131 denotes sperm
T17 898-903 http://purl.obolibrary.org/obo/MAT_0000218 denotes sperm
T18 1033-1038 http://purl.obolibrary.org/obo/MAT_0000131 denotes sperm
T19 1033-1038 http://purl.obolibrary.org/obo/MAT_0000218 denotes sperm
T20 1444-1449 http://purl.obolibrary.org/obo/MAT_0000131 denotes sperm
T21 1444-1449 http://purl.obolibrary.org/obo/MAT_0000218 denotes sperm
T22 1516-1521 http://purl.obolibrary.org/obo/MAT_0000131 denotes sperm
T23 1516-1521 http://purl.obolibrary.org/obo/MAT_0000218 denotes sperm
T24 1633-1638 http://purl.obolibrary.org/obo/MAT_0000131 denotes sperm
T25 1633-1638 http://purl.obolibrary.org/obo/MAT_0000218 denotes sperm
T26 1735-1740 http://purl.obolibrary.org/obo/MAT_0000131 denotes sperm
T27 1735-1740 http://purl.obolibrary.org/obo/MAT_0000218 denotes sperm
T28 1770-1775 http://purl.obolibrary.org/obo/MAT_0000131 denotes sperm
T29 1770-1775 http://purl.obolibrary.org/obo/MAT_0000218 denotes sperm
T30 1973-1978 http://purl.obolibrary.org/obo/MAT_0000131 denotes sperm
T31 1973-1978 http://purl.obolibrary.org/obo/MAT_0000218 denotes sperm
T32 2067-2072 http://purl.obolibrary.org/obo/MAT_0000131 denotes sperm
T33 2067-2072 http://purl.obolibrary.org/obo/MAT_0000218 denotes sperm
T34 2265-2270 http://purl.obolibrary.org/obo/MAT_0000131 denotes sperm
T35 2265-2270 http://purl.obolibrary.org/obo/MAT_0000218 denotes sperm
T36 2413-2418 http://purl.obolibrary.org/obo/MAT_0000131 denotes sperm
T37 2413-2418 http://purl.obolibrary.org/obo/MAT_0000218 denotes sperm
T38 2481-2486 http://purl.obolibrary.org/obo/MAT_0000131 denotes sperm
T39 2481-2486 http://purl.obolibrary.org/obo/MAT_0000218 denotes sperm
T40 2542-2547 http://purl.obolibrary.org/obo/MAT_0000131 denotes sperm
T41 2542-2547 http://purl.obolibrary.org/obo/MAT_0000218 denotes sperm
T42 2681-2686 http://purl.obolibrary.org/obo/MAT_0000131 denotes sperm
T43 2681-2686 http://purl.obolibrary.org/obo/MAT_0000218 denotes sperm

sentences

Id Subject Object Predicate Lexical cue
T1 0-110 Sentence denotes Human sperm phosphoproteome reveals differential phosphoprotein signatures that regulate human sperm motility.
T2 111-234 Sentence denotes Human sperm motility is essential for fertilization and among pathologies underlying male infertility is asthenozoospermia.
T3 235-315 Sentence denotes Nevertheless, mechanisms regulating sperm motility are not completely unraveled.
T4 316-543 Sentence denotes This work investigates phosphoproteins underlying human sperm motility by using differential phosphoproteomic in two human sperm subpopulations: high (HM) and low (LM) motility, obtained by centrifugation in a density gradient.
T5 544-727 Sentence denotes Phosphoproteomics (HPLC-MS/MS triple TOF), comparing human LM and HM phosphoproteomes, identified 210 phosphopeptides with different abundance that correspond with 119 sperm proteins.
T6 728-955 Sentence denotes Analysis showed that 40% of phosphoproteins in LM spermatozoa are involved in metabolism, (catabolism, protein transport, lipid biosynthesis), 25% in spermatogenesis and sperm function, 8% in immune system and 6% in DNA repair.
T7 956-1100 Sentence denotes In HM spermatozoa, 48% of phosphoproteins are related to spermatogenesis and sperm function (motility), whereas 8% are associated to metabolism.
T8 1101-1175 Sentence denotes GSK3α resulted one of the most abundant phosphoproteins in HM spermatozoa.
T9 1176-1254 Sentence denotes Western blot confirmed that GSK3α phosphorylation is higher in HM spermatozoa.
T10 1255-1612 Sentence denotes Summarizing, this study i) identified phosphoproteins in two human spermatozoa populations, ii) supports that human spermatozoa rely in protein phosphorylation, such as GSK3 α, to regulate sperm motility, iv) raises the challenge of using some identified human sperm phosphorylated proteins (GSK3α) as targets to develop into clinically relevant biomarkers.
T11 1613-1626 Sentence denotes SIGNIFICANCE:
T12 1627-1898 Sentence denotes Human sperm phosphoproteome analyzed by nano HPLC-MS/MS triple TOF identifies the differential abundance of sperm phosphoproteins in two human sperm populations exhibiting high motility (HM) and/or low motility (LM) that were isolated from normozoospermic healthy donors.
T13 1899-2143 Sentence denotes Majority of human phosphoproteins found in LM spermatozoa are involved in sperm metabolism (40%), whereas those in HM spermatozoa are associated to spermatogenesis and sperm function, as motility (48%), and only 8% are associated to metabolism.
T14 2144-2320 Sentence denotes One of the most abundant phosphoproteins found in HM spermatozoa is GSK3α, kinase directly involved in the regulation of sperm motility that was also validated by western blot.
T15 2321-2564 Sentence denotes The biological relevance of this study is based in the fact that supports that mature human sperm cells rely in protein phosphorylation to efficiently regulate sperm motility and allows identifying those regulatory human sperm phosphoproteins.
T16 2565-2844 Sentence denotes This work will clearly impacts the human reproductive field as it raises the challenge of consider identified human sperm phosphoproteins, such as GSK3α, as potential biological targets to develop into relevant biomarkers for the human clinic or assisted reproductive technology.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 0-5 OrganismTaxon denotes Human NCBItxid:9606
T2 89-94 OrganismTaxon denotes human NCBItxid:9606
T3 111-116 OrganismTaxon denotes Human NCBItxid:9606
T4 366-371 OrganismTaxon denotes human NCBItxid:9606
T5 433-438 OrganismTaxon denotes human NCBItxid:9606
T6 597-602 OrganismTaxon denotes human NCBItxid:9606
T7 1316-1321 OrganismTaxon denotes human NCBItxid:9606
T8 1365-1370 OrganismTaxon denotes human NCBItxid:9606
T9 1510-1515 OrganismTaxon denotes human NCBItxid:9606
T10 1627-1632 OrganismTaxon denotes Human NCBItxid:9606
T11 1764-1769 OrganismTaxon denotes human NCBItxid:9606
T12 1911-1916 OrganismTaxon denotes human NCBItxid:9606
T13 2407-2412 OrganismTaxon denotes human NCBItxid:9606
T14 2536-2541 OrganismTaxon denotes human NCBItxid:9606
T15 2600-2605 OrganismTaxon denotes human NCBItxid:9606
T16 2675-2680 OrganismTaxon denotes human NCBItxid:9606
T17 2795-2800 OrganismTaxon denotes human NCBItxid:9606

GlyCosmos6-CLO

Id Subject Object Predicate Lexical cue
T1 480-482 http://purl.obolibrary.org/obo/CLO_0007336 denotes LM
T2 603-605 http://purl.obolibrary.org/obo/CLO_0007336 denotes LM
T3 775-777 http://purl.obolibrary.org/obo/CLO_0007336 denotes LM
T4 1839-1841 http://purl.obolibrary.org/obo/CLO_0007336 denotes LM
T5 1942-1944 http://purl.obolibrary.org/obo/CLO_0007336 denotes LM
T6 2419-2424 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 196-212 Disease denotes male infertility http://purl.obolibrary.org/obo/MONDO_0005372